LOCUS       NM_057199               1292 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus natural cytotoxicity triggering receptor 1
            (Ncr1), mRNA.
ACCESSION   NM_057199
VERSION     NM_057199.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   Jiang,H.J., Wang,X.X., Luo,B.F., Cong,X., Jin,Q., Qin,H.,
            Zhang,H.Y., Kong,X.S., Wei,L. and Feng,B.
  TITLE     Direct antiviral agents upregulate natural killer cell potential
            activity in chronic hepatitis C patients
  JOURNAL   Clin Exp Med 19 (3), 299-308 (2019)
   PUBMED   31218578
REFERENCE   2  (bases 1 to 1292)
  AUTHORS   Pallmer,K., Barnstorf,I., Baumann,N.S., Borsa,M., Jonjic,S. and
            Oxenius,A.
  TITLE     NK cells negatively regulate CD8 T cells via natural cytotoxicity
            receptor (NCR) 1 during LCMV infection
  JOURNAL   PLoS Pathog 15 (4), e1007725 (2019)
   PUBMED   30995287
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1292)
  AUTHORS   Wang,X.X., Pan,X.B., Han,J.C., Cong,X., Jin,Q., Kong,X.S., Wei,L.
            and Feng,B.
  TITLE     HBsAg stimulates NKG2D receptor expression on natural killer cells
            and inhibits hepatitis C virus replication
  JOURNAL   Hepatobiliary Pancreat Dis Int 17 (3), 233-240 (2018)
   PUBMED   29625837
REFERENCE   4  (bases 1 to 1292)
  AUTHORS   Jang,Y., Gerbec,Z.J., Won,T., Choi,B., Podsiad,A., B Moore,B.,
            Malarkannan,S. and Laouar,Y.
  TITLE     Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus
            Identified in CD45.1 Congenic Mice with Consequences in Mouse
            Susceptibility to Infection
  JOURNAL   J Immunol 200 (6), 1982-1987 (2018)
   PUBMED   29440507
REFERENCE   5  (bases 1 to 1292)
  AUTHORS   Miletic,A., Lenartic,M., Popovic,B., Brizic,I., Trsan,T.,
            Miklic,K., Mandelboim,O., Krmpotic,A. and Jonjic,S.
  TITLE     NCR1-deficiency diminishes the generation of protective murine
            cytomegalovirus antibodies by limiting follicular helper T-cell
            maturation
  JOURNAL   Eur J Immunol 47 (9), 1443-1456 (2017)
   PUBMED   28643847
REFERENCE   6  (bases 1 to 1292)
  AUTHORS   Luque,J., Lozano,J.M., Garcia-Jurado,G., Soriano-Sarabia,N.,
            Gonzalez,R., Vallejo,A., Leal,M. and Pena,J.
  TITLE     NK-associated regulatory receptors in a structured HAART
            interruption of HIV-1-positive individuals
  JOURNAL   AIDS Res Hum Retroviruses 24 (8), 1037-1042 (2008)
   PUBMED   18724804
REFERENCE   7  (bases 1 to 1292)
  AUTHORS   Golden-Mason,L., Castelblanco,N., O'Farrelly,C. and Rosen,H.R.
  TITLE     Phenotypic and functional changes of cytotoxic CD56pos natural T
            cells determine outcome of acute hepatitis C virus infection
  JOURNAL   J Virol 81 (17), 9292-9298 (2007)
   PUBMED   17553896
REFERENCE   8  (bases 1 to 1292)
  AUTHORS   Nattermann,J., Feldmann,G., Ahlenstiel,G., Langhans,B.,
            Sauerbruch,T. and Spengler,U.
  TITLE     Surface expression and cytolytic function of natural killer cell
            receptors is altered in chronic hepatitis C
  JOURNAL   Gut 55 (6), 869-877 (2006)
   PUBMED   16322112
REFERENCE   9  (bases 1 to 1292)
  AUTHORS   Westgaard,I.H., Berg,S.F., Vaage,J.T., Wang,L.L., Yokoyama,W.M.,
            Dissen,E. and Fossum,S.
  TITLE     Rat NKp46 activates natural killer cell cytotoxicity and is
            associated with FcepsilonRIgamma and CD3zeta
  JOURNAL   J Leukoc Biol 76 (6), 1200-1206 (2004)
   PUBMED   15356098
  REMARK    GeneRIF: NKp46 activates natural killer cell cytotoxicity by
            similar pathways as CD16.
REFERENCE   10 (bases 1 to 1292)
  AUTHORS   Falco,M., Cantoni,C., Bottino,C., Moretta,A. and Biassoni,R.
  TITLE     Identification of the rat homologue of the human NKp46 triggering
            receptor
  JOURNAL   Immunol Lett 68 (2-3), 411-414 (1999)
   PUBMED   10424451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On May 7, 2021 this sequence version replaced NM_057199.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF082533.1, AJ012741.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000001.1  78665188-78665255   c
            69-104              JAXUCZ010000001.1  78665074-78665109   c
            105-389             JAXUCZ010000001.1  78664603-78664887   c
            390-668             JAXUCZ010000001.1  78662003-78662281   c
            669-719             JAXUCZ010000001.1  78661749-78661799   c
            720-767             JAXUCZ010000001.1  78659670-78659717   c
            768-1063            JAXUCZ010000001.1  78659265-78659560   c
            1064-1292           JAXUCZ010000001.1  78657409-78657637   c
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1292
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /note="natural cytotoxicity triggering receptor 1"
                     /db_xref="GeneID:117547"
                     /db_xref="RGD:621288"
     exon            1..68
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1012
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /note="rAR-1; NKACTR; NK receptor KILR-1; rat-activating
                     receptor 1; natural killer cell p46-related protein;
                     lymphocyte antigen 94 homolog (activating NK-receptor;
                     NK-p46)"
                     /codon_start=1
                     /product="natural cytotoxicity triggering receptor 1
                     precursor"
                     /protein_id="NP_476547.1"
                     /db_xref="GeneID:117547"
                     /db_xref="RGD:621288"
                     /translation="MLPTLTALLCLGLCLSQRINTEKQTLPKPIIWAKPSIMVTKGNS
                     VNIWCQGAQSASEYQLYFEGSFFALERPKSSRSMNKVKFFISQMTSHTAGIYTCFYQS
                     GELWSESSNPLKLVVTGLYDTPTLWVHPGPEVTLGENVTFSCHLKTATSKFFLLKERE
                     SNHIQHKYGNIQAEFPMGPVTRAHRGTYRCFGSYNDYAWSFPSEPVTLLITGEVENTS
                     LAPTDPVSSLDYWEFDLSTKESGLQKDSAFWDHTAQNLIRIGLACIIVMALVWLLAED
                     WLSRRKDHEKLNRLTSWECRGRRRMHRYHEEEQRDAISMRELKATPGDM"
     exon            69..104
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /inference="alignment:Splign:2.1.0"
     exon            105..389
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /inference="alignment:Splign:2.1.0"
     exon            390..668
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /inference="alignment:Splign:2.1.0"
     exon            669..719
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /inference="alignment:Splign:2.1.0"
     exon            720..767
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1063
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1292
                     /gene="Ncr1"
                     /gene_synonym="KILR-1; Ly94; Nk-p46; Nkp46"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatacacta ttcagcaccg gactggctac tggtatgctg ccaacactca ctgccctact
       61 ctgccttggt ctatgtctga gccaaaggat caacactgaa aaacagactc tcccaaaacc
      121 catcatctgg gccaaaccta gtatcatggt cacaaaagga aactcggtga acatctggtg
      181 tcagggggct cagagtgctt ctgagtatca actgtacttt gaaggaagct tttttgcctt
      241 ggagagacca aagtcatcga gatcgatgaa taaagtcaag ttcttcattt cacaaatgac
      301 ctcacatact gcagggatct acacctgctt ctatcagagt ggagagctct ggtcagagtc
      361 aagcaacccc ctgaaactgg tggtaactgg tctgtatgac acacccaccc tctgggttca
      421 cccagggcct gaggtaacct tgggggagaa tgttaccttc tcttgccatc tgaagactgc
      481 aacaagcaaa ttctttctgc tcaaggagag agaatccaac catatccagc ataaatatgg
      541 gaacatccaa gcagagttcc ccatgggccc tgtgactaga gctcacagag ggacatacag
      601 atgttttggc tcttacaacg actatgcatg gtcttttccc agtgagcctg tgacactact
      661 catcacagga gaggttgaga acaccagcct tgcacccaca gaccctgttt cttctcttga
      721 ttattgggag tttgaccttt caaccaaaga atcaggattg cagaaggact ctgccttctg
      781 ggatcacaca gcccagaatc tcattcggat tggcctggca tgcataatcg tgatggctct
      841 agtatggctt ttggctgaag actggctcag caggaggaag gatcatgaga agctcaatag
      901 attaacaagt tgggaatgca ggggaagacg gagaatgcat cgttaccatg aagaggagca
      961 aagagatgca atatctatga gggaactgaa ggcaactcct ggggatatgt gagctccatg
     1021 ttaccccctg gaggaagaaa gaggtctttg caggaatgga ggggtacctc agtctggatc
     1081 aatgggagtg gaggcccttg ttcctgtgaa ggcttgatgc cccagcatag gggaatgcta
     1141 aggcagtaag gcagggatgg atgggtgggg gagcaccctc atagatgcag ggaggagggg
     1201 atggaacagg gagttttcag aggggaaacc gggaaggggg ataacatttg aaatgtaaat
     1261 aaataaaata accaataaaa attttaaaaa ta
//
