LOCUS       NM_001399535            3562 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus neuron-derived neurotrophic factor (Ndnf), mRNA.
ACCESSION   NM_001399535 XM_039108693
VERSION     NM_001399535.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3562)
  AUTHORS   Ohashi,K., Enomoto,T., Joki,Y., Shibata,R., Ogura,Y., Kataoka,Y.,
            Shimizu,Y., Kambara,T., Uemura,Y., Yuasa,D., Matsuo,K.,
            Hayakawa,S., Hiramatsu-Ito,M., Murohara,T. and Ouchi,N.
  TITLE     Neuron-derived neurotrophic factor functions as a novel modulator
            that enhances endothelial cell function and revascularization
            processes
  JOURNAL   J Biol Chem 289 (20), 14132-14144 (2014)
   PUBMED   24706764
REFERENCE   2  (bases 1 to 3562)
  AUTHORS   Kuang,X.L., Zhao,X.M., Xu,H.F., Shi,Y.Y., Deng,J.B. and Sun,G.T.
  TITLE     Spatio-temporal expression of a novel neuron-derived neurotrophic
            factor (NDNF) in mouse brains during development
  JOURNAL   BMC Neurosci 11, 137 (2010)
   PUBMED   20969804
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3562)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jan 10, 2022 this sequence version replaced XM_039108693.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.16651.1,
                                           SRR26643290.16298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-487               JAXUCZ010000004.1  96274147-96274633
            488-676             JAXUCZ010000004.1  96302249-96302437
            677-801             JAXUCZ010000004.1  96307308-96307432
            802-3562            JAXUCZ010000004.1  96308864-96311624
FEATURES             Location/Qualifiers
     source          1..3562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..3562
                     /gene="Ndnf"
                     /gene_synonym="AABR07060833.1; RGD1311080"
                     /note="neuron-derived neurotrophic factor"
                     /db_xref="GeneID:312401"
                     /db_xref="RGD:1311080"
     exon            1..487
                     /gene="Ndnf"
                     /gene_synonym="AABR07060833.1; RGD1311080"
                     /inference="alignment:Splign:2.1.0"
     exon            488..676
                     /gene="Ndnf"
                     /gene_synonym="AABR07060833.1; RGD1311080"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..2195
                     /gene="Ndnf"
                     /gene_synonym="AABR07060833.1; RGD1311080"
                     /note="protein NDNF"
                     /codon_start=1
                     /product="protein NDNF precursor"
                     /protein_id="NP_001386464.1"
                     /db_xref="GeneID:312401"
                     /db_xref="RGD:1311080"
                     /translation="MELLYWCLLCLLLPLTSRTQKLPTRDEELFQMQIRDKALFHDSS
                     VIPDGAEISSYLFRDTPRRYFFMVEEDNTPLSVTVTPCDAPLEWKLSLQELPEESSAD
                     GSGDPEPLDQQKQQMTDVEGTELFSYKGNDVEYFLSSSSPSGLYQLELLSTEKDTHFK
                     VYATTTPESDQPYPDLPYDPRVDVTSIGRTTVTLAWKQSPTASMLKQPIEYCVVINKE
                     HNFKSLCAAETKMSADDAFMVAPKPGLDFSPFDFAHFGFPTDNLGKDRSFLAKPSPKV
                     GRHVYWRPKVDIKKICIGSKNIFTVSDLKPNTQYYFDVFMVNTNTNMSTAFVGAFART
                     KEEAKQKTVELKDGRVTDVVVKRKGKKFLRFAPVSSHQKVTLFIHSCMDTVQVQVRRD
                     GKLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNKKGASMLKILATTRPSKHAFPSLPDD
                     TRIKAFDKLRTCSSVTVAWLGTQERRKFCIYRKEVGGNYSEEQKRRERNQCLGPDTRK
                     KSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGHSVKYQSKLVKTRK
                     VC"
     exon            677..801
                     /gene="Ndnf"
                     /gene_synonym="AABR07060833.1; RGD1311080"
                     /inference="alignment:Splign:2.1.0"
     exon            802..3562
                     /gene="Ndnf"
                     /gene_synonym="AABR07060833.1; RGD1311080"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactccttg cccggagcgg cgagagagca gagcttagtg agccgcgtac agccgccgcc
       61 tctgtcgccg gtgcaccgga ctctgcctct gcatcccgcg cgggcattca gcgagccagc
      121 ctgtccggca gtgccagctc cattcaacat ccccccgcca cccgtcgccc gcatctgcct
      181 gcgctgtccc gcgacccccg gcccggcgct gccgcctgag ccacttcgct gcaacttctg
      241 cggccgcgtg tcgccggcct tctgcccgcc ttggaagttt gcagcgctcg ccacaaagtt
      301 cggacacttg ggcatttcat tttgccctag cgtgcaggtc ccctcggttg gtggatcctg
      361 gtacttgaca tcttggtggg atcccgggac ctgggttttg tccgcacagc acactcccgg
      421 ggagaaaaaa aaaataacca accaaacaaa ctttcctctt cccgctagaa aaaacaaatt
      481 ctttaaggat ggagctgctc tactggtgtt tgctgtgcct cctgttacca ctcacctcca
      541 ggacccagaa gctgcccacc agagatgagg aactttttca gatgcagatc cgggataagg
      601 cattgtttca cgattcatcc gtgattccag atggagctga aatcagcagt tacctattta
      661 gagatacacc tagaaggtat ttcttcatgg ttgaggaaga taacacccca ctgtcagtca
      721 cagtgacacc ttgtgatgcg cctttggaat ggaagcttag cctccaggag ctgcctgagg
      781 agtccagtgc agatgggtca ggtgacccag aaccacttga ccagcagaag cagcagatga
      841 ctgatgtgga gggcacagaa ctgttctcct acaagggcaa tgatgtagag tattttctgt
      901 cttcaagttc cccatctggt ttgtatcagt tggagcttct ttcaacagag aaagacacac
      961 atttcaaagt atatgccacc accactccag aatctgatca accataccct gacttaccat
     1021 atgaccccag agttgatgtg acctctattg gacgtaccac agtcactttg gcctggaagc
     1081 aaagccccac agcttctatg ctgaaacaac ccatagagta ctgtgtggtc atcaacaagg
     1141 agcacaattt caaaagcctt tgtgcagcag aaacaaaaat gagtgcagat gatgccttca
     1201 tggtggcgcc caaacctggc ctagacttta gcccctttga ctttgcccat ttcggatttc
     1261 caacagataa tttgggtaag gatcgcagct tcctggcaaa gccttctccc aaagtggggc
     1321 gccatgtcta ctggaggcct aaggttgaca taaaaaaaat ctgcatagga agtaaaaata
     1381 ttttcacagt ctccgacctg aagcccaata cccagtacta ctttgatgtc ttcatggtca
     1441 ataccaacac taacatgagc acagcttttg tgggtgcctt tgccaggacc aaggaggagg
     1501 caaaacagaa gacagtggag ctcaaagatg ggagggtcac agatgtggtc gttaaaagga
     1561 aagggaaaaa gtttctacgg tttgctccag tctcctctca ccaaaaagtc accctcttta
     1621 ttcactcttg tatggacact gttcaagtcc aagtgagaag agatgggaag ctgcttctgt
     1681 cacagaatgt ggaaggcatt cggcagttcc agttaagagg aaaacccaaa ggaaagtacc
     1741 tcattcgact gaaaggcaac aagaaaggag catcaatgtt gaaaatacta gccaccacca
     1801 ggcccagtaa gcacgcattc ccctctcttc ctgatgacac aagaatcaaa gcctttgaca
     1861 agctacgcac ttgctcttca gtcacggtgg cttggcttgg cacccaagag aggagaaagt
     1921 tttgtatcta cagaaaggaa gtgggtggaa actacagtga agagcagaag agaagagaga
     1981 gaaaccagtg cctaggacca gacaccagaa agaagtcaga gaaggttctt tgcaagtact
     2041 tccacagcca aaacctgcag aaagcagtga cgacagagac aatcagagat ctgcaacctg
     2101 gcaagtctta cctactggac gtttatgttg taggacatgg gggacactct gtgaagtatc
     2161 agagtaaact tgtgaaaaca aggaaggtct gttagttacc ttaagtgaag atcagtagaa
     2221 ctcccggaga gatatggaat cacactgcct gttactgact actctcatga caaacagaag
     2281 ttgtacttga aagaaaggat aacaacatgt gtacattgat gcctgtgtaa tgtaacgtgg
     2341 agacttgtat tcacgcacac ctgtggtact tagggtccat ctgtctaatg ctggctaatg
     2401 tcaaaggaag agagtatctt gatggatgcc actccttact ttgaccattg catgaacttc
     2461 ttctaaatta ttttattacc taaaatttta aaatatgcca ttcgttgcac acattcacaa
     2521 atgcaaatca ttcctctcta tagatgttag gggaaattta tatataaata tataaatata
     2581 aattatttta taaagtctgt tttaaatgtt ggtgtttcta ttattgtaag ctattaaatt
     2641 ttttctctgt taaagtatag acctaatcta agatcgcatc atcctctaag cagtaatatt
     2701 gttgtaaatt cttatttgtt cagtaaaaca tttaaatgct gtcagtatgt atcccatgta
     2761 aaaacttgat atacaatata ttcatgtaca taaaattaag aatattagat tattacacta
     2821 ttcatttttc caagcagtac tgtggtatat tcaatctctt acctgtcctt aaaactgctt
     2881 ttctgtaagt tggcaccaaa atttagtctt attcagtagc taggggaaac gttgcctgtc
     2941 ttgacattga ctctgcaggc tctaccaaag cagcatgagg gcacttttat cctctacaga
     3001 ctttacttgg aaatcccaag gcatcatgga accacaagat tcagaaacac tggtcattgt
     3061 taatcaccta aaacaatatg actttaggag gatgttactg cccactattc cctttcccat
     3121 tgacaaagtt aaggaaatgg taggtgtgga cacaatgaca ccgtgaaata ccttctatca
     3181 taagaaattg tcatttgtaa aatcctgact ctaaaccctt gtgttctatg gctacagtgg
     3241 ggacaggcac aatggtgctg tcctctgcat gctggcacag ccttggctgt caagagttca
     3301 ccagcgtcat tgctatggag tataggaata ctatggctga gacagggcta cttataactc
     3361 cctatgatgt gtgctctacc ttaccttaag agaaaataga ctgttgtgcc atactctcta
     3421 acttcttagc agtaactttc agcaaaatta atgcatccat gcgatgcagg aacaacatct
     3481 gaactaattt tttgaaagct gacgactata taccaatgct ttatttaagt agcttcaata
     3541 aatggagaaa ctgacaaatg aa
//
