LOCUS       NM_001108814            1925 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus norrin cystine knot growth factor NDP (Ndp),
            mRNA.
ACCESSION   NM_001108814 XM_001058815 XM_343763
VERSION     NM_001108814.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Chao,W.H., Lai,M.Y., Pan,H.T., Shiu,H.W., Chen,M.M. and Chao,H.M.
  TITLE     Dendrobium nobile Lindley and its bibenzyl component moscatilin are
            able to protect retinal cells from ischemia/hypoxia by
            dowregulating placental growth factor and upregulating Norrie
            disease protein
  JOURNAL   BMC Complement Altern Med 18 (1), 193 (2018)
   PUBMED   29933759
  REMARK    GeneRIF: Studied the influence of dendrobium nobile Lindley (DNL)
            extract and its bibenzyl component moscatilin on the expression of
            placental growth factor (PLGF) and Norrie disease protein (NDP) in
            hypoxia model in retinal cells. Found DNL and moscatilin are able
            to protect against retinal ischemic/hypoxic changes respectively by
            downregulating PLGF and upregulating NDP.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Chen,Y., Zhang,Y., Tang,J., Liu,F., Hu,Q., Luo,C., Tang,J., Feng,H.
            and Zhang,J.H.
  TITLE     Norrin protected blood-brain barrier via frizzled-4/beta-catenin
            pathway after subarachnoid hemorrhage in rats
  JOURNAL   Stroke 46 (2), 529-536 (2015)
   PUBMED   25550365
  REMARK    GeneRIF: Norrin upregulation protected blood-brain barrier
            integrity and improved outcome after subarachnoid hemorrhage.
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Hsu,P.J., Wu,F.J., Kudo,M., Hsiao,C.L., Hsueh,A.J. and Luo,C.W.
  TITLE     A naturally occurring Lgr4 splice variant encodes a soluble
            antagonist useful for demonstrating the gonadal roles of Lgr4 in
            mammals
  JOURNAL   PLoS One 9 (9), e106804 (2014)
   PUBMED   25188337
  REMARK    GeneRIF: The endogenously expressed Lgr4 may act as an antagonist
            molecule that helps to fine-tune the R-spondin/norrin-mediated
            Lgr4-Wnt signaling during gonadal development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Cruciat,C.M. and Niehrs,C.
  TITLE     Secreted and transmembrane wnt inhibitors and activators
  JOURNAL   Cold Spring Harb Perspect Biol 5 (3), a015081 (2013)
   PUBMED   23085770
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1925)
  AUTHORS   Kaloglu,C., Cesur,I. and Bulut,H.E.
  TITLE     Norrin immunolocalization and its possible functions in rat
            endometrium during the estrus cycle and early pregnancy
  JOURNAL   Dev Growth Differ 53 (7), 887-896 (2011)
   PUBMED   21899531
  REMARK    GeneRIF: Norrin might regulate the decidual reaction and the
            placental angiogenesis along with the survival and the
            differentiation of luminal and glandular epithelial and decidual
            cells in rats.
REFERENCE   6  (bases 1 to 1925)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Comparative genomics on Norrie disease gene
  JOURNAL   Int J Mol Med 15 (5), 885-889 (2005)
   PUBMED   15806314
REFERENCE   7  (bases 1 to 1925)
  AUTHORS   Xu,Q., Wang,Y., Dabdoub,A., Smallwood,P.M., Williams,J., Woods,C.,
            Kelley,M.W., Jiang,L., Tasman,W., Zhang,K. and Nathans,J.
  TITLE     Vascular development in the retina and inner ear: control by Norrin
            and Frizzled-4, a high-affinity ligand-receptor pair
  JOURNAL   Cell 116 (6), 883-895 (2004)
   PUBMED   15035989
REFERENCE   8  (bases 1 to 1925)
  AUTHORS   Shastry,B.S., Pendergast,S.D., Hartzer,M.K., Liu,X. and Trese,M.T.
  TITLE     Identification of missense mutations in the Norrie disease gene
            associated with advanced retinopathy of prematurity
  JOURNAL   Arch Ophthalmol 115 (5), 651-655 (1997)
   PUBMED   9152134
REFERENCE   9  (bases 1 to 1925)
  AUTHORS   Chen,Z.Y., Battinelli,E.M., Fielder,A., Bundey,S., Sims,K.,
            Breakefield,X.O. and Craig,I.W.
  TITLE     A mutation in the Norrie disease gene (NDP) associated with
            X-linked familial exudative vitreoretinopathy
  JOURNAL   Nat Genet 5 (2), 180-183 (1993)
   PUBMED   8252044
REFERENCE   10 (bases 1 to 1925)
  AUTHORS   Berger,W., Meindl,A., van de Pol,T.J., Cremers,F.P., Ropers,H.H.,
            Doerner,C., Monaco,A., Bergen,A.A., Lebo,R., Warburg,M. et al.
  TITLE     Isolation of a candidate gene for Norrie disease by positional
            cloning
  JOURNAL   Nat Genet 1 (3), 199-203 (1992)
   PUBMED   1303235
  REMARK    Erratum:[Nat Genet. 1992 Sep;2(1):84. PMID: 1303256]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474009.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343763.3, XM_001058815.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB577208.1, CB741466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..1925
                     /gene="Ndp"
                     /gene_synonym="Ndph; RGD1563968"
                     /note="norrin cystine knot growth factor NDP"
                     /db_xref="GeneID:363443"
                     /db_xref="RGD:1563968"
     exon            1..349
                     /gene="Ndp"
                     /gene_synonym="Ndph; RGD1563968"
                     /inference="alignment:Splign:2.1.0"
     exon            350..729
                     /gene="Ndp"
                     /gene_synonym="Ndph; RGD1563968"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..957
                     /gene="Ndp"
                     /gene_synonym="Ndph; RGD1563968"
                     /note="norrin; Norrie disease homolog; Norrie disease
                     (pseudoglioma); NDP, norrin cystine knot growth factor;
                     norrin-like"
                     /codon_start=1
                     /product="norrin precursor"
                     /protein_id="NP_001102284.1"
                     /db_xref="GeneID:363443"
                     /db_xref="RGD:1563968"
                     /translation="MRNHVLAASISMLSLLAIMGDTDSKTDSSFLMDSQRCMRHHYVD
                     SISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLK
                     ALRLRCSGGMRLTATYRYILSCHCEECSS"
     exon            730..1925
                     /gene="Ndp"
                     /gene_synonym="Ndph; RGD1563968"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtgggcag aggctgtgag tccccgataa agagagcgcc taacatttcc gtggtattcc
       61 catttgctag tgcgctgctg cggccacacg cctgattgat atatgcctgc aatggcactt
      121 ttccatttga cactctccct ctctctccct ctccctctct ctccctctct ctctctccct
      181 ctctctccct gggtcgctta aacaacagtc ctaacttttg tgtgttgcaa atataaaagg
      241 caagccatgt gacagaggga cagaagaaca aaagcatttg gaagtaacag gacctctttc
      301 tagctctcag aaaagtctga gaagaaagga gccctgcgtt tcccccaagc tgtgtagcag
      361 gcactgcggt gatggtgatc ggttgcaagt gaaagaagca agacaaactc ctgcatacaa
      421 aggacaatga caaccagaaa acggcagccc catcctgccc tggccttgaa agggattgga
      481 tcctaggagg tggcagcatt tcagatctat tgtcctctgt cgccctctgc tgttcttctg
      541 gagaagtttc cccttacaac aatgagaaat catgtactag ctgcatccat ttctatgctc
      601 tccctgctgg ccataatggg agatacagac agcaaaacag acagctcgtt cctgatggac
      661 tctcaacgct gcatgaggca ccattatgtc gattctatca gtcacccatt gtacaaatgt
      721 agctcaaaga tggtgctcct ggccagatgt gaggggcact gcagccaggc atcacgctct
      781 gaacccttgg tgtccttcag cactgtcctc aagcaacctt tccgttcctc ctgtcactgc
      841 tgccgacccc agacttccaa gctgaaggct ctgcgtctgc gttgctcagg gggcatgcga
      901 cttactgcca cttaccggta catcctctcc tgtcactgtg aggaatgcag ctcctgaggc
      961 ttgctgatga ttggctttct ggctggcaca accacaggag caattcaacc tgctagagaa
     1021 ggactggcaa gaaaagagtt aaggcagata aagatggagc aagtaccaca ggattgtgca
     1081 tactctagtc ctaaagactc gatgtgcttt caacagaaag tgactctggg agcttgctct
     1141 tcattccctt ctcctttctg tggaagaatt tcttttggtt acttttcaga ttcaggcatt
     1201 tccccttttg gctctgattg tggtttgggt tcctgacagc tctgtattag tgggaaaatg
     1261 tggggccctg tgcaagagca cgtcaggtgg tccctatttg gtgcatatta gggaagaatt
     1321 taccgaagtc tccttcagtt gttgtttccc cttgttgttt tggtctaaga tttgcctcta
     1381 aaggttccca gtttcaaggt ctggacacca agtccatgga tatgtttaga gaggtttact
     1441 cacagccagc taactgctac taaataacta acacacgggt tctttcatgt gacagcggga
     1501 ctcctgacca ctatagttgt tattcagaaa tgacttaggg gatataaagg tggcagaagg
     1561 aatttataat ctgaagactt ttgcaggtaa atgatggtaa acttttgtga ggaagcaggc
     1621 tttcacacat atacactcag atggatcctg tcttggctct ggagaaggca tacattacat
     1681 gtggcatgga gaacacatca tactcttgat tgagcattag tcaagcatta gtctacttgt
     1741 gggtgtgcaa tagcttcagc catatcttga atgtcattcc ctaacatcca cctgtctatg
     1801 tgaagtttgt tgccataatg gtggcccggc ttatcctctg aaaactttgt tttcaatata
     1861 cttttagtcc ttgaagctca aattttgaat ctccccatgt tttgaaataa aaatagagta
     1921 ccttc
//
