LOCUS       NM_181822                817 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus natural cytotoxicity triggering receptor 3
            (Ncr3), mRNA.
ACCESSION   NM_181822 XM_215310
VERSION     NM_181822.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 817)
  AUTHORS   Terra Junior,O.N., Maldonado Gde,C., Alfradique,G.R., Lisboa
            Vda,C., Arnobio,A., de Lima,D.B., Diamond,H.R. and de Souza,M.H.
  TITLE     Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS
            and Cancer: A Cross-Sectional Study
  JOURNAL   ScientificWorldJournal 2016, 2085871 (2016)
   PUBMED   27382604
REFERENCE   2  (bases 1 to 817)
  AUTHORS   Herrmann,J., Berberich,H., Hartmann,J., Beyer,S., Davies,K. and
            Koch,J.
  TITLE     Homo-oligomerization of the activating natural killer cell receptor
            NKp30 ectodomain increases its binding affinity for cellular
            ligands
  JOURNAL   J Biol Chem 289 (2), 765-777 (2014)
   PUBMED   24275655
REFERENCE   3  (bases 1 to 817)
  AUTHORS   Ji,H.F., Wang,J., Yu,L., Niu,J.Q., Ayana,D.A. and Jiang,Y.F.
  TITLE     High frequencies of CD158b+ NK cells are associated with persistent
            hepatitis C virus infections
  JOURNAL   Ann Hepatol 12 (4), 539-547 (2013)
   PUBMED   23813131
REFERENCE   4  (bases 1 to 817)
  AUTHORS   Hartmann,J., Tran,T.V., Kaudeer,J., Oberle,K., Herrmann,J.,
            Quagliano,I., Abel,T., Cohnen,A., Gatterdam,V., Jacobs,A.,
            Wollscheid,B., Tampe,R., Watzl,C., Diefenbach,A. and Koch,J.
  TITLE     The stalk domain and the glycosylation status of the activating
            natural killer cell receptor NKp30 are important for ligand binding
  JOURNAL   J Biol Chem 287 (37), 31527-31539 (2012)
   PUBMED   22807449
REFERENCE   5  (bases 1 to 817)
  AUTHORS   Bozzano,F., Picciotto,A., Costa,P., Marras,F., Fazio,V., Hirsch,I.,
            Olive,D., Moretta,L. and De Maria,A.
  TITLE     Activating NK cell receptor expression/function (NKp30, NKp46,
            DNAM-1) during chronic viraemic HCV infection is associated with
            the outcome of combined treatment
  JOURNAL   Eur J Immunol 41 (10), 2905-2914 (2011)
   PUBMED   21695691
REFERENCE   6  (bases 1 to 817)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   7  (bases 1 to 817)
  AUTHORS   Hsieh,C.L., Ogura,Y., Obara,H., Ali,U.A., Rodriguez,G.M.,
            Nepomuceno,R.R., Martinez,O.M. and Krams,S.M.
  TITLE     Identification, cloning, and characterization of a novel rat
            natural killer receptor, RNKP30: a molecule expressed in liver
            allografts
  JOURNAL   Transplantation 77 (1), 121-128 (2004)
   PUBMED   14724446
  REMARK    GeneRIF: RNKp30 is a glycosylated surface NK cell receptor with
            limited polymorphism. This putative activation receptor is
            expressed in liver allografts and may participate in the innate
            immune response after transplantation.
REFERENCE   8  (bases 1 to 817)
  AUTHORS   Backman-Petersson,E., Miller,J.R., Hollyoake,M., Aguado,B. and
            Butcher,G.W.
  TITLE     Molecular characterization of the novel rat NK receptor 1C7
  JOURNAL   Eur J Immunol 33 (2), 342-351 (2003)
   PUBMED   12548565
  REMARK    GeneRIF: cDNA from the rat 1C7 gene encodes a protein of 192 AA
            residues containing a single IgV-set domain in the extracellular
            region & a positively charged residue in the transmembrane region.
            1C7 may be an NK-activating receptor. [1C7]
REFERENCE   9  (bases 1 to 817)
  AUTHORS   Hsieh,C.L., Obara,H., Ogura,Y., Martinez,O.M. and Krams,S.M.
  TITLE     NK cells and transplantation
  JOURNAL   Transpl Immunol 9 (2-4), 111-114 (2002)
   PUBMED   12180816
  REMARK    Review article
REFERENCE   10 (bases 1 to 817)
  AUTHORS   Sivakamasundari,R., Raghunathan,A., Zhang,C.Y., Chowdhury,R.R. and
            Weissman,S.M.
  TITLE     Expression and cellular localization of the protein encoded by the
            1C7 gene: a recently described component of the MHC
  JOURNAL   Immunogenetics 51 (8-9), 723-732 (2000)
   PUBMED   10941844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883046.1.
            
            On Oct 1, 2009 this sequence version replaced NM_181822.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY273824.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               BX883046.1         30619-30843
            226-570             BX883046.1         35253-35597
            571-702             BX883046.1         35701-35832
            703-817             BX883046.1         35943-36057
FEATURES             Location/Qualifiers
     source          1..817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..817
                     /gene="Ncr3"
                     /gene_synonym="1C7; Nkp30"
                     /note="natural cytotoxicity triggering receptor 3"
                     /db_xref="GeneID:294251"
                     /db_xref="RGD:727881"
     exon            1..225
                     /gene="Ncr3"
                     /gene_synonym="1C7; Nkp30"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..761
                     /gene="Ncr3"
                     /gene_synonym="1C7; Nkp30"
                     /note="NK-p30; natural killer cell p30-related protein; NK
                     receptor 1c7"
                     /codon_start=1
                     /product="natural cytotoxicity triggering receptor 3
                     precursor"
                     /protein_id="NP_861543.2"
                     /db_xref="GeneID:294251"
                     /db_xref="RGD:727881"
                     /translation="MGGMAKVLLVVFIMVYAGSCAVWVSQPPEIRAQEGTTASLPCSF
                     NASRGKAAIGSATWYQDKVAPGMELSNVTPGFRGRVASFSVSQFIRGHKAGLLIQDIQ
                     SHDARIYVCRVEVLGLGVGTGNGTRLVVEKEPPQQASNAEPERAAYTSLLLRAGVYAL
                     SFLSVATGSVIYYQGKCLCHVGNTATPPTASEERF"
     exon            226..570
                     /gene="Ncr3"
                     /gene_synonym="1C7; Nkp30"
                     /inference="alignment:Splign:2.1.0"
     exon            571..702
                     /gene="Ncr3"
                     /gene_synonym="1C7; Nkp30"
                     /inference="alignment:Splign:2.1.0"
     exon            703..817
                     /gene="Ncr3"
                     /gene_synonym="1C7; Nkp30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccagagggt ccaggcatgt ccatcagggc catcttttct ccttagtggg acatggccca
       61 aagtcccaag cagtggaggt tcttgacaag tcatgtgtga gtcctacttg tcctaggctc
      121 cggtagtcga tcctctactt agacctcacc actgaggtcc gtccgcttcg ccaatgggag
      181 gtatggccaa ggtgctgctg gtcgtcttca tcatggttta tgcaggatcc tgtgctgtct
      241 gggtgtctca gccccctgag attcgtgcac aagagggcac cactgcctcc ctgccctgtt
      301 cgttcaatgc cagcagaggg aaagcggcca ttggctctgc cacatggtac caagacaaag
      361 tagccccggg gatggagttg agcaacgtga ccccagggtt caggggccga gtggcctctt
      421 tttctgtttc ccagttcatt agaggccaca aggccgggct gctcatacag gacatccaaa
      481 gccatgacgc cagaatctac gtgtgcagag tggaggtgct aggcctgggc gtcggaacag
      541 gaaacgggac tcggctggtg gtggagaaag agcctcctca acaagcctcc aacgcagagc
      601 cagagcgagc tgcctacaca agtctcctcc ttcgcgctgg cgtctatgcc ctcagctttc
      661 tctctgtggc caccggcagt gtcatctatt accagggcaa atgtctctgt cacgtgggaa
      721 acaccgccac tcctcccaca gcctctgagg agcgattcta aatcccaaag atccagcact
      781 caaagaggcc ggcaataaat ccttacattt tctcgta
//
