LOCUS       NM_053347               2153 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus nudE neurodevelopment protein 1 (Nde1), mRNA.
ACCESSION   NM_053347 XM_003750778
VERSION     NM_053347.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Doobin,D.J., Kemal,S., Dantas,T.J. and Vallee,R.B.
  TITLE     Severe NDE1-mediated microcephaly results from neural progenitor
            cell cycle arrests at multiple specific stages
  JOURNAL   Nat Commun 7, 12551 (2016)
   PUBMED   27553190
  REMARK    GeneRIF: the severity of NDE1-associated microcephaly results not
            from defects in mitosis, but rather the inability of neural
            progenitors to ever reach this stage
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2153)
  AUTHORS   Soares,D.C., Bradshaw,N.J., Zou,J., Kennaway,C.K., Hamilton,R.S.,
            Chen,Z.A., Wear,M.A., Blackburn,E.A., Bramham,J., Bottcher,B.,
            Millar,J.K., Barlow,P.N., Walkinshaw,M.D., Rappsilber,J. and
            Porteous,D.J.
  TITLE     The mitosis and neurodevelopment proteins NDE1 and NDEL1 form
            dimers, tetramers, and polymers with a folded back structure in
            solution
  JOURNAL   J Biol Chem 287 (39), 32381-32393 (2012)
   PUBMED   22843697
REFERENCE   3  (bases 1 to 2153)
  AUTHORS   McKenney,R.J., Weil,S.J., Scherer,J. and Vallee,R.B.
  TITLE     Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and
            dynactin
  JOURNAL   J Biol Chem 286 (45), 39615-39622 (2011)
   PUBMED   21911489
  REMARK    GeneRIF: Mutually exclusive cytoplasmic dynein regulation by
            NudE-Lis1 and dynactin.
REFERENCE   4  (bases 1 to 2153)
  AUTHORS   Bakircioglu,M., Carvalho,O.P., Khurshid,M., Cox,J.J., Tuysuz,B.,
            Barak,T., Yilmaz,S., Caglayan,O., Dincer,A., Nicholas,A.K.,
            Quarrell,O., Springell,K., Karbani,G., Malik,S., Gannon,C.,
            Sheridan,E., Crosier,M., Lisgo,S.N., Lindsay,S., Bilguvar,K.,
            Gergely,F., Gunel,M. and Woods,C.G.
  TITLE     The essential role of centrosomal NDE1 in human cerebral cortex
            neurogenesis
  JOURNAL   Am J Hum Genet 88 (5), 523-535 (2011)
   PUBMED   21529752
REFERENCE   5  (bases 1 to 2153)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 2153)
  AUTHORS   Sasaki,S., Mori,D., Toyo-oka,K., Chen,A., Garrett-Beal,L.,
            Muramatsu,M., Miyagawa,S., Hiraiwa,N., Yoshiki,A., Wynshaw-Boris,A.
            and Hirotsune,S.
  TITLE     Complete loss of Ndel1 results in neuronal migration defects and
            early embryonic lethality
  JOURNAL   Mol Cell Biol 25 (17), 7812-7827 (2005)
   PUBMED   16107726
REFERENCE   7  (bases 1 to 2153)
  AUTHORS   Cybulska-Klosowicz,A., Mazarakis,N.K., Van Dellen,A., Blakemore,C.,
            Hannan,A.J. and Kossut,M.
  TITLE     Impaired learning-dependent cortical plasticity in Huntington's
            disease transgenic mice
  JOURNAL   Neurobiol Dis 17 (3), 427-434 (2004)
   PUBMED   15571978
REFERENCE   8  (bases 1 to 2153)
  AUTHORS   Feng,Y. and Walsh,C.A.
  TITLE     Mitotic spindle regulation by Nde1 controls cerebral cortical size
  JOURNAL   Neuron 44 (2), 279-293 (2004)
   PUBMED   15473967
REFERENCE   9  (bases 1 to 2153)
  AUTHORS   Feng,Y., Olson,E.C., Stukenberg,P.T., Flanagan,L.A., Kirschner,M.W.
            and Walsh,C.A.
  TITLE     LIS1 regulates CNS lamination by interacting with mNudE, a central
            component of the centrosome
  JOURNAL   Neuron 28 (3), 665-679 (2000)
   PUBMED   11163258
REFERENCE   10 (bases 1 to 2153)
  AUTHORS   Kitagawa,M., Umezu,M., Aoki,J., Koizumi,H., Arai,H. and Inoue,K.
  TITLE     Direct association of LIS1, the lissencephaly gene product, with a
            mammalian homologue of a fungal nuclear distribution protein, rNUDE
  JOURNAL   FEBS Lett 479 (1-2), 57-62 (2000)
   PUBMED   10940388
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053347.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF240463.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000010.1  1383353-1383435     c
            84-237              JAXUCZ010000010.1  1382397-1382550     c
            238-386             JAXUCZ010000010.1  1380223-1380371     c
            387-523             JAXUCZ010000010.1  1364970-1365106     c
            524-703             JAXUCZ010000010.1  1354839-1355018     c
            704-795             JAXUCZ010000010.1  1351309-1351400     c
            796-941             JAXUCZ010000010.1  1349682-1349827     c
            942-2153            JAXUCZ010000010.1  1347018-1348229     c
FEATURES             Location/Qualifiers
     source          1..2153
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..2153
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /note="nudE neurodevelopment protein 1"
                     /db_xref="GeneID:83836"
                     /db_xref="RGD:620038"
     CDS             1..1035
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /note="LIS1-interacting protein NUDE1; rNudE; nuclear
                     distribution gene E homolog 1; nudE nuclear distribution
                     gene E homolog 1; nudE nuclear distribution E homolog 1;
                     nuclear distribution protein nudE homolog 1-like"
                     /codon_start=1
                     /product="nuclear distribution protein nudE homolog 1"
                     /protein_id="NP_445799.1"
                     /db_xref="GeneID:83836"
                     /db_xref="RGD:620038"
                     /translation="MEDSGKTFGSEEEETNYWRDLAMTYKQRAENTQEELREFQEGSR
                     EYEAELETQLQQAETRNRDLLSENNRLRMELESVKEKFEMQHSEGYRQISALEDDLAH
                     TKAIKDQLQKYIRELEQANDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKE
                     NLLESVQRLKDEARDLRQELAVQQKQDKPRTPMPSSGETKRTDMAVQATGSAPSTPIT
                     HQGSSSGLNTPETFRCGLGSPSSGTPLTPAARISALNIVGDLLRKVGALESKLASCKN
                     FMYDQSPSRKSGPALGRGTKNRDGIDRRPGSTAVGDKGSGKRLEFAKPSSQLSSPALP
                     STQGVVKLLL"
     exon            1..83
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            84..237
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            238..386
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            387..523
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            524..703
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            704..795
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            796..941
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            942..2153
                     /gene="Nde1"
                     /gene_synonym="Nude"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggact caggaaagac ttttggatca gaggaggaag aaacaaacta ttggagagac
       61 ctggccatga cctacaagca gagggcagag aatactcagg aggaactccg agaattccag
      121 gaaggaagcc gggaatatga agctgaattg gagactcagc tgcagcaagc tgaaaccaga
      181 aaccgggacc tattatcaga gaataaccgc cttcgaatgg agctggagtc tgtgaaggag
      241 aagtttgaaa tgcagcattc agagggttac cggcagatct cggccttgga ggatgacctg
      301 gctcatacaa aagccattaa agaccaactg cagaaataca tcagggagct ggaacaagcc
      361 aatgatgacc tggaaagagc caaacgagcc acaatcatgt ccctggaaga ctttgagcag
      421 cgtttgaatc aagccattga aagaaatgcc ttcctagaga gtgagctgga tgagaaggaa
      481 aatcttctag aatctgtgca gagactgaag gatgaagctc gagatcttcg gcaggaattg
      541 gctgtgcagc agaagcaaga caagccccgg acacccatgc ccagctcagg ggaaaccaaa
      601 aggacagaca tggctgtaca ggccacaggc tctgcaccat ctactccaat aactcaccaa
      661 ggatccagct ctggtttgaa cacaccagaa acgttcagat gtggcctggg cagtcccagt
      721 agtggaaccc cactcacacc tgcagcccgg atatcagcct taaacatcgt tggggacctg
      781 cttcggaaag ttggggccct ggagtccaaa ctagcatcat gcaagaactt catgtatgat
      841 cagtccccaa gccggaaaag cgggccagcc ttgggccgag gaaccaaaaa cagagacggt
      901 attgacagaa ggccaggcag caccgctgtg ggcgataaag ggtcaggaaa acgcttggag
      961 tttgcgaagc cgtcctcaca gctctcatca ccagcgctgc catccaccca gggtgtggtc
     1021 aagcttttgc tttaggacca gtgggaactg cgccctcacc tatcttccct actttatagt
     1081 cagcttttag ttattttttt tttcaaggta atttgagaaa taagagacca catcaccagc
     1141 atttactttg tgctatgcag cctaagctaa ggctgtgtgt ggcccagtcc ctagcagtgg
     1201 atgtcactaa aatgagctcc ccaaccccaa ccaggcagct ctaaggtatg atttcattga
     1261 ctacctagag ttttaatagc ctccagaggt gctttgaata tgcgtaatct tcagagcagg
     1321 actaaagccc agctcaggag ctctctgcag cctacttcca gctgaagcta tattctggaa
     1381 catttcctgg tgcttttaaa gcatgattaa attttatcta ggactgggag actacagagg
     1441 caaaaggcta tatttaaacc atctgctaaa agtactactc atgtaccttt gacacttcaa
     1501 cactgttggc ctcataggtc agtgggaggt tatcctctac agataaaccc tgactcgtgt
     1561 ctctcctgag tcccctgccc tggtgttggg agtggcatgt gcatcaggac cctggacagc
     1621 ttgcgttgga ctggcctttg ttacaccatc cctaagaaca gaacttcatc tagcagcttc
     1681 ttccagacac cacagagcaa ccagggtgac tgaagcacga gatggagatt accaccagct
     1741 gctccatcgg atgtggaaaa atcagcacag gctctacaat gccagctcgc ctcatctctg
     1801 gtgtgtgatg cttgctgcct cacacttcga tccacaatga gaaaagcaca cttatactag
     1861 agcgtgacac cctccacttg gctactaact tatttcctag ttgatgagca aaactggcct
     1921 agcatcagac ctagaacttt gtgtgtgcta ctgacattca cagggtgatt ttaagctgct
     1981 tggttatttg ttctccttag acataataac tggggaaaga tgaactttat tttttataaa
     2041 aaataaaacc aaaagaaatg cctgttcaat agatgtgtgt gtcagtcctt ccatgtctgt
     2101 gcacgtggcc atgaagtttg tttttgttca accaagtaat aaaataatag aac
//
