LOCUS       NM_053734               2800 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus neutrophil cytosolic factor 1 (Ncf1), mRNA.
ACCESSION   NM_053734
VERSION     NM_053734.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2800)
  AUTHORS   Cao,M., Mao,Z., Peng,M., Zhao,Q., Sun,X., Yan,J. and Yuan,W.
  TITLE     Extracellular cyclophilin A induces cardiac hypertrophy via the
            ERK/p47phox pathway
  JOURNAL   Mol Cell Endocrinol 518, 110990 (2020)
   PUBMED   32805334
  REMARK    GeneRIF: Extracellular cyclophilin A induces cardiac hypertrophy
            via the ERK/p47phox pathway.
REFERENCE   2  (bases 1 to 2800)
  AUTHORS   Li,Y.J., Zhao,W., Yu,X.J., Li,F.X., Liu,Z.T., Li,L. and Xu,S.Y.
  TITLE     Activation of p47phox as a Mechanism of Bupivacaine-Induced Burst
            Production of Reactive Oxygen Species and Neural Toxicity
  JOURNAL   Oxid Med Cell Longev 2017, 8539026 (2017)
   PUBMED   28751934
  REMARK    GeneRIF: enhancing p47phox membrane translocation is a major
            mechanism whereby bupivacaine induced neurotoxicity and that
            pretreatment with VAS2870 or local p47phox gene knockdown
            attenuated bupivacaine-induced neuronal cell injury.
REFERENCE   3  (bases 1 to 2800)
  AUTHORS   Winiarska,K., Dzik,J.M., Labudda,M., Focht,D., Sierakowski,B.,
            Owczarek,A., Komorowski,L. and Bielecki,W.
  TITLE     Melatonin nephroprotective action in Zucker diabetic fatty rats
            involves its inhibitory effect on NADPH oxidase
  JOURNAL   J Pineal Res 60 (1), 109-117 (2016)
   PUBMED   26514550
  REMARK    GeneRIF: it is concluded that: (i) melatonin beneficial action
            against diabetic nephropathy involves attenuation of the excessive
            activity of Nox; and (ii) the mechanism of melatonin inhibitory
            effect on Nox is based on the mitigation of expression and membrane
            translocation of its regulatory subunits.
REFERENCE   4  (bases 1 to 2800)
  AUTHORS   Sharma,N.M., Rabeler,B., Zheng,H., Raichlin,E. and Patel,K.P.
  TITLE     Exercise Training Attenuates Upregulation of p47(phox) and
            p67(phox) in Hearts of Diabetic Rats
  JOURNAL   Oxid Med Cell Longev 2016, 5868913 (2016)
   PUBMED   26989452
  REMARK    GeneRIF: Exercise Training attenuates the increased expression of
            p47(phox) and p67(phox) in the hearts of diabetic rats which could
            be an underlying mechanism for improving intracardiac matrix and
            thus cardiac function and prevent cardiac remodeling in diabetic
            cardiomyopathy.
REFERENCE   5  (bases 1 to 2800)
  AUTHORS   Lian,S., Xia,Y., Khoi,P.N., Ung,T.T., Yoon,H.J., Kim,N.H., Kim,K.K.
            and Jung,Y.D.
  TITLE     Cadmium induces matrix metalloproteinase-9 expression via
            ROS-dependent EGFR, NF-small ka, CyrillicB, and AP-1 pathways in
            human endothelial cells
  JOURNAL   Toxicology 338, 104-116 (2015)
   PUBMED   26514923
REFERENCE   6  (bases 1 to 2800)
  AUTHORS   Jackson,S.H., Gallin,J.I. and Holland,S.M.
  TITLE     The p47phox mouse knock-out model of chronic granulomatous disease
  JOURNAL   J Exp Med 182 (3), 751-758 (1995)
   PUBMED   7650482
REFERENCE   7  (bases 1 to 2800)
  AUTHORS   Volpp,B.D. and Lin,Y.
  TITLE     In vitro molecular reconstitution of the respiratory burst in B
            lymphoblasts from p47-phox-deficient chronic granulomatous disease
  JOURNAL   J Clin Invest 91 (1), 201-207 (1993)
   PUBMED   7678602
REFERENCE   8  (bases 1 to 2800)
  AUTHORS   Francke,U., Hsieh,C.L., Foellmer,B.E., Lomax,K.J., Malech,H.L. and
            Leto,T.L.
  TITLE     Genes for two autosomal recessive forms of chronic granulomatous
            disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1)
  JOURNAL   Am J Hum Genet 47 (3), 483-492 (1990)
   PUBMED   2393022
REFERENCE   9  (bases 1 to 2800)
  AUTHORS   Volpp,B.D., Nauseef,W.M., Donelson,J.E., Moser,D.R. and Clark,R.A.
  TITLE     Cloning of the cDNA and functional expression of the 47-kilodalton
            cytosolic component of human neutrophil respiratory burst oxidase
  JOURNAL   Proc Natl Acad Sci U S A 86 (18), 7195-7199 (1989)
   PUBMED   2550933
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1989 Dec;86(23):9563]
REFERENCE   10 (bases 1 to 2800)
  AUTHORS   Lomax,K.J., Leto,T.L., Nunoi,H., Gallin,J.I. and Malech,H.L.
  TITLE     Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in
            chronic granulomatous disease
  JOURNAL   Science 245 (4916), 409-412 (1989)
   PUBMED   2547247
  REMARK    Erratum:[Science 1989 Nov 24;246(4933):987]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061810.1.
            
            On Dec 20, 2003 this sequence version replaced NM_053734.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061810.1, AF547392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2800
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2800
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /note="neutrophil cytosolic factor 1"
                     /db_xref="GeneID:114553"
                     /db_xref="RGD:61307"
     exon            1..86
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1184
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /note="phagocyte oxidase 47 kDa; neutrophil cytosol factor
                     1; neutrophil cytosol factor 1-like"
                     /codon_start=1
                     /product="neutrophil cytosolic factor 1"
                     /protein_id="NP_446186.2"
                     /db_xref="GeneID:114553"
                     /db_xref="RGD:61307"
                     /translation="MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRKF
                     TEIYEFHKMLKEMFPIEAGEIHTENRVIPHLPAPRWYDGQRAAESRQGTLTEYFNSLM
                     GLPVKISRCPHLLNFFKVRPDDLKLPNDSQVKKPETYLTAKDGKNNVADITGPIILQT
                     YRAIADYEKGSKTEMTVATGDVVDVVEKSESGWWFCQMKTKRGWVPASYLEPLDSPDE
                     AEDPDPNYAGEPYVTIKAYAAVEEDEVSLSEGEAIEVIHKLLDGWWVVRKGDITGYFP
                     SMYLQKAGEEITQAQRQIRSRGAPPRRSTIRNAQSIHQRSRKRLSQDTYRRNSVRFLQ
                     QRRRPARPGPQSPDSKDNPSTPRAKPQPAVPPRPSSDLILHRCTESTKRKLTSAV"
     exon            87..167
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            168..243
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            244..409
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            410..465
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            466..588
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            589..696
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            697..814
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            815..922
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1065
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..2758
                     /gene="Ncf1"
                     /gene_synonym="Ncf-1; p47phox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccactgccc agccatgggg gacaccttca ttcgccacat cgccctcctg ggcttcgaga
       61 aacgcttcgt ccccagccaa cactatgtgt acatgttcct ggttaagtgg caggacctgt
      121 cggagaaggt ggtctacaga aaattcaccg agatctacga gttccataaa atgttaaagg
      181 agatgttccc cattgaggcc ggtgagatcc acacagaaaa cagagtcatc cctcacctcc
      241 cagctcccag gtggtatgat gggcagcgtg cagcggagag ccgccaggga acgctcaccg
      301 agtacttcaa cagcctcatg ggactgcccg tgaagatctc ccgctgccca cacctcttga
      361 acttcttcaa agtgcggccc gatgacctga agctgcccaa tgacagccag gtgaagaagc
      421 cagagacata cctgacggcc aaagatggca agaataatgt agctgacatc acgggtccca
      481 tcatccttca gacctatcgg gccatcgctg actacgagaa gggttccaaa acagagatga
      541 ccgtggcgac gggagatgtg gtggatgtcg tagagaaaag cgagagtggc tggtggtttt
      601 gccagatgaa gacaaaacga ggttgggtcc ctgcatccta tttggagccc cttgacagcc
      661 ctgatgaggc agaggacccc gatcccaact acgcaggtga accgtatgta accatcaaag
      721 cgtacgctgc tgttgaagag gatgaggtgt ccctgtctga gggtgaagcc atcgaggtca
      781 ttcataagct cctagatggc tggtgggtgg tcaggaaagg ggacatcacc ggctacttcc
      841 catccatgta tctgcagaag gctggggagg agataaccca ggcccagcga cagattagaa
      901 gccgcggggc accacctcgc aggtcgacca tccgcaatgc acagagcatc caccagcgtt
      961 ctcggaagcg cctcagccag gacacctatc gccgcaacag cgtccgattc ctgcagcagc
     1021 gcagacgccc ggcgcgacct gggccgcaga gccctgactc aaaggacaat ccatcgactc
     1081 cgcgcgccaa accacagcct gcggtgcctc cgagacccag ctcggacctc atcctgcacc
     1141 gctgcacaga gagcaccaag aggaaactga cgtccgccgt gtgaggggcg gctgcactga
     1201 aaggcggtcc tatccctacc cttgtatata tttgtatata gcctcaggtc agaggctcct
     1261 accctgcttt aatgtttgga atggactcag actctgcagc aaaggacagg actgggtttc
     1321 tctccacggg tattgctagg atgagaggag gcagtcagcg ttgctggggg gtttgcagga
     1381 acaaaaaagg tctgattacc cgctgcctta gtcttgacca aggtcaagtt tgcagaaggc
     1441 caagtgtctt aggaacgccc taaggaaact gtttctcaac ctgttggcca tgaccccttt
     1501 ggggagggtg tcgaaagact ctttctcaga agttgcctta gatcattgga aaacacagat
     1561 attatttttt tttttttcgg agctggggac cgaacccagg gccttgcgct cgctaggcaa
     1621 gcactctacc gctgagctaa atccccaacc cccccccccc acagatatta tttttataga
     1681 tatttatatt acgatttata caagtagcaa aatgacagct atgaagtagc aatgaaaata
     1741 attgtatgat tgggggtccc cacaacattg gaaactaact gtattaaggg gtacagcact
     1801 aggaaggttg agaagcactg tcctaggggc tcagaatgtt gcctggttgg tagagtgctt
     1861 gactagcatg caccagggcc tggcttccat tcccagcatc ccataattgg gcttgtccgt
     1921 gttccaacat ctgggcggaa tttcacagcc aaaggtcaag aggactgctg ttacgttcaa
     1981 ggtcggcctg ggccacgtag ggaattcgag atcagatcta gttacagtgt gggatcctgt
     2041 ctcaaaccac cccatcccac aacataacct tggcatgggg tctcggggtt gtggcggaaa
     2101 gcagtcatta gtggataatg cttggtattc tccttgtttt catgtctcta agaccttgcc
     2161 ggtatttcca ttcccaaatg caaagaaacc gtgctgactg gatctatgtc accgtgacac
     2221 aagctggtgt catctaaggg agggcacctc agctgaggaa acgcctccat ggggctggaa
     2281 agatagctca gtggttaaga gcactggctg cttttccaga ggactggggt tcaatttcca
     2341 gcattcacag ggtaggtcac atcggcctgt aactccagtt ttagggagtc tgacaccctc
     2401 tcacagacat atatgcaaac aaaataccaa tgcatataaa ataaaaatgc acattgaaaa
     2461 aaatttaaag gagggaaaat gcgaccataa gatccagctg taaagcattt tcttggtgat
     2521 tgatggggga gggcccaatc catggtgggt ggtgccatcc tgggctggtg gtcctgggtt
     2581 ctataagaga gcaagctgag caagccagta agtaacatcc ctccatggcc tctgcgtcag
     2641 cccctgcctc ctggtttctg ccctgcttga agtccctgtc ctgcctgagt tcctgtgctg
     2701 acttttttca gcgatgaaca gtgtggaagt gtaatcggaa taaacccttt cctccccaaa
     2761 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
