LOCUS       NM_001271103            8307 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nuclear receptor co-repressor 1 (Ncor1), mRNA.
ACCESSION   NM_001271103 XM_001077495 XM_577103
VERSION     NM_001271103.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8307)
  AUTHORS   Hong-Wei,G., Lan,L., De-Guo,X., Zhong-Hao,L., Peng,R.,
            Zhi-Qiang,L., Guo-Qiang,S. and Ming-Zhi,G.
  TITLE     NCoR negatively regulates adipogenic differentiation of mesenchymal
            stem cells
  JOURNAL   In Vitro Cell Dev Biol Anim 51 (7), 749-758 (2015)
   PUBMED   26019118
  REMARK    GeneRIF: NCoR negatively regulates adipogenic differentiation of
            mesenchymal stem cells.
REFERENCE   2  (bases 1 to 8307)
  AUTHORS   Aninye,I.O., Matsumoto,S., Sidhaye,A.R. and Wondisford,F.E.
  TITLE     Circadian regulation of Tshb gene expression by Rev-Erbalpha
            (NR1D1) and nuclear corepressor 1 (NCOR1)
  JOURNAL   J Biol Chem 289 (24), 17070-17077 (2014)
   PUBMED   24794873
REFERENCE   3  (bases 1 to 8307)
  AUTHORS   Vella,K.R., Ramadoss,P., Costa-E-Sousa,R.H., Astapova,I., Ye,F.D.,
            Holtz,K.A., Harris,J.C. and Hollenberg,A.N.
  TITLE     Thyroid hormone signaling in vivo requires a balance between
            coactivators and corepressors
  JOURNAL   Mol Cell Biol 34 (9), 1564-1575 (2014)
   PUBMED   24550004
REFERENCE   4  (bases 1 to 8307)
  AUTHORS   Soriano,F.X., Chawla,S., Skehel,P. and Hardingham,G.E.
  TITLE     SMRT-mediated co-shuttling enables export of class IIa HDACs
            independent of their CaM kinase phosphorylation sites
  JOURNAL   J Neurochem 124 (1), 26-35 (2013)
   PUBMED   23083128
  REMARK    GeneRIF: SMRT-mediated co-shuttling enables export of class IIa
            HDACs independent of their CaM kinase phosphorylation sites.
REFERENCE   5  (bases 1 to 8307)
  AUTHORS   Qu,F., Wang,F.F., Yin,R., Ding,G.L., El-Prince,M., Gao,Q.,
            Shi,B.W., Pan,H.H., Huang,Y.T., Jin,M., Leung,P.C., Sheng,J.Z. and
            Huang,H.F.
  TITLE     A molecular mechanism underlying ovarian dysfunction of polycystic
            ovary syndrome: hyperandrogenism induces epigenetic alterations in
            the granulosa cells
  JOURNAL   J Mol Med (Berl) 90 (8), 911-923 (2012)
   PUBMED   22349439
  REMARK    GeneRIF: PCOS rat models also showed alterations of PPARG1, NCOR1,
            and HDAC3 mRNA expression and methylation changes of PPARG1 and
            NCOR1, consistent with the results from humans.
REFERENCE   6  (bases 1 to 8307)
  AUTHORS   Harding,H.P., Atkins,G.B., Jaffe,A.B., Seo,W.J. and Lazar,M.A.
  TITLE     Transcriptional activation and repression by RORalpha, an orphan
            nuclear receptor required for cerebellar development
  JOURNAL   Mol Endocrinol 11 (11), 1737-1746 (1997)
   PUBMED   9328355
REFERENCE   7  (bases 1 to 8307)
  AUTHORS   Heinzel,T., Lavinsky,R.M., Mullen,T.M., Soderstrom,M.,
            Laherty,C.D., Torchia,J., Yang,W.M., Brard,G., Ngo,S.D.,
            Davie,J.R., Seto,E., Eisenman,R.N., Rose,D.W., Glass,C.K. and
            Rosenfeld,M.G.
  TITLE     A complex containing N-CoR, mSin3 and histone deacetylase mediates
            transcriptional repression
  JOURNAL   Nature 387 (6628), 43-48 (1997)
   PUBMED   9139820
REFERENCE   8  (bases 1 to 8307)
  AUTHORS   Seol,W., Mahon,M.J., Lee,Y.K. and Moore,D.D.
  TITLE     Two receptor interacting domains in the nuclear hormone receptor
            corepressor RIP13/N-CoR
  JOURNAL   Mol Endocrinol 10 (12), 1646-1655 (1996)
   PUBMED   8961273
REFERENCE   9  (bases 1 to 8307)
  AUTHORS   Horlein,A.J., Naar,A.M., Heinzel,T., Torchia,J., Gloss,B.,
            Kurokawa,R., Ryan,A., Kamei,Y., Soderstrom,M., Glass,C.K. et al.
  TITLE     Ligand-independent repression by the thyroid hormone receptor
            mediated by a nuclear receptor co-repressor
  JOURNAL   Nature 377 (6548), 397-404 (1995)
   PUBMED   7566114
REFERENCE   10 (bases 1 to 8307)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_577103.4, XM_001077495.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000010.1  47640192-47640350   c
            160-337             JAXUCZ010000010.1  47620845-47621022   c
            338-474             JAXUCZ010000010.1  47618640-47618776   c
            475-667             JAXUCZ010000010.1  47610165-47610357   c
            668-850             JAXUCZ010000010.1  47604586-47604768   c
            851-964             JAXUCZ010000010.1  47597341-47597454   c
            965-1021            JAXUCZ010000010.1  47589036-47589092   c
            1022-1074           JAXUCZ010000010.1  47588343-47588395   c
            1075-1141           JAXUCZ010000010.1  47585943-47586009   c
            1142-1314           JAXUCZ010000010.1  47583062-47583234   c
            1315-1405           JAXUCZ010000010.1  47579650-47579740   c
            1406-1584           JAXUCZ010000010.1  47576045-47576223   c
            1585-1639           JAXUCZ010000010.1  47574634-47574688   c
            1640-1741           JAXUCZ010000010.1  47573195-47573296   c
            1742-1866           JAXUCZ010000010.1  47568699-47568823   c
            1867-2081           JAXUCZ010000010.1  47564741-47564955   c
            2082-2176           JAXUCZ010000010.1  47563425-47563519   c
            2177-2303           JAXUCZ010000010.1  47558203-47558329   c
            2304-2850           JAXUCZ010000010.1  47553128-47553674   c
            2851-2980           JAXUCZ010000010.1  47550043-47550172   c
            2981-3176           JAXUCZ010000010.1  47548136-47548331   c
            3177-3337           JAXUCZ010000010.1  47540771-47540931   c
            3338-3455           JAXUCZ010000010.1  47535347-47535464   c
            3456-3557           JAXUCZ010000010.1  47535151-47535252   c
            3558-3658           JAXUCZ010000010.1  47533726-47533826   c
            3659-3827           JAXUCZ010000010.1  47531546-47531714   c
            3828-3971           JAXUCZ010000010.1  47529648-47529791   c
            3972-4004           JAXUCZ010000010.1  47525497-47525529   c
            4005-4261           JAXUCZ010000010.1  47524889-47525145   c
            4262-4616           JAXUCZ010000010.1  47524219-47524573   c
            4617-4838           JAXUCZ010000010.1  47521956-47522177   c
            4839-5045           JAXUCZ010000010.1  47520496-47520702   c
            5046-5195           JAXUCZ010000010.1  47519933-47520082   c
            5196-5381           JAXUCZ010000010.1  47519358-47519543   c
            5382-5547           JAXUCZ010000010.1  47516334-47516499   c
            5548-6041           JAXUCZ010000010.1  47515504-47515997   c
            6042-6170           JAXUCZ010000010.1  47512638-47512766   c
            6171-6334           JAXUCZ010000010.1  47511776-47511939   c
            6335-6546           JAXUCZ010000010.1  47511254-47511465   c
            6547-6690           JAXUCZ010000010.1  47509177-47509320   c
            6691-6833           JAXUCZ010000010.1  47507297-47507439   c
            6834-6887           JAXUCZ010000010.1  47503383-47503436   c
            6888-7109           JAXUCZ010000010.1  47502984-47503205   c
            7110-7286           JAXUCZ010000010.1  47501256-47501432   c
            7287-8307           JAXUCZ010000010.1  47498852-47499872   c
FEATURES             Location/Qualifiers
     source          1..8307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..8307
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /note="nuclear receptor co-repressor 1"
                     /db_xref="GeneID:54299"
                     /db_xref="RGD:3612"
     exon            1..159
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            160..337
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..7474
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /note="N-CoR; N-CoR1; N-Cor/SMRT corepressor, Rip13; NCoR"
                     /codon_start=1
                     /product="nuclear receptor corepressor 1"
                     /protein_id="NP_001258032.1"
                     /db_xref="GeneID:54299"
                     /db_xref="RGD:3612"
                     /translation="MSSSGYPPNQGAFSTEQSRYPSQSVQYTFPSTRHQQEFAVPDYR
                     SSHIEVSQASQLLQQQQQQQQLRRRPSLLSEFHPGSDRPQERRTGYEQFHSGPSPVDH
                     DSLESKRPRLEPVSDAHFQRVSAAVLPLVHTLPEGLRASADAKKDSAFGGKHEAPSSP
                     LAGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPP
                     EPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVY
                     HENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKA
                     KESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQE
                     NNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFK
                     DKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIAR
                     PSQEEKVEEKEEDKAEKMEKKEEEKKDDEEKDEKEESKETTKEKDRTEATAEETEERE
                     QVTPRGRKTANSQGRRKGRITRSMTSEAAAASAAAAATEEPPPPLPPPPEPVSTEPVE
                     TSRWTEEEMEVAKKGNIQQCIIYNSASRKPREERDVSQCESVASTVSAQEDEDIEASN
                     EEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPA
                     PCASPSSAVPTTKPAESESVEAQVTDSASVETAEPMDVDHEECGAQGSSVLDPPAPTK
                     ADSVDPEIQVPENTASKGEGDAKDRDLESASEKTEARDEDLVVAEQMQRPEPQSDNDS
                     SATCSADEDVDGEPERQRVFPMDAKPSLLNPPGSILISSPIKPNPLDLPQLQHRAAVI
                     PPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQIDLECRSSTSPCG
                     TSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIM
                     GGSISQGTPGTYLTSHSQAYTPEAAKPSVGSISLGLPRQQESTKSAPLTYIKQEEFSP
                     RSQNSQPEGLLVRAQHEGVVRGTAGAVQEGSITRGTPASKISVESISSLRGSITQGTP
                     ALPQAGIPTEALVKGPVSRMPIEESSPEKVREEAASKGHVIYEGKSGHILSYDNIKNA
                     REGTRSPRTAHEMSLKRSYESVEGNVKQGMSMRESPVSAAPLEERTVLSGSIMQGTPR
                     ATAESFEDGLKYPKQIKRESPPSRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDIL
                     TQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLPRGML
                     EIVPENIKVVERGKYEDVKAGEPVRPRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDD
                     SSARRTPVSYQNTISRGSPMMNRTSDGSSSKTTSHERKSALTPTQRESVPAKSPVPAV
                     DSVVSHSPFDPHHRSTTAGEVYRSHLPTHLDPAMPFHRALDPAAAYLFQRQLSPTPGY
                     PSQYQLYAMENTRQTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDL
                     TNMPPTILVPHAGGTSTPPMDRITYIPGTQITFPPRPYNAASLSPGHPTHLAAAASAE
                     REREREREKERERERERERERERERERERERERERERITAAPTDLYLRPGSEQPGRPG
                     SHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPSGGPSISQ
                     GLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEDNVRSRSAAVSEQQQ
                     LEQKNLEVEKRSVQCVCTSSALPSGKPQPHASVVYSEAGKDKGPPPKSRYEEELRTRG
                     KTTITAANFIDVIITRQIASDKDARERGSQSSDSSSSLSSHRYEAPSDAIEVISPASS
                     PAPPQEKPQAYQPEMVKANQAENESPQQYEGPLHHYRSQQGSPSPQQQPPLPPSSQAE
                     GMGQVPRTHRLITLADHICQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVRTKPSS
                     RYSPESQSQTVLHPRPGPRVSPENLVDKSRGSRPGKSPERSHIPSEPYEPISPPQGPA
                     VHEKQDSMLLLSQRGMDPAEQRSDSRSPGSISYLPSFFTKLESTSPMVKSKKQEIFRK
                     LNSSGGGDSDMAAAQPGTEIFNLPAVTTSGAVSSRSHSFADPASNLGLEDIIRKALMG
                     SFDDKVEDHGVVMPHPVGVVPGSASTSVVTSSETRRDEGDPSPHSGVCKPKLINKSNS
                     RKSKSPIPGQNYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTI
                     RMLSSTPPTPIACAPSAITQAAPHQQSRIWEREPAPLLSAQYETLSDSDD"
     exon            338..474
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            475..667
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            668..850
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            851..964
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1021
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1074
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1141
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1314
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1405
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1584
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1639
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1741
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1866
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2081
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2176
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2303
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2850
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2980
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3176
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3337
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3455
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3557
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3658
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3827
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3971
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            3972..4004
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4261
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4616
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            4617..4838
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            4839..5045
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            5046..5195
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            5196..5381
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            5382..5547
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            5548..6041
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            6042..6170
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            6171..6334
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            6335..6546
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            6547..6690
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            6691..6833
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            6834..6887
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            6888..7109
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            7110..7286
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
     exon            7287..8307
                     /gene="Ncor1"
                     /gene_synonym="Rxrip13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaagatgg cggctaaggt ggcgaagctg cggcggcggc cggagtgagc gcccagctcg
       61 ccgcgccgag cgagggccgg gcgtagggcc gcgcgccggg gccgcgccct ggtcgtccgg
      121 ccgtggggcg cgccggctct cacgctccgc cagctcccgg ttgcttccta gaaacatgat
      181 tgtttattgg acttgatctc acagcccagt gaggacgtct ttactgataa tgtcaagttc
      241 aggttaccct cccaaccaag gagctttcag cacagagcaa agtcgttatc cttcacagtc
      301 tgtccagtat acctttccca gtacccggca ccagcaggaa tttgcagttc ctgactatcg
      361 ctcttctcac atcgaagtta gtcaggcatc gcagctctta cagcagcagc agcagcagca
      421 gcagcttcga aggcgacctt ccttgctttc agaatttcac ccaggttctg acaggcctca
      481 agagagaaga actggatatg aacagtttca ctcaggaccc tcaccagtgg atcatgattc
      541 cttggagtcc aagcgtccac gcctggagcc agtttctgat gcccatttcc agcgtgttag
      601 tgctgcggtt ttacctttag ttcacacgct gccagagggg ttgagggcgt ctgcagatgc
      661 taagaaggat tcggcatttg gaggcaaaca tgaagctcca tcctctccat tggctgggca
      721 accatgtgga gatgatcaaa acgcttcacc ttcaaagctc tcaaaggaag agttaataca
      781 gagtatggac cgggtagaca gagagattgc aaaagtagag cagcagatcc ttaaattgaa
      841 aaagaaacaa caacagctag aagaagaagc agctaagcct cctgagccgg agaagcctgt
      901 gtcccctcct cctgtggaac agaaacaccg tagtattgtc caaattattt atgatgagaa
      961 tcggaaaaaa gctgaagaag ctcataaaat atttgaaggt cttggcccaa aagttgaatt
     1021 gccactctat aaccagccgt cagataccaa ggtgtaccat gagaacatca agacaaacca
     1081 ggtgatgagg aaaaaactca ttttattttt taaaagaaga aatcatgcaa gaaaacaaag
     1141 ggaacaaaaa atctgccagc gttatgatca actcatggag gcatgggaga aaaaagtgga
     1201 cagaatagaa aataatcctc ggaggaaagc aaaagaaagc aaaacaaggg aatactatga
     1261 gaagcagttt ccagaaattc gaaaacaaag agaacaacaa gaaagatttc agcgagttgg
     1321 tcagagggga gctggtcttt cagccaccat tgctaggagt gagcatgaga tttccgaaat
     1381 tattgatggc ctttctgagc aggagaataa tgagaaacaa atgcggcagc tttctgtgat
     1441 tcccccgatg atgtttgatg cagaacaaag aagggtcaag ttcatcaata tgaatgggct
     1501 catggaggat ccaatgaagg tttataaaga cagacagttt atgaatgttt ggactgacca
     1561 cgaaaaggag atctttaagg acaagtttat ccagcaccca aaaaactttg gactaattgc
     1621 atcctatttg gaaaggaaga gcgtgcctga ttgtgtttta tattactatt taaccaagaa
     1681 aaacgagaat tataaagccc ttgtgagaag aaattatggg aaacgcagag gcagaaatca
     1741 gcagattgcc cgtccctcac aagaagaaaa agtagaagaa aaagaagagg ataaagcaga
     1801 aaaaatggag aaaaaggaag aagaaaagaa ggatgatgaa gaaaaagatg agaaggaaga
     1861 gtctaaagaa acaaccaagg aaaaggatag aacagaagcc acagcagaag aaactgagga
     1921 gagagagcag gtcactccaa gggggcgaaa gactgctaac agccaagggc gtcggaaggg
     1981 ccggatcacc aggtccatga caagtgaagc tgcagctgcc agtgctgctg ctgcagccac
     2041 tgaggagccc cctccaccgc tgccaccacc cccagagccc gtttctacag aaccagttga
     2101 gacttcaaga tggacggaag aagaaatgga agttgctaaa aaaggtaata tacagcaatg
     2161 tataatatac aacagtgctt cacgaaaacc ccgtgaggaa cgagatgtgt ctcagtgtga
     2221 aagtgttgct tccactgtgt ctgcccagga ggatgaagat attgaagcct cgaatgagga
     2281 ggagaatcca gaagatagtg aaggtgctga aaatagttct gatacagaaa gtgctccctc
     2341 tccttcacca gttgaagctg ccaagtccag tgaagacagc agtgaaaatg ctgcttctcg
     2401 aggaaacacc gaacctgtgg ctgagcttga ggccaccact gaccctgcac cctgtgcatc
     2461 tccctcttca gcagttccaa ccacaaaacc agcagaaagt gaaagcgtgg aggcccaggt
     2521 gactgacagc gccagtgtgg agaccgcaga gccgatggat gtagaccatg aggagtgcgg
     2581 tgcccaaggc agttctgttc ttgatccacc agcccctacc aaagctgact ccgtggaccc
     2641 agaaatacag gtaccagaaa acactgcatc taaaggtgaa ggggatgcca aggacagaga
     2701 cttggagagc gccagtgaga agacagaggc tagagatgaa gacttggtag tggctgagca
     2761 gatgcagagg cctgaaccac agtcagacaa cgactccagt gccacatgca gtgcagacga
     2821 ggatgtcgat ggagagccag agaggcagag agtgtttccc atggatgcaa agccttcact
     2881 gttaaatcct ccaggatcaa tactaatctc atcccccatt aaaccaaacc cattggatct
     2941 gccacagctt cagcatcgag ctgctgttat tccaccaatg gtttcttgca ccccatgtaa
     3001 tataccaatt ggaacacctg taagtggcta tgctctttac caacggcaca ttaaggccat
     3061 gcatgagtca gcactcctgg aggaacagcg gcagaggcaa gaacagatag acttggagtg
     3121 cagaagttct acaagcccgt gtggcacttc taagagtcca aacagggaat gggaagtcct
     3181 ccaacctgct ccacatcaag tgataactaa ccttcctgaa ggggttcggc ttccaacaac
     3241 acgaccaacc aggccaccac ctcccctcat cccatcgtcc aaaaccacag tagcatcaga
     3301 aaaaccatcc tttataatgg gagggtccat ctcacaggga actcctggca cttacttgac
     3361 ttctcatagt caggcttata ctccggaagc agctaagccc tcagtggggt ctatctctct
     3421 tggattgcca cggcagcagg aatctaccaa gtcagctcct ttgacctaca tcaagcagga
     3481 agaattttct ccacgaagcc aaaactcaca gcctgagggt ttattggtga gagcgcagca
     3541 tgaaggtgtg gtcagaggca ctgcaggggc tgtccaagaa ggaagtataa ctcggggaac
     3601 tccagccagc aagatctcag tggagagcat ttcatccttg cggggctcta ttacccaggg
     3661 gaccccagct ctgccccagg ctggcatacc aacagaggct ttggtgaagg gacctgtttc
     3721 caggatgcca attgaggaaa gcagtcctga gaaggtcaga gaggaagctg catccaaagg
     3781 ccatgtcatc tatgaaggca aaagtggaca tatcttatca tatgacaata ttaagaatgc
     3841 ccgagaaggg actcggagtc caagaacagc tcatgaaatg agtttaaaaa gaagctatga
     3901 gtcagtggaa ggaaatgtaa agcaaggcat gtcgatgagg gagtctcctg tgtcagcagc
     3961 acctttagag gaaaggactg tgctgtctgg ttccataatg cagggcacac ctagagcaac
     4021 agccgaaagc tttgaagatg gccttaaata ccccaaacag ataaaaaggg aaagccctcc
     4081 tagtcgagca tttgaaggtg ccattaccaa aggaaaacca tacgatggca tcaccaccat
     4141 caaagaaatg gggcgttcca ttcatgaaat tccaagacaa gatattctaa ctcaggaaag
     4201 ccggaaaact ccagaagtgg tccagagcac gaggccaata attgagggtt ccatttccca
     4261 gggcacacca ataaaatttg acaacaactc aggtcaatca gctatcaaac acaatgtgaa
     4321 gtccttaatc acagggccta gcaaactacc ccgaggaatg ctggaaattg taccagaaaa
     4381 cataaaagta gtagaacggg gaaaatatga ggacgtgaaa gcaggcgaac cagtgcgacc
     4441 ccggcacacg tcagtggtga gctctggccc ctccgttctc aggtctacac ttcatgaagc
     4501 tcccaaagca cagttgagcc cgggaatcta tgatgacagc agtgctcgca ggactcctgt
     4561 gagttaccag aacaccatat ccagaggctc ccccatgatg aacagaactt ctgatggttc
     4621 ttccagcaag actaccagcc acgagaggaa gtcagctctg accccaaccc aaagagaaag
     4681 tgtcccagcc aagtctccag tgcctgccgt ggactccgtc gtgagtcaca gtccatttga
     4741 cccccatcat aggagtacca ctgcaggaga ggtttatcgg agccatcttc ccacgcactt
     4801 ggatccagcc atgccctttc acagggcttt ggatcctgct gctgcttacc tgtttcagag
     4861 acagctttca ccaaccccag gatacccaag tcagtaccag ctttatgcaa tggagaatac
     4921 aagacagaca atcctaaatg attacattac ctcacagcag atgcaagtga atttgcgccc
     4981 tgatgttgcc aggggactgt ccccacgaga gcagccactg ggtctccctt atccagctac
     5041 aagaggaatc attgacctga ccaatatgcc tccaacaatc ttagtgcctc atgcaggggg
     5101 gacaagcacc cctcccatgg acagaatcac ttatatccct ggtacacaga ttactttccc
     5161 tccgaggcca tacaatgctg cttctttgtc tccaggacac ccgacacacc ttgcagcagc
     5221 tgcaagtgct gagagagaac gagagcggga aagggagaag gagcgagaga gagagcgtga
     5281 gcgcgagcgc gaacgtgaac gcgaacgcga acgtgaacgc gaacgcgagc gtgagcgtga
     5341 aaggatcact gctgctccca ctgacctcta cctacgacca ggttcagaac agccaggccg
     5401 ccctggtagc cacggatatg ttcgctcccc ttccccttca gtaagaactc aggagaccat
     5461 gttgcaacag agacccagtg ttttccaggg aaccaatgga accagtgtga tcacgccttt
     5521 ggatccaact gctcagctac gaatcatgcc actgccttct gggggccctt ccataagtca
     5581 aggcctgcca gcctcccgtt acaacactgc tgcggatgcc ctggctgctc ttgtggacgc
     5641 tgcagcttct gcaccccaga tggatgtttc caaaacaaaa gagagtaagc atgaagctgc
     5701 caggttagaa gacaatgtga gaagcaggtc agcagcagtt agtgagcagc agcagctaga
     5761 gcagaaaaac ctggaggtgg agaagagatc tgttcagtgt gtgtgcacct cttcagccct
     5821 tccaagtggc aagccccagc ctcatgcctc cgtagtgtat tctgaggctg ggaaagataa
     5881 agggcctcct ccaaaatcca gatatgagga agagctaagg acccgaggga agactaccat
     5941 tactgcagct aacttcatag acgtgatcat cacccggcaa attgcctcgg acaaggatgc
     6001 aagggaacgt ggctctcaaa gttcagactc ttctagtagc ttgtcttctc acaggtatga
     6061 agcacctagt gatgctattg aggtgataag tcctgccagc tcacctgcac caccccagga
     6121 aaaaccacag gcctatcagc cagagatggt taaggcaaat caagcagaaa atgagtcccc
     6181 tcaacagtat gaaggaccac tgcatcatta tcggtcccag cagggatcac cgtctccaca
     6241 gcaacagcca ccactgcccc catcgtccca ggcagaggga atgggacagg tgcccaggac
     6301 ccatcgactg atcacacttg ctgaccacat ctgtcaaatt atcacacaag attttgctag
     6361 aaatcaagtt ccctcgcagc cttctacttc tacattccaa acttcaccat ctgctttgtc
     6421 gtccacacct gtaagaacta aaccgtcaag tcgctacagc ccagagtctc agtctcagac
     6481 tgtcttgcat cccagaccag gtcctagagt ctctccagaa aatcttgtgg ataaatcccg
     6541 gggaagcagg cctggaaaat ccccagagag gagtcacatc ccatcggagc cctatgagcc
     6601 catctcccca ccccaaggtc ctgctgtgca tgagaagcag gacagcatgc tgctcttgtc
     6661 acaaagggga atggatcctg ccgagcaaag gagtgattct cgatcaccag gaagtataag
     6721 ctacttgcct tcattcttca ccaagcttga aagcacatca cccatggtta aatcaaagaa
     6781 gcaggaaatt tttcgtaagt tgaactcctc tggtggaggt gactctgata tggcagctgc
     6841 tcagccagga acagagatct tcaatctgcc agcagttact acatcaggtg cagtaagctc
     6901 aagaagccat tcttttgctg atcctgccag taatcttggt ctagaagaca tcatcagaaa
     6961 agctctcatg ggaagtttcg atgacaaagt tgaagatcat ggtgttgtca tgcctcatcc
     7021 tgtgggagtt gtccctggta gtgctagcac ctcagttgtg acgagcagtg agacacggag
     7081 agatgaaggg gacccatcac ctcattcagg agtgtgcaaa ccaaagctga tcaacaaatc
     7141 gaacagcagg aagtctaaat ctcctattcc tgggcagaac tacttaggaa ctgaaaggcc
     7201 ttcttctgtc tcctctgtac attcagaggg tgattaccac aggcagacac caggatgggc
     7261 ttgggaagac aggccgtctt caacaggctc cactcagttc ccttacaacc ctctgaccat
     7321 ccggatgctg agcagtaccc cgccaacccc gatcgcctgt gccccgtcag ccatcaccca
     7381 ggcagctccg catcaacaga gccgcatctg ggagcgggag ccggccccgc tcctctcagc
     7441 acagtatgag acactgtctg acagtgacga ctgagctgca caggagagca ctctggcttt
     7501 gattttaatt gcagataaaa aaaaaaaatc tgccctccta tgatttgtgc ccagagactt
     7561 ctcaggagag ccagggctac ggatgaggaa gaaatgatgg aaattcattt ggaaaaatca
     7621 aatgggaaaa aaaaaatttg cctccaatac aggcaattca atggattata acagtggaga
     7681 gttgtagagt tttttttaaa actggacaat tcttgttctt acatctgttt gtaaagaaaa
     7741 ccatgatgtc tttaaatcac tcttctgtaa atagatgacc tttttgcagt gtatcccctt
     7801 gctgtagtat ctggtgtact taaatttaaa tcagcgaatc aacacttggg gtaattttta
     7861 aaattctttg tgtatctttt taaccccagc cttctaaaca acctcacaca gcccagttcc
     7921 acagtgctgg ctgtcatggg cattgtactt ttgtttcctc gaaattcagc tttcccagtg
     7981 atgtttaaat cttgtggaaa tacttaggtt tttaacacat accctgtcat aaagcctgta
     8041 tgaggtcaaa ggcaggagca gcagaactgt catattgtga gttccagtgc aggctttact
     8101 ttcttcatta gtagcactga aaaaattact gcatgggtat gttatagttc agttttaaag
     8161 tttaaaggct tattcgaggc atacctcaat gtttatgcac actggtaatt taaccatgcc
     8221 cctaagtatt cttctgcatt tgatgcagcc caacaaagct tctgttctga aataaatttt
     8281 gactatcctg tccatagcta cagtata
//
