LOCUS       NM_001106781             597 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit A12
            (Ndufa12), mRNA.
ACCESSION   NM_001106781 XM_001080378 XM_216880
VERSION     NM_001106781.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 597)
  AUTHORS   Guo R, Zong S, Wu M, Gu J and Yang M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 597)
  AUTHORS   Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley
            MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A and
            Ryan MT.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 597)
  AUTHORS   Wang Z, Fan M, Candas D, Zhang TQ, Qin L, Eldridge A,
            Wachsmann-Hogiu S, Ahmed KM, Chromy BA, Nantajit D, Duru N, He F,
            Chen M, Finkel T, Weinstein LS and Li JJ.
  TITLE     Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle
            G2/M progression
  JOURNAL   Dev Cell 29 (2), 217-232 (2014)
   PUBMED   24746669
REFERENCE   4  (bases 1 to 597)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 597)
  AUTHORS   Murray J, Taylor SW, Zhang B, Ghosh SS and Capaldi RA.
  TITLE     Oxidative damage to mitochondrial complex I due to peroxynitrite:
            identification of reactive tyrosines by mass spectrometry
  JOURNAL   J Biol Chem 278 (39), 37223-37230 (2003)
   PUBMED   12857734
REFERENCE   6  (bases 1 to 597)
  AUTHORS   Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF,
            Ghosh SS and Capaldi RA.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   7  (bases 1 to 597)
  AUTHORS   Xiao HS, Huang QH, Zhang FX, Bao L, Lu YJ, Guo C, Yang L, Huang WJ,
            Fu G, Xu SH, Cheng XP, Yan Q, Zhu ZD, Zhang X, Chen Z, Han ZG and
            Zhang X.
  TITLE     Identification of gene expression profile of dorsal root ganglion
            in the rat peripheral axotomy model of neuropathic pain
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8360-8365 (2002)
   PUBMED   12060780
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ205274.1, BF555697.1 and BG671355.1.
            
            On Jan 10, 2008 this sequence version replaced NM_001106781.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224477.1, DV724680.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BQ205274.1         536-567             c
            33-149              BF555697.1         8-124
            150-597             BG671355.1         1-448
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..597
                     /gene="Ndufa12"
                     /gene_synonym="RGD1311462"
                     /note="NADH:ubiquinone oxidoreductase subunit A12"
                     /db_xref="GeneID:299739"
                     /db_xref="RGD:1311462"
     exon            1..108
                     /gene="Ndufa12"
                     /gene_synonym="RGD1311462"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..460
                     /gene="Ndufa12"
                     /gene_synonym="RGD1311462"
                     /note="NADH dehydrogenase (ubiquinone) 1 alpha subcomplex,
                     12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
                     subunit 12-like"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 12"
                     /protein_id="NP_001100251.2"
                     /db_xref="GeneID:299739"
                     /db_xref="RGD:1311462"
                     /translation="MEQLRVLKRGLQQVTGHGGLRGLLRVFFRANDIRLGTLVGEDKY
                     GNKYYEDNKQFFGRHRWVIYTTEMNGKNTFWDVDGSMVPPEWHRWLHCMTDDPPTTKP
                     LTARKFIWTNHKFNVSATPEQYVPYSTTRKKIQEWVPPSTPYK"
     exon            109..191
                     /gene="Ndufa12"
                     /gene_synonym="RGD1311462"
                     /inference="alignment:Splign:2.1.0"
     exon            192..279
                     /gene="Ndufa12"
                     /gene_synonym="RGD1311462"
                     /inference="alignment:Splign:2.1.0"
     exon            280..550
                     /gene="Ndufa12"
                     /gene_synonym="RGD1311462"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcgggcc acgcagttca gaatggagca actgcgggtc ctgaagcgcg ggctgcagca
       61 ggtcaccggc cacggcggcc tgcggggcct cctacgggtt ttcttcaggg caaatgatat
      121 aaggctcggt accttggtgg gggaagacaa atacggaaac aaatactacg aagacaacaa
      181 gcagtttttt ggccgtcacc gatgggtcat atacaccacc gaaatgaatg gcaaaaacac
      241 attctgggat gtggatggaa gcatggtgcc tcctgaatgg caccgctggc ttcactgcat
      301 gactgacgac cctccaacaa caaaaccact gactgctcgt aagttcattt ggacaaacca
      361 taagttcaat gtgagtgcta ctccagagca atacgtccct tactccacca ccaggaagaa
      421 gatccaagaa tgggtgccac cctcgacacc ttacaagtga caacagtgaa cgctgttcct
      481 agcacttccg ggctagttca ggactgtcct tagctgacca tgagcttgat taaaattgct
      541 tgacccagca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
