LOCUS       NM_001395569            7162 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus nuclear receptor coactivator 1 (Ncoa1), mRNA.
ACCESSION   NM_001395569 XM_039112183
VERSION     NM_001395569.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7162)
  AUTHORS   Shen L, Liu Y, Tso P, Wang DQ, Davidson WS, Woods SC and Liu M.
  TITLE     Silencing steroid receptor coactivator-1 in the nucleus of the
            solitary tract reduces estrogenic effects on feeding and
            apolipoprotein A-IV expression
  JOURNAL   J Biol Chem 293 (6), 2091-2101 (2018)
   PUBMED   29263093
  REMARK    GeneRIF: Reduced levels of endogenous SRC-1 and apoA-IV expression
            are responsible for the impaired E2's anorectic action in obese
            females.
REFERENCE   2  (bases 1 to 7162)
  AUTHORS   Whitaker AM, Farooq MA, Edwards S and Gilpin NW.
  TITLE     Post-traumatic stress avoidance is attenuated by corticosterone and
            associated with brain levels of steroid receptor co-activator-1 in
            rats
  JOURNAL   Stress 19 (1), 69-77 (2016)
   PUBMED   26482332
  REMARK    GeneRIF: In post-traumatic avoiders, predator-odor exposure led to
            lower SRC-1 expression in paraventricular nucleus and central
            amygdala, and higher expression in the ventral hippocampus.
REFERENCE   3  (bases 1 to 7162)
  AUTHORS   Liu M, Huangfu X, Zhao Y, Zhang D and Zhang J.
  TITLE     Steroid receptor coactivator-1 mediates letrozole induced
            downregulation of postsynaptic protein PSD-95 in the hippocampus of
            adult female rats
  JOURNAL   J Steroid Biochem Mol Biol 154, 168-175 (2015)
   PUBMED   26223010
  REMARK    GeneRIF: results provided the first evidence that SRC-1 mediated
            endogenous estrogen regulation of hippocampal synaptic plasticity
            by targeting the expression of synaptic protein PSD-95
REFERENCE   4  (bases 1 to 7162)
  AUTHORS   Vella KR, Ramadoss P, Costa-E-Sousa RH, Astapova I, Ye FD, Holtz
            KA, Harris JC and Hollenberg AN.
  TITLE     Thyroid hormone signaling in vivo requires a balance between
            coactivators and corepressors
  JOURNAL   Mol Cell Biol 34 (9), 1564-1575 (2014)
   PUBMED   24550004
REFERENCE   5  (bases 1 to 7162)
  AUTHORS   Bian C, Zhu K, Guo Q, Xiong Y, Cai W and Zhang J.
  TITLE     Sex differences and synchronous development of steroid receptor
            coactivator-1 and synaptic proteins in the hippocampus of postnatal
            female and male C57BL/6 mice
  JOURNAL   Steroids 77 (1-2), 149-156 (2012)
   PUBMED   22085911
REFERENCE   6  (bases 1 to 7162)
  AUTHORS   Martinez de Arrieta C, Koibuchi N and Chin WW.
  TITLE     Coactivator and corepressor gene expression in rat cerebellum
            during postnatal development and the effect of altered thyroid
            status
  JOURNAL   Endocrinology 141 (5), 1693-1698 (2000)
   PUBMED   10803578
REFERENCE   7  (bases 1 to 7162)
  AUTHORS   Mak HY, Hoare S, Henttu PM and Parker MG.
  TITLE     Molecular determinants of the estrogen receptor-coactivator
            interface
  JOURNAL   Mol Cell Biol 19 (5), 3895-3903 (1999)
   PUBMED   10207113
REFERENCE   8  (bases 1 to 7162)
  AUTHORS   McInerney EM, Rose DW, Flynn SE, Westin S, Mullen TM, Krones A,
            Inostroza J, Torchia J, Nolte RT, Assa-Munt N, Milburn MV, Glass CK
            and Rosenfeld MG.
  TITLE     Determinants of coactivator LXXLL motif specificity in nuclear
            receptor transcriptional activation
  JOURNAL   Genes Dev 12 (21), 3357-3368 (1998)
   PUBMED   9808623
REFERENCE   9  (bases 1 to 7162)
  AUTHORS   Misiti S, Schomburg L, Yen PM and Chin WW.
  TITLE     Expression and hormonal regulation of coactivator and corepressor
            genes
  JOURNAL   Endocrinology 139 (5), 2493-2500 (1998)
   PUBMED   9564863
REFERENCE   10 (bases 1 to 7162)
  AUTHORS   Hayashi Y, Ohmori S, Ito T and Seo H.
  TITLE     A splicing variant of Steroid Receptor Coactivator-1 (SRC-1E): the
            major isoform of SRC-1 to mediate thyroid hormone action
  JOURNAL   Biochem Biophys Res Commun 236 (1), 83-87 (1997)
   PUBMED   9223431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000164.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001395569.2.
            
            On Jul 20, 2021 this sequence version replaced XM_039112183.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               JACYVU010000164.1  3764290-3764615     c
            327-461             JACYVU010000164.1  3701784-3701918     c
            462-620             JACYVU010000164.1  3626254-3626412     c
            621-726             JACYVU010000164.1  3618429-3618534     c
            727-893             JACYVU010000164.1  3612986-3613152     c
            894-991             JACYVU010000164.1  3609661-3609758     c
            992-1169            JACYVU010000164.1  3600138-3600315     c
            1170-1349           JACYVU010000164.1  3593363-3593542     c
            1350-1445           JACYVU010000164.1  3590755-3590850     c
            1446-1586           JACYVU010000164.1  3585794-3585934     c
            1587-1734           JACYVU010000164.1  3576389-3576536     c
            1735-3064           JACYVU010000164.1  3573829-3575158     c
            3065-3245           JACYVU010000164.1  3570610-3570790     c
            3246-3363           JACYVU010000164.1  3556156-3556273     c
            3364-3532           JACYVU010000164.1  3554018-3554186     c
            3533-3847           JACYVU010000164.1  3553500-3553814     c
            3848-3949           JACYVU010000164.1  3550432-3550533     c
            3950-4352           JACYVU010000164.1  3541684-3542086     c
            4353-4524           JACYVU010000164.1  3535433-3535604     c
            4525-4708           JACYVU010000164.1  3531284-3531467     c
            4709-4798           JACYVU010000164.1  3526830-3526919     c
            4799-4853           JACYVU010000164.1  3523166-3523220     c
            4854-7162           JACYVU010000164.1  3520772-3523080     c
FEATURES             Location/Qualifiers
     source          1..7162
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..7162
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /note="nuclear receptor coactivator 1"
                     /db_xref="GeneID:313929"
                     /db_xref="RGD:1309046"
     exon            1..326
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..461
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..620
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..726
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             638..4843
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /EC_number="2.3.1.48"
                     /note="steroid receptor coactivator 1"
                     /codon_start=1
                     /product="nuclear receptor coactivator 1"
                     /protein_id="NP_001382498.1"
                     /db_xref="GeneID:313929"
                     /db_xref="RGD:1309046"
                     /translation="MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLE
                     ELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSS
                     SQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSIL
                     HVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRY
                     EVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISID
                     TSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILND
                     GTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRINPSVNP
                     GISPAHGVTRSSTLPPSNNNMVSARANRQQSTDLNSGSSHSNSSSSQGSFGCSPGNQI
                     VASVALSQGQAGSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQANSGLATRARMSNNS
                     FPPNIPTLSSPVGITSGACSNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMS
                     SQNSPSRLSMQPAKAESKDNKEIASILNEMIQSDNSANEGKPLDSGLLHNNDRLSDGD
                     SKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHS
                     SLTERHKILHRLLQEGSPSDITTLSVEPEKKDSASASTAMSVSGQAQGSASIKLELDA
                     SKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPAPVTKPA
                     PEEVKLESQSQFSADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVPGVNIKSEILPAS
                     LQPTPARSAPRLNRLPELELEAIDNQFGQPGAGDQIPWANNTVTAINQSKPEDQCISS
                     QLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVL
                     SERFPPQQATPPLMMEDRPTLYPQPYSSPSPTAGLSGPFQGMVRQKPSLGTMPVQVTP
                     PRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAP
                     VGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNN
                     IPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATR
                     SSMVNRGMAGNMGGQFGTGISPQMQQNVFQYPGSGLVPQAEANFAPSLSPGSSMVPMP
                     IPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSIT
                     VSMAGGNANVQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDL
                     LKTEADGNQDKKTEEFFSVVTTD"
     exon            727..893
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..991
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1169
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1349
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1445
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1586
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1734
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..3064
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3245
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3363
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3532
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3847
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3949
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4352
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..4524
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4708
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4709..4798
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4799..4853
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4854..7162
                     /gene="Ncoa1"
                     /gene_synonym="SRC-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggcgagc gggagactga cgcgattcac cttgtccggt cgtccgtcgg tcggagcgcg
       61 gcctcaagcg cctcggctgc agttcgctgt tgttccctca agcacagctt gcgccggggt
      121 ggttctgcat ccccctgaag tggggggact ccagctccgg aggagggggc cggagagccg
      181 aggcggcggc ggcggcggcg ggttgcctgg gccccgggga cgggcgcccg gcccgaggag
      241 tggcggagtc cgcggcggcg ccgccacagt cgcgagcgag cgcggcgcag gggagcgcgg
      301 cccagaggcg gcggcggcag aggcagatct gtccctacta aaggaaatga aactggaatt
      361 gacctgatga taacaccaag gcccttcaga caagatcaca gaggaggaaa cctggcttcc
      421 aaatgaagac accaacattc agaatttcta cttattcaaa gttgttcgtg taattgacct
      481 taaatgaggg gagagcaaat cgactagcac catctctgga caccactgcg ttcctccact
      541 cccccagaag ccgccctctg gagcactcaa tttgaccata tctgctttga ggactcagta
      601 tgaacaaaga agtctcccag gtgtgaagtt catcaacatg agtggccttg gggacagttc
      661 atccgaccct gcgaacccag actcacataa gagaaaagga tcgccatgtg acacactggc
      721 atcaagtact gagaagaggc gcagggagca agaaaataag tatttagaag aactagctga
      781 attactgtct gccaacatca gtgacattga cagcttgagt gtaaaaccag ataaatgcaa
      841 gatcttgaag aagacagtag atcagataca gctaatgaag agaatggagc aagagaaatc
      901 cacaactgat gatgacgtgc agaagtccga catctcatcg agcagtcaag gagtgataga
      961 gaaggagtcg ctgggccccc ttcttctgga ggctttggat ggatttttct ttgttgtgaa
     1021 ctgtgaagga agaattgtat ttgtgtcaga aaatgtgacc agctacctgg gttacaatca
     1081 ggaagaatta atgaatacca gcgtctacag catactgcat gtgggagatc atgcagaatt
     1141 tgtcaagaat ctactaccaa aatcactagt aaatggagtt ccttggcctc aagaggcaac
     1201 acgccgaaac agccatacat ttaactgcag gatgctgatt caccctcccg atgagccagg
     1261 cactgagaac caagaagctt gccagcgcta tgaagtaatg cagtgtttca cggtgtcaca
     1321 gccaaaatca atccaagaag atggcgaaga tttccagtcg tgtttgattt gtattgctcg
     1381 tcgattacct cggcctccag ccattacagg tgtagaatcc tttatgacca agcaagatac
     1441 tacaggcaaa atcatctcta ttgacactag ctccctgaga gctgctggca ggactggctg
     1501 ggaagattta gtaaggaaat gtatctatgc ttttttccaa cctcagggca gagagccatc
     1561 ttatgcccga cagctgtttc aagaagtgat gactcgtggc actgcctcca gcccatccta
     1621 tagattcata ttgaatgatg ggacaatgct tagcgcccac accaagtgta aactttgcta
     1681 ccctcaaagt cctgacatgc agcctttcat catgggaatt catatcatcg acagggagca
     1741 cagtgggctt tctcctcaag atgacactaa ttctggaatg tcaattcccc gaataaaccc
     1801 ctcagtcaat cctggtatct ctccagccca tggtgtgacc cgttcatcca cgttgccacc
     1861 atccaacaac aacatggtct ctgccagagc aaaccgccag cagagcacag accttaacag
     1921 cggcagcagt cacagtaact ctagcagcag ccaagggagc tttggatgct cacctggaaa
     1981 tcagattgta gccagcgttg ccttaagcca gggacaggca ggttcccaga gcagtaatcc
     2041 gtctttaaac ctcaataatt ctcctatgga aggtacagga atttccctcg cacagttcat
     2101 gtctccgagg agacaagcta attctggctt ggcaacaagg gccaggatgt caaacaattc
     2161 atttcctcca aatattccaa cattaagctc cccggttggc atcactagcg gtgcctgtag
     2221 taataataac cgatcctatt ccaatatccc agtaacatct ttacaaggta tgaatgaagg
     2281 acccaataat tctgttggct tctctgccgg ctctccagtc cttcggcaga tgagctcaca
     2341 gaattcacct agcagattaa gtatgcaacc agcaaaagcc gagtccaaag acaacaaaga
     2401 gattgcatcc attttaaatg aaatgattca gtcagacaac agtgctaacg aaggcaagcc
     2461 tctggactca ggacttctgc ataacaatga cagactctca gatggagaca gtaagtactc
     2521 tcaaactagt cacaaactag tacagctatt gacgactacc gcagagcagc agttacggca
     2581 tgctgacata gacacgagct gcaaagacgt cctgtcctgc actggcactt ccagctccgc
     2641 ctcctctaac ccctcaggag gtacttgtcc ctcttcccac agctctctga ctgagcggca
     2701 taaaattctg catcggcttt tacaggaggg cagcccctca gacatcacca ccttgtctgt
     2761 ggaacccgaa aagaaggaca gtgcgtcagc ttctactgct atgtcagtgt ctggacaagc
     2821 ccaggggagt gccagcataa aactagaact ggatgcttca aagaaaaaag agtcaaaaga
     2881 ccatcagctc ctacgctacc ttttagacaa agatgagaaa gatttaagat caactccaaa
     2941 cctgagcctg gatgacgtaa aggtcaaagt ggagaagaaa gagcagatgg atccttgtaa
     3001 cacaaaccca gccccagtga ccaaacctgc tcccgaggag gttaaactcg agtcccagag
     3061 ccagttttca gctgaccttg accagtttga tcagttattg cccacactgg agaaggcagc
     3121 gcagttgccg ggcttgtgtg agacagacag aatggatggt gcggtccccg gtgtgaacat
     3181 caagtcggag atcctgcccg cttcacttca gcccacccct gccagatctg ctcccaggct
     3241 gaacagattg cctgaactag aattagaagc aatcgataac cagtttggac aaccaggagc
     3301 aggggatcag attccatggg caaataatac tgtgacggcg ataaatcaga gtaaaccaga
     3361 agaccaatgt attagctcac agttggatga gctcctctgt ccaccaacaa cagtagaagg
     3421 aagaaatgat gagaaggccc ttctggaaca actggtgtct ttcctcagtg gcaaagatga
     3481 gacggagctg gccgagctag acagagcgct ggggattgac aaacttgtac agggaggtgg
     3541 attagatgta ttatctgaga gatttccacc acagcaagca acaccacctt tgatgatgga
     3601 agacaggccc accctctatc cccagccata ctcgtctcct tctcccaccg ccggtctctc
     3661 tggccctttc caaggcatgg tccgacagaa gccttcactg ggtactatgc cggttcaagt
     3721 aacacctcct cgaggaacct tttcacccaa catgggcatg caaccccggc agactctaaa
     3781 tagacctcca gctgcaccca accagcttcg gctgcagctg cagcagcggc tacaggggca
     3841 gcagcagttg atgcaccaaa accggcaagc tatcttgaac cagtttgcag caaatgctcc
     3901 tgttggcatg aacatgaggt caggcatgca gcagcagata acacctcagc cacccctgaa
     3961 tgctcagatg ttggcacagc gccaacggga gctgtacagt cagcagcatc gacagaggca
     4021 aattatccag cagcaaagag ccatgctcat gaggcaccaa agctttggga acaacatccc
     4081 tccttcatcc ggactcccag ttcaaatggg gaacccccgt cttcctcagg gtgctccaca
     4141 gcagttcccc tacccaccaa actatggtac aaatccagga accccacctg cttctaccag
     4201 ccctttctct caactggcag caaaccctga ggcatccttg gccacccgca gcagcatggt
     4261 gaacagaggc atggcaggga acatgggagg acagtttggt actggcatca gtccgcagat
     4321 gcagcagaat gtcttccagt acccagggtc aggactggtt ccccaagctg aggccaactt
     4381 tgccccatct ctaagccctg ggagctccat ggtgccgatg ccaatccctc ctcaaagctc
     4441 tctgctccaa caaactccac ccacttctgg gtaccagtca ccggacatga aggcctggca
     4501 gcaaggaaca atgggaaaca acaatgtgtt cagtcaagcc gtccagagcc agcctgcccc
     4561 tgcacagcca ggagtgtaca acaacatgag catcaccgtg tccatggcag gtggaaacgc
     4621 aaacgttcag aacatgaatc caatgatggg ccagatgcaa atgagctctc tgcagatgcc
     4681 agggatgaac actgtgtgct ctgagcagat gaatgatcca gcactgagac acacaggcct
     4741 ctactgcaac cagctctcat ccactgacct tctcaaaacc gaagcagatg gaaaccagga
     4801 caagaagaca gaagagttct tctctgtggt gactacagac tagaggagct ctacaggtgc
     4861 agcagcttca ggtgtttgct gacgtccagt gtacagtgaa cctggtaggc ggggaccctt
     4921 acctgaacca gcctggtcct ctgggaactc aaaaacccac gtcaggacca cagacccccc
     4981 aggcccagca gaagagcctc cttcagcagc tactgactga ataaccactt ttaaaggaat
     5041 gtgaaattta aataatagac atgcagagtt atacaaatat attatatatt tttctgagat
     5101 ttttgatatc tcaatctgca gccattcttc aggtcgtagc atttggagca aaaaaaaaaa
     5161 aaaaaaaaaa aaaaagaaaa gaaaaaagtt cacttttgtt gggagattga gaggtggtgt
     5221 ttttgtttcc ttctttgtaa aggccttgga tattgaaaag aataacaagg cagaacagtt
     5281 ggacaatctt atttcttgag ccaaaagtta attattctta tttttataat cagtcattgg
     5341 cttcttatct ggataaaggc ttttggaggg aaaccaaaat aacgagttcg gaggggagga
     5401 cgaagccctg cctcactggc tcagggctgt ccctgccctg gaagaagagc cttggggccc
     5461 cacctgtctg tccaccaaag gctgtcacgc tcctcccacc acagcccccc tcccctgccc
     5521 ccaggcagct tgtgcgcaca atcagcttct tcaagcaact ccgcccgatc tgttggcacc
     5581 gagagattat tttgcgtcta cacatgtacc cttctccttt ttataaagat ggatttaaac
     5641 cacgatgcct ccaggagaga ggatgaaata ggtgtgttca ccacggaatc caaaaatgca
     5701 gtttgggggg aaaatgcaat aatttttgat aagatgggtg aaggacaaga accgagttct
     5761 atcaattatt gtagatacga ttttctgatt aagtctgcgg ggaaggcagc ctgttctttc
     5821 tgcttttact ctgttaacag caaggtagct aaagttattt aaaataaaat taagtttatg
     5881 atccgagtag ctttttttcc cttaaatctc actgtaaata tattttgatt tcttgtagaa
     5941 attgattttg ttctgtttaa ttttatgctt tttttcatcc tcttggtttt tctaaatttg
     6001 tgtgtgaaat ataatgttga ttgaactgca attatatttg gctggtaatt cgttatccca
     6061 gtaactgtga agccatgtat ggatttactt tgggtctcat caaagtggca ccgctggaaa
     6121 gagcaattct agctgagctg atcaaagtac acaggccgct tgtatgaagg gaagtcagcg
     6181 ctcaaagaaa atctcctctt tttgtctcag aataactttg ggaatttgaa tttccatcag
     6241 tgcaaatgtg tttctctgtt ctgctccgag gccctcgtct tgttattctg ccacatccca
     6301 gctcaccctg gccctccaag aaaggagcca gcaaaccgac tctagtgcta gcagttctgc
     6361 tacaggctgg gagagcttga gcaagcatgg ccagagaggc caagggagac ctcccgtgct
     6421 aaccttgccc gacacctggc ctgtgggcga caacactgac cttctgcacc agctacctct
     6481 gctcgcacgg cagagaaaag gccataagaa ccaatgcaga tgaggagcat ggactcaaga
     6541 cttcaaggaa gaagccattt ccccaggtcc ttccttctgc atctcaccgc ccctggtaca
     6601 aacaactcca taagaacagc atctactcag aaactacagg actttgaaac tggtggaagg
     6661 gctcatgtgg tagcagctat gaaacagaaa taggaccctc agttacagac attctctttt
     6721 ttagttttcc agaaagtgca tccctgatct catccatttc cagcttgaaa gcccagccat
     6781 gttactctag ttcctaccaa actgctctaa gaggtcgttt ccattttgtt tgtgataata
     6841 aacatgcaga cttcaggaag tccaccttta attcagcatt ccagatggag tttcctgact
     6901 ccgggcttgt gcgtaaggac ctagaaaaga acagcagtaa ggaaagttgg agatgctaat
     6961 gtcctccccc atccccactg caccttaaag tatgcatgtc accttcaagg ttttataatt
     7021 gcactgtttg ttttatgtat gtacagatta aaattattgc tacatttgag gaaaataaaa
     7081 ttgcttgctt ctatgtaatt cctgtcattc cacaggaaat tgacttttcc agctactgaa
     7141 tagaatttgt ttaacaacct ca
//
