LOCUS       NM_001008558            1600 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus necdin, MAGE family member (Ndn), mRNA.
ACCESSION   NM_001008558 XM_218733
VERSION     NM_001008558.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1600)
  AUTHORS   Wu,M., Yang,C., Tao,B., Bu,S. and Guay-Woodford,L.M.
  TITLE     The ciliary protein cystin forms a regulatory complex with necdin
            to modulate Myc expression
  JOURNAL   PLoS One 8 (12), e83062 (2013)
   PUBMED   24349431
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1600)
  AUTHORS   Lavi-Itzkovitz,A., Tcherpakov,M., Levy,Z., Itzkovitz,S.,
            Muscatelli,F. and Fainzilber,M.
  TITLE     Functional consequences of necdin nucleocytoplasmic localization
  JOURNAL   PLoS One 7 (3), e33786 (2012)
   PUBMED   22442722
  REMARK    GeneRIF: necdin has multiple roles within protein complexes in
            different subcellular compartments, and indicate that it can
            utilize multiple karyopherin-dependent pathways to modulate its
            localization.
REFERENCE   3  (bases 1 to 1600)
  AUTHORS   Ingraham,C.A., Wertalik,L. and Schor,N.F.
  TITLE     Necdin and neurotrophin receptors: interactors of relevance for
            neuronal resistance to oxidant stress
  JOURNAL   Pediatr Res 69 (4), 279-284 (2011)
   PUBMED   21150695
  REMARK    GeneRIF: Data suggest that the effects of necdin deletion on the
            developing nervous system may depend on the relative expression of
            p75NTR and TrkA in the cells of particular regions of the nervous
            system.
REFERENCE   4  (bases 1 to 1600)
  AUTHORS   Zhu,N.L., Wang,J. and Tsukamoto,H.
  TITLE     The Necdin-Wnt pathway causes epigenetic peroxisome
            proliferator-activated receptor gamma repression in hepatic
            stellate cells
  JOURNAL   J Biol Chem 285 (40), 30463-30471 (2010)
   PUBMED   20663865
  REMARK    GeneRIF: The Necdin-Wnt pathway causes epigenetic peroxisome
            proliferator-activated receptor gamma repression in hepatic
            stellate cells.
REFERENCE   5  (bases 1 to 1600)
  AUTHORS   Kuwajima,T., Hasegawa,K. and Yoshikawa,K.
  TITLE     Necdin promotes tangential migration of neocortical interneurons
            from basal forebrain
  JOURNAL   J Neurosci 30 (10), 3709-3714 (2010)
   PUBMED   20220004
  REMARK    GeneRIF: Necdin evolved to promote development of neocortical
            gamma-aminobutyric acid (GABAergic) neurons during mammalian
            forebrain development.
REFERENCE   6  (bases 1 to 1600)
  AUTHORS   Ren,J., Lee,S., Pagliardini,S., Gerard,M., Stewart,C.L., Greer,J.J.
            and Wevrick,R.
  TITLE     Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene
            necdin, results in congenital deficiency of central respiratory
            drive in neonatal mice
  JOURNAL   J Neurosci 23 (5), 1569-1573 (2003)
   PUBMED   12629158
REFERENCE   7  (bases 1 to 1600)
  AUTHORS   Tcherpakov,M., Bronfman,F.C., Conticello,S.G., Vaskovsky,A.,
            Levy,Z., Niinobe,M., Yoshikawa,K., Arenas,E. and Fainzilber,M.
  TITLE     The p75 neurotrophin receptor interacts with multiple MAGE proteins
  JOURNAL   J Biol Chem 277 (51), 49101-49104 (2002)
   PUBMED   12414813
  REMARK    GeneRIF: Necdin and MAGE-H1 are interactors for the intracellular
            domain of p75.
REFERENCE   8  (bases 1 to 1600)
  AUTHORS   Niinobe,M., Koyama,K. and Yoshikawa,K.
  TITLE     Cellular and subcellular localization of necdin in fetal and adult
            mouse brain
  JOURNAL   Dev Neurosci 22 (4), 310-319 (2000)
   PUBMED   10965153
REFERENCE   9  (bases 1 to 1600)
  AUTHORS   Gerard,M., Hernandez,L., Wevrick,R. and Stewart,C.L.
  TITLE     Disruption of the mouse necdin gene results in early post-natal
            lethality
  JOURNAL   Nat Genet 23 (2), 199-202 (1999)
   PUBMED   10508517
REFERENCE   10 (bases 1 to 1600)
  AUTHORS   Nakada,Y., Taniura,H., Uetsuki,T., Inazawa,J. and Yoshikawa,K.
  TITLE     The human chromosomal gene for necdin, a neuronal growth
            suppressor, in the Prader-Willi syndrome deletion region
  JOURNAL   Gene 213 (1-2), 65-72 (1998)
   PUBMED   9630521
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 9, 2021 this sequence version replaced NM_001008558.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC087630.1, SRR26360176.2353862.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1600              JAXUCZ010000001.1  125261059-125262658
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1600
                     /gene="Ndn"
                     /note="necdin, MAGE family member"
                     /db_xref="GeneID:308690"
                     /db_xref="RGD:1310526"
     exon            1..1600
                     /gene="Ndn"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1045
                     /gene="Ndn"
                     /note="necdin homolog; necdin, melanoma antigen (MAGE)
                     family member"
                     /codon_start=1
                     /product="necdin"
                     /protein_id="NP_001008558.2"
                     /db_xref="GeneID:308690"
                     /db_xref="RGD:1310526"
                     /translation="MSEQSKDLSDPNFAAEDPDTEMQVSDAVPVGVPPPAPLAANLSG
                     PSCAPEGPMAAPQASPPPAERFEEVDPKILQQAAEEGRAHQPQSPARPIPAPPAPAQL
                     VQKAHELMWYVLVKDQKRMVLWFPDMVKEVMGSYKKWCRSILRRTSVILARVFGLHLR
                     LTNLHTMEFALVKALSPEELDRVALNNRMPMTGLLLMILSLIYVKGRGAREGAVWNVL
                     RILGLRPWKKHSTFGDVRKIITEEFVQQNYLKYQRVPHIEPPEYEFFWGPRANREITK
                     MQIMEFLARVFKKDPQAWPSRYREALEQARALREANLVAQAPRSSVSED"
ORIGIN      
        1 cactgaggca gtgcaggctc cgagagctcc gagtcgcagc ggtcctgctc tgatcaaaag
       61 acgcagaatg tcggaacaaa gtaaggacct gagcgaccct aactttgccg ctgaggaccc
      121 cgacactgag atgcaggtca gcgatgctgt tccggtgggg gtccctcctc ccgctcctct
      181 ggccgcgaac ctctcagggc catcgtgcgc tccggaaggc cctatggcag ccccacaggc
      241 ctcgccacca cctgcagaac ggtttgaaga ggttgaccct aagatcctgc agcaggccgc
      301 agaagagggc cgcgcccacc agccccagag cccagcccgg ccgatcccag caccgccggc
      361 ccctgcccag ctggtgcaga aggcgcacga gctcatgtgg tacgtgttgg tcaaggacca
      421 gaagaggatg gtcctctggt ttccagacat ggtgaaagag gtcatgggca gctacaagaa
      481 gtggtgcaga agcatcctca ggcgcaccag cgtcatcctc gccagagttt tcgggctgca
      541 cctgaggctg accaatctcc acaccatgga gttcgccctg gtcaaagcac tcagcccaga
      601 agagctggac agagtcgcgc tgaacaaccg tatgcccatg acaggtctcc tgctcatgat
      661 cctgagtctc atctatgtga agggccgcgg ggccagagag ggtgcggtct ggaatgtgct
      721 gcgcatcctg gggctgaggc cctggaagaa gcactccacc ttcggagatg tgagaaagat
      781 tatcaccgag gagttcgtcc agcagaatta cctgaagtac cagcgtgtgc cccacatcga
      841 gcctcccgag tacgagttct tctggggccc cagagctaac cgtgaaatca ccaagatgca
      901 gatcatggag ttcctggcca gagtctttaa gaaggatccc caggcttggc cttcccgcta
      961 cagagaggct ctggagcagg ccagagctct gcgggaggct aatcttgtcg cccaggcccc
     1021 ccgcagcagt gtctctgagg actaaaatgt ccaggagcac attgatagtt tctgacccat
     1081 actagggctg tgtaagggtg gggttggaca ttagagtatc ccagattcat agtgcagtat
     1141 ttcatgtata gtttttaagt tttccatcca gtgctttttt tatcttgtaa tgcaatgtat
     1201 tcagttgtgt actcgtgtag tgtttaaaat tgatgcatgt gtgttttata agtgagcaag
     1261 ttggtacttt cacttctgtg ctttcttgga tttttgtaca agagatgtgc tgtgctaaac
     1321 ttgtgaaata cattgaggtg ttctgtatct tgttctttga atgggactga tggtccgtat
     1381 cgacaaagaa ggccctggag agttagcagg acttaacaac aacacagacc tgaccaagag
     1441 aaaggtcagg gtccctctcc atatgactcc aactggcaca ggaaacatcc atgtggaatg
     1501 gactgatttg aactggactg ttttcagttt aagcacttag cacactttgc aaaacatgta
     1561 tccaacccca ccataaataa actttaaaat gagcattaaa
//
