LOCUS       NM_001013059            1741 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus Nedd4 family interacting protein 1 (Ndfip1),
            mRNA.
ACCESSION   NM_001013059 XM_214564
VERSION     NM_001013059.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Low,L.H., Chow,Y.L., Li,Y., Goh,C.P., Putz,U., Silke,J., Ouchi,T.,
            Howitt,J. and Tan,S.S.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Lackovic,J., Howitt,J., Callaway,J.K., Silke,J., Bartlett,P. and
            Tan,S.S.
  TITLE     Differential regulation of Nedd4 ubiquitin ligases and their
            adaptor protein Ndfip1 in a rat model of ischemic stroke
  JOURNAL   Exp Neurol 235 (1), 326-335 (2012)
   PUBMED   22417925
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Foot,N.J., Dalton,H.E., Shearwin-Whyatt,L.M., Dorstyn,L., Tan,S.S.,
            Yang,B. and Kumar,S.
  TITLE     Regulation of the divalent metal ion transporter DMT1 and iron
            homeostasis by a ubiquitin-dependent mechanism involving Ndfips and
            WWP2
  JOURNAL   Blood 112 (10), 4268-4275 (2008)
   PUBMED   18776082
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Oliver,P.M., Cao,X., Worthen,G.S., Shi,P., Briones,N., MacLeod,M.,
            White,J., Kirby,P., Kappler,J., Marrack,P. and Yang,B.
  TITLE     Ndfip1 protein promotes the function of itch ubiquitin ligase to
            prevent T cell activation and T helper 2 cell-mediated inflammation
  JOURNAL   Immunity 25 (6), 929-940 (2006)
   PUBMED   17137798
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Harvey,K.F., Shearwin-Whyatt,L.M., Fotia,A., Parton,R.G. and
            Kumar,S.
  TITLE     N4WBP5, a potential target for ubiquitination by the Nedd4 family
            of proteins, is a novel Golgi-associated protein
  JOURNAL   J Biol Chem 277 (11), 9307-9317 (2002)
   PUBMED   11748237
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085887.1.
            
            On Apr 20, 2005 this sequence version replaced XM_214564.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085887.1, FQ229568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1741
                     /gene="Ndfip1"
                     /note="Nedd4 family interacting protein 1"
                     /db_xref="GeneID:291609"
                     /db_xref="RGD:1310053"
     exon            1..197
                     /gene="Ndfip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..800
                     /gene="Ndfip1"
                     /codon_start=1
                     /product="NEDD4 family-interacting protein 1"
                     /protein_id="NP_001013077.1"
                     /db_xref="GeneID:291609"
                     /db_xref="RGD:1310053"
                     /translation="MALALAALAAVEPACGTGYQQLQNEEEPGEREQTAGDAPPPYSS
                     ISAESAAYFDYKDESGFPKPPSYNVATTLPSYDEAERTKAEATIPLVPGRDEDFVGRD
                     DFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKW
                     ILIVRFSTYFPGYFDGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPRTRVL
                     FIY"
     exon            198..285
                     /gene="Ndfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..416
                     /gene="Ndfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..504
                     /gene="Ndfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..629
                     /gene="Ndfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..696
                     /gene="Ndfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..802
                     /gene="Ndfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1711
                     /gene="Ndfip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgtccct gcgtcggcag cggccatcca cacgccgcgg cgcgtacctc tcggcctccc
       61 ggcgaccccc agccgcggca cccgcgctcg ttcagctctc tcgctcgccc tccttccctg
      121 aggcctgctg cgccatggct ttggcgttgg cggcgctggc ggcggtggag ccggcctgcg
      181 gcactgggta ccagcagttg cagaatgaag aggagcctgg ggagcgggaa cagactgcgg
      241 gtgacgcccc tccaccctac agcagcatct ctgcggagag tgcagcatat tttgactaca
      301 aagatgaatc tgggtttcca aagcccccat cttataatgt ggctacaaca ctgcccagct
      361 atgacgaggc tgagagaacc aaggctgaag ccaccatccc tttggttcct ggaagagatg
      421 aagattttgt gggtcgggat gattttgatg atgctgacca gctgaggata ggaaacgatg
      481 ggatttttat gttaaccttt ttcatggcat tcctcttcaa ctggattggg tttttcttgt
      541 ctttttgcct gaccacctca gctgcgggaa ggtatggggc catctcagga tttggtcttt
      601 ctctaattaa gtggatcctt attgtcaggt tttccaccta tttccctgga tactttgatg
      661 gccagtactg gctctggtgg gtgttcttgg ttttaggctt tctcctgttt ctcagaggat
      721 ttatcaatta tgcaaaagtt cggaagatgc cagaaacttt ctcaaatctc cccaggacca
      781 gagttctctt tatttattaa agatgtcttc tggcaaagct tcctgcactg atgaagtccc
      841 tcgagaagcg agagcacctg caggaagtga atcaccacca ggatggagga acagtcacct
      901 gctttaaaaa ataaagtact gttgaaaaag atcatttctc tctatttgtt cctaggtgta
      961 aaatgttaat agttaatgca gaattctgta atcatcgaat cattagtggt taatgtttgt
     1021 aaaagctctt gcaatcaagt ctgtgatgta ttattaataa tgccttatat attgtttgta
     1081 gtcattttaa atagcatgag ccatgtccct atagtcagta gggggcaatc ttgctttatt
     1141 catcctccat ctcaaagcag atttgaaatt acagattagt gtaagctatg gataaggctg
     1201 gctgtttgaa aaggggtttt ctcaaaagtc aaaactttgg ttatgactgc atttctgcac
     1261 ataatccata tttcctgttc aaattaatct agaaatgcgt ttaattgtac tgtgtgtgaa
     1321 catctggaag caaaaccata gtgcaaagtt cactgtaatg ttaacaaaaa atgtcctcaa
     1381 ttggtaaata agcattactt tttcatagtc tatattcaga aattaccttt tcattccgta
     1441 gttctgtgta gttcatataa aatggaaagg gcaaagatag attcagatta aatattaaat
     1501 attcttctgc aaactggata gaatctcaga gggtcaggag caaagagtta gtttggaact
     1561 tttgagagga tccctaacat tctgtactcc ttgcttttac aactgttgta actgtagaat
     1621 gatgtgcttg ctgcccaagt gctagttcac tttggttggt atattaaact gtaaatacaa
     1681 tagaacatta ataaatgtct cttgtgtagc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 a
//
