LOCUS       NM_001106153             560 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit A2
            (Ndufa2), mRNA.
ACCESSION   NM_001106153 XM_001064098 XM_214570
VERSION     NM_001106153.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 560)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 560)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   3  (bases 1 to 560)
  AUTHORS   Armand-Ugon,M., Ansoleaga,B., Berjaoui,S. and Ferrer,I.
  TITLE     Reduced Mitochondrial Activity is Early and Steady in the
            Entorhinal Cortex but it is Mainly Unmodified in the Frontal Cortex
            in Alzheimer's Disease
  JOURNAL   Curr Alzheimer Res 14 (12), 1327-1334 (2017)
   PUBMED   28474567
REFERENCE   4  (bases 1 to 560)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 560)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   6  (bases 1 to 560)
  AUTHORS   Vogel,R.O., Dieteren,C.E., van den Heuvel,L.P., Willems,P.H.,
            Smeitink,J.A., Koopman,W.J. and Nijtmans,L.G.
  TITLE     Identification of mitochondrial complex I assembly intermediates by
            tracing tagged NDUFS3 demonstrates the entry point of mitochondrial
            subunits
  JOURNAL   J Biol Chem 282 (10), 7582-7590 (2007)
   PUBMED   17209039
REFERENCE   7  (bases 1 to 560)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 560)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001064098.1, XM_214570.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE114096.1, CF978085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..560
                     /gene="Ndufa2"
                     /note="NADH:ubiquinone oxidoreductase subunit A2"
                     /db_xref="GeneID:291660"
                     /db_xref="RGD:1309997"
     exon            1..124
                     /gene="Ndufa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..323
                     /gene="Ndufa2"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase (ubiquinone) 1 alpha subcomplex,
                     2"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 2"
                     /protein_id="NP_001099623.1"
                     /db_xref="GeneID:291660"
                     /db_xref="RGD:1309997"
                     /translation="MAAASRVVGAKQVLREIRIHLCQRSPGSQGVRDFIQQRYVELKK
                     AHPDLPILIRECSEVQPKLWARYAFGQEKNVSLNNLSAAEVTKAMENVLSGKA"
     exon            125..231
                     /gene="Ndufa2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..560
                     /gene="Ndufa2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgattggg tgctcctttg ctagcaaaga tggcggccgc aagccgagta gtcggtgcaa
       61 agcaggtact gcgtgagatt cgcattcact tatgccagcg ttccccaggc agccagggtg
      121 tgagagattt catccagcaa cggtacgtgg agctgaagaa ggcgcacccc gacctgccca
      181 ttctaatccg cgaatgttca gaggtgcagc ccaagctctg ggcccgttat gcttttggcc
      241 aagagaagaa tgtgtctctg aacaatctga gtgctgctga ggtgaccaaa gccatggaga
      301 atgtgctaag tggcaaagca tgaagtgtct ccactgagga ctgaacaagc ccaccagaac
      361 ctactggact ggagacaatg tggggaaatg tgttcttttg gttcttataa agcttacgct
      421 gtacagtgtt gcttcagaat gttctcctca ttaccttttc cctcttactg cgcaaacact
      481 gaggcaaagt agctttatat aaaaatacta ttttatttct catcaataaa ccccagctac
      541 ccgctgggat gtcgcatgtc
//
