LOCUS       NM_001271091            2924 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus NDRG family member 4 (Ndrg4), transcript variant
            1, mRNA.
ACCESSION   NM_001271091
VERSION     NM_001271091.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2924)
  AUTHORS   Zhu,H., Wang,X. and Chen,S.
  TITLE     Downregulation of MiR-218-5p Protects Against Oxygen-Glucose
            Deprivation/Reperfusion-Induced Injuries of PC12 Cells via
            Upregulating N-myc Downstream Regulated Gene 4 (NDRG4)
  JOURNAL   Med Sci Monit 26, e920101 (2020)
   PUBMED   32048632
  REMARK    GeneRIF: Downregulation of MiR-218-5p Protects Against
            Oxygen-Glucose Deprivation/Reperfusion-Induced Injuries of PC12
            Cells via Upregulating N-myc Downstream Regulated Gene 4 (NDRG4).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2924)
  AUTHORS   Wen,L., Liu,L., Li,J., Tong,L., Zhang,K., Zhang,Q. and Li,C.
  TITLE     NDRG4 protects against cerebral ischemia injury by inhibiting
            p53-mediated apoptosis
  JOURNAL   Brain Res Bull 146, 104-111 (2019)
   PUBMED   30593880
  REMARK    GeneRIF: Authors found that NDRG4 expression was upregulated during
            the early stage and decreased 24 h after ischemia/reperfusion (I/R)
            injury, and NDRG4 overexpression decreased the infarct size and
            mitigated the neurological deficits induced by I/R injury by
            inhibiting apoptosis.
REFERENCE   3  (bases 1 to 2924)
  AUTHORS   Xing,Y., Tang,B., Zhu,C., Li,W., Li,Z., Zhao,J., Gong,W.D.,
            Wu,Z.Q., Zhu,C.C. and Zhang,Y.Q.
  TITLE     N-myc downstream-regulated gene 4, up-regulated by tumor necrosis
            factor-alpha and nuclear factor kappa B, aggravates cardiac
            ischemia/reperfusion injury by inhibiting reperfusion injury
            salvage kinase pathway
  JOURNAL   Basic Res Cardiol 111 (2), 11 (2016)
   PUBMED   26780215
  REMARK    GeneRIF: expression increased in injured neonatal ventricular
            myocytes
REFERENCE   4  (bases 1 to 2924)
  AUTHORS   Benesh,E.C., Miller,P.M., Pfaltzgraff,E.R., Grega-Larson,N.E.,
            Hager,H.A., Sung,B.H., Qu,X., Baldwin,H.S., Weaver,A.M. and
            Bader,D.M.
  TITLE     Bves and NDRG4 regulate directional epicardial cell migration
            through autocrine extracellular matrix deposition
  JOURNAL   Mol Biol Cell 24 (22), 3496-3510 (2013)
   PUBMED   24048452
REFERENCE   5  (bases 1 to 2924)
  AUTHORS   Ding,W., Zhang,J., Yoon,J.G., Shi,D., Foltz,G. and Lin,B.
  TITLE     NDRG4 is downregulated in glioblastoma and inhibits cell
            proliferation
  JOURNAL   OMICS 16 (5), 263-267 (2012)
   PUBMED   22489821
REFERENCE   6  (bases 1 to 2924)
  AUTHORS   Maeda,A., Hongo,S. and Miyazaki,A.
  TITLE     Genomic organization, expression, and comparative analysis of
            noncoding region of the rat Ndrg4 gene
  JOURNAL   Gene 324, 149-158 (2004)
   PUBMED   14693380
REFERENCE   7  (bases 1 to 2924)
  AUTHORS   Nishimoto,S., Tawara,J., Toyoda,H., Kitamura,K. and Komurasaki,T.
  TITLE     A novel homocysteine-responsive gene, smap8, modulates mitogenesis
            in rat vascular smooth muscle cells
  JOURNAL   Eur J Biochem 270 (11), 2521-2531 (2003)
   PUBMED   12755708
  REMARK    GeneRIF: smap8 is involved in the regulation of mitogenic
            signalling in vascular smooth muscle cells, possibly in response to
            a homocysteine-induced injury [SMAP8]
REFERENCE   8  (bases 1 to 2924)
  AUTHORS   Ohki,T., Hongo,S., Nakada,N., Maeda,A. and Takeda,M.
  TITLE     Inhibition of neurite outgrowth by reduced level of NDRG4 protein
            in antisense transfected PC12 cells
  JOURNAL   Brain Res Dev Brain Res 135 (1-2), 55-63 (2002)
   PUBMED   11978393
REFERENCE   9  (bases 1 to 2924)
  AUTHORS   Nakada,N., Hongo,S., Ohki,T., Maeda,A. and Takeda,M.
  TITLE     Molecular characterization of NDRG4/Bdm1 protein isoforms that are
            differentially regulated during rat brain development
  JOURNAL   Brain Res Dev Brain Res 135 (1-2), 45-53 (2002)
   PUBMED   11978392
  REMARK    GeneRIF: Molecular characterization of NDRG4 protein isoforms that
            are differentially regulated during rat brain development.
REFERENCE   10 (bases 1 to 2924)
  AUTHORS   Yamauchi,Y., Hongo,S., Ohashi,T., Shioda,S., Zhou,C., Nakai,Y.,
            Nishinaka,N., Takahashi,R., Takeda,F. and Takeda,M.
  TITLE     Molecular cloning and characterization of a novel developmentally
            regulated gene, Bdm1, showing predominant expression in postnatal
            rat brain
  JOURNAL   Brain Res Mol Brain Res 68 (1-2), 149-158 (1999)
   PUBMED   10320792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1, FM054107.1, CB585874.1 and CB713901.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY217032.1, SRR26360194.1612767.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000019.1  9392828-9392972     c
            146-240             JAXUCZ010000019.1  9374530-9374624     c
            241-285             JAXUCZ010000019.1  9371762-9371806     c
            286-768             FM054107.1         104-586
            769-1163            CB585874.1         191-585
            1164-1287           CB713901.1         344-467
            1288-2924           JAXUCZ010000019.1  9357470-9359106     c
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..2924
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /note="NDRG family member 4"
                     /db_xref="GeneID:64457"
                     /db_xref="RGD:621593"
     exon            1..145
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1323
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     development-related protein; N-myc downstream regulated 4;
                     protein NDRG4; brain development-related molecule 1; N-myc
                     downstream regulated gene 4"
                     /codon_start=1
                     /product="protein NDRG4 isoform 1"
                     /protein_id="NP_001258020.1"
                     /db_xref="GeneID:64457"
                     /db_xref="RGD:621593"
                     /translation="MKVLGHRLQLLTGLLLHDVTMAGLQELRFPEEKPLLRGQDATEL
                     DNPDAFLSVVDTDWKEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTL
                     FNLEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLATMLPSVVQHFGFKYV
                     IGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSTLPDTVL
                     SHLFSQEELVNNTELVQSYRQQISSVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKT
                     LRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYF
                     LQGMGYIAHLKDRRLSGGAVPSASMTRLARSRTASLTSASSVDGSRPQPCTHSDSSEG
                     MGQVNHTMEVSC"
     exon            146..240
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            241..285
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            286..391
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            392..512
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            513..575
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            576..636
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            637..723
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            724..780
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            781..884
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            885..941
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            942..993
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1041
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1077
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1129
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1168
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..2924
                     /gene="Ndrg4"
                     /gene_synonym="Bdm1; Ndr4; smap8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgcactac cggctgctgc tcccgccgct cccgctctcc cgccgctcct ctctgcggct
       61 actgcgcgcc tcgccccggg cggcccagcg cgctcctccg acgccgagat gaaggtgctg
      121 ggacacaggc tccaactgct gacagggctt ctgctccacg acgtgaccat ggcggggctg
      181 caggagctgc gatttcctga ggagaagccc cttctccggg gccaggatgc caccgagctg
      241 gataaccccg atgccttcct ctcagttgtg gacacggact ggaaggaaca tgacattgag
      301 acgccttatg gcctcctgca tgtggtgatc cggggctctc ccaaagggaa ccgcccagcc
      361 atccttacct accacgatgt gggtctcaat cacaagctgt gcttcaacac cctgttcaac
      421 ttggaggaca tgcaggagat caccaaacac ttcgtggtgt gccatgtgga tgcccctggg
      481 cagcaggtgg gagcgtcaca gttccctcag ggataccagt tcccctccat ggagcagctg
      541 gcgaccatgc tcccgagtgt ggtacagcac tttggattca agtacgtgat tggcatcgga
      601 gtgggggccg gagcgtatgt gctcgccaag tttgcactca tcttccctga tttggtggag
      661 gggctggtgt tgatgaacat tgaccccaat ggcaaaggct ggattgattg ggctgccacg
      721 aagctctccg gcttgaccag cactttgcca gatactgtac tctcccatct cttcagccag
      781 gaggagctgg tgaacaacac ggagctggtg cagagctacc ggcagcagat ctcgagcgtg
      841 gtgaaccagg ccaaccttca gctcttctgg aacatgtaca atagccgcag agatcttgac
      901 attaaccggc ctgggacagt gcccaatgcc aagacactcc gctgcccagt gatgctggtg
      961 gtcggtgaca atgcacctgc tgaggacggg gtggttgagt gtaactccaa actggaccca
     1021 accactacaa ccttcctgaa gatggcagac tctggtggtc ttcctcaggt gacccagcca
     1081 gggaagctga ctgaggcctt caaatacttc ctgcagggca tgggctacat tgcacacttg
     1141 aaggaccgaa ggctcagtgg aggagcagtg ccctcagcca gcatgacccg ccttgcgcgc
     1201 tctcgtaccg cgtccctcac cagcgccagt tctgtggatg gtagccgccc tcagccctgc
     1261 acccactcag acagcagtga ggggatgggc caggtcaacc acaccatgga ggtgtcctgc
     1321 tgaagtcctc gtcctgccca agacacccgc ttacctgccc ccaggtccca ctgccatctt
     1381 cgcaccggct catcttccct ctggtttatt tttgtgagag tgaaggggag gaaatggggt
     1441 tacttctctt ttacttaaaa cgaagggatc caccttagga cggcgcagaa caacagtctt
     1501 agaggatgtg aagggctcac cttatacact cgcatctcac cggccactgg ttgatacggc
     1561 ccccttcgtc tgcccgtctg gggtgtggcc aggatgtagg acatagtacg aaagaaagca
     1621 cagcccaccc cctggagctg gcagataggg agtttgaaga tggcaggtgc tgagccaagg
     1681 ctctgttgtg agtgggagtc agaccagtgg ggagccgtcc cttttctgta acccttgtac
     1741 caagcacacc taacagtaga ggtgacagtc atgaggacag tagccacaag agagcgctct
     1801 gagcagtcag ccattttcct ggtgctctct gggcaggaca tgatagaagg ctagccaggc
     1861 tgaagacaga atatggagaa ccctgacatg ggggcaggaa ccccatactc tgccaccaca
     1921 gggccatgtc ccaccctgag gcaaaggtca cctggtctct cttgtccccg ttggtagagg
     1981 tgaaatgttg atggctttgt atgctgtgta cagcccctga gaacttcatg gttgcccctt
     2041 tgggagctgg caggtactgt aggtccctcc tatcccaggt ttcaaacagc gagtgtttgt
     2101 cacagtgccc tggtcgacct gggccggcgt gtcacagaca ttattacttg agaagtgagc
     2161 attaggaaga tacaagacag aaagatacaa tgacctctgc ttgctgaagg ggctggaaat
     2221 ggcctgctcc ttgtgtggga gatgggttat tctccagatg aacaaaggct ccgtacctcc
     2281 tacagcccgc aactatgtct gccacctgac catgtagact ctcacagccc agagctattg
     2341 tgtcagccat ccccagagaa gagagagagc acttaagtgt gaatatgggg tgggcgtgat
     2401 gtatgtggtg ttgtgtgggt gttctgaggc aggaggacac ctacatccgt gtgtctgtgg
     2461 catatgccac cccttctttc tgtaactgta agccatttcc agactgctct gaagtccagt
     2521 ggagtgtatc ctatccctgg ttctgttcac tcacgtgctt ccgtgaatac cgagtgtgac
     2581 tgtttaaagc tggcagaatt aatcccttac tgtagatagc acttcaagta ttggacatct
     2641 ttttgctgtg ttcttaagat atctataaat acctatacat tatatatata tgtatgtata
     2701 tcgggtcctt ctgtatgtgg tttcccattg atggttgtct tctctttggt caggatgaac
     2761 ttttaatgga gttcattact tccctctctg tacaaagtta agagcctaat tttgtgtatt
     2821 ctggtggctg ataagagact ttgagattac aaaatgcaaa acaaaaatcc ttattgatat
     2881 agaaagatat ctgtgcagaa aaactaataa agaaattaag cgta
//
