LOCUS       NM_199495               1990 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit A10
            (Ndufa10), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_199495 XM_234089
VERSION     NM_199495.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 1990)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 1990)
  AUTHORS   Huang,L., Jin,X., Xia,L., Wang,X., Yu,Y., Liu,C., Shao,D., Fang,N.
            and Meng,C.
  TITLE     Characterization of mitochondrial NADH dehydrogenase 1alpha
            subcomplex 10 variants in cardiac muscles from normal Wistar rats
            and spontaneously hypertensive rats: Implications in the
            pathogenesis of hypertension
  JOURNAL   Mol Med Rep 13 (1), 961-966 (2016)
   PUBMED   26648553
  REMARK    GeneRIF: ass spectrometric analysis revealed that the replacement
            of an aspartate residue with asparagine at amino acid position 120
            was the biochemical difference between the two Ndufa10 isoforms
REFERENCE   4  (bases 1 to 1990)
  AUTHORS   Morais,V.A., Haddad,D., Craessaerts,K., De Bock,P.J., Swerts,J.,
            Vilain,S., Aerts,L., Overbergh,L., Grunewald,A., Seibler,P.,
            Klein,C., Gevaert,K., Verstreken,P. and De Strooper,B.
  TITLE     PINK1 loss-of-function mutations affect mitochondrial complex I
            activity via NdufA10 ubiquinone uncoupling
  JOURNAL   Science 344 (6180), 203-207 (2014)
   PUBMED   24652937
REFERENCE   5  (bases 1 to 1990)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   6  (bases 1 to 1990)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1990)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000215.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_199495.4.
            
            On Nov 27, 2020 this sequence version replaced NM_199495.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ209525.1, CF110923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JACYVU010000215.1  26111359-26111492   c
            135-303             JACYVU010000215.1  26108825-26108993   c
            304-519             JACYVU010000215.1  26107858-26108073   c
            520-606             JACYVU010000215.1  26105089-26105175   c
            607-728             JACYVU010000215.1  26102139-26102260   c
            729-808             JACYVU010000215.1  26100812-26100891   c
            809-863             JACYVU010000215.1  26100058-26100112   c
            864-949             JACYVU010000215.1  26098241-26098326   c
            950-1058            JACYVU010000215.1  26090125-26090233   c
            1059-1990           JACYVU010000215.1  26076725-26077656   c
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..1990
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /note="NADH:ubiquinone oxidoreductase subunit A10"
                     /db_xref="GeneID:678759"
                     /db_xref="RGD:727968"
     exon            1..134
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1127
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
                     subunit 10, mitochondrial; CI-42kD; complex I-42kD;
                     NADH-ubiquinone oxidoreductase 42 kDa subunit; NADH
                     dehydrogenase (ubiquinone) 1 alpha subcomplex 10"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 10, mitochondrial precursor"
                     /protein_id="NP_955789.2"
                     /db_xref="GeneID:678759"
                     /db_xref="RGD:727968"
                     /translation="MALRLLRLVPASASARGLAAGAQRVGRIHTSVHCKLRYGLLASI
                     LGDKTTKKLHEYSRVITVDGNICSGKNKLARDIAEQLGMKHYPEAGIQYSSSTTGDGR
                     PLDIEFSGSCSLEKFYDNPKSNDGNSYRLQSWLYASRLLQYSDALEHLLSTGQGVVLE
                     RSIYSDFVFLEAMYNQGFIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVPVSEIQSRI
                     QKKGDPHEMKVTSAYLQDIEDAYKKTFLPKMSEICEVLVYSSWEAEDSTKVVEDIEYL
                     NYNKGPWLKQDDRTFHNLRMLVQDKREVLNYTTVPVYLPEITIGAHQGSRIYDSFREL
                     PGRKYAPGYNADVGDKWIWLK"
     exon            135..303
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     exon            304..519
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     exon            520..606
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     exon            607..728
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     exon            729..808
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     exon            809..863
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     exon            864..949
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1058
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1990
                     /gene="Ndufa10"
                     /gene_synonym="ndufa10l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataggaccct gtcgcgttca cgtccctctg gtccttgagc cggcgcaggc agcgaagcaa
       61 tggccttgag gttgctgaga cttgtcccgg cgtcggcgtc cgcgcgcggc ctcgcggccg
      121 gagcccagcg cgtgggacga attcatacca gtgtgcactg caagctgagg tacgggcttt
      181 tggcttccat tctcggtgat aagacaacca aaaagctgca tgagtacagc cgagtgataa
      241 cagtagatgg caacatatgc tctgggaaaa acaagctcgc aagggacatc gcagagcagc
      301 taggcatgaa gcactatccg gaagcaggga tacagtactc aagcagcacc acgggtgacg
      361 gaaggcccct cgacatagag tttagtggca gctgtagttt agagaaattt tatgacaatc
      421 ccaaaagcaa cgacggcaac agctaccgcc tacagtcctg gctttatgcc agccgcctcc
      481 tgcagtactc agatgccctg gagcacctct tgagcacagg acaaggtgtg gtcttggagc
      541 gttccatcta cagtgacttt gtcttcctgg aggcaatgta caaccagggc ttcatccgaa
      601 agcagtgtgt ggaccactat aatgaaatta agcggcttac tcttccagag tacctgccac
      661 cacatgcagt catctatatc gatgtgcctg tgtcagaaat acagagcagg atccagaaga
      721 aaggagatcc acatgaaatg aaggtcacct ctgcctatct ccaagacatc gaggatgcct
      781 acaagaaaac cttcctccca aaaatgagtg agatatgcga ggtgttggtg tacagttcct
      841 gggaagctga agactcaacc aaggtggtag aggacattga gtaccttaac tacaacaaag
      901 gaccttggct taaacaggat gatcggacct ttcacaacct gcggatgctg gtccaggata
      961 agagagaagt gctgaattac acgaccgtcc cggtttacct cccagaaatc actattggag
     1021 ctcatcaggg tagccggatc tacgacagct tcagagagct gccaggccgc aagtacgccc
     1081 ctgggtacaa tgccgatgtg ggtgacaagt ggatctggct gaagtgaatg gtggcctctg
     1141 cctggctgtg tcacagctac gaagaagtct gctctgccca actctatgaa ctccaaagct
     1201 ttacaagaca acaggaaaaa agcaaatgat caagaaattg ccagaaaaaa gtgatctaac
     1261 aaaaagagtc tgccctatgc ctactcagag tttgaagaat caacttccat tgacaaggtt
     1321 ctggaacctt ctagcgtttg gaatcatctg ggggaaaaca aaacaaagct ggtctgctga
     1381 aagcccagct cccactggaa gccctgtgtc ccagtgctgt ttccttgagc tcttccaact
     1441 tgaagaaata aagccggctc tgtagcccct caccctgtgt ctgcgtggca cacacgtgcc
     1501 tgggggctga ggatgctcag ccctgcgccc cccagccctg ccctgcagtt tgggtcactc
     1561 acacagtgct gaagcgtttt tttttttttt tttttttctg aagcatttgt tcttttaaca
     1621 gcacattaga gcaaaacggg aaagaagaat gaccatagac tagcagaacc tcgtcttaga
     1681 gcaggctcat tcctggccgc cctcggggct ccctgctctt gtctctgaag cacaagctga
     1741 gtatagaatg tgggtacaca tgctcttatc aaacatgagg gtgccatccc aagtggaaag
     1801 cgcagtggcg tctaattgtt cacctgagga ggagtcctta ggaactggtg tcatctgcat
     1861 tgctgttcag gagctgcttt aagttgtctg tcctaagctg caagtctgtg ccgcgaatcc
     1921 tgctgtggct gctccgagca cgtgtaactt acatttaact taattaaaag ttaatgaaat
     1981 ttagcactca
//
