LOCUS       NM_001414951            4713 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NCK associated protein 1 like (Nckap1l),
            transcript variant 1, mRNA.
ACCESSION   NM_001414951 XM_008765753
VERSION     NM_001414951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4713)
  AUTHORS   Chan,M.M., Wooden,J.M., Tsang,M., Gilligan,D.M., Hirenallur-S,D.K.,
            Finney,G.L., Rynes,E., Maccoss,M., Ramirez,J.A., Park,H. and
            Iritani,B.M.
  TITLE     Hematopoietic protein-1 regulates the actin membrane skeleton and
            membrane stability in murine erythrocytes
  JOURNAL   PLoS One 8 (2), e54902 (2013)
   PUBMED   23424621
REFERENCE   2  (bases 1 to 4713)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 4713)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 4713)
  AUTHORS   Park,H., Staehling-Hampton,K., Appleby,M.W., Brunkow,M.E.,
            Habib,T., Zhang,Y., Ramsdell,F., Liggitt,H.D., Freie,B., Tsang,M.,
            Carlson,G., Friend,S., Frevert,C. and Iritani,B.M.
  TITLE     A point mutation in the murine Hem1 gene reveals an essential role
            for Hematopoietic protein 1 in lymphopoiesis and innate immunity
  JOURNAL   J Exp Med 205 (12), 2899-2913 (2008)
   PUBMED   19015308
REFERENCE   5  (bases 1 to 4713)
  AUTHORS   Joshi,A.D., Hegde,G.V., Dickinson,J.D., Mittal,A.K., Lynch,J.C.,
            Eudy,J.D., Armitage,J.O., Bierman,P.J., Bociek,R.G., Devetten,M.P.,
            Vose,J.M. and Joshi,S.S.
  TITLE     ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing
            B-cell chronic lymphocytic leukemia
  JOURNAL   Clin Cancer Res 13 (18 Pt 1), 5295-5304 (2007)
   PUBMED   17875758
REFERENCE   6  (bases 1 to 4713)
  AUTHORS   Weiner,O.D., Rentel,M.C., Ott,A., Brown,G.E., Jedrychowski,M.,
            Yaffe,M.B., Gygi,S.P., Cantley,L.C., Bourne,H.R. and Kirschner,M.W.
  TITLE     Hem-1 complexes are essential for Rac activation, actin
            polymerization, and myosin regulation during neutrophil chemotaxis
  JOURNAL   PLoS Biol 4 (2), e38 (2006)
   PUBMED   16417406
REFERENCE   7  (bases 1 to 4713)
  AUTHORS   Baumgartner,S., Martin,D., Chiquet-Ehrismann,R., Sutton,J.,
            Desai,A., Huang,I., Kato,K. and Hromas,R.
  TITLE     The HEM proteins: a novel family of tissue-specific transmembrane
            proteins expressed from invertebrates through mammals with an
            essential function in oogenesis
  JOURNAL   J Mol Biol 251 (1), 41-49 (1995)
   PUBMED   7643388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 16, 2022 this sequence version replaced XM_008765753.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.32298.1,
                                           SRR26643284.10900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000007.1  136455929-136456080
            153-263             JAXUCZ010000007.1  136457105-136457215
            264-356             JAXUCZ010000007.1  136457950-136458042
            357-413             JAXUCZ010000007.1  136463759-136463815
            414-556             JAXUCZ010000007.1  136464982-136465124
            557-647             JAXUCZ010000007.1  136465970-136466060
            648-785             JAXUCZ010000007.1  136466147-136466284
            786-834             JAXUCZ010000007.1  136467850-136467898
            835-991             JAXUCZ010000007.1  136467988-136468144
            992-1048            JAXUCZ010000007.1  136474679-136474735
            1049-1145           JAXUCZ010000007.1  136474958-136475054
            1146-1255           JAXUCZ010000007.1  136476155-136476264
            1256-1388           JAXUCZ010000007.1  136476381-136476513
            1389-1470           JAXUCZ010000007.1  136476853-136476934
            1471-1529           JAXUCZ010000007.1  136477129-136477187
            1530-1675           JAXUCZ010000007.1  136477497-136477642
            1676-1808           JAXUCZ010000007.1  136478967-136479099
            1809-1928           JAXUCZ010000007.1  136479364-136479483
            1929-2074           JAXUCZ010000007.1  136481751-136481896
            2075-2206           JAXUCZ010000007.1  136482192-136482323
            2207-2425           JAXUCZ010000007.1  136485052-136485270
            2426-2556           JAXUCZ010000007.1  136486609-136486739
            2557-2654           JAXUCZ010000007.1  136489402-136489499
            2655-2748           JAXUCZ010000007.1  136489609-136489702
            2749-2831           JAXUCZ010000007.1  136489865-136489947
            2832-2912           JAXUCZ010000007.1  136490181-136490261
            2913-3006           JAXUCZ010000007.1  136492698-136492791
            3007-3123           JAXUCZ010000007.1  136493633-136493749
            3124-3233           JAXUCZ010000007.1  136494152-136494261
            3234-3323           JAXUCZ010000007.1  136495854-136495943
            3324-4713           JAXUCZ010000007.1  136499995-136501384
FEATURES             Location/Qualifiers
     source          1..4713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..4713
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /note="NCK associated protein 1 like"
                     /db_xref="GeneID:315348"
                     /db_xref="RGD:1312032"
     exon            1..152
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..3455
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hematopoietic protein 1; nck-associated protein 1-like"
                     /codon_start=1
                     /product="nck-associated protein 1-like isoform 1"
                     /protein_id="NP_001401880.1"
                     /db_xref="GeneID:315348"
                     /db_xref="RGD:1312032"
                     /translation="MSLTSAYQHKLAEKLTILNDRGQGVLIRMYNIKKTCSDPKSKPP
                     FLLEKSMESCLKYINKKFPNIDVRNSTQHLGPVHREKAEIIRFLTNYYQSFVDVMEFR
                     DHVYELLNTIDACQCHFDINLNFDFTRSYLDLIVTYTSVILLLSRIEDRRLLIGMYNC
                     AHEMLHGHGDPSFPRLGQMVLEYDHPLKKLTEEFGPHTKAVSGALLSLYFLFVRRNQG
                     AEQWRSAQLLSLISSPPAMINPANSDTMACEYLSVEVMERWIIIGFLLCHGCLNSNSQ
                     CQKLWKLCLEGSLYITLIREDVLQVHKVTEDLFSSLKGYSKRVADIKESKEHAITNSG
                     QFHCQRRQFLRTAVKELETVLNDEPGLLGPKALFAFMALSFIRDEVTWLVRHTENVTK
                     TKTPEDYADSSIAELLFLLEEIRALVRRHIKVIQQYHLQYLARFDVLVLSDIIQNLTV
                     CPEEESVIMSSFVSTLSSLNLKQVDNEEKFDFSGLRLDWFRLQAYTSVAKAPLHLHEN
                     PDLAKVMNLIIFHSQMLDSVEKMLVETSDLSTFCFHLRTFEKMFATTLEEPTMLRYTI
                     AFPLICAHFVHCIHEMCPEEYPHLKNHGLHHCNSFLEELAKQTSNCVLEICAEQRNLN
                     EQLLPKHCATTISKAKNRKSMKQRQAPRKGEPERDKPGAESHRKNRSLVTNMDKLHLN
                     LTELALAMNHVHSFSVFEHTIFPSEYLSSHLESRLNRAIVSLAGYNATTQEILRPSEL
                     LAGVKAYTSFIQSLAQFLGTDASRIVRNALLQQTQPLDSCGEQTVTTLYTNWYLESLL
                     RQASSGTIVLSPAMQAFISLPRDGEQNFSAEEFSDISEMRALAEILGPYGMKFLSENL
                     MWHVTSQIVELKKLVVENMDILVQIRSNFTKPELMASLLPQLTGAENVLKRMTIIGVI
                     LSFRAMAQEGLQEVFSAHCPFLMGPIECLKEFVTPDTDIKVTLSVFELACAAGVSCDI
                     DPALVAAIANLKADNSSPEEEYKVACLLLIFLAVSLPLLATDPSSFFSIEKDGYNNNI
                     HCLTKAIIQVSAALFTLYNKNIETHLKEFLVVASVSLLQLGQETDKLKTRNRESISLL
                     MRLVVEESPFLTLDMLESCFPYVLLRNAYREVSRAFYLNRLPASSH"
     exon            153..263
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..356
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..413
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..556
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..647
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..785
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..834
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..991
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1048
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1145
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1255
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1388
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1470
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1529
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1675
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1808
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1928
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2074
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2206
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2425
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2556
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2654
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2748
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2831
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2912
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3006
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3123
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3233
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3323
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..4713
                     /gene="Nckap1l"
                     /gene_synonym="Hem1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcaattgg gtcttgctat ccggatggtc tttttttctc ggtggccatc atgtctttga
       61 cctctgctta ccagcataag ttagcagaaa agctcacgat cctgaatgac cggggtcaag
      121 gagttctcat tcgcatgtac aacatcaaga agacctgttc agatccaaaa tccaagccac
      181 ctttcttact ggaaaagtcc atggaatcat gtctcaagta catcaacaag aagtttccca
      241 acatagatgt ccgaaacagc acgcaacatt taggaccagt gcatcgtgaa aaagctgaga
      301 taattagatt tctcactaac tactaccagt catttgtgga tgtcatggaa tttcgggatc
      361 atgtatatga acttctcaac accatcgatg cctgccagtg tcattttgat atcaatctca
      421 acttcgactt cactcggagc tacctggact tgattgtgac ttacacctca gtcattttac
      481 tcctgtcacg gatcgaggac cgcaggctac tcatcggcat gtacaactgt gcccatgaga
      541 tgctccatgg gcacggcgac cccagttttc ctcgcctggg ccagatggta ctagaatatg
      601 accatcctct gaagaagctg acagaagaat ttggacctca cacaaaggct gtgagtggag
      661 ccctgctctc tctgtacttc ctctttgttc ggaggaacca gggagctgag cagtggcgca
      721 gtgcccagct cctaagcctc atcagcagcc ccccggccat gattaaccct gctaactcag
      781 acacaatggc ctgcgagtat ctgtctgtgg aagtgatgga gcgatggatc ataattgggt
      841 ttcttctttg tcacgggtgc ctcaactcca acagccagtg ccagaagctg tggaagctgt
      901 gtctggaggg ttccctgtac atcaccctca tccgggaaga tgtgctacag gtgcacaagg
      961 tcaccgaaga cctgttcagc agtttgaaag ggtacagtaa gcgagtagca gacatcaagg
     1021 agagcaagga acatgccatt acaaacagtg gccagtttca ctgtcaacgg aggcagtttc
     1081 tgcggacagc tgtgaaggag ttggagactg tgttaaatga tgagccaggc ctgctgggtc
     1141 ctaaggccct ttttgctttc atggccctgt ctttcattcg tgatgaggtc acttggctgg
     1201 ttcgccatac agaaaatgtc accaagacta agacacccga agactatgct gactcgagca
     1261 tcgcagagct tctcttcctg ttggaggaga tcagggctct ggtccgaaga cacatcaaag
     1321 tgatccagca gtaccatctc cagtacctgg ccagatttga tgtcctcgtg cttagtgaca
     1381 tcattcagaa cctgactgtg tgtcccgagg aggagtctgt cattatgtcc tcctttgtta
     1441 gtacgctatc ctctctgaat cttaagcaag ttgataatga agagaaattt gacttttctg
     1501 gattaaggct ggactggttt cgcctacagg catataccag tgtggcaaag gcacctttgc
     1561 acctgcacga gaaccctgac ctggccaagg tcatgaacct catcatcttt cactcccaga
     1621 tgttggactc agtagagaaa atgctggtgg agacctctga cctttctact ttctgctttc
     1681 acctccgtac ctttgagaag atgtttgcta cgaccctgga ggaaccaacc atgcttcgct
     1741 acaccatcgc cttccccctg atttgtgctc attttgtcca ctgcattcat gaaatgtgcc
     1801 cagaggagta ccctcacctg aagaaccatg gtcttcacca ctgcaactcc ttcctggaag
     1861 agctggccaa gcagaccagc aactgtgtgc ttgagatatg tgctgaacag cggaacctga
     1921 acgaacagct tctacccaaa cactgtgcca ccaccatcag caaagccaag aacaggaagt
     1981 ccatgaagca gaggcaagct cccaggaaag gagagcctga gagggacaag ccaggagcag
     2041 agagccaccg aaagaaccgc agccttgtca cgaacatgga caagctacat ttaaacttga
     2101 ctgagttggc actggcaatg aatcatgtgc acagtttctc tgtgtttgaa cacaccatct
     2161 tcccatcaga gtatctcagc agtcacctgg agtccaggct caacagagcc atcgtgtctt
     2221 tggctggcta caatgccaca acccaggaga tccttaggcc ttccgagctt ttggcaggag
     2281 tcaaggcgta caccagtttc atccagtcat tggcacagtt cttgggcaca gatgcttcca
     2341 gaattgttcg caatgccctc ctgcagcaga cgcagccgct ggactcatgt ggcgagcaga
     2401 cagtcaccac tctctacaca aactggtacc tagaaagtct actcagacag gcgagcagtg
     2461 gaaccatcgt cctctctcca gccatgcagg ccttcatcag ccttccccga gatggggagc
     2521 agaacttcag tgctgaggag ttctcagaca tctctgagat gcgagccttg gctgaaattc
     2581 ttggccccta tggcatgaag ttcctgagtg aaaacctgat gtggcacgtg acttctcaga
     2641 ttgtggagct gaagaaactt gtggtggaaa acatggatat cctggttcag atcagatcca
     2701 acttcaccaa gccagaattg atggcatctc tgctgcccca gctgacaggg gctgaaaatg
     2761 tgctaaaacg aatgaccatc attggggtga ttctcagttt tagggccatg gcccaagagg
     2821 gacttcagga ggttttttct gcccactgtc cctttctcat gggccccatt gagtgcctga
     2881 aggagtttgt caccccagac acagacatta aggtcaccct gagtgtcttt gagctggcgt
     2941 gtgctgcagg ggtgagctgt gacattgacc cggccttggt ggctgccatt gccaatctga
     3001 aagctgataa ctcatcccct gaagaagagt acaaggtggc gtgcctactt ttgattttcc
     3061 tcgctgtttc cctcccactc cttgccactg acccttcttc cttcttcagc attgagaaag
     3121 atggctacaa caacaacatc cactgtttga ccaaagccat catccaggtg tctgctgccc
     3181 ttttcactct gtacaacaag aacattgaaa cgcacctcaa ggagtttctg gtggtggcct
     3241 ctgtcagcct cttgcagctg ggccaggaga ctgacaagct caaaaccaga aatcgtgaat
     3301 ccatttctct gctcatgcgc ttggtggtgg aggagtcacc cttcttgacc ctggacatgc
     3361 tggagtcctg tttcccttac gttctactac gcaatgccta tcgggaggtt tcccgggcct
     3421 tctacctgaa ccgtctgcca gccagttccc actgaagggc cttctggagc tgccaagagc
     3481 cacactgcag tgaaagttgc agccgtttct tcaaaagggg agaagagtgg gagggtgccc
     3541 agggagagac aggtcaggcc ccacagctga aagggataag gaggactatc tagggctgag
     3601 gagtcatgga gaagtgggac aggctggggc catggaggac aatgtataga taaaggggtg
     3661 tggaactaca tgtatgaatt tttaaccatg aaaaaaaaaa aaacagtgac ctataagcat
     3721 attgtgtatc ttctggtgac tccagcttaa gctctgacag gcatggttct ctccgacctt
     3781 catcactatt ctaggataat gttggcgggc agagatgatc aatcatcata ttaaaccata
     3841 atgagcttat aatcctcccg ctggagctgc tattgtctcc tgcacattca ttaggacgat
     3901 tatctcctct cttccttttc caaatgtgtt cagcaaacgt ccagcctgct cccactgcag
     3961 cagagcagca caggcaccca tttctcttcg aagggctctt ggtccttctc accttgactc
     4021 cattccccaa tggtattcct cctccagagg tatcgtgtcc agcttactct cctacccact
     4081 gtgggtaaaa agtatatctc ccttgctctc actgtgcctg cttttccttg tgtgtctcca
     4141 cagcccagac tggagagagg taatgcagat cacctgacag ccaagtgaaa ctgactcatg
     4201 tgggttttcc ctcctacatc attaggggga tattctacct cctaatgggt gggactaact
     4261 taacccctaa tccccttgtc agcctcagta cagctgttgc tccaggcagg gacttctctt
     4321 gtagatctta aatttcacgt accttattag gtcggagggc ccaagagtag ggatccttga
     4381 gggagtacaa gctgtttcaa cttagccctt ttctgtacta attagaattt caagtgtcat
     4441 agagcccggg gcatttaaga tagcgctaac tgggtttagt aactctgtgg cagagagcag
     4501 ttaaccccat ctttcattca cacagtcatc gccagggagg gctggagtaa cagatcataa
     4561 gtgtcacagg tccagaatag ttggaatggg aaaatgtaat tagcgagttg attaattagg
     4621 gtcatgccca tgcttccatt atgaaaagga agcaattgtt gttggctttc agcaaaacca
     4681 tccagctttc attaaaccaa tttgatagct gtt
//
