LOCUS       NM_001034008            3430 bp    mRNA    linear   ROD 17-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4),
            transcript variant 2, mRNA.
ACCESSION   NM_001034008
VERSION     NM_001034008.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3430)
  AUTHORS   Li,F., Wang,F., Wang,L., Wang,J., Wei,S., Meng,J., Li,Y., Feng,L.
            and Jiang,P.
  TITLE     m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting
            ferritinophagy to alleviate secondary injury after intracerebral
            haemorrhage
  JOURNAL   Epigenetics 19 (1), 2326868 (2024)
   PUBMED   38465865
  REMARK    GeneRIF: m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting
            ferritinophagy to alleviate secondary injury after intracerebral
            haemorrhage.
REFERENCE   2  (bases 1 to 3430)
  AUTHORS   Bogdan,A.R., Miyazawa,M., Hashimoto,K. and Tsuji,Y.
  TITLE     Regulators of Iron Homeostasis: New Players in Metabolism, Cell
            Death, and Disease
  JOURNAL   Trends Biochem Sci 41 (3), 274-286 (2016)
   PUBMED   26725301
  REMARK    Review article
REFERENCE   3  (bases 1 to 3430)
  AUTHORS   Lane,D.J., Merlot,A.M., Huang,M.L., Bae,D.H., Jansson,P.J.,
            Sahni,S., Kalinowski,D.S. and Richardson,D.R.
  TITLE     Cellular iron uptake, trafficking and metabolism: Key molecules and
            mechanisms and their roles in disease
  JOURNAL   Biochim Biophys Acta 1853 (5), 1130-1144 (2015)
   PUBMED   25661197
  REMARK    Review article
REFERENCE   4  (bases 1 to 3430)
  AUTHORS   Dowdle,W.E., Nyfeler,B., Nagel,J., Elling,R.A., Liu,S.,
            Triantafellow,E., Menon,S., Wang,Z., Honda,A., Pardee,G.,
            Cantwell,J., Luu,C., Cornella-Taracido,I., Harrington,E.,
            Fekkes,P., Lei,H., Fang,Q., Digan,M.E., Burdick,D., Powers,A.F.,
            Helliwell,S.B., D'Aquin,S., Bastien,J., Wang,H., Wiederschain,D.,
            Kuerth,J., Bergman,P., Schwalb,D., Thomas,J., Ugwonali,S.,
            Harbinski,F., Tallarico,J., Wilson,C.J., Myer,V.E., Porter,J.A.,
            Bussiere,D.E., Finan,P.M., Labow,M.A., Mao,X., Hamann,L.G.,
            Manning,B.D., Valdez,R.A., Nicholson,T., Schirle,M., Knapp,M.S.,
            Keaney,E.P. and Murphy,L.O.
  TITLE     Selective VPS34 inhibitor blocks autophagy and uncovers a role for
            NCOA4 in ferritin degradation and iron homeostasis in vivo
  JOURNAL   Nat Cell Biol 16 (11), 1069-1079 (2014)
   PUBMED   25327288
REFERENCE   5  (bases 1 to 3430)
  AUTHORS   Tai,P.J., Huang,Y.H., Shih,C.H., Chen,R.N., Chen,C.D., Chen,W.J.,
            Wang,C.S. and Lin,K.H.
  TITLE     Direct regulation of androgen receptor-associated protein 70 by
            thyroid hormone and its receptors
  JOURNAL   Endocrinology 148 (7), 3485-3495 (2007)
   PUBMED   17412801
REFERENCE   6  (bases 1 to 3430)
  AUTHORS   Quezada,S., Avellaira,C., Johnson,M.C., Gabler,F., Fuentes,A. and
            Vega,M.
  TITLE     Evaluation of steroid receptors, coregulators, and molecules
            associated with uterine receptivity in secretory endometria from
            untreated women with polycystic ovary syndrome
  JOURNAL   Fertil Steril 85 (4), 1017-1026 (2006)
   PUBMED   16580389
REFERENCE   7  (bases 1 to 3430)
  AUTHORS   Hu,Y.C., Yeh,S., Yeh,S.D., Sampson,E.R., Huang,J., Li,P., Hsu,C.L.,
            Ting,H.J., Lin,H.K., Wang,L., Kim,E., Ni,J. and Chang,C.
  TITLE     Functional domain and motif analyses of androgen receptor
            coregulator ARA70 and its differential expression in prostate
            cancer
  JOURNAL   J Biol Chem 279 (32), 33438-33446 (2004)
   PUBMED   15166229
  REMARK    Erratum:[J Biol Chem. 2020 Dec 11;295(50):17382. PMID: 33310747]
REFERENCE   8  (bases 1 to 3430)
  AUTHORS   Li,P., Yu,X., Ge,K., Melamed,J., Roeder,R.G. and Wang,Z.
  TITLE     Heterogeneous expression and functions of androgen receptor
            co-factors in primary prostate cancer
  JOURNAL   Am J Pathol 161 (4), 1467-1474 (2002)
   PUBMED   12368219
REFERENCE   9  (bases 1 to 3430)
  AUTHORS   Kollara,A., Kahn,H.J., Marks,A. and Brown,T.J.
  TITLE     Loss of androgen receptor associated protein 70 (ARA70) expression
            in a subset of HER2-positive breast cancers
  JOURNAL   Breast Cancer Res Treat 67 (3), 245-253 (2001)
   PUBMED   11561770
REFERENCE   10 (bases 1 to 3430)
  AUTHORS   Shaw,P.A., Rittenberg,P.V. and Brown,T.J.
  TITLE     Activation of androgen receptor-associated protein 70 (ARA70) mRNA
            expression in ovarian cancer
  JOURNAL   Gynecol Oncol 80 (2), 132-138 (2001)
   PUBMED   11161850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB758330.1, CV119475.1, BC061839.1, AI031008.1, CV795771.1 and
            AI112421.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript. Variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160817.1, SRR8487231.115066.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                CB758330.1         58-146
            90-673              CV119475.1         68-651
            674-2386            BC061839.1         717-2429
            2387-2708           AI031008.1         7-328
            2709-2976           BC061839.1         2741-3008
            2977-3396           CV795771.1         36-455              c
            3397-3430           AI112421.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..3430
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3430
                     /gene="Ncoa4"
                     /note="nuclear receptor coactivator 4"
                     /db_xref="GeneID:619385"
                     /db_xref="RGD:1563014"
     exon            1..89
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     exon            90..244
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1972
                     /gene="Ncoa4"
                     /codon_start=1
                     /product="nuclear receptor coactivator 4"
                     /protein_id="NP_001029180.1"
                     /db_xref="GeneID:619385"
                     /db_xref="RGD:1563014"
                     /translation="MNTSLEQSGCCSSRETLLRCSDARRELELAIGGVLRAEQQMKDN
                     LREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWLMGQFNCL
                     IHQLEITQNKDLANQVALCLERLGSLTLKPEDSTVLLFEADASALRQTITTFGSLKTI
                     QIPEHLMAHPSSSSVRPFLEKRGYTQVPEQKSASSGTAVSLSEWLLVSKPAIGPQAPY
                     VPSTNPQDWLTPKQTLENSQTSARICSDAWGNLKGLENWLLNSHQQEIPGKPSSSKCN
                     SHCSTSSFSTEDEKVEDVEVLDQDELDLSDWLVTPQEPRDLEKPVNGRSDTSDKFKLL
                     FQVFREPYNVNDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLEAKKSLPVPGVI
                     TEGWLVQNHQDTCKVEEVCKANEPCTSFAECVCDDSCEKEAMHKWLLKKEGKDKNGMP
                     MGPKSESEKHRESLSLWLCPSRNELTEHAKTPKTTAPARIADSFHIIRNSSLSEWLIG
                     PTCKGGGPKEVPNMEERASKEMLKSPMATYWRPFNTADWVLPGKKVGNLSQFSSGEDK
                     WLLRKKAQEVFLNSPLQEERNFRSDCYGLPAVCDLFACMQLKVDKDKWLYRAPLQM"
     exon            245..385
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     exon            386..474
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     exon            475..583
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     exon            584..673
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     exon            674..817
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1825
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1966
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..3416
                     /gene="Ncoa4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3391..3396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa4"
     polyA_site      3416
                     /gene="Ncoa4"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 tctgccttca gggtccggct ccttccgtgg ctgagtgtct gggtcggtcc aaggtccgct
       61 cggatcaccg gaagaagccc tgccagctgg aacagtgagc agaatgaata catccctgga
      121 gcagagtggc tgctgcagta gtagagagac acttctgagg tgcagtgatg caaggaggga
      181 gctggagctt gcgattggtg gagtcctccg ggccgagcag caaatgaaag ataatctacg
      241 agaggtgaaa gctcagattc acagctgcat tagtcgccac ctggaatgcc ttcgaagccg
      301 agaggtgtgg ctcaacgagc aggtggatct catctatcag ctgaaggagg agacgctgca
      361 gcagcaggct cagcagctgt actggctaat gggccaattc aattgtctta ttcatcaact
      421 ggagattacc cagaacaagg atcttgccaa tcaagtcgcg ctgtgcttgg agagactggg
      481 cagtttgacc cttaagcctg aggattctac tgtcctgctc tttgaagcag atgcatctgc
      541 cctgcgtcag accatcacca cgtttgggtc cctcaagacc attcaaattc ctgagcacct
      601 gatggctcat cctagttctt caagtgtcag gcctttcctg gagaaaagag gttataccca
      661 ggtgccagag cagaagtcag catccagcgg cacagctgtt tctctcagtg aatggcttct
      721 tgtaagcaaa cctgccattg gtcctcaggc tccatacgta cccagtacca acccacagga
      781 ctggctcacc ccaaaacaga ccttggagaa cagtcagact tctgccagaa tctgcagcga
      841 tgcctggggc aatctgaagg gcttagaaaa ctggctcctt aacagtcatc aacaagaaat
      901 tcctggaaaa ccaagttcct caaaatgtaa tagccattgt agcaccagtt ctttctctac
      961 tgaagatgaa aaggttgaag atgtagaggt cctcgatcaa gacgagctgg acctgtctga
     1021 ttggttggtg actcctcagg aaccccgtga tctggagaag cctgtgaatg gccgctctga
     1081 caccagtgac aagtttaagc tcttgttcca ggtgttcaga gagccctaca atgtgaatga
     1141 ttggcttgtc aagcctgact cctgtaccaa ctgtcagggt aaccagccca gaggtgtgga
     1201 gattgagaac ctgggcaatc tgaaatgcct gaatgaccac ttggaggcta aaaagtcatt
     1261 gccagtcccc ggcgtaatca ccgagggctg gcttgtccag aaccatcagg acacatgtaa
     1321 agtagaggaa gtctgcaaag ccaacgagcc ctgcaccagc tttgcagagt gtgtgtgtga
     1381 tgacagctgt gagaaggaag cgatgcataa atggcttctg aagaaagaag ggaaggacaa
     1441 gaatggaatg cctatgggac ccaaatctga gtctgagaaa cacagagagt ccctgtctct
     1501 gtggctttgc ccttctagaa atgagctaac agaacacgct aagacaccca agactacggc
     1561 tcctgctaga attgctgact ccttccacat cataaggaat agctccttgt cagagtggct
     1621 tattgggcct acatgcaaag gaggaggccc caaggaagtg cccaatatgg aggagagagc
     1681 tagcaaagaa atgcttaaaa gccccatggc cacttactgg cgtcctttta acactgctga
     1741 ctgggtctta ccaggaaaga aagtgggaaa ccttagtcag ttctcctcgg gagaagataa
     1801 gtggctactt cgaaagaagg cacaggaagt atttcttaat tcacccctac aagaagaacg
     1861 taactttcgc tcagattgtt acggcctccc ggcagtttgt gatctctttg cctgtatgca
     1921 gcttaaagtt gataaggaca aatggctgta cagagcccct cttcagatgt gaaggagtgg
     1981 atactagagt ggagcatctt ccctgcagat tctcgcacat cgtgagctga gtgaccgtga
     2041 cctgccaacc attgtgcatt ccaggcctga ctagtcggct tagttcctct cctgcttagt
     2101 tttgaactag taaacagaaa tcataaactg agttaagtct gtgagttgag gcttgaagtg
     2161 aaggtgatta ttcttatgga agcagtaact tgattgactc ccatagtaga aaccgcatcc
     2221 cggtacacag gcctttacag cttctgtaac aaacactagt tttaaaagtg aaatatttct
     2281 acatcaagtg tgttaatgtg ttcaaggtag taaagctctc tagctttcgt cctttagctg
     2341 tctctcctgt cactggctcc tagtgatttg ggtttttttt tttttttttt tttttttggt
     2401 tcagttgata tatagaatat ttcacacaaa taattaacct tgccaataca gtatattttt
     2461 ccctactgaa tctctattag ttacattgca attttgatac tcaccagata tttagcctac
     2521 atgtcatttc taacatttct catttgaaaa gaaaagttgc ctttatttct tcccaagtat
     2581 ccagtaagct ctttgaaagg acttaccgtt tcaggaccac tcttagggca atcagagccc
     2641 cctaaagtcc tacaaacctt ggctttaact aaggagtcct aggccaatta aagcagaagt
     2701 aaaatgtgct aggaatgaat gtagtacctg aaccactcat cgtcctaagg atttattggt
     2761 gcatcctgtg gaagtggaag ctgagcttga cacctggtgc tcttaactag ggatacagtc
     2821 catgtcctgt cacttcaagc acagcatcct gaacctccaa aagtacagtg cagtgatgtc
     2881 ttgactaaca ggctgtgctc aatacttgtg ccttggagtg tttccctgaa acttcacaga
     2941 actgacatcc ttgggttatg tctgtatttt agaaaggaga gtagcaggat tgatctttta
     3001 caattcttca ggatagcagc tgctttctaa gctttgaact attaatatta agcctctgag
     3061 ttgcctatgc tattggaagt acttttggga gaattttatg gttcttccca cagtgacatt
     3121 accatagagc tttactaaag ctccaaatca tagctgaaaa gagctccata ttttcttacg
     3181 tccccccaga tgccactgag tattaaatcg ttggtaggta aaaacaattt taaggagcct
     3241 ttccaacatt ttaggttgcg gggaactttg tggtttcttt tttgaggtct aacacactgt
     3301 atttcacatt attaaaacat aattttaagt taatcactat tgctaatgtt atataaaact
     3361 ttcttttgca ttgataagtt ttatatctcc attaaaagca taattgccac atcacaaaaa
     3421 aaaaaaaaaa
//
