LOCUS       NM_001191849            7542 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus N-deacetylase and N-sulfotransferase 4 (Ndst4),
            mRNA.
ACCESSION   NM_001191849 XM_017590979 XM_342336
VERSION     NM_001191849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7542)
  AUTHORS   Aikawa J, Grobe K, Tsujimoto M and Esko JD.
  TITLE     Multiple isozymes of heparan sulfate/heparin GlcNAc
            N-deacetylase/GlcN N-sulfotransferase. Structure and activity of
            the fourth member, NDST4
  JOURNAL   J Biol Chem 276 (8), 5876-5882 (2001)
   PUBMED   11087757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000079.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001191849.3.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_017590979.2, NM_001191849.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN14984014,
                              SAMN14984024 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               JACYVU010000079.1  886540-886957
            419-1635            JACYVU010000079.1  912104-913320
            1636-1723           JACYVU010000079.1  1040554-1040641
            1724-1878           JACYVU010000079.1  1046678-1046832
            1879-2064           JACYVU010000079.1  1089464-1089649
            2065-2193           JACYVU010000079.1  1092745-1092873
            2194-2376           JACYVU010000079.1  1168904-1169086
            2377-2473           JACYVU010000079.1  1184031-1184127
            2474-2597           JACYVU010000079.1  1194144-1194267
            2598-2772           JACYVU010000079.1  1196122-1196296
            2773-2943           JACYVU010000079.1  1203053-1203223
            2944-3053           JACYVU010000079.1  1204685-1204794
            3054-3156           JACYVU010000079.1  1212177-1212279
            3157-7542           JACYVU010000079.1  1214659-1219044
FEATURES             Location/Qualifiers
     source          1..7542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..7542
                     /gene="Ndst4"
                     /note="N-deacetylase and N-sulfotransferase 4"
                     /db_xref="GeneID:362035"
                     /db_xref="RGD:1306531"
     exon            1..418
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            419..1635
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     CDS             658..3276
                     /gene="Ndst4"
                     /EC_number="2.8.2.8"
                     /note="N-deacetylase/N-sulfotransferase (heparin
                     glucosaminyl) 4; N-deacetylase/N-sulfotransferase (heparan
                     glucosaminyl) 4; N-deacetylase/N-sulfotransferase 4"
                     /codon_start=1
                     /product="bifunctional heparan sulfate
                     N-deacetylase/N-sulfotransferase 4"
                     /protein_id="NP_001178778.1"
                     /db_xref="GeneID:362035"
                     /db_xref="RGD:1306531"
                     /translation="MNLIVKFRRSFRTLIVLLATFCLVSIVISAYFLYSGYKQEMTLV
                     ETTAEAECADIKNLPYRSIELKTIKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESS
                     RFQYQMVIAPGKGDIPPLTDSGKGKYTLIIYENILKYVSMDSWNRELLEKYCIEYSVS
                     IIGFHKANENSLPTTQLKGFPLNLFNNVALKDCSVNPQSPLLHITKGPKVEKGPLPGE
                     DWTIFQYNHSTYQPVLLTELQTEKSLSFLSSQTLYATIIQDLGLHDGIQRVLFGNNLN
                     FWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNVKDVKALLETQNL
                     LRTQVANFTFNLGFSGKFYHTGTEEEDAGDDLLLRSVDEFWWFPHMWSHMQPHLFHNE
                     SSLVEQMILNKEFALEHGIPINLGYAVAPHHSGVYPVHIQLYAAWKKVWGIQVTSTEE
                     YPHLKPARYRKGFIHNNIMVLPRQTCGLFTHTIFYKEYPGGPQELDKSIKGGELFLTI
                     LLNPISIFMTHLSNYGNDRLGLYTFVNLANFVHSWTNLKLQTLPPVQLAHKYFELFPE
                     QKDPLWQNPCDDKRHKDIWSREKTCDHLPKFLVIGPQKTGTTALYLFLLMHPSIVSNL
                     PSPKTFEEVQFFNGNNYHKGIEWYMDFFPTPSNITSDFLFEKSANYFHSEEAPKRAAS
                     LVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALRFNFYEVITTGHWAPPDLKTLQRR
                     CLVPGWYAVHIERWLAYFSTSQLLIIDGQQLRSDPATVMDEVQKFLGVTPHYNYSEAL
                     TFDPQKGFWCQLLEGGKTKCLGKSKGRRYPPMDPESRTFLSSYYRDHNVELSKLLHRL
                     GQPLPSWLRQELQKVR"
     exon            1636..1723
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1878
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2064
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2193
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2376
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2473
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2597
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2772
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2943
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3053
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3156
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..7542
                     /gene="Ndst4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttagcaaga ggcgcagcag cagtggcaga ggcagacagg agcagctggt attccggtga
       61 ttaaatagtt ctcatagcct ttttgctgta cccagtctgc tccctggtgt aatgctcgtg
      121 tccgagaagg aagctgcatt ttaacggtgt gctgaacaga ggtctgaatc attccagctg
      181 gctgcttgtt ttgaaaagga caatgtgtgt ataaataaaa agactgctgg aagggtccag
      241 acaccagcac cggagctgag gagtgctctc agaatcctgt tgaggcagat ggcacggact
      301 gaaagctccg ctaattaacg tggagtcaag taaacctgaa ttctggaaat ctcggtttct
      361 aactccggat aaattcaagt tagcaaaaga aaaaatacat attgaaatgc ttctctagat
      421 aatgcttaaa ggactctgca gcagttcttg gtattggaca tagcatctca gctgttgcct
      481 tcctggtctg ctggtctacc agatttgact catttgtgat tccttcgaga atctcccatg
      541 atttgcaatg gttacatgaa tgtttgggaa gggaaactgg taccatctca ctatatgttc
      601 gccatggcac attagggaaa gaagccagaa aaggctccca acgcattgat ttttaaaatg
      661 aatcttattg taaagtttcg gagaagcttt cgaacactga ttgttctctt agctaccttt
      721 tgtttggtga gcatcgtcat ttctgcctac ttcctgtact ctggctacaa acaggaaatg
      781 acccttgtcg aaactactgc agaagcagag tgcgctgaca tcaaaaacct tccttatcgg
      841 tctatagaac tgaaaaccat caagcctatt gatacatcca aaactgatcc cactgtcctt
      901 ctctttgtag agagccagta ttcgcaactt ggtcaagata ttatagcaat cttggagtcc
      961 agccggtttc agtaccagat ggtcattgct ccaggcaagg gagacatacc tcctcttacc
     1021 gatagtggca aggggaagta cacattgatt atttacgaaa acattttgaa gtacgtcagc
     1081 atggactcat ggaaccggga gcttttagaa aaatactgta tagaatacag tgttagcatt
     1141 attggttttc ataaagccaa tgagaacagc ttgccgacta cacaactgaa agggtttcct
     1201 ttgaacttat tcaataatgt agctctgaag gactgctctg tgaaccccca gtctcctctg
     1261 cttcatatta ccaaaggccc caaagttgaa aagggacctc ttcctgggga agactggaca
     1321 attttccaat ataaccattc tacctaccag ccagtgcttt taactgagtt acaaacagaa
     1381 aagtccctct ctttcttgtc cagccaaaca ctctatgcga caataattca ggatctgggg
     1441 cttcatgatg ggatccagcg agttcttttt ggtaacaatt tgaacttttg gttgcacaag
     1501 ctcattttca tagacgccat ctctttcttg tcgggcaaga ggctgacact atccttggac
     1561 aggtacatcc ttgtggacat tgatgacata tttgtgggga aggagggcac aaggatgaat
     1621 gtcaaagatg tgaaggcatt actagagact caaaatttac tgcgcactca ggttgcaaat
     1681 tttaccttca accttggatt ttcagggaag ttttaccaca cagggactga agaagaagat
     1741 gcaggggatg accttctgct gaggtctgtg gatgagttct ggtggtttcc tcatatgtgg
     1801 agtcacatgc agccccacct gttccacaat gagtcttctt tagtggaaca gatgattctt
     1861 aacaaagaat ttgccctgga acatggaatt ccgatcaacc tgggctatgc agtggcccca
     1921 catcattcag gagtctaccc agtccatatt cagctttatg cagcttggaa gaaggtctgg
     1981 ggtattcagg tcaccagcac tgaagaatat ccacatctaa agcctgcacg gtaccggaag
     2041 ggtttcattc acaacaacat catggtcctc cctcgacaga cctgtgggct gttcacgcat
     2101 actattttct acaaggagta tccaggagga cctcaagaat tggataaaag tatcaaagga
     2161 ggtgaacttt tcctcacaat tcttctaaat ccaatcagca ttttcatgac gcatctgtct
     2221 aactacggca atgaccgcct cggcttatac acctttgtga acttggccaa ctttgtgcac
     2281 agctggacca acttgaaact gcagaccctg ccaccagtgc aactggccca taagtacttc
     2341 gaactcttcc ctgagcagaa agaccctctc tggcagaatc catgtgatga taaacgacac
     2401 aaggacatct ggtccaggga gaaaacttgt gatcatttac ccaaattcct tgtgattggg
     2461 ccacagaaaa caggaacaac cgcgctttat ttatttcttc ttatgcaccc ttccatcgtc
     2521 agcaatctcc ctagcccgaa aaccttcgaa gaagttcaat tttttaacgg caacaactat
     2581 cacaagggaa ttgagtggta tatggacttc tttcccactc cttccaacat taccagtgat
     2641 ttcctgtttg aaaagagtgc taactacttc cactcagaag aggctcccaa gagagccgcg
     2701 tctcttgttc ccaaggccaa gatcatcact atcctcatag acccctcaga cagggcgtat
     2761 tcctggtacc agcaccaacg atctcatgaa gatccggctg ccctgaggtt caatttctat
     2821 gaagttatca cgacaggaca ctgggcccct cctgatttaa aaacattgca gaggcgatgt
     2881 ctggtgcctg ggtggtatgc agtacatata gaaagatggc tggcctactt ttctacttcc
     2941 cagttgctaa ttattgatgg acaacagctg agatctgacc cagcaacggt gatggatgaa
     3001 gtccagaagt ttctaggagt tacacctcat tataattact ctgaggcact gacgtttgat
     3061 cctcaaaaag gcttttggtg tcaactactg gaaggaggga aaaccaaatg tctcgggaag
     3121 agcaaaggac ggaggtaccc acccatggat ccagagtcca gaactttcct ctccagttac
     3181 taccgcgacc acaacgtgga gctctcgaag ctgctgcaca ggttggggca gcctctgccc
     3241 tcgtggctaa gacaggagct gcagaaagtg agatagcgcc ctggaggagc acatgacact
     3301 gcgtcatcat taaggagaaa aaggaatcca tgcctttccc tacacgcgtg actgattgcc
     3361 aggagaggac tatgaataaa aatccccatc gatgtttttc atcaaatgaa gacatatatg
     3421 cacgcattgg caattattag cattattctt tacttaagga ttttggaaaa taaaatgtgg
     3481 ggtttgcggc aatatccagt gtctaatctg gggatcacca cacacagctc acttcctctg
     3541 ttatccagat ttcaggtcac caattcacga atgctcgact gtatgcaaat taccagttta
     3601 aacttccagg aaaagataag gactaaagag tctaaaaatg aattcaggtg gaacccagtg
     3661 tttgaatgaa gggctaatgt ttctaagcac cgtttatcag ttggtccagc ttctccttgc
     3721 gagaggggct ccactttcgc tgagcatcct ctgtcaacac aaggacatgc caccctcaga
     3781 aaactcctgc acggtctctg gagagcccca ataaaacggg agagtgtgat tctgaatgta
     3841 gtaccctaga aagtgagggc catctttaat gggcccatga tcttgctaca ttatcagttt
     3901 aggttttcct accttggcag tgattgagca tttatacata ttttgttcac tcttctaaat
     3961 agggaggaaa aaaacttgat ttactagaag tgtaaacacc tagatgtatt tgcaggtcta
     4021 aataggcatg gcgccttctc tgtaagaaat atgtccatct ctttgaagca tgatgtttta
     4081 tgtctgccac tgcactttct atggtaaagt tttgctgtct atgtttaaaa acatttaaaa
     4141 cttaccttat acttcaaact tacctatttg aacatcacca attctctcta acttgaactc
     4201 aatttcatag acatgaaact cacgagttca ttttaaggca agaagtgtca ttttgttttg
     4261 agttacaagt tcctatagta tttgaaggct atgtaagcca tgttggttgg aacttcatcc
     4321 tctttgtcaa cgatgagctg gaaaagctta atttatcttt tcagtgatac atgaagataa
     4381 atttactaga acaggcaacc aaggtgatgg cgagaacatt acccacaaat ctccctcctc
     4441 tggaacagtt tttctagagg ctgtaaataa tagcatcatt tattctcact ttaattcaat
     4501 aacaaacatg tagtttttat tttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     4561 tgtgtgtgag agagagagag agagagagag agagagagag agagagagag agatgaatta
     4621 gacaaacaaa tccaatttgg ttattccaaa agagcattgg tgtctcttta tacattgaaa
     4681 atcaacttgt catctatatt tcactatgat ttttggttat tttctggttt ttcttagaac
     4741 tcctgtctaa aggctcttga tctttatcag aaaaatgttt ctttgtcatc tttaatggta
     4801 taaatcacaa taatttccca gtttcatttt tggctgtggg acatagagtc tcacccttat
     4861 tacttatata aaagtgttat acgttctatt aaaatggtga aaaagtaacc atggtgatat
     4921 acgtaaacca ctatcattta ttcaccgttg ccctcccagt tctactatat atctgggtca
     4981 gcctgccctc aattgtgcaa tcttcctgcc ttcccctcta ccgcactggg actgcacatg
     5041 ttcaaggcta ggcccagctc taattattat tttattgacc caaagaaaaa aatcttcttt
     5101 acaggggatt aaaatggtaa ttatagaatg aggacatttt catatcaaat aatatcaata
     5161 tcaatatcaa tataactcaa gaacatccaa ctcatcacca catttagcaa tgacatgaat
     5221 ttttctgcat ttttcacatt ttactaatga atccatatcg gttacctacc tacctatacc
     5281 tgaaagcaaa atgtcatccc aacttaacca ctctcttttt ttctgcctgg ttattcgaat
     5341 cattacatgt atttttcttg ctatctttga taatgaaatg agcaactgta tataattatt
     5401 aacaagattt tatctaaaag ttagaagtaa cctagaatat gaaactctgc attctagtag
     5461 ttgggaaatc tcagctttaa tattttcctc tttaatgatt tctttccaca tcagtaatgt
     5521 cgtctcagaa tttaatagca taattcttta gaatttcaaa ttacaccttc agttctaaga
     5581 gacatacatt tatttaaata ttagaatatc ttttctatcc tgacgcatac tgacatggtc
     5641 tcttcatgcc tttccagact gttggagccc tgcggaacat acaatatacc tgtcaactac
     5701 ttcattttgt taactggaaa aatagaattt gtttcagata ccaaatccta aaagttatat
     5761 tatgaaaatt catctaaaat aaaatttaga ttccatttaa taatgaccaa aacacaattt
     5821 aaaaaaaaaa acatgaagaa cagtattact ggttttgtac atacacacac acacacacac
     5881 acacacacac acacacacac gcagagagag agagacagag agagacagag agagagagag
     5941 agacagagag acgtctatgt ttttgtgcct aaattttagc aagccctact tacatctagt
     6001 cttgtgctgc tttttaagta ttactgcttt aatgtaacac aaagtaacct atattccaga
     6061 cttattgatt gatctctctt aaattacagg aaacaaggta tttatataga aacaatatta
     6121 aagccttcta tttctggtgg tgaccgaaaa tactttctgc ttgagaaagg cagggagact
     6181 caaaagtagc atgggccaac tgacttcata gagctgactg tctaatctag tagtctattc
     6241 tcattgtttt cttttttcca aaatcaactt tagaaatgca atcctggcag aaaactagac
     6301 atacgcttca aaatgtgcaa acataaaatg tgttgtgtct aagaaacctg aagagctttt
     6361 gatcaagcca gtaattttct ttgtaagcca gtgagacacc ctggataagc aaagagaaaa
     6421 ctgcattgac tgaaatgaaa tccttaaagg tgccgttgtc acaaaagagt aagggactat
     6481 gaccatctct tcttcagaat aaaccctgct gctggtacag ccacaggagt gatgctgttg
     6541 gttcagaagc tggcttttac gtgtcagttg attactcctt ccctggtctt catgattgca
     6601 tatacaattg ctggatgtca agcatcaaat gcaaaccgga aatgggtttt cgaaatcggc
     6661 atcctcaacc cggttccgcc tctcagtagc cgtgtggcct tagataattt gtggaacttc
     6721 cctgagccac agtcttgttt ttattttttt tttcttactc tgtacagtaa agacaataaa
     6781 agaattcctg tgaggttatt ataacctatt actaaaagta tgtttgcata acagcacaat
     6841 ggctgaaata gttgtgctta aatatattag tcctaaaaat aatatataac taatcatggc
     6901 tttcttctct tccatcaaat aggagtgtgt gttttctact actgttaata atgagacgtg
     6961 tttaataaaa tatgtaattg tatttggtca aaggagagat ggtcttccta ttcactaccc
     7021 aagagtggat tctgtgctgc tcgctgccct gctctggcga tgataatcag gaacgaggta
     7081 gcacctactt tgctcagatg gcctttcctc ctcccggtga cacctttgta tttactcact
     7141 ggtagttctg tcctttctgt ctctctctgt aattcttttc tagcccagtg gatacattac
     7201 caaaaaatgt ctgatggaga ccttgcgttt cctcaacaaa tgaggggttt aatggtggta
     7261 gatgtgaaaa tatattctac gaaggcatgt acaataaaga attaattctg tcaatcttta
     7321 cttagaaatt acaagaaaat gtctgtgggt ctctacaaat ctcaacttcc gccatctaat
     7381 gaaagctttt gttctgtaga tgaaaacact ttattatata tacatttata ttatatattt
     7441 ataaatatca agcgacatta ttttctgtat tcgcccatga caaatatata atacatccca
     7501 ggtaaatcag cagacaaacc attaaaaatg ttgagatatt ta
//
