LOCUS       NM_024361               4044 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus N-deacetylase and N-sulfotransferase 1 (Ndst1),
            mRNA.
ACCESSION   NM_024361
VERSION     NM_024361.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4044)
  AUTHORS   Sun,H., Liu,J., Su,Y., Li,F., Zhang,M., Li,J. and Song,M.
  TITLE     The role and mechanism of NDST1/NULP1 regulating right ventricular
            hypertrophy in hypoxic pulmonary hypertension
  JOURNAL   Gen Physiol Biophys 41 (5), 407-416 (2022)
   PUBMED   36222339
  REMARK    GeneRIF: The role and mechanism of NDST1/NULP1 regulating right
            ventricular hypertrophy in hypoxic pulmonary hypertension.
REFERENCE   2  (bases 1 to 4044)
  AUTHORS   Takahashi,T., Friedmacher,F., Zimmer,J. and Puri,P.
  TITLE     Down-regulation of N-deacetylase-N-sulfotransferase-1 signaling in
            the developing diaphragmatic vasculature of nitrofen-induced
            congenital diaphragmatic hernia
  JOURNAL   J Pediatr Surg 52 (6), 1035-1039 (2017)
   PUBMED   28363469
  REMARK    GeneRIF: Relative mRNA expression of Ndst1 and Slit3 was
            significantly decreased in pleuroperitoneal folds, developing
            diaphragms and fully muscularized diaphragms, and endothelial cells
            within the diaphragmatic vasculature of nitrofen-exposed fetuses
            compared to controls.
REFERENCE   3  (bases 1 to 4044)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   4  (bases 1 to 4044)
  AUTHORS   Sheng,J., Liu,R., Xu,Y. and Liu,J.
  TITLE     The dominating role of N-deacetylase/N-sulfotransferase 1 in
            forming domain structures in heparan sulfate
  JOURNAL   J Biol Chem 286 (22), 19768-19776 (2011)
   PUBMED   21454625
  REMARK    GeneRIF: the regulating role of NDST-1 in mapping the sulfation
            patterns of HS.
REFERENCE   5  (bases 1 to 4044)
  AUTHORS   Grobe,K., Inatani,M., Pallerla,S.R., Castagnola,J., Yamaguchi,Y.
            and Esko,J.D.
  TITLE     Cerebral hypoplasia and craniofacial defects in mice lacking
            heparan sulfate Ndst1 gene function
  JOURNAL   Development 132 (16), 3777-3786 (2005)
   PUBMED   16020517
REFERENCE   6  (bases 1 to 4044)
  AUTHORS   Fan,G., Xiao,L., Cheng,L., Wang,X., Sun,B. and Hu,G.
  TITLE     Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia
            and neonatal respiratory distress in mice
  JOURNAL   FEBS Lett 467 (1), 7-11 (2000)
   PUBMED   10664446
REFERENCE   7  (bases 1 to 4044)
  AUTHORS   Aikawa,J. and Esko,J.D.
  TITLE     Molecular cloning and expression of a third member of the heparan
            sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family
  JOURNAL   J Biol Chem 274 (5), 2690-2695 (1999)
   PUBMED   9915799
REFERENCE   8  (bases 1 to 4044)
  AUTHORS   Wei,Z. and Swiedler,S.J.
  TITLE     Functional analysis of conserved cysteines in heparan sulfate
            N-deacetylase-N-sulfotransferases
  JOURNAL   J Biol Chem 274 (4), 1966-1970 (1999)
   PUBMED   9890952
REFERENCE   9  (bases 1 to 4044)
  AUTHORS   Wei,Z., Swiedler,S.J., Ishihara,M., Orellana,A. and Hirschberg,C.B.
  TITLE     A single protein catalyzes both N-deacetylation and N-sulfation
            during the biosynthesis of heparan sulfate
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3885-3888 (1993)
   PUBMED   8483907
REFERENCE   10 (bases 1 to 4044)
  AUTHORS   Hashimoto,Y., Orellana,A., Gil,G. and Hirschberg,C.B.
  TITLE     Molecular cloning and expression of rat liver N-heparan sulfate
            sulfotransferase
  JOURNAL   J Biol Chem 267 (22), 15744-15750 (1992)
   PUBMED   1379236
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 26, 2020 this sequence version replaced NM_024361.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M92042.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000018.1  56448570-56448610   c
            42-954              JAXUCZ010000018.1  56433134-56434046   c
            955-1449            JAXUCZ010000018.1  56428032-56428526   c
            1450-1537           JAXUCZ010000018.1  56425734-56425821   c
            1538-1692           JAXUCZ010000018.1  56424362-56424516   c
            1693-1878           JAXUCZ010000018.1  56423487-56423672   c
            1879-2007           JAXUCZ010000018.1  56422232-56422360   c
            2008-2190           JAXUCZ010000018.1  56421419-56421601   c
            2191-2287           JAXUCZ010000018.1  56420369-56420465   c
            2288-2411           JAXUCZ010000018.1  56418784-56418907   c
            2412-2586           JAXUCZ010000018.1  56416809-56416983   c
            2587-2757           JAXUCZ010000018.1  56413733-56413903   c
            2758-2867           JAXUCZ010000018.1  56413388-56413497   c
            2868-2970           JAXUCZ010000018.1  56412907-56413009   c
            2971-4044           JAXUCZ010000018.1  56411200-56412273   c
FEATURES             Location/Qualifiers
     source          1..4044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..4044
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /note="N-deacetylase and N-sulfotransferase 1"
                     /db_xref="GeneID:29633"
                     /db_xref="RGD:69303"
     exon            1..41
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            42..954
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..3090
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /EC_number="2.8.2.8"
                     /note="NDST-1; HSNST 1; N-HSST 1; N-heparan sulfate
                     sulfotransferase 1; glucosaminyl
                     N-deacetylase/N-sulfotransferase 1; [Heparan
                     sulfate]-glucosamine N-sulfotransferase 1;
                     N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1;
                     heparan sulfate-N-deacetylase/N-sulfotransferase; Golgi
                     heparan sulfate N-deacetylase/N-sulfotransferase"
                     /codon_start=1
                     /product="bifunctional heparan sulfate
                     N-deacetylase/N-sulfotransferase 1"
                     /protein_id="NP_077337.1"
                     /db_xref="GeneID:29633"
                     /db_xref="RGD:69303"
                     /translation="MPALACLRRLCRHLSPQAVLFLLFVFCLFSVFVSAYYLYGWNRG
                     LEPSADASESDCGDPPPVAPSRLLPIKPVQAVAPSRTDPLVLVFVESLYSQLGQEVVA
                     ILESSRFKYRTEIAPGKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCV
                     AYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKG
                     VLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGI
                     QRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVED
                     VKALFDTQNELRTHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWS
                     HMQPHLFHNQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQV
                     WNIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSSELDKI
                     INGGELFLTVLLNPISVFMTHLSNYGNDRLGLYTFKHLVRFLHSWTNLRLQTLPPVQL
                     AQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFL
                     GMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYMEFFPIPSNTTSDFYFEKSANYFD
                     SEVAPRRAAALLPKAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGPDA
                     SSKLRALQNRCLVPGWYATHIERWLSAFHANQILVLDGKLLRTEPAKVMDTVQKFLGV
                     TSTVDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEMDLDSRAFLKDYYRDHN
                     IELSKLLYKMGQTLPTWLREDLQNTR"
     exon            955..1449
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1537
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1692
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1878
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2007
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2190
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2287
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2411
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2586
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2757
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2867
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2970
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..4044
                     /gene="Ndst1"
                     /gene_synonym="Hsst; N-HSST"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaagacaga atatcagtcc tccctccgtt tcccaggtca gctccctagc ctttaccctg
       61 tgggcccaac gtgaagagcg tgaagagcgc ggcatgcagc accccctggc tggcccggtg
      121 tcttttgacc tgctgttgac tgctcccagg aggccctgac gccctggggc acttttgctc
      181 tgcacaggac cacgttgggg tttgccatgg tgacataaag gggtgtagag gaaggaagga
      241 gcaagaccag cctgtagact gtgcccctgg ctgggcgaaa gggccagggg cccggagcct
      301 tctctccact gccctctgaa cgtctcactt cctaagtctc tgcatttctc agtcagtgga
      361 caacttttgg aactcctgtg tgaggacttc gggggaccag gccaggctgg gcctctgctg
      421 gttgagatct cgggggccag aatgcctgcc ctggcgtgcc tccggaggct gtgtcggcac
      481 ctgtccccac aggctgtcct gttcctgctg tttgtcttct gcctgttcag cgtgtttgtc
      541 tcggcctact acctatatgg ttggaaccgg ggcctcgagc cctcggcaga tgcttctgag
      601 tccgactgcg gggacccacc acctgtcgcc cctagccgtc tcctgccaat caagcctgtg
      661 caggcggtcg ccccttctcg aacagacccg ctggtgctgg tatttgtgga gagcctctat
      721 tcacagctgg gccaggaggt ggtggccatc ctggaatcca gtcgcttcaa gtaccgaaca
      781 gaaattgcac cggggaaggg ggacatgccc acactcacag acaagggccg aggccgcttc
      841 gccctcatca tctatgagaa catcctcaag tatgtcaacc tggatgcctg gaaccgggag
      901 ctgctggaca agtactgtgt ggcctacggc gtgggcatca ttggcttctt caaggccaat
      961 gagaacagcc tgctgagtgc acagctcaaa ggcttccctc ttttcctgca ttcgaacctg
     1021 ggcttgaaag actgcagcat caaccccaag tccccactgc tgtacgtgac acggcccagt
     1081 gaggtagaga aaggtgtgct gcccggagag gactggacgg tgttccagtc taaccactct
     1141 acctatgagc cagtgctgct ggccaagacg cgctcctctg agtccatccc acacctgggc
     1201 gcagatgccg gcctgcatgc tgccctgcac gctactgtgg tccaggacct gggcctccat
     1261 gacggcattc agcgtgtgct gtttggcaac aacctcaact tttggctgca taagctcgtc
     1321 ttcgtggacg ctgtggcctt cctcacaggg aagcgcctct cactgccttt ggaccgatac
     1381 atcctggtgg acattgatga catttttgta ggcaaggagg gcacacgcat gaaggtggag
     1441 gatgtgaagg ccctgtttga tacacagaat gaacttcgta cacatatccc aaacttcacc
     1501 ttcaacctgg gctactcagg gaaattcttc cacacaggta ccgatgctga ggatgctggg
     1561 gacgacctgc tgctgtccta tgtgaaagag ttctggtggt tcccccacat gtggagccat
     1621 atgcaacccc acctcttcca caaccagtct gtgctggctg agcagatggc cctgaacaag
     1681 aagttcgctg tcgagcacgg cattcccaca gatatggggt atgcagtggc accccaccac
     1741 tctggtgtgt accctgtgca tgtgcagctg tatgaggcct ggaagcaagt gtggaacatc
     1801 cgtgtgacca gcacagagga gtacccgcat ctgaagcctg cccgttaccg ccgtggcttc
     1861 atccacaatg gcatcatggt cctccctcgg cagacctgtg gtctctttac acacaccatc
     1921 ttctacaacg agtaccctgg aggctccagt gagctggaca agatcatcaa tgggggcgag
     1981 ctctttctta ctgtgctcct caatcctatc agcgtcttca tgacacactt atccaactat
     2041 ggaaatgacc gcctgggact gtacaccttc aagcacctgg tgcgcttcct gcactcctgg
     2101 accaacctga ggctgcagac gctgccccct gtgcagctgg cccagaagta cttccagatc
     2161 ttttctgagg agaaggaccc actttggcag gatccctgtg aggacaaacg ccacaaagac
     2221 atctggtcta aggagaagac atgtgatcgc ttcccaaagc tgctcatcat tggcccccag
     2281 aaaacaggca ccacagccct ctacctgttc ctgggcatgc accccgacct cagcagcaac
     2341 taccccagct ccgagacctt tgaggagatc cagtttttta atggccacaa ctatcacaaa
     2401 ggcatcgact ggtacatgga attcttccct attccctcca acaccacctc tgacttctac
     2461 tttgaaaaaa gtgccaacta ctttgattca gaagtggcac cacggcgagc agctgcccta
     2521 ttgcccaagg ccaaggttct caccatcctc atcaatccag ccgaccgggc ttactcctgg
     2581 taccagcacc agcgggccca tgatgacccg gtggccctaa agtacacctt ccatgaggtg
     2641 atcacagctg gccctgacgc atcctcaaag ctgcgtgccc tccagaaccg atgcctggtc
     2701 cccggctggt atgccactca tattgaacgc tggctcagcg cctttcatgc caaccagatc
     2761 ctggtcttgg atggcaaact gctgcgaaca gaacctgcca aagtgatgga cacagtgcag
     2821 aaattcctcg gggtgaccag cacggttgac taccataaaa ccttggcgtt tgacccaaag
     2881 aaaggatttt ggtgccagct gctcgaagga ggaaaaacca agtgtctggg aaaaagcaag
     2941 ggacggaaat atccagagat ggacctggat tcccgagcct tcctaaagga ttactaccgg
     3001 gaccacaaca ttgagctctc taagctgctg tataagatgg gccagacact gcccacctgg
     3061 ctgcgggaag acctccagaa caccaggtag ccttggccac cacagccagc cagaacgctt
     3121 gtgttagcag ggatgtcctg cctcacactg agccagactg acctgcctcg aaggatgctg
     3181 gccccagcca gccaggagca acgagcaata ccctgctaag gcccaccaga gccggaagcc
     3241 caggcaggtc tgcaagcgcc tcagagcatc cactgctgga tgtgtggctg tgggacctct
     3301 gtgggaccag aggtccattc cgttccttcg cagcctccct gcctggggag agcacttcct
     3361 gttggtggaa ggtcatttcc tggtaggagg agtcctggag actctctcct gtccctcact
     3421 gtgttcggcc agtcctgccc tgttctgtgt cataccaccc ctgctccagc aggatgtccc
     3481 ctcagtatta gctgtcatat ttctctgtcc tccagacagt aagggagagg agcgcagctg
     3541 ggcctctcgc ccaactagag agaaagactg ggcatgtccc tgagggtttg agccaggccc
     3601 cgccagggtt taggtaggca cccagatgca ctcatagatt gaatgtgagg gtggccatct
     3661 tgagaggaca tacgactcag tatttgggtt attagtatca atctcatctc ccctttgggg
     3721 gaaagactct ctggtcccta ttgtatccac ctagtgctca tggtctcttg ttggccctgg
     3781 gccactgccc tgccactggg cccagagaca tgggccttgg ccctgtcctg ttcacctgga
     3841 tgtgacctgt ggtgtttcct gtggtaaagg ctgaggcgag tcaggagtct gccagtgttc
     3901 atactcccat gtacatatac tgtctcccag ccaccgcctc ggcccggcag gcaagcagag
     3961 tcagcagcac tgctctctac tgctttgcct ggcaacctgt ggctgagggt ccccagagac
     4021 ccccccaacc tcccaaatac taag
//
