LOCUS       NM_012749               2501 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nucleolin (Ncl), mRNA.
ACCESSION   NM_012749
VERSION     NM_012749.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2501)
  AUTHORS   Chen,C., Liu,M., Tang,Y., Sun,H., Lin,X., Liang,P. and Jiang,B.
  TITLE     LncRNA H19 is involved in myocardial ischemic preconditioning via
            increasing the stability of nucleolin protein
  JOURNAL   J Cell Physiol 235 (9), 5985-5994 (2020)
   PUBMED   31975412
  REMARK    GeneRIF: LncRNA H19 is involved in myocardial ischemic
            preconditioning via increasing the stability of nucleolin protein.
REFERENCE   2  (bases 1 to 2501)
  AUTHORS   Fang,L., Zhang,P.F., Wang,K.K., Xiao,Z.L., Yang,M. and Yu,Z.X.
  TITLE     Nucleolin promotes Ang II-induced phenotypic transformation of
            vascular smooth muscle cells via interaction with tropoelastin mRNA
  JOURNAL   Int J Mol Med 43 (4), 1597-1610 (2019)
   PUBMED   30720050
  REMARK    GeneRIF: Upregulation of nucleolin had an important role in Ang
            IIinduced vascular smooth muscle cell phenotypic transformation,
            and its underlying mechanism may be through interacting with
            tropoelastin mRNA, leading to its increased stability and protein
            expression.
REFERENCE   3  (bases 1 to 2501)
  AUTHORS   Tong,Z., Tang,Y., Jiang,B., Wu,Y., Liu,Y., Li,Y. and Xiao,X.
  TITLE     Phosphorylation of nucleolin is indispensable to upregulate miR-21
            and inhibit apoptosis in cardiomyocytes
  JOURNAL   J Cell Physiol 234 (4), 4044-4053 (2019)
   PUBMED   30256395
  REMARK    GeneRIF: Phosphorylated nucleolin interacted with Ago2 in the
            cytoplasm to protect the cardiomyocytes from oxidative stress by
            up-expression of miR-21.
REFERENCE   4  (bases 1 to 2501)
  AUTHORS   Sun,H., Tong,Z., Fang,Y., Jiang,B., Liang,P., Tang,Y., Li,Y., Wu,Y.
            and Xiao,X.
  TITLE     Nucleolin protects against doxorubicin-induced cardiotoxicity via
            upregulating microRNA-21
  JOURNAL   J Cell Physiol 233 (12), 9516-9525 (2018)
   PUBMED   29968904
  REMARK    GeneRIF: These results have demonstrated that nucleolin is involved
            in the regulation of Doxorubicin-induced cardiac injury and
            dysfunction via the regulation of miRNA-21.
REFERENCE   5  (bases 1 to 2501)
  AUTHORS   Durut,N. and Saez-Vasquez,J.
  TITLE     Nucleolin: dual roles in rDNA chromatin transcription
  JOURNAL   Gene 556 (1), 7-12 (2015)
   PUBMED   25225127
  REMARK    Review article
REFERENCE   6  (bases 1 to 2501)
  AUTHORS   Sipos,K. and Olson,M.O.
  TITLE     Nucleolin promotes secondary structure in ribosomal RNA
  JOURNAL   Biochem Biophys Res Commun 177 (2), 673-678 (1991)
   PUBMED   2049089
REFERENCE   7  (bases 1 to 2501)
  AUTHORS   Biggiogera,M., Burki,K., Kaufmann,S.H., Shaper,J.H., Gas,N.,
            Amalric,F. and Fakan,S.
  TITLE     Nucleolar distribution of proteins B23 and nucleolin in mouse
            preimplantation embryos as visualized by immunoelectron microscopy
  JOURNAL   Development 110 (4), 1263-1270 (1990)
   PUBMED   2100262
REFERENCE   8  (bases 1 to 2501)
  AUTHORS   Bourbon,H.M. and Amalric,F.
  TITLE     Nucleolin gene organization in rodents: highly conserved sequences
            within three of the 13 introns
  JOURNAL   Gene 88 (2), 187-196 (1990)
   PUBMED   2347493
REFERENCE   9  (bases 1 to 2501)
  AUTHORS   Bourbon,H.M., Prudhomme,M. and Amalric,F.
  TITLE     Sequence and structure of the nucleolin promoter in rodents:
            characterization of a strikingly conserved CpG island
  JOURNAL   Gene 68 (1), 73-84 (1988)
   PUBMED   2906027
REFERENCE   10 (bases 1 to 2501)
  AUTHORS   Herrera,A.H. and Olson,M.O.
  TITLE     Association of protein C23 with rapidly labeled nucleolar RNA
  JOURNAL   Biochemistry 25 (20), 6258-6264 (1986)
   PUBMED   3790520
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085751.1.
            
            On Dec 5, 2007 this sequence version replaced NM_012749.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2501
                     /gene="Ncl"
                     /note="nucleolin"
                     /db_xref="GeneID:25135"
                     /db_xref="RGD:3153"
     exon            1..144
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2271
                     /gene="Ncl"
                     /note="nucleolin-like protein"
                     /codon_start=1
                     /product="nucleolin"
                     /protein_id="NP_036881.2"
                     /db_xref="GeneID:25135"
                     /db_xref="RGD:3153"
                     /translation="MVKLAKAGKTHGESKKMAPPPKEVEEDSEDEEMSEDEDDSSGEE
                     EVVIPQKKGKKATTTPAKKVVVSQTKKAAVPTPAKKAAVTPGKKAAATPAKKAVTPAK
                     VVPTPGKKGAAQAKALVPTPGKKGAVTPAKGAKNGKNAKKEDSDEDEDEEDEDDSDED
                     EDEEDEFEPPVVKGVKPAKAAPAAPASEDEDEEDDDDEEDDDDDDEEEEEEDDSEEEV
                     MEITPAKGKKTPAKVVPVKAKSVAEEEEDDEDDEDEEEDEDEEDEEDDEDEDEEEEEE
                     PVKAAPGKRKKEMTKQKEAPEAKKQKIEGSEPTTPFNLFIGNLNPNKSVAELKVAISE
                     LFAKNDLAAVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSK
                     KVRAARTLLAKNLSFNITEDELKEVFEDAVEIRLVSQDGRSKGIAYIEFKSEADAEKN
                     LEEKQGAEIDGRSVSLYYTGEKGQRQERTGKNSTWSGESKTLVLSNLSYSATEETLQE
                     VFEKATFIKVPQNPHGKSKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGPRG
                     SPNARSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSE
                     EDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGG
                     RGRGGFGGRGGFRGGRGGGGDFKPQGKKTKFE"
     exon            145..261
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            262..763
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            764..952
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1039
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1181
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1306
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1430
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1585
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1709
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1843
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1970
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2194
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2395
                     /gene="Ncl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcaggcg gttgtacgtg ctccagagtc ttcattaccc gccgatccag tcgtcttcgc
       61 gtgggttccg ctaagctctt ctgagctgct cgctctctac acacgccgtc gccgtaatcc
      121 gccatcatgg tgaaactcgc aaaggccggc aaaacccacg gagagtccaa gaaaatggct
      181 cctcctccaa aggaggtgga agaagatagt gaggatgaag aaatgtcaga agatgaagat
      241 gacagcagtg gagaagagga ggttgtcatc cctcagaaga aaggcaaaaa ggctaccaca
      301 actccagcaa agaaggtggt tgtttcacaa acaaaaaagg ctgcagttcc cacaccagct
      361 aagaaagcag ctgttacccc aggcaaaaag gcagcagcca caccagccaa gaaagctgtt
      421 acaccagcca aagtagttcc aacacctggt aaaaagggag ctgcacaagc aaaagcattg
      481 gtaccaactc ctggtaaaaa gggagctgtc actccagcca agggggctaa gaatggtaag
      541 aatgccaaga aggaagacag cgatgaggat gaagatgaag aggatgaaga tgacagcgat
      601 gaggatgaag atgaagagga tgaatttgag ccaccggtag taaaaggagt gaaaccagca
      661 aaagcagctc ctgctgctcc tgcctcagag gatgaggatg aggaagatga tgatgatgaa
      721 gaagatgatg atgatgatga tgaagaggag gaggaggaag atgactctga ggaagaagtt
      781 atggagatca caccagccaa aggaaagaaa actcctgcaa aagttgttcc tgtgaaagcc
      841 aagagtgtgg ccgaggagga ggaagatgat gaggatgatg aagatgaaga ggaggatgaa
      901 gatgaagaag atgaagagga cgatgaagat gaggatgagg aagaagagga agaacctgtt
      961 aaagcagcac ctggaaaacg gaagaaggag atgaccaagc agaaagaagc ccctgaagcc
     1021 aagaaacaga aaatagaagg ctcagaacca actacacctt tcaacctgtt cattggaaac
     1081 cttaatccaa acaagtctgt tgctgaatta aaagttgcca tcagtgaact ttttgctaaa
     1141 aatgatcttg ctgctgtgga tgtcagaact ggtacaaata ggaaatttgg ttatgttgat
     1201 tttgagtctg ctgaagacct agaaaaggcc ctggagctca ctggtttaaa agtgtttggc
     1261 aatgaaatta aactagaaaa accaaaagga agagatagta agaaagttcg agctgcaaga
     1321 acacttttag ccaaaaacct ctctttcaac atcactgagg atgaattaaa agaagtgttt
     1381 gaagatgctg tggagatcag attagtcagc caggatggga gaagtaaagg gattgcttat
     1441 attgaattta agtctgaggc tgatgcagag aaaaacttgg aagaaaagca gggggcagaa
     1501 attgatggac ggtctgtttc actctactac actggagaga aaggacaaag gcaagagaga
     1561 actggaaaga atagcacttg gagtggtgaa tcaaagactt tggttttaag taacctttcc
     1621 tacagtgcaa cagaagaaac acttcaggaa gtattcgaga aagcaacctt tattaaagtg
     1681 ccccagaacc cacatggcaa atctaaaggg tatgcattta tagaatttgc ttcatttgaa
     1741 gatgctaaag aagctttaaa ttcctgtaat aaaatggaaa ttgagggcag aacaatcagg
     1801 ctggagttgc aaggacccag gggatcacct aatgcgagaa gtcagccatc caaaactctg
     1861 tttgtcaaag gtctgtctga ggataccact gaagagacct taaaagaatc atttgagggc
     1921 tctgttcgtg caagaatagt aactgatcgg gaaactggtt cttctaaagg gtttggtttt
     1981 gtagacttta atagtgagga agatgccaaa gctgccaagg aggccatgga agatggagaa
     2041 attgatggaa acaaagttac cttggactgg gccaaaccta agggtgaagg tggctttggt
     2101 ggtcgaggtg gaggcagagg aggtttcgga ggcagaggtg gtggcagagg cggaagaggc
     2161 ggatttggcg gaagaggccg gggaggcttt ggaggcagag gaggcttccg aggcggcaga
     2221 ggaggcgggg gagacttcaa gccacaagga aagaagacga agtttgaata gttccttcca
     2281 tcccattctt tccctcttca ttttaaagaa aggactctgg agtttttact ctgttacctg
     2341 ttgaatgaca gagcctttta aggacattcc aagacagtaa agatcctaaa ctctgaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
