LOCUS       NM_001011991            2906 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus N-myc downstream regulated 1 (Ndrg1), mRNA.
ACCESSION   NM_001011991 XM_216923
VERSION     NM_001011991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2906)
  AUTHORS   Liu,Y., Luo,Y., Shi,X., Lu,Y., Li,H., Fu,G., Li,X. and Shan,L.
  TITLE     Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary
            hypertension
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166794 (2023)
   PUBMED   37356737
  REMARK    GeneRIF: Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary
            hypertension.
REFERENCE   2  (bases 1 to 2906)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2906)
  AUTHORS   Tang,M.K., Liang,Y.J., Chan,J.Y., Wong,S.W., Chen,E., Yao,Y.,
            Gan,J., Xiao,L., Leung,H.C., Kung,H.F., Wang,H. and Lee,K.K.
  TITLE     Promyelocytic leukemia (PML) protein plays important roles in
            regulating cell adhesion, morphology, proliferation and migration
  JOURNAL   PLoS One 8 (3), e59477 (2013)
   PUBMED   23555679
REFERENCE   4  (bases 1 to 2906)
  AUTHORS   Ultanir,S.K., Hertz,N.T., Li,G., Ge,W.P., Burlingame,A.L.,
            Pleasure,S.J., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Chemical genetic identification of NDR1/2 kinase substrates AAK1
            and Rabin8 Uncovers their roles in dendrite arborization and spine
            development
  JOURNAL   Neuron 73 (6), 1127-1142 (2012)
   PUBMED   22445341
REFERENCE   5  (bases 1 to 2906)
  AUTHORS   Chen,B., Longtine,M.S., Sadovsky,Y. and Nelson,D.M.
  TITLE     Hypoxia downregulates p53 but induces apoptosis and enhances
            expression of BAD in cultures of human syncytiotrophoblasts
  JOURNAL   Am J Physiol Cell Physiol 299 (5), C968-C976 (2010)
   PUBMED   20810912
REFERENCE   6  (bases 1 to 2906)
  AUTHORS   Kim,K.T., Ongusaha,P.P., Hong,Y.K., Kurdistani,S.K., Nakamura,M.,
            Lu,K.P. and Lee,S.W.
  TITLE     Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint
  JOURNAL   J Biol Chem 279 (37), 38597-38602 (2004)
   PUBMED   15247272
REFERENCE   7  (bases 1 to 2906)
  AUTHORS   Okuda,T., Higashi,Y., Kokame,K., Tanaka,C., Kondoh,H. and Miyata,T.
  TITLE     Ndrg1-deficient mice exhibit a progressive demyelinating disorder
            of peripheral nerves
  JOURNAL   Mol Cell Biol 24 (9), 3949-3956 (2004)
   PUBMED   15082788
REFERENCE   8  (bases 1 to 2906)
  AUTHORS   Taketomi,Y., Sugiki,T., Saito,T., Ishii,Si., Hisada,M.,
            Suzuki-Nishimura,T., Uchida,M.K., Moon,T.C., Chang,H.W., Natori,Y.,
            Miyazawa,S., Kikuchi-Yanoshita,R., Murakami,M. and Kudo,I.
  TITLE     Identification of NDRG1 as an early inducible gene during in vitro
            maturation of cultured mast cells
  JOURNAL   Biochem Biophys Res Commun 306 (2), 339-346 (2003)
   PUBMED   12804568
REFERENCE   9  (bases 1 to 2906)
  AUTHORS   Lachat,P., Shaw,P., Gebhard,S., van Belzen,N., Chaubert,P. and
            Bosman,F.T.
  TITLE     Expression of NDRG1, a differentiation-related gene, in human
            tissues
  JOURNAL   Histochem Cell Biol 118 (5), 399-408 (2002)
   PUBMED   12432451
REFERENCE   10 (bases 1 to 2906)
  AUTHORS   Kurdistani,S.K., Arizti,P., Reimer,C.L., Sugrue,M.M., Aaronson,S.A.
            and Lee,S.W.
  TITLE     Inhibition of tumor cell growth by RTP/rit42 and its responsiveness
            to p53 and DNA damage
  JOURNAL   Cancer Res 58 (19), 4439-4444 (1998)
   PUBMED   9766676
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081898.1.
            
            On Feb 11, 2005 this sequence version replaced XM_216923.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081898.1, FQ212154.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2906
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /note="N-myc downstream regulated 1"
                     /db_xref="GeneID:299923"
                     /db_xref="RGD:1307303"
     exon            1..121
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..202
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1324
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /note="protein Ndr1; N-myc downstream-regulated gene 1
                     protein; N-myc downstream regulated gene 1"
                     /codon_start=1
                     /product="protein NDRG1"
                     /protein_id="NP_001011991.1"
                     /db_xref="GeneID:299923"
                     /db_xref="RGD:1307303"
                     /translation="MSRELHDVDLAEVKPLVEKGESITGLLQEFDVQEQDIETLHGSL
                     HVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDG
                     APSFPVGYMYPSMDQLAEMLPGVLHKFGLKSVIGMGTGAGAYILTRFALNNPEMVEGL
                     VLMNVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEIHSNVEVVHTYRQHILND
                     MNPSNLHLFISAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDNSPAVDAVVECNSKL
                     DPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSV
                     TSLEGTRSRSHTSEGPRSRSHTSEGSRSRSHTSEDARLNITPSSGATGNNAGPKSMEV
                     SC"
     exon            203..238
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..344
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..465
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..528
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..589
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..676
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..733
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..837
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..894
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..946
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..994
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1030
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1082
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..2876
                     /gene="Ndrg1"
                     /gene_synonym="Ndr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctaccctc tcgagctgcc agcagattgc tcacccatct tcttccctct cttcacctcc
       61 cgcggggcgc tgcaccttca gccttgctgt tggctccttt ccgtgcttcc ttgctggtta
      121 ggtctgtgat agcacggaaa tgtcccgaga gctacatgac gtggacctcg ccgaggtgaa
      181 gcctctggtg gaaaaggggg agagcatcac tggtctcctg caagagttcg atgttcagga
      241 gcaggacatt gagaccctac atggctccct gcatgtcact ctgtgtggaa cccccaaggg
      301 caaccgtcct gtcatcctca cgtatcacga catcggcatg aaccacaaga cctgctacaa
      361 ccctctcttc aactctgagg atatgcaaga gatcacacaa cattttgcgg tctgccatgt
      421 ggatgcccct ggccaacagg atggtgcccc ttccttccca gtggggtaca tgtatccctc
      481 aatggatcag ttggctgaaa tgcttcctgg agtccttcac aagtttgggc ttaagagtgt
      541 cattggcatg gggacaggag ctggcgccta catcctgacc cgctttgcac tcaacaaccc
      601 tgagatggtg gagggccttg tgctcatgaa tgtgaatccc tgtgctgaag gctggatgga
      661 ctgggctgcc tccaagatct caggatggac ccaagccctg ccagacatgg tggtgtccca
      721 cctcttcggc aaggaggaga tacacagcaa tgtggaggtg gtgcacacgt accgccagca
      781 catcctcaac gacatgaacc cgagcaacct gcacctgttc atcagcgcct acaacagccg
      841 gagagacctg gagattgagc ggccaatgcc tggaacccac actgtcaccc tgcagtgccc
      901 tgctctgctc gtggttggag acaactctcc tgccgtggat gctgtggtgg aatgcaattc
      961 caaattggac ccaacgaaga ccaccctact caagatggca gactgtggag gccttcctca
     1021 gatctctcag cctgccaagc ttgcagaggc cttcaagtac tttgtgcagg gcatgggata
     1081 catgccttct gccagcatga ctcgcctgat gcggtcccgc acagcctctg gctccagtgt
     1141 cacatccctg gagggcaccc gtagccgctc ccataccagc gaggggcccc gaagtcgctc
     1201 acacacaagt gaggggtccc gtagccgctc ccataccagt gaggatgccc gtctgaacat
     1261 cacccccagc tcgggtgcca cagggaacaa tgccgggccc aagtccatgg aggtgtcctg
     1321 ctaagcagtc tgcatcagtc atcctggact ggtggtctct tccttagccc ccaacccttg
     1381 cctgccaccc tacgctaatg cggtattaat ctaaagctgc ttttgtaaga atgaactctg
     1441 gcggtggcag acccaggctg ttcaagctgc ctcctgggac cagggtgggt ggtggtggac
     1501 caaaggcaag aggcagttca gtgttccgat ctgctaacaa gtggcctggt ggaccctctc
     1561 tctaccctca gataccaaac tgccaaaact aagaaatata tagctgtaac actgcctggc
     1621 tccaagccca ggctgatcca gcatcctggt ctacaggcat tttgccagcc tgcctacttc
     1681 ctgtttcctc cccactaaac tcattcctgg aaacaaacgt agttctgttt tgaaaggaaa
     1741 gagaggaagg aaagttgggc accttattca aagtagggaa aacaagaaag agaaagcggt
     1801 gggatctagg gcaggtagag gaaaaacaag tctactaggc tcacttgaag gaattgattt
     1861 tagagttctg aatgctgaaa ctcgcaacct gtttttctgg caacctttta acatgcaggg
     1921 gaaactagtc acaaactcct ggctttatag agaaagtgat tccgcaaata cttcagtggt
     1981 ttaaggctct tgctatgtag tttatgtacc ccatcatacc cagcttccat tccacagtga
     2041 atgagtggat gatacctttg tccctgggga agatggtttt gatttgtagt tgcattcttt
     2101 gaggtggagg gagaacccag caggtgacag tggtccttgt ctgggatgag tctctaggca
     2161 tgggaaggat ggggatagaa tgagcatggg atttgacgac taatgttagg accaagtgat
     2221 agaacctggt gggtgtggat ttccatgaat accagcctgt gatctggaat cttgtgagaa
     2281 tgagtcacac cttgtctccc attattgata tgtagcattg actttaaact tgataactga
     2341 atgtctctca cctggcccct tgctggttct tcagagagaa ccatgtgtac tgctggggga
     2401 atgactggtt tttggattct gtacattccg tgggaacttg cttccctttc ctgcccctcc
     2461 tgctgactgg gtttgcagca ttggcctctc taagcaatgc cagcctaatg cccatgccct
     2521 atactactgt ctttcgattc ttactgtggc taaccttgga attttcctat aggaaatgtg
     2581 atcagatcag agacacttga ctgttgggag tcagccctca aggcttggtg agtcccagga
     2641 tcttggagtt gctagaggaa tgtagtcaca ccatgtaggt ggcatgagag aaaaggaatc
     2701 agtttacctg ccaactccta ctatggagcc ttccactgac cttgtgtaga aagatcaggg
     2761 atccaggcta gagtgactga atgctgacaa gaaatcattg tattatgtct ttccaggaca
     2821 gtttcttaat gagatgtttg tatttatttc cagaccaata aatttgtaac tttgcaaaaa
     2881 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
