LOCUS       NM_001013923            2619 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus NDRG family member 3 (Ndrg3), mRNA.
ACCESSION   NM_001013923 XM_215910
VERSION     NM_001013923.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   Yang,Z., Wu,W., Ou,P., Wu,M., Zeng,F., Zhou,B. and Wu,S.
  TITLE     MiR-122-5p knockdown protects against APAP-mediated liver injury
            through up-regulating NDRG3
  JOURNAL   Mol Cell Biochem 476 (2), 1257-1267 (2021)
   PUBMED   33247804
  REMARK    GeneRIF: MiR-122-5p knockdown protects against APAP-mediated liver
            injury through up-regulating NDRG3.
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Yao,Y., Wang,W., Jing,L., Wang,Y., Li,M., Hou,X., Wang,J., Peng,T.,
            Teng,J. and Jia,Y.
  TITLE     Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by
            Targeting NDRG3
  JOURNAL   Neurochem Res 42 (2), 446-454 (2017)
   PUBMED   27812761
  REMARK    GeneRIF: In the hypoxic response of cerebral ischemia, NDRG3
            expression was found to be regulated by let-7f microRNA.
REFERENCE   3  (bases 1 to 2619)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2619)
  AUTHORS   Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Yu,Y. and He,F.
  TITLE     Characterization and expression of three novel
            differentiation-related genes belong to the human NDRG gene family
  JOURNAL   Mol Cell Biochem 229 (1-2), 35-44 (2002)
   PUBMED   11936845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 7, 2023 this sequence version replaced NM_001013923.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078946.1, SRR26360176.1904276.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000003.1  166070828-166070911 c
            85-185              JAXUCZ010000003.1  166049787-166049887 c
            186-221             JAXUCZ010000003.1  166038132-166038167 c
            222-327             JAXUCZ010000003.1  166030051-166030156 c
            328-448             JAXUCZ010000003.1  166028284-166028404 c
            449-511             JAXUCZ010000003.1  166026525-166026587 c
            512-572             JAXUCZ010000003.1  166024341-166024401 c
            573-659             JAXUCZ010000003.1  166023993-166024079 c
            660-716             JAXUCZ010000003.1  166020767-166020823 c
            717-820             JAXUCZ010000003.1  166018726-166018829 c
            821-886             JAXUCZ010000003.1  166017722-166017787 c
            887-938             JAXUCZ010000003.1  166017586-166017637 c
            939-986             JAXUCZ010000003.1  166015311-166015358 c
            987-1022            JAXUCZ010000003.1  166011876-166011911 c
            1023-1074           JAXUCZ010000003.1  166011677-166011728 c
            1075-2619           JAXUCZ010000003.1  166007556-166009100 c
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2619
                     /gene="Ndrg3"
                     /note="NDRG family member 3"
                     /db_xref="GeneID:296318"
                     /db_xref="RGD:1359424"
     exon            1..84
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            85..185
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1256
                     /gene="Ndrg3"
                     /note="N-myc downstream regulated 3; N-myc
                     downstream-regulated gene 3 protein; N-myc downstream
                     regulated gene 3-like"
                     /codon_start=1
                     /product="protein NDRG3"
                     /protein_id="NP_001013945.1"
                     /db_xref="GeneID:296318"
                     /db_xref="RGD:1359424"
                     /translation="MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETPHGMVHV
                     TIRGLPKGNRPVILTYHDIGLNHKSCFNTFFNFEDMQEITQHFAVCHVDAPGQQEAAP
                     SFPTGYQYPTMDELAEMLPPVLTHLSMKSIIGIGVGAGAYILSRFALNHPELVEGLVL
                     INIDPCAKGWIDWAASKLSGLTTNVVDIILAHHFGQEELQANLDLIQTYRLHIAQDIN
                     QENLQLFLGSYNGRRDLEIERPILGQNDNRLKTLKCSTLLVVGDNSPAVEAVVECNSR
                     LDPINTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSS
                     SIGSGESPFSRSVTSNQSDGTQESCESPDVLDRHQTMEVSC"
     exon            186..221
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            222..327
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            328..448
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..511
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..572
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..659
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            660..716
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            717..820
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            821..886
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            887..938
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            939..986
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1022
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1074
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..2619
                     /gene="Ndrg3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttcccc cgcccctcct tgctggtgct gctggagctg ccgctgctgc tgctgtagat
       61 tgacggcccg cgctagagct tcagagaacc ggtttacttt tgagacctga ctactctgag
      121 ccgacctcat ggatgaactt caggatgttc agctcacaga gatcaaacca ctcctgaatg
      181 ataagaatgg cacacgaaac ttccaggact ttgactgtca ggaacatgac attgaaacac
      241 cccatggtat ggtccacgtc accataagag gcttaccaaa aggaaacaga cctgttatcc
      301 tgacatacca tgacattggg ctcaaccata aatcctgctt caacacgttc ttcaactttg
      361 aggatatgca agagatcacc cagcactttg ctgtctgtca cgtggatgcc ccaggccaac
      421 aggaagcagc accctccttc ccaacagggt atcagtaccc caccatggat gagctggctg
      481 agatgctgcc tcccgttctt acacacctga gtatgaagag catcattggc attggagttg
      541 gagcaggagc ctacatcctc agcagatttg cactcaatca tccagagctg gtagaaggtc
      601 ttgtgctcat taacattgac ccgtgtgcta aaggctggat tgactgggca gcttccaaac
      661 tctccggctt gaccaccaac gtcgtggaca taattttggc tcatcacttc gggcaggagg
      721 agttgcaggc caatttggac ctcattcaaa catacagact gcacattgct caagatatca
      781 atcaagaaaa tctccagctc ttcctgggtt cctataatgg acgcagagac ctggagatcg
      841 aaagacctat tctgggccaa aatgataaca gattgaaaac attaaagtgt tctactttac
      901 tggtggttgg ggacaattca cctgctgtgg aagctgtggt tgaatgtaat tctcgcctcg
      961 accctataaa tacaactttg ctaaagatgg cagactgtgg aggactgccc caagtagttc
     1021 agcctgggaa gctcaccgag gccttcaagt actttttgca gggaatgggc tacataccat
     1081 ctgccagcat gacccggctc gcccgatcac gaacccactc cacctcaagt agcattggct
     1141 ctggagaaag tcccttcagc aggtctgtga ccagcaatca gtcagatgga actcaagaat
     1201 cctgtgagtc ccctgatgtc ctggacagac accagaccat ggaagtgtct tgctaagcag
     1261 atgctcctcc cctggaccat gcaagtccct cctccttgaa atgaccactc cataatagaa
     1321 catttcattc cgtcagctgg cctccacttt ctttcactca tgcatggcca cagcatctct
     1381 ctctagtagg ctggattatc attctctctg cccttttgta tgtaccgaga accacaccca
     1441 tgccattact gtaacattcc aacaccttga tctgatccga tctccatatc ttctcttgcc
     1501 agcctttccc tgcgctccct caaatatgta tctgacgaga ctctttaatt cccaactcca
     1561 tgtgtgtgcg agcacgcgtg tctgtgtctg tgtgtgcata gttctgtgat tttagacatg
     1621 ctttcttgta gtgcttctgc aaagggactt ttttgaattc tcagtggcat ttttaaggga
     1681 aatatgcaga gtggatatct gggtgggata ggccacaaga ttggattttg gttccacttg
     1741 gacaactaac aatatttgta gagtgatttc aggagagagc aggtctgagg aatatgtgag
     1801 gctatagtta ctgtgtgggc cactggtgag gtaacgatta cacagatagg caggcagggt
     1861 ggcagtcacc tcccctgtcc acgtggattc atacctgtca tcgtgtaagt cagagggagg
     1921 gatctgaagc ctgtgagtga tgtctggtac actgtggagt tttctccaga gaagtggcct
     1981 aagccctcgg ttagccgaga aagatggaaa gcaaagcgcc aggcttcgct ctacagagag
     2041 aaagtgctgt ccctgaagca tctgagtcca cttaccagac acccaggcat cagcaggaag
     2101 tgcctcctgg tctgagggag agcggttctc catccctcgg tcccagagaa cagagtgata
     2161 tttgaaaatg ccatcgatgg tgagggtttt attggggaag aggaaggacc gttagcacac
     2221 accatcatgg taaataagtg gagcctaagt gtcagcagac atgatgaaag ccaagtcacc
     2281 ttgaaggtga cttttctggg aaggtcttaa gcatgtaatg tcccttaata ggagggaaag
     2341 ggacaatctc agggcagcct tgtccaggta gaaatatttt gcccccctgt ctgttgttgg
     2401 tgaggggtca caccagccag ggagaccctc tgggaagaag ctgccacaca caaggactct
     2461 ggaaggatcc acatgtgagc ccagccaggg tcatacggtt cccaacctga ggaaaaggtt
     2521 tttcacacac tccttgcttt ctgctgagat aagaaaggtg tcactctgca gagtgtgact
     2581 ttttacaggt taaataaagc tgtatatgtc tcattgtta
//
