LOCUS       NM_001107818            2338 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus NADPH dependent diflavin oxidoreductase 1
            (Ndor1), mRNA.
ACCESSION   NM_001107818 XM_001072474 XM_231049
VERSION     NM_001107818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2338)
  AUTHORS   Paul VD and Lill R.
  TITLE     Biogenesis of cytosolic and nuclear iron-sulfur proteins and their
            role in genome stability
  JOURNAL   Biochim Biophys Acta 1853 (6), 1528-1539 (2015)
   PUBMED   25583461
  REMARK    Review article
REFERENCE   2  (bases 1 to 2338)
  AUTHORS   Maio N and Rouault TA.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   3  (bases 1 to 2338)
  AUTHORS   Hamdane D, Xia C, Im SC, Zhang H, Kim JJ and Waskell L.
  TITLE     Structure and function of an NADPH-cytochrome P450 oxidoreductase
            in an open conformation capable of reducing cytochrome P450
  JOURNAL   J Biol Chem 284 (17), 11374-11384 (2009)
   PUBMED   19171935
  REMARK    GeneRIF: analysis of the structure of NADPH-cytochrome P450
            oxidoreductase in an open conformation capable of reducing
            cytochrome P450
REFERENCE   4  (bases 1 to 2338)
  AUTHORS   Kwasnicka-Crawford DA and Vincent SR.
  TITLE     Role of a novel dual flavin reductase (NR1) and an associated
            histidine triad protein (DCS-1) in menadione-induced cytotoxicity
  JOURNAL   Biochem Biophys Res Commun 336 (2), 565-571 (2005)
   PUBMED   16140270
REFERENCE   5  (bases 1 to 2338)
  AUTHORS   Finn RD, Wilkie M, Smith G and Paine MJ.
  TITLE     Identification of a functionally impaired allele of human novel
            oxidoreductase 1 (NDOR1), NDOR1*1
  JOURNAL   Pharmacogenet Genomics 15 (6), 381-386 (2005)
   PUBMED   15900210
REFERENCE   6  (bases 1 to 2338)
  AUTHORS   Finn RD, Basran J, Roitel O, Wolf CR, Munro AW, Paine MJ and
            Scrutton NS.
  TITLE     Determination of the redox potentials and electron transfer
            properties of the FAD- and FMN-binding domains of the human
            oxidoreductase NR1
  JOURNAL   Eur J Biochem 270 (6), 1164-1175 (2003)
   PUBMED   12631275
REFERENCE   7  (bases 1 to 2338)
  AUTHORS   Paine MJ, Garner AP, Powell D, Sibbald J, Sales M, Pratt N, Smith
            T, Tew DG and Wolf CR.
  TITLE     Cloning and characterization of a novel human dual flavin reductase
  JOURNAL   J Biol Chem 275 (2), 1471-1478 (2000)
   PUBMED   10625700
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_231049.4, XM_001072474.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2338
                     /gene="Ndor1"
                     /note="NADPH dependent diflavin oxidoreductase 1"
                     /db_xref="GeneID:311799"
                     /db_xref="RGD:1308479"
     exon            1..209
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1871
                     /gene="Ndor1"
                     /EC_number="1.6.-.-"
                     /codon_start=1
                     /product="NADPH-dependent diflavin oxidoreductase 1"
                     /protein_id="NP_001101288.1"
                     /db_xref="GeneID:311799"
                     /db_xref="RGD:1308479"
                     /translation="MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYS
                     VANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSTSLCQMDFAVLGLGDSSY
                     AKFNFVAKKLHRRLLQLGGNALVPPCLGDDQHELGPDAAIDPWVGDLWEKIMTMYPVP
                     LDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNLASSAPQTPPSELQPFLAPVVTNQR
                     VTGPQHFQDVRLMEFDITESNISFAAGDVVLILPSNSEAHTKQFCQLLCLDPNQFFTL
                     KPREPGVPYPPGLPQHCTVWHLVSQYLDIASVPRRSFFELLACLSPHALEREKLLEFS
                     SARGQEELWEYCNRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLA
                     HPRRLQILVAVVKYQTRLKEPRRGLCSSWLASLTPGQAGPVRVPLWVRPGSLVFPKTP
                     GTPIIMVGPGTGVAPFRAAIQERVAHGQMGNVLFFGCRQRDQDFYWQTEWQELEQRGC
                     LTLVTAFSREQAQKVYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYMPTDVSEALTA
                     IFQEEGRLSTTDAAAYLARLQQTLRFQTETWA"
     exon            210..287
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..385
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..484
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..586
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..796
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..918
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1139
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1247
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1362
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1512
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1631
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1726
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..2338
                     /gene="Ndor1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgacagcg gaagggggaa gttagtgggt gtgaggttct ggtcgggctg cgcggtctgt
       61 ccggcgtgtg cgggatgcag gttccacagc ttctggtgct tttcggtagc cagactggca
      121 cagctcagga cgaggcggag aggctgggcc gcgaggcccg gcgccggcgg ctaggttgcc
      181 gcgtgcaagc tttggactct tactccgtgg cgaatctcat tagggagccc ctggtgatat
      241 ttgtttgtgc gactacaggc caaggagacc ctcctgacaa catgaagaac ttctggaggt
      301 tcatattccg gaagagcctg ccatccacct ccctctgtca aatggatttt gctgtcctag
      361 gcctcgggga ttcctcatat gccaagttca actttgtggc caagaagctc catcgcaggc
      421 tgctgcagct aggaggcaat gccctcgtgc ctccgtgtct gggtgacgac cagcatgagt
      481 tagggcccga tgctgccatt gacccctggg taggagacct ttgggagaag ataatgacta
      541 tgtaccctgt acccctcgac attcctgaga tccctcatgg agtccccttg ccctccaagt
      601 tcatcttcca gtttcttcag gaggtcccca gcataggggc tgaggagctg aacctcgcca
      661 gttcagcccc tcagacaccc ccctcagagt tacagccctt tctggctcct gtggtcacca
      721 accagagggt cactggcccc caacacttcc aggacgttcg gctgatggag tttgacatta
      781 cagagtcgaa tatcagtttt gctgctggcg atgttgtctt aattctgccc tctaactcgg
      841 aggcccacac caagcagttc tgccaactgt tgtgcctgga ccccaatcag tttttcacac
      901 ttaagccacg ggaaccaggt gtcccttacc caccagggct gcctcagcac tgcactgtgt
      961 ggcaccttgt gtcgcagtac ttggacattg ccagcgtgcc ccgccgttcc ttctttgagc
     1021 tcttggcttg tctctcccca catgcactgg agcgggagaa gctgctggaa ttcagctccg
     1081 ccagaggaca ggaagagctc tgggagtact gtaatcggcc ccgcagaacc atcttggagg
     1141 tgctgtgtga cttcccacac acggcgggtg ccattcctcc agactacctt ttggacttga
     1201 tccctcggat ccgtccccgg gccttctcca ttgcttcatc cctactggct caccccagga
     1261 ggctacagat ccttgtggct gtggtaaagt accagactcg cctgaaggag ccccgccgtg
     1321 gcctctgctc ctcctggcta gcatccctga ctcctgggca agccggacct gtccgggtgc
     1381 ctctgtgggt tcggcctggg agcctagtgt tcccaaaaac accaggcaca cccattatca
     1441 tggtggggcc tggaactggt gtggccccct tccgagcagc cattcaagaa cgagtggccc
     1501 atgggcaaat gggaaacgtc ttattcttcg gctgccgcca gcgggatcag gacttctact
     1561 ggcagactga gtggcaggag ctagagcaga ggggctgcct gaccctggtt acagccttct
     1621 cccgggagca ggcacagaag gtgtatgtgc agcaccggct ccgagagctg gggccacttg
     1681 tctgggagct gctggatggc caaggtgcct acttctactt agcaggcaat gccaagtata
     1741 tgcctacgga tgtttcggaa gccctcacag ccatttttca agaagaagga cgactctcca
     1801 ccacagatgc agctgcctac cttgccaggc tccagcagac actgcgcttc cagactgaga
     1861 cctgggcctg aggagccact tgaagctcac acacacactg acagctacac aggggagcct
     1921 gctggagtct agagggccca ttgttacctt tcgccctcta atcccagaac actggttaga
     1981 ctcacagttg aacttttttg gtccatctga ccaggaagac agtccctgca tacagccaaa
     2041 ctcagtggaa cccagtgtcc catacatagc cccagtgcag cctgcactcc tggttttctc
     2101 tcagtcccct tcattctgcc ccaaatctgc accctagtcc atacctccaa gggcctgcta
     2161 agccctccaa ggggtgtaga gctgggagtg ggctgcactg cccctctgac cgtgccattc
     2221 ccgttacctg tgcaactcag gctcagttga aaagccacca ggggccaagt ctcctgagca
     2281 ttgagaatgg gcaaagtcgt ctgtcttcag gtctgtaaac atgagtaaac tgcctggg
//
