LOCUS       NM_001393927            3298 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus NCK interacting protein with SH3 domain
            (Nckipsd), mRNA.
ACCESSION   NM_001393927 XM_006243753
VERSION     NM_001393927.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3298)
  AUTHORS   Cho,I.H., Lee,M.J., Kim,D.H., Kim,B., Bae,J., Choi,K.Y., Kim,S.M.,
            Huh,Y.H., Lee,K.H., Kim,C.H. and Song,W.K.
  TITLE     SPIN90 dephosphorylation is required for cofilin-mediated actin
            depolymerization in NMDA-stimulated hippocampal neurons
  JOURNAL   Cell Mol Life Sci 70 (22), 4369-4383 (2013)
   PUBMED   23765104
REFERENCE   2  (bases 1 to 3298)
  AUTHORS   Cho,I.H., Kim,D.H., Lee,M.J., Bae,J., Lee,K.H. and Song,W.K.
  TITLE     SPIN90 phosphorylation modulates spine structure and synaptic
            function
  JOURNAL   PLoS One 8 (1), e54276 (2013)
   PUBMED   23342115
REFERENCE   3  (bases 1 to 3298)
  AUTHORS   Kim,S.M., Bae,J., Cho,I.H., Choi,K.Y., Park,Y.J., Ryu,J.H.,
            Chun,J.S. and Song,W.K.
  TITLE     Control of growth cone motility and neurite outgrowth by SPIN90
  JOURNAL   Exp Cell Res 317 (16), 2276-2287 (2011)
   PUBMED   21763308
  REMARK    GeneRIF: SPIN90 plays critical roles in controlling growth cone
            dynamics and neurite outgrowth during neuronal development.
REFERENCE   4  (bases 1 to 3298)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   5  (bases 1 to 3298)
  AUTHORS   Lee,S., Lee,K., Hwang,S., Kim,S.H., Song,W.K., Park,Z.Y. and
            Chang,S.
  TITLE     SPIN90/WISH interacts with PSD-95 and regulates dendritic
            spinogenesis via an N-WASP-independent mechanism
  JOURNAL   EMBO J 25 (20), 4983-4995 (2006)
   PUBMED   16990791
  REMARK    GeneRIF: SPIN90/WISH is a downstream effector of PSD-95-dependent
            synaptic remodeling.
REFERENCE   6  (bases 1 to 3298)
  AUTHORS   Kim,S.H., Choi,H.J., Lee,K.W., Hong,N.H., Sung,B.H., Choi,K.Y.,
            Kim,S.M., Chang,S., Eom,S.H. and Song,W.K.
  TITLE     Interaction of SPIN90 with syndapin is implicated in
            clathrin-mediated endocytic pathway in fibroblasts
  JOURNAL   Genes Cells 11 (10), 1197-1211 (2006)
   PUBMED   16999739
  REMARK    GeneRIF: SPIN90-PRD, a syndapin-binding domain, significantly
            inhibited endocytosis, and the inhibition was reversed by
            co-expression of syndapin.
REFERENCE   7  (bases 1 to 3298)
  AUTHORS   Kim,Y., Kim,S., Lee,S., Kim,S.H., Kim,Y., Park,Z.Y., Song,W.K. and
            Chang,S.
  TITLE     Interaction of SPIN90 with dynamin I and its participation in
            synaptic vesicle endocytosis
  JOURNAL   J Neurosci 25 (41), 9515-9523 (2005)
   PUBMED   16221862
  REMARK    GeneRIF: 90 kDa SH3 protein interacting with Nck (SPIN90) can
            modulate the interactions of dynamin I with other endocytic
            proteins that cooperate in the coated vesicle formation, thus
            regulating synaptic vesicle endocytosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 23, 2021 this sequence version replaced XM_006243753.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.46722.1,
                                           SRR26643290.30974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000008.1  118390696-118390944
            250-359             JAXUCZ010000008.1  118393467-118393576
            360-564             JAXUCZ010000008.1  118393855-118394059
            565-655             JAXUCZ010000008.1  118394193-118394283
            656-1146            JAXUCZ010000008.1  118394499-118394989
            1147-1317           JAXUCZ010000008.1  118396129-118396299
            1318-1404           JAXUCZ010000008.1  118396414-118396500
            1405-1543           JAXUCZ010000008.1  118396689-118396827
            1544-1624           JAXUCZ010000008.1  118396925-118397005
            1625-1753           JAXUCZ010000008.1  118397190-118397318
            1754-1846           JAXUCZ010000008.1  118397418-118397510
            1847-2019           JAXUCZ010000008.1  118397602-118397774
            2020-3298           JAXUCZ010000008.1  118399840-118401118
FEATURES             Location/Qualifiers
     source          1..3298
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3298
                     /gene="Nckipsd"
                     /note="NCK interacting protein with SH3 domain"
                     /db_xref="GeneID:301009"
                     /db_xref="RGD:1311323"
     exon            1..249
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2223
                     /gene="Nckipsd"
                     /codon_start=1
                     /product="NCK-interacting protein with SH3 domain"
                     /protein_id="NP_001380856.1"
                     /db_xref="GeneID:301009"
                     /db_xref="RGD:1311323"
                     /translation="MYRALYAFRSAEPNAMAFAAGETFLVLERSSTHWWLAARARSGE
                     TGYVPPAYLHRLQGMEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKE
                     TLSRRGTSAASASVMTPSTSDHHLDTAVSRQPNGVCRTGFERQHSLPSSEHLGTDGAL
                     YQVPPQPRRAAPATPPPPVKRRDREALVISGSGGRTAVPSGGSSVSSGSSVSSTSMDT
                     LYTGSSPSELGPSCSPTPPPVPRRSAHTTVSQAQPSPSKAPSPEPPAEEVAAETNSAP
                     DDLEALDALSPETTEEKPATETVVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHI
                     QASVPASSPVMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRS
                     WALYEDEDVIRCYLEELLHILTDADPEVCKKMCKRSDFESVLALVAYYQMEHRASLRL
                     LLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALVLAMVFSMGE
                     AVPYAHYEHLGTPFAQFLLSIVEDGLPLDATEQLPDLCMNLLLALNLHLTAPDQNVIM
                     AALSKHTNVKIFSEKLLLLLNRGDDPVRIFRHEPQPPHSVLKFLQDVFSSAATASIFY
                     HTDMMALIDITVRQIADLSPGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDLQATLRRI
                     LTEEETSPQCQMDRMIVQEMYKEFPDLGEVPS"
     exon            250..359
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            360..564
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            565..655
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            656..1146
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1317
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1404
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1543
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1624
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1753
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1846
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2019
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..3298
                     /gene="Nckipsd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcagggcc tgggcttccc ggcactgcaa ccttcgtcgc gtacccagca ccggcgcggc
       61 gcagagcggc ccggcctcat gtaccgcgcg ctgtatgcgt tccgctccgc ggagcccaac
      121 gccatggcgt tcgctgcagg cgaaaccttc ctggtgctgg agcgcagcag cacgcactgg
      181 tggttagcgg cacgggcgcg cagtggcgag accgggtacg tgccgcctgc ctacctgcat
      241 cgcctgcagg gcatggagca agatgtcctc caagctattg accgggccat tgaggctgtg
      301 cacaacacag ccatgcgaga tggtggcaag tacagcctgg aacagcgtgg agtccttcag
      361 aagcttattc atcatcggaa agagaccttg tctcgaaggg gcacctcagc tgccagtgct
      421 tcggttatga ccccatccac cagtgaccac catttggaca ctgctgtatc taggcagccc
      481 aatggggtgt gtcgaactgg gtttgaacgg cagcatagcc tacccagttc tgagcatctc
      541 gggacagatg gagccctcta ccaggtccca ccacagcctc ggcgagcagc acctgccacc
      601 ccacccccac cagtgaagcg ccgagaccgt gaggccctgg tgatctcagg gagtggtggc
      661 cgcacagcag taccctctgg aggtagttct gtgtctagtg gctcttcagt cagcagcacc
      721 tccatggaca cactctacac tggctctagc ccctctgagc tgggtcccag ctgctcaccc
      781 acacctccgc ctgtacctcg ccgaagtgcc cacactacag tgtcccaggc ccagccctct
      841 ccctccaagg caccatcccc ggagccccct gctgaggaag tggcagctga aacaaactca
      901 gcccctgatg acctcgaagc tctggatgcc ctgagcccag agaccacaga ggagaagcca
      961 gctactgaga cagttgtgcc aaggaccatt ggggcagagc tgatggaact tgttcggaga
     1021 aacactggtc tgagccacga attatgtcgt gtggccattg gtgtcgtggt gggtcacatc
     1081 caggcctccg taccagccag ctcgcctgtc atggagcagg tcctcctctc gctggtagag
     1141 ggcaaggacc tgagcacagc cctaccctcg gggcaggtct gccatgacca gcagagactg
     1201 gaggtgatct ttgcagacct ggctagaagg aaggatgacg cccagcagcg cagctgggct
     1261 ctttacgagg atgaggatgt catccgctgc taccttgagg aactgttgca catcctgacg
     1321 gatgcagatc ctgaagtttg caagaaaatg tgcaaaagga gtgacttcga atctgtccta
     1381 gccttggtgg cctattacca aatggaacac cgagcgtcac ttcggctgct gctcctcaag
     1441 tgcttcggcg ccatgtgcag cctggacgca gcaatcatct ctactctggt ctcttctgtg
     1501 ctacctgtgg aattggcacg ggacatgcag accgacacac aggaccacca gaagctctgt
     1561 tattccgccc ttgtcctggc catggtcttc tccatgggag aggcggtgcc ctacgcacac
     1621 tatgaacacc tgggtacacc ctttgcccag ttcctactga gcatcgttga ggatggcctg
     1681 cccctggacg ctacagagca gctgccagac ctctgcatga acctgcttct ggctctcaac
     1741 ctgcacctga cagctcctga ccagaatgtc atcatggctg ccttaagcaa gcacaccaac
     1801 gtgaagatct tctcagagaa gctgcttttg cttctgaaca gaggggacga tcctgtgcgt
     1861 atcttcagac atgagcccca gccgccacac tctgtcctca agttcctgca ggacgtgttc
     1921 agcagcgctg ccacggcctc catcttctac cacacagaca tgatggcgct cattgacatc
     1981 actgtgcgcc agattgccga cctgtcacct ggagacaagc tacgcatgga gtacctctcc
     2041 ctgatgcatg ccgtggtccg ctccacaccc tacctccagc accggcatcg gctgtctgac
     2101 ctgcaggcta cactgcggcg catcctgact gaggaagaga cctcacccca gtgccagatg
     2161 gaccgcatga ttgtccaaga gatgtacaag gagtttccgg acctgggaga ggtccccagc
     2221 tagcacttct ctttactccc ttctctgcag ccctgggagg gtgcagagaa ctcaggggct
     2281 ttgctctaag gatgttttgc actgatattg tgaggtgata aaagattaga agggacctga
     2341 gccgggcccc ttacctgaag tcagtgtaag gggccagata taggactggg gaccacagtc
     2401 tgggacctct gttggggcag aggaatgtgc aagctgaagg ccttctattt gctggtaggc
     2461 tgcctcttca gcatgtcacc cccaccccgt cctcatgtgc atacccagag tcctgctgct
     2521 gctccgggct gggctgctgc tatccctacc cactgtcttg gccgggcctc agcaggccgt
     2581 gtccgtaggg tgagggaggc gccttctgtc agctctgtgc tttgccttag ctttgcagtg
     2641 agtgctgctc atgtgcagcc tttgtcccct taccccctta gggaccgctg tccctcagtc
     2701 ccctgctttc agccccagag gccttggcca agctgttgcc ttgaaagcag gatcctagag
     2761 acaggccatc catcctgcag ccccatggga caggatgatg gtgctgagaa agccaatgac
     2821 agaatctatt ttctctggaa aaaaaaaaaa aaagtaggcc aaaagccatg tgtattttcc
     2881 tatgtaccac agcttacctt cagaaataaa ttataggcgt caggaatcgg gcttccctgt
     2941 atgatcctga ggggagagga tgggaagggt ggtgggggct cagcacctca cacctccagc
     3001 ttaacatctg cagcccagag aggtgatggc ccttgacaag actggcctct cccatgcttc
     3061 ctctagggcc cagccgcagc cactgcccca gggcacacct gtagggagct atcccttttg
     3121 ggtcccattc ctatcttggc catggtggtg cacaccctta atcccagcac ctgggaggca
     3181 gacagacaga taaccacaat cagccgagtt tacatagttc caggccatcc agggctatat
     3241 agggagagcc tatctcacta agaaaacaag taaaataaag ttatcgaatc ctgtcgtc
//
