LOCUS       NM_001191716            2776 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus N-deacetylase and N-sulfotransferase 3 (Ndst3),
            mRNA.
ACCESSION   NM_001191716 XM_227665
VERSION     NM_001191716.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2776)
  AUTHORS   Aikawa,J., Grobe,K., Tsujimoto,M. and Esko,J.D.
  TITLE     Multiple isozymes of heparan sulfate/heparin GlcNAc
            N-deacetylase/GlcN N-sulfotransferase. Structure and activity of
            the fourth member, NDST4
  JOURNAL   J Biol Chem 276 (8), 5876-5882 (2001)
   PUBMED   11087757
REFERENCE   2  (bases 1 to 2776)
  AUTHORS   Aikawa,J. and Esko,J.D.
  TITLE     Molecular cloning and expression of a third member of the heparan
            sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family
  JOURNAL   J Biol Chem 274 (5), 2690-2695 (1999)
   PUBMED   9915799
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_227665.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.13443.1,
                                           SRR26643298.13442.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1134              JAXUCZ010000002.1  214538031-214539164 c
            1135-1222           JAXUCZ010000002.1  214498478-214498565 c
            1223-1377           JAXUCZ010000002.1  214491488-214491642 c
            1378-1563           JAXUCZ010000002.1  214469538-214469723 c
            1564-1692           JAXUCZ010000002.1  214465550-214465678 c
            1693-1875           JAXUCZ010000002.1  214422732-214422914 c
            1876-1972           JAXUCZ010000002.1  214420409-214420505 c
            1973-2096           JAXUCZ010000002.1  214416879-214417002 c
            2097-2271           JAXUCZ010000002.1  214412715-214412889 c
            2272-2442           JAXUCZ010000002.1  214408989-214409159 c
            2443-2552           JAXUCZ010000002.1  214406843-214406952 c
            2553-2655           JAXUCZ010000002.1  214391708-214391810 c
            2656-2776           JAXUCZ010000002.1  214389447-214389567 c
FEATURES             Location/Qualifiers
     source          1..2776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2776
                     /gene="Ndst3"
                     /note="N-deacetylase and N-sulfotransferase 3"
                     /db_xref="GeneID:295430"
                     /db_xref="RGD:1310960"
     exon            1..1134
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2775
                     /gene="Ndst3"
                     /EC_number="2.8.2.8"
                     /note="N-deacetylase/N-sulfotransferase (heparan
                     glucosaminyl) 3; N-deacetylase/N-sulfotransferase 3"
                     /codon_start=1
                     /product="bifunctional heparan sulfate
                     N-deacetylase/N-sulfotransferase 3"
                     /protein_id="NP_001178645.1"
                     /db_xref="GeneID:295430"
                     /db_xref="RGD:1310960"
                     /translation="MSFIMKPHRHFQRTLILLATFCMVSIVISAYYLYSGYKQESEVS
                     GRASVVDCGDLQHIPSRLMEAKRTMISDASRTDPTVLVFVESQYSSLGQDIIMMLESI
                     RFHYHTEIAPGKGDLPALTDNVKGKYILIIYENILKYINMDSWNRSLLDKYCIEYGVG
                     IIGFHKTNEKTLQSFQSQGFPFSISGNLAVKDCCINPHSPLLRVTKSSKLDRGSLPGA
                     DWTVFQINHSTYQPVIFAKVKTPENLSPPISKHAFYATIIHDLGLHDGIQRVLFGNNL
                     NFWLHKLIFIDALSFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQN
                     LLRSQITNFTFNLGFSGKFYHTGTEEEDAGDDCLLGSVDEFWWFPHMWSHMQPHLFHN
                     ESSLIEQMILNKKFALEHGIPTDMGYAVSPHHSGVYPVHVQLYEAWKKVWNIKITSTE
                     EYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPRELDKSIHGGELFFT
                     VVLNPISIFMTHLSNYGNDRLGSYTFVNLANFVQTWTNLRLQTLPPAQLAHKYFELFP
                     DQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLVIGPQKTGTTALCLFLIMHPSILSN
                     SPSPKSFEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYFHSEEAPKRAA
                     SLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVISAGPNAPWELRTLQK
                     RCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTAPATVMDEVQKFLGVSPHYNYSEA
                     LTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRAFLSSYYRDHNVELSKLLHR
                     LGQPLPSWLRQELQKVR"
     exon            1135..1222
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1377
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1563
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1692
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1875
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1972
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2096
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2271
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2442
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2552
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2655
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2776
                     /gene="Ndst3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtttcctg tgagtccaga tatgcgatcc agatgtgctg caatggtgac ataaactgtt
       61 gactgagact aggagcgtgc ctgaaacgcc atccttcctc ctattttttt ttaatggtgc
      121 ttctattgga atagtcaacg aagtgcatcc aacatgagtt ttatcatgaa acctcacaga
      181 cactttcaaa gaacactgat tctgcttgcc accttttgta tggtgagcat cgttatttct
      241 gcttactacc tgtacagcgg ctacaaacag gaaagtgaag tctctgggcg ggcttcggta
      301 gtggactgtg gtgacctcca gcacatacca tccaggctga tggaagcgaa gaggacaatg
      361 atttctgatg cttcaaggac agaccccaca gtcctagtgt ttgtggaaag ccagtactca
      421 tctcttggtc aagacatcat tatgatgcta gaatccatcc ggttccatta tcacacagaa
      481 atcgctcctg gaaaaggcga tcttccagcg cttacagaca atgtgaaagg caaatacatt
      541 ctcattatat atgagaatat tctaaagtat ataaacatgg actcttggaa tagaagcctc
      601 ttagataaat actgtataga gtatggtgtg ggtatcattg gattccacaa aaccaatgag
      661 aaaacccttc agagctttca atcccagggc ttcccctttt ccataagtgg aaacctggca
      721 gtaaaagatt gctgtattaa tcctcactcc cctctccttc gtgtgaccaa atcatccaag
      781 cttgacagag gttctttacc tggagctgac tggacagttt ttcagattaa tcactccacc
      841 taccagccag taatatttgc caaagttaag actccagaaa acctttctcc tcccatctct
      901 aaacatgcat tttatgccac tatcatacat gacctggggc ttcatgacgg gatccagcga
      961 gttctttttg gcaacaactt gaacttttgg ctgcacaagc tcattttcat agatgccctc
     1021 tccttcttgt cagggaaaag actgacactg tccttggaca ggtacatcct tgtggacatt
     1081 gacgacatat ttgtggggaa ggagggcaca aggatgaaca ccaatgatgt caaggccctg
     1141 ctcgacactc agaatctttt gcgctcacaa atcaccaact ttactttcaa ccttggattt
     1201 tcagggaaat tttatcacac gggaaccgaa gaagaagatg caggggatga ctgtctgttg
     1261 gggtctgtgg atgagttctg gtggtttcct cacatgtgga gtcacatgca gccccatctc
     1321 ttccataatg agtcgtcttt aatagagcag atgattctca acaaaaagtt cgccttagag
     1381 catggcatcc ctacggacat gggctacgca gtgtcccctc accattcagg tgtctacccc
     1441 gtacacgttc aactttatga ggcctggaag aaggtttgga atattaaaat caccagcact
     1501 gaagaatatc cacatctgaa accagctagg tatcggagag gcttcatcca caaaaacatc
     1561 atggttctcc cgagacaaac ctgtggactc ttcacccaca cgattttcta caaggagtac
     1621 ccagggggcc ccagggaact ggacaagagt attcatggag gggagctctt cttcactgtg
     1681 gttctcaacc caatcagtat tttcatgacc cacttgtcta actatggaaa cgaccggctg
     1741 ggatcataca catttgtgaa cctagccaat ttcgtgcaga cctggaccaa cctgcgcctt
     1801 cagaccctgc ctccggctca gctggctcac aaatattttg agctctttcc tgatcagaaa
     1861 gaccctctct ggcagaatcc ctgtgatgac aaacgccaca gagacatttg gtctaaagaa
     1921 aaaacctgcg atcgcttacc aaaattcttg gtaataggac cccagaaaac tggtaccact
     1981 gccttgtgtc tgttcctgat tatgcatcct tccatcctta gtaactcccc cagcccaaaa
     2041 tcctttgagg aggtacagtt ctttaataga aataactacc acagggggat tgattggtac
     2101 atggatttct tcccagtccc atctaatgtc accactgact ttctgtttga gaagagtgct
     2161 aattacttcc attcagagga agctcctaag agagctgctt ctctagtccc gaaagccaag
     2221 atcatcacca tactcattga cccgtcagac cgagcgtact cctggtacca gcatcagcga
     2281 tcccacgaag accccgcagc tctgaaattt agcttctatg aagtgatctc tgctgggccc
     2341 aatgcaccct gggaactccg aaccctgcag aagagatgcc tggtccctgg atggtacgcc
     2401 agccacatcg agagatggct tgtttatttc cctccatttc agctgctaat cattgacggg
     2461 cagcagctaa gaactgcccc tgcgacagtg atggatgaag tccagaagtt tctaggagtc
     2521 tcgcctcatt ataattactc cgaagcttta acgtttgatt ctcataaagg cttctggtgt
     2581 cagttgctgg aagaagggaa aacaaaatgt cttgggaaga gtaaaggaag aaaataccca
     2641 ccaatggact cggatagcag agcgtttctg tccagctact accgagacca caacgtggag
     2701 ctctcgaagc tgctgcacag actcgggcag cctctgccct cgtggctgag acaggagctg
     2761 cagaaagtga gatagc
//
