LOCUS       NM_001127304            1496 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus neutrophil cytosolic factor 4 (Ncf4), mRNA.
ACCESSION   NM_001127304 XM_001074363 XM_576306
VERSION     NM_001127304.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Ansari MA, Roberts KN and Scheff SW.
  TITLE     A time course of NADPH-oxidase up-regulation and endothelial nitric
            oxide synthase activation in the hippocampus following neurotrauma
  JOURNAL   Free Radic Biol Med 77, 21-29 (2014)
   PUBMED   25224032
  REMARK    GeneRIF: The levels of cytosolic p67Phox, p47Phox, and p40Phox were
            increased in membrane fractions following traumatic brain injury.
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Olsson LM, Lindqvist AK, Kallberg H, Padyukov L, Burkhardt H,
            Alfredsson L, Klareskog L and Holmdahl R.
  TITLE     A case-control study of rheumatoid arthritis identifies an
            associated single nucleotide polymorphism in the NCF4 gene,
            supporting a role for the NADPH-oxidase complex in autoimmunity
  JOURNAL   Arthritis Res Ther 9 (5), R98 (2007)
   PUBMED   17897462
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Shukla S, Jha RK, Laloraya M and Kumar PG.
  TITLE     Identification of non-mitochondrial NADPH oxidase and the
            spatio-temporal organization of its components in mouse spermatozoa
  JOURNAL   Biochem Biophys Res Commun 331 (2), 476-483 (2005)
   PUBMED   15850784
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson
            KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L and
            Williams RL.
  TITLE     The crystal structure of the PX domain from p40(phox) bound to
            phosphatidylinositol 3-phosphate
  JOURNAL   Mol Cell 8 (4), 829-839 (2001)
   PUBMED   11684018
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Wientjes FB, Hsuan JJ, Totty NF and Segal AW.
  TITLE     p40phox, a third cytosolic component of the activation complex of
            the NADPH oxidase to contain src homology 3 domains
  JOURNAL   Biochem J 296 (Pt 3) (Pt 3), 557-561 (1993)
   PUBMED   8280052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before May 11, 2008 this sequence version replaced
            XM_576306.2, XM_001074363.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1496
                     /gene="Ncf4"
                     /note="neutrophil cytosolic factor 4"
                     /db_xref="GeneID:500904"
                     /db_xref="RGD:1593157"
     exon            1..265
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1253
                     /gene="Ncf4"
                     /codon_start=1
                     /product="neutrophil cytosol factor 4"
                     /protein_id="NP_001120776.1"
                     /db_xref="GeneID:500904"
                     /db_xref="RGD:1593157"
                     /translation="MALAQQLRSESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIE
                     VKTKGGSKYLIYRRYRQFYALQSKLEERFGPESKNSPFTCSLPTLPAKVYMGVKQEIA
                     ETRIPALNAYMKNLLSLPVCVLMDPDVRIFFYQSAYDAEQVPQALRRLRPRTRKIKGV
                     TPQGPSMDRMEAPRAEALFDFTGNSKLELSFKAGDVIFLLSKINKDWLEGTTQGATGI
                     FPGSFVKILKDFPEDEDTTNWLRCYFYEDTGKTIKDIAVEEDLSSTPLFKDLLALMRR
                     EFQREDIALNYQDAEGDLVRLLSDEDVGLMVKQAQGLPSQKRLFPWKLHVTQKDNYGV
                     YNTVP"
     exon            266..350
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     exon            351..504
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     exon            505..575
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     exon            576..703
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     exon            704..761
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     exon            762..860
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     exon            861..991
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1057
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1496
                     /gene="Ncf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagtggg tgagaagaag tgtggagcca ggcagctcag agtctcaagg aggtacttca
       61 aggagggtcc agagaagctg gggagggagg gacctcctca aagggtgctc ccgaggacac
      121 cccgagcttt caggaagctc ccagatgcac ataggaggaa gtgagaggtg aactcagcct
      181 cagcctggct gggcaaggcc ttcatctatc tgctttcctg actactgaca gccatggccc
      241 tggcccagca gctgcgatca gagagcgatt ttgagcagct tccagatgat gtggccatct
      301 cagccaacat cgctgacatc gaggagaaga ggggcttcac cagccacttt gtgtttgtca
      361 tcgaggtaaa gacaaaagga ggatccaagt atctcatcta ccgccgatat cgccagttct
      421 acgccctgca gagcaagctg gaggagcggt ttggaccaga gagcaagaac agcccattca
      481 cctgcagcct gcccacactg ccagccaaag tctacatggg tgtcaaacaa gagattgctg
      541 agactcggat cccggccctc aatgcctaca tgaagaacct cctgagcctg ccggtctgcg
      601 tgctgatgga ccccgacgtc agaatattct tctatcagtc tgcttacgac gcagagcagg
      661 tgcctcaggc acttcgtagg ctccgaccgc gcacgcgcaa aatcaagggc gtgactccac
      721 aagggcccag catggaccgc atggaagctc caagagcaga ggccttgttt gacttcactg
      781 ggaacagcaa actggagcta agtttcaaag ctggagatgt gatcttcctt ctcagtaaga
      841 tcaacaaaga ctggttggag ggcacaaccc agggagccac aggcatcttc ccagggtctt
      901 tcgtgaagat cctcaaggac ttccccgaag acgaggacac taccaactgg ctgcgatgct
      961 acttctacga agacacaggc aaaaccatca aggacattgc agtggaggag gacctcagca
     1021 gcacccccct gttcaaagac ctgctagcac tcatgaggcg tgaattccag agagaggaca
     1081 ttgcccttaa ttaccaagat gctgaggggg acctggttcg gctgctgtca gatgaggatg
     1141 tgggactcat ggtgaagcag gcccaaggcc tcccctccca gaagcgcctc ttcccctgga
     1201 agctgcacgt cacccagaag gacaattacg gtgtctacaa caccgtaccc tgagtcacag
     1261 ggacccagtg gcaaggatgg gtactcagca aaggacctta ccttccaaga acatgaagac
     1321 cctccaggag gctggcacaa gatgcaaacc tcctgggcca gagtgcccac tggacaggat
     1381 tctacttaat ttttgacact ttacctttgg attaaataaa ccattctgtg tcaaagggcc
     1441 agtgttggga aatgagattt tgtggaggaa cggggagtaa aatgtaattg attaag
//
