LOCUS       NM_001276714            6694 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor coactivator 6 (Ncoa6), mRNA.
ACCESSION   NM_001276714 XM_001064189 XM_342552
VERSION     NM_001276714.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6694)
  AUTHORS   Antoniou,A., Khudayberdiev,S., Idziak,A., Bicker,S., Jacob,R. and
            Schratt,G.
  TITLE     The dynamic recruitment of TRBP to neuronal membranes mediates
            dendritogenesis during development
  JOURNAL   EMBO Rep 19 (3) (2018)
   PUBMED   29263199
  REMARK    GeneRIF: the processing of a subset of neuronal precursor
            microRNAs, among them the dendritically localized pre-miR16, was
            impaired. Decreased production of miR-16-5p, which targeted the
            BDNF mRNA itself, was rescued by expression of a membrane-targeted
            TRBP Moreover, miR-16-5p or membrane-targeted TRBP expression
            blocked BDNF-induced dendritogenesis, demonstrating the importance
            of neuronal TRBP dynamics
REFERENCE   2  (bases 1 to 6694)
  AUTHORS   Ding,J., Chen,J., Wang,Y., Kataoka,M., Ma,L., Zhou,P., Hu,X.,
            Lin,Z., Nie,M., Deng,Z.L., Pu,W.T. and Wang,D.Z.
  TITLE     Trbp regulates heart function through microRNA-mediated Sox6
            repression
  JOURNAL   Nat Genet 47 (7), 776-783 (2015)
   PUBMED   26029872
REFERENCE   3  (bases 1 to 6694)
  AUTHORS   Tony,H., Meng,K., Wu,B., Yu,A., Zeng,Q., Yu,K. and Zhong,Y.
  TITLE     MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes
            Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves
            Cardiac Function after Myocardial Infarction
  JOURNAL   Mediators Inflamm 2015, 479123 (2015)
   PUBMED   26688617
REFERENCE   4  (bases 1 to 6694)
  AUTHORS   Zhang,Z., Takeuchi,H., Gao,J., Wang,D., James,D.J., Martin,T.F.J.
            and Hirata,M.
  TITLE     PRIP (phospholipase C-related but catalytically inactive protein)
            inhibits exocytosis by direct interactions with syntaxin 1 and
            SNAP-25 through its C2 domain
  JOURNAL   J Biol Chem 288 (11), 7769-7780 (2013)
   PUBMED   23341457
  REMARK    GeneRIF: PRIP inhibits regulated exocytosis through the interaction
            of its C2 domain with syntaxin 1 and SNAP-25, potentially competing
            with accessory proteins such as synaptotagmin I and by directly
            inhibiting trans-SNARE complex formation
REFERENCE   5  (bases 1 to 6694)
  AUTHORS   Shilatifard,A.
  TITLE     The COMPASS family of histone H3K4 methylases: mechanisms of
            regulation in development and disease pathogenesis
  JOURNAL   Annu Rev Biochem 81, 65-95 (2012)
   PUBMED   22663077
  REMARK    Review article
REFERENCE   6  (bases 1 to 6694)
  AUTHORS   Mahajan,M.A. and Samuels,H.H.
  TITLE     A new family of nuclear receptor coregulators that integrate
            nuclear receptor signaling through CREB-binding protein
  JOURNAL   Mol Cell Biol 20 (14), 5048-5063 (2000)
   PUBMED   10866662
REFERENCE   7  (bases 1 to 6694)
  AUTHORS   Ko,L., Cardona,G.R. and Chin,W.W.
  TITLE     Thyroid hormone receptor-binding protein, an LXXLL motif-containing
            protein, functions as a general coactivator
  JOURNAL   Proc Natl Acad Sci U S A 97 (11), 6212-6217 (2000)
   PUBMED   10823961
REFERENCE   8  (bases 1 to 6694)
  AUTHORS   Zhu,Y., Kan,L., Qi,C., Kanwar,Y.S., Yeldandi,A.V., Rao,M.S. and
            Reddy,J.K.
  TITLE     Isolation and characterization of peroxisome proliferator-activated
            receptor (PPAR) interacting protein (PRIP) as a coactivator for
            PPAR
  JOURNAL   J Biol Chem 275 (18), 13510-13516 (2000)
   PUBMED   10788465
REFERENCE   9  (bases 1 to 6694)
  AUTHORS   Caira,F., Antonson,P., Pelto-Huikko,M., Treuter,E. and
            Gustafsson,J.A.
  TITLE     Cloning and characterization of RAP250, a novel nuclear receptor
            coactivator
  JOURNAL   J Biol Chem 275 (8), 5308-5317 (2000)
   PUBMED   10681503
REFERENCE   10 (bases 1 to 6694)
  AUTHORS   Lee,S.K., Anzick,S.L., Choi,J.E., Bubendorf,L., Guan,X.Y.,
            Jung,Y.K., Kallioniemi,O.P., Kononen,J., Trent,J.M., Azorsa,D.,
            Jhun,B.H., Cheong,J.H., Lee,Y.C., Meltzer,P.S. and Lee,J.W.
  TITLE     A nuclear factor, ASC-2, as a cancer-amplified transcriptional
            coactivator essential for ligand-dependent transactivation by
            nuclear receptors in vivo
  JOURNAL   J Biol Chem 274 (48), 34283-34293 (1999)
   PUBMED   10567404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_001276714.2.
            
            On or before Mar 1, 2013 this sequence version replaced
            XM_001064189.3, XM_342552.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.1138663.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000003.1  164391541-164391775 c
            236-391             JAXUCZ010000003.1  164387828-164387983 c
            392-514             JAXUCZ010000003.1  164383798-164383920 c
            515-643             JAXUCZ010000003.1  164382076-164382204 c
            644-1516            JAXUCZ010000003.1  164380277-164381149 c
            1517-1663           JAXUCZ010000003.1  164378238-164378384 c
            1664-2780           JAXUCZ010000003.1  164373451-164374567 c
            2781-2902           JAXUCZ010000003.1  164370877-164370998 c
            2903-5878           JAXUCZ010000003.1  164364918-164367893 c
            5879-5947           JAXUCZ010000003.1  164362079-164362147 c
            5948-5984           JAXUCZ010000003.1  164359011-164359047 c
            5985-6133           JAXUCZ010000003.1  164355344-164355492 c
            6134-6694           JAXUCZ010000003.1  164351062-164351622 c
FEATURES             Location/Qualifiers
     source          1..6694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41-q42"
     gene            1..6694
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /note="nuclear receptor coactivator 6"
                     /db_xref="GeneID:116464"
                     /db_xref="RGD:620111"
     CDS             1..6177
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /note="peroxisome proliferator-activated
                     receptor-interacting protein; PPAR-interacting protein;
                     activating signal cointegrator 2; amplified in breast
                     cancer protein 3; nuclear receptor-activating protein, 250
                     kDa; cancer-amplified transcriptional coactivator ASC-2;
                     thyroid hormone receptor binding protein"
                     /codon_start=1
                     /product="nuclear receptor coactivator 6"
                     /protein_id="NP_001263643.1"
                     /db_xref="GeneID:116464"
                     /db_xref="RGD:620111"
                     /translation="MVLDDLPNFEDIYTSLCSSTMGDSEVEFDSGLEDDDTKSDSILE
                     DSTIFVAFKGNIDDKDFKWKLDTILQSVPGLLHMESSKLKVQKVEPWNSVRVTFNIPR
                     EAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALGQNRSQDVRMNGPVVSGNSVR
                     MEAGFPMASGPGLIRMTSPATVMMPQGGNASSSMMAPGPNPELQPRTPRPASQSDAMD
                     PLLSGLHIQQQSHPSGSLPPAHHPMQPVPVNRQMNPANFPQLQQQQQQQQQQQQQQQQ
                     QQQQQLQTRPLQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGPM
                     TTNQGWKKAPLPSPMQAQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNP
                     GQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMG
                     PRPPQNNPLSQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPSQGPPSLHPGLGGMP
                     KRLPPGFSAGQANPNFMQGQVPSTTAATPGNSGALQLQANQSVQHAGGQGAGPPQNQM
                     QVSHGPPNMMQPSLMGIHGNINNQQAGSSGVPQVTLGSMQGQPQQGPPSQLMGMHQQI
                     VPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQ
                     QGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMPGPAQIM
                     RGPTPNMQGNMVQFTGQMSGQMLPQQGPVSNSPSQVMGIQGQVLRPPGPSPHMAQQHT
                     DPATTANNDVNLSQMMPDVSMQQTSMVPPHVQSMQGNSASGSHFSGHGVSFNAPFGGA
                     PNGTQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKQKKKK
                     PPRKKKNCHQDLNTPDSRPAGLEEVDQQSLPGEQGINLDNTGPKLPDFSNRPPGYPTQ
                     PVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQPQPQPPPPSQPQSQQQQQQMM
                     MMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRVPMQQSGNVPVMVSLQGPASVPPSP
                     DKQRMPMPVNTPLGSNSRKMVYQESPQNSSSPLGEMPSLPEAGGSEVPSVSGGPSNMP
                     SHLVVSQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRP
                     KTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLN
                     RGFDQQGLNPTTLKAIGQAPSNLTVSNPPNFAAPQAHKLDSVVVSSGKQSNPGTTKRA
                     SPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTLLQNMELPRNVLVGPTPLA
                     NPPLSGSFPNNNGLNSQNPTVPAPAVGTVVEDNKESLNVPQDSDCQNSQGRKEQVNTE
                     LKAVPIQEAKMVVPEDQSKKDGQPLDPNKLPSVEENKTLMSPAMREAPTSLSQLLDNS
                     GAPNVTIKPPGLTDLEVTPPAVSGEDLKKASVIPTLQDPSSKEPSNSLNLPHSNEPCS
                     TLAHPELSEVSSNIAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAA
                     LPTHLQSALMSTVVTMPNVGNKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGS
                     QPSTIPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVTPNVPSSSPAPNIQTGRP
                     LVLSSRATPVPLPSPPCTSSPVVAPNPSVQQVKELNPDEASPQTNTSADQSTLPSSQP
                     TTVVSPLLANSPGSSANRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYG
                     ADGETEGPGLETTTPGLMGTEQCSTELDSKTPTPSAPTLLKMTSSPMGPSSTSTGPIL
                     PGGALPTSVRSVVTTLVPSELISTAPTTKGNHGGITSEPLAGGLVEEKVGSHPELLPS
                     IAPSQTLVPKESPATALQGSVGRPELEANAAIASGQSSEPKETVEKSKTPSRRNSRTE
                     EPTMASENVENGHRKRSSRPASASSSTKDITGAVQSKRRKSK"
     exon            1..235
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            236..391
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            392..514
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            515..643
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            644..1516
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1663
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..2780
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2902
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..5878
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            5879..5947
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            5948..5984
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            5985..6133
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
     exon            6134..6694
                     /gene="Ncoa6"
                     /gene_synonym="Aib3; NRC; PRIP; RAP250; Trbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggttttgg atgaccttcc aaactttgaa gacatctata cttccttgtg ttcatcaaca
       61 atgggagact cagaggtgga gtttgactct ggactagaag atgatgacac aaaaagtgat
      121 agtattttgg aggattctac aatttttgta gccttcaaag gaaatataga tgataaagac
      181 ttcaaatgga aactggatac aatcttacag agtgtgcccg gcttgttaca catggaatcc
      241 agcaagctga aggtacagaa agtggagccc tggaacagcg tgcgagtcac attcaacatc
      301 ccccgggaag cagcagagcg gttacggatc ctggctcaga gcaacaacca gcagcttcgg
      361 gatctgggga ttctctccgt tcagattgaa ggggaaggtg ctatcaacct ggctttgggt
      421 cagaaccgaa gccaagacgt gagaatgaat ggacccgtgg tatctggaaa ttccgttagg
      481 atggaggcag gatttcccat ggcaagtggt ccaggactaa taagaatgac aagccctgcc
      541 actgttatga tgccccaggg cgggaacgca tcatcttcca tgatggcacc aggccccaat
      601 ccagaactgc aacccaggac tcctcgccct gcttctcagt cagatgcgat ggatccactt
      661 ctctctggac tccatataca gcaacagagt catccctcag gatctttacc tccagcgcat
      721 cacccaatgc aacctgttcc tgtgaacaga caaatgaacc cagctaattt tccccagctg
      781 cagcaacagc agcagcaaca gcagcagcag cagcagcagc agcaacagca gcagcagcaa
      841 cagttgcaga ctagaccttt acaacaacat cagcagcaac agccacaggg gattcgacca
      901 cagtttactg ctccaactca ggtgcctgtt cctccaggct ggaaccagct gccttctgga
      961 gccttacagc ctccaccagc ccagggatct ctgggcccaa tgactacaaa tcaagggtgg
     1021 aagaaggctc ccttgcctag cccaatgcaa gcgcaacttc aggcaagacc ttccttagcc
     1081 acggtacaga caccttctca ccctccccct ccttatcctt ttggcagcca acaagcctca
     1141 caagcccata caaactttcc tcaaatgagc aacccaggcc agttcacagc tcctcagatg
     1201 aagagcttgc agggaggacc ctccagggtc ccaacccccc tgcaacagcc ccacctcacc
     1261 aacaagtctc ctgcctcctc accctcctcc ttccagcagg gatcccctgc atcctcccca
     1321 acggttaacc aaactcagca gcagatggga ccaaggccac ctcaaaataa cccactttcc
     1381 cagggatttc agcagcctgt cagctctccg ggtcggaatc ctatggttca acagggaaat
     1441 gtgccaccta acttcatggt gatgcagcag cagccaccaa gccaggggcc accgagttta
     1501 cacccaggcc taggaggaat gcctaaacgc ctcccacctg gcttctcagc aggacaggcc
     1561 aatcccaact ttatgcaagg tcaggtgcct tccaccacag cagccacccc tgggaattca
     1621 ggagcccttc agctgcaagc aaatcaaagt gtccagcatg caggtggtca aggagctggt
     1681 cctcctcaaa accagatgca ggtgtctcac gggccaccaa atatgatgca acccagcctc
     1741 atgggaattc atggcaacat aaacaaccag caggctggta gctctggggt tcctcaggtg
     1801 accctgggca gcatgcaagg ccagccccag cagggcccac catctcagct aatgggcatg
     1861 caccaacaga ttgtgccctc acagggccaa atggcccagc agcaaggaac tttgaaccct
     1921 caaaacccta tgatcctttc aagggcccag cttatgccac agggccagat gatggtgaac
     1981 gctcagaacc aaaatcttgg accttcaccc caaaggatga ccccacccaa gcagatgctt
     2041 ccccagcagg gcccacaaat gatggcgcca cataaccaga tgatggggcc tcaggggcaa
     2101 gtgttgctcc agcagaatcc aatgatagag caaataatga ccaatcagat gcaggggaat
     2161 aaggcgcaat ttaattctca gaaccaatcc aacgtcatgc cgggaccagc acagataatg
     2221 aggggaccaa ctcctaacat gcaaggaaac atggtgcaat tcacaggaca gatgtcagga
     2281 cagatgctgc ctcagcaagg gcctgtgagc aacagtccat ctcaggttat ggggattcag
     2341 gggcaggttc tgcggccacc aggacccagc ccacacatgg cccagcaaca tactgatcct
     2401 gctactacag caaataatga tgtcaacttg tctcagatga tgcctgatgt tagcatgcaa
     2461 caaaccagca tggtccctcc acatgtgcag agcatgcagg gaaacagtgc ttcgggaagc
     2521 cacttctcag gccatggagt gtctttcaat gcaccattcg gtggtgcacc caatggaact
     2581 cagatgtctt gtggtcaaaa tccaggcttt ccagtaaata aggatgtaac gttaacaagc
     2641 ccattgttgg tcaacttact gcaaagtgac atttcagcag gtcattttgg cgtaaacaat
     2701 aaacaaaata ataccaacgc gaataaacag aagaagaaga aaccaccgcg gaagaagaaa
     2761 aattgtcacc aggatctaaa caccccagat agtcgtccag ctggtctaga ggaagttgat
     2821 caacagtcat tacctggaga acaaggaatc aatttggaca acacaggccc taaactgcca
     2881 gacttttcaa accggccacc aggttatcct acacaaccag ttgaacagag gccactgcag
     2941 cagatgcctc ctcaactcat gcagcatgtg gcacccccac cacagccacc acagcagcag
     3001 ccacaaccac aactgcctca acagcagcca cagccgcagc caccaccacc tagtcagcca
     3061 cagtcgcagc agcagcagca gcagatgatg atgatgctca tgatgcagca agatcccaaa
     3121 tccattaggc ttccggtctc ccaaaatgtc catcctccac ggggtcctct gaacccagac
     3181 tcccaaagag tgcccatgca acagagtggc aatgtgcctg tcatggttag tttgcaagga
     3241 cctgcctctg tgccaccgtc acctgataaa caaaggatgc caatgcctgt gaatactccg
     3301 ctgggaagta attcaagaaa gatggtatac caggagagcc cacagaattc cagctcacca
     3361 ctaggagaga tgccctcact tcctgaagct ggtggcagtg aagtaccatc tgtttcagga
     3421 ggcccaagta acatgccctc gcatttagta gtttctcaga atcaattaat gatgacagga
     3481 cccaaacctg gaccatctcc cctttcagca actcaaggtg caactcccca gcagcctcct
     3541 gtaaactcct tgcctagttc ccatggccac cactttccaa atgtggctgc accaacccaa
     3601 acatctaggc ctaaaacacc aaacagagcc agccccagac cctattatcc tcagacgccc
     3661 aacaaccgcc ctcctagcac agaaccttca gaaatcagtc tctctccaga aagactcaat
     3721 gcttccatag caggactctt ccctccacag attaatattc ctttacctcc caggccaaac
     3781 ttaaataggg gctttgatca acagggctta aatccaacaa ctctgaaggc cattgggcaa
     3841 gcaccttcaa atctcactgt aagtaatcct cctaactttg ctgccccaca agctcataaa
     3901 ttagattctg tggtggtgag ttctggaaaa cagtctaatc ctggaacaac aaaacgggca
     3961 agtccaagca acagtcgcag gtctagtccg gggtccagta gaaagactac cccaagtcct
     4021 ggaaggcaaa attcaaaagc ccctaaactt actctggctt ctcaaacaag cacaaccctg
     4081 ttgcagaaca tggagctgcc tagaaatgtg ttggttggtc ccactccact tgccaatccc
     4141 cctttatctg gaagctttcc taacaataat gggcttaatt cccagaatcc caccgtgcct
     4201 gcgcctgcag tggggactgt tgttgaggat aacaaagaga gcttgaatgt tcctcaggac
     4261 agtgattgcc agaattccca ggggaggaag gaacaggtaa acactgagct gaaagcagtc
     4321 cctatccaag aagctaaaat ggttgtcccc gaagatcagt ccaaaaagga tgggcaacct
     4381 ttggatccta acaaactccc cagtgtagaa gagaacaaaa ctttgatgtc tcctgccatg
     4441 agagaagcac caacatcact aagccaactt ctcgacaact ctggagctcc taatgtgacc
     4501 attaaacccc ctgggcttac agatctggaa gtaacacctc cagcagtttc aggagaggac
     4561 ctcaaaaaag catctgtcat tcccacactg caggatccgt cttctaaaga accctctaat
     4621 tctttaaact tacctcacag taacgagccg tgttcaaccc ttgcgcatcc agaattgagt
     4681 gaggtcagct caaacattgc accaagcatc cctccagtaa tgtcaagacc tgtcagctct
     4741 tcctccattt ctactccctt acccccaaac caaataactg tatttgttac ttccaacccc
     4801 ataaccactt catctaacac atcagcagcc ctgccaactc acttgcagtc tgcattgatg
     4861 tcgacagtcg tcacgatgcc caacgtgggt aacaaagtta tggtttctga gggacagtca
     4921 gctgctcaat ctaatgcccg gcctcagttc attacacctg tctttatcaa ttcatcttca
     4981 ataattcagg ttatgaaagg atcacagcca agcacaatcc ctgcaacccc attgacaacc
     5041 aacagtggcc tgatgcctcc ctctgtcgca gttgttggac ctttacacat acctcagaac
     5101 ataaaatttt cttcagctcc tgtaacacct aatgtcccct ccagtagtcc tgctccaaat
     5161 atacagacag gtcggccatt ggtccttagc tcacgagcca ctcctgttcc gctgccttcc
     5221 cctccttgta catcctctcc agtcgtcgct cctaatcctt ctgtccagca agtaaaagaa
     5281 ttaaatccag atgaggctag tcctcagacg aacacctcag cagaccagag cactctgcct
     5341 tcttcacaac caaccacagt agtttctccc cttttggcca atagtccagg ctcctctgcc
     5401 aatcggcgaa gcccagtctc atccagtaag ggcaaaggaa aagtggacaa aattggccag
     5461 attttgctga ccaaagcttg taagaaagtt acaggctctc tggagaaagg ggaagaacag
     5521 tatggtgcag atggagaaac tgaaggccca gggctagaga ccacaactcc tgggctaatg
     5581 ggaacagagc agtgctccac agagctggac agtaaaaccc caacaccctc agcacccact
     5641 ctcctaaaaa tgacctctag ccccatgggc ccaagctcca cctcaacagg acccatctta
     5701 cctggcggtg ctcttcccac cagtgtacgc tctgtagtaa ccacattggt accctctgag
     5761 ctcatctcca cagcgccaac cacaaaaggc aatcatggtg ggataacatc tgagccactt
     5821 gcaggtggcc tagtggagga gaaggtggga tcccatccag agcttctacc cagcatagcc
     5881 ccttcacaga ctttagtccc aaaggaatct ccagccacag cactgcaggg ctctgttggc
     5941 agaccagaac ttgaggcaaa tgctgccata gcctctggac aaagcagtga gccaaaagag
     6001 acagttgaga agtccaaaac ccccagccga agaaactctc gaactgagga gccaactatg
     6061 gcttctgaga atgtggaaaa tggacatcga aaaagatctt ctcgacctgc ttcagcctcc
     6121 agctctacta aagatataac tggtgcagtg caatctaagc gaagaaaatc caagtaagca
     6181 agcaggaaga tgacttgata cttgtaaatg tttgtgaatt ttacaaagag caattttcag
     6241 ctgtgacttt ttaaatctat ttctgtacag tcagtcattt taataacgta atgacgcggt
     6301 ccttttccta atccctaaaa cctgtctcat aaagtgtaat ggggagcagc ccttttggtg
     6361 ttgcaaaatg aagttcaagg cttctaaaat gttgccatgt attgaaagga gctaatgcca
     6421 ttgtaaatgt tattagtttc acatttcttg agcagcctag agtacagggt gaacatttgt
     6481 agatcttgta atgatgtatt gtgctgtgga agtactgtgt gtgaatagca gtagtggggc
     6541 aaaaagcaat cttgtcattt ggaaatgtaa ataattttat tatatagtgt tttggatgta
     6601 tttgttgtag aaatggacca gtgaataaag agaatctaag ggtttgtaca atgtgaaata
     6661 ctgaacgtgt taaataaatg tctttgtcat agaa
//
