LOCUS       NM_001127524            2099 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus neutral cholesterol ester hydrolase 1 (Nceh1),
            mRNA.
ACCESSION   NM_001127524 XR_008069
VERSION     NM_001127524.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Redshaw,N., Camps,C., Sharma,V., Motallebipour,M., Guzman-Ayala,M.,
            Oikonomopoulos,S., Thymiakou,E., Ragoussis,J. and Episkopou,V.
  TITLE     TGF-beta/Smad2/3 signaling directly regulates several miRNAs in
            mouse ES cells and early embryos
  JOURNAL   PLoS One 8 (1), e55186 (2013)
   PUBMED   23390484
REFERENCE   2  (bases 1 to 2099)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2099)
  AUTHORS   Nomura,D.K., Leung,D., Chiang,K.P., Quistad,G.B., Cravatt,B.F. and
            Casida,J.E.
  TITLE     A brain detoxifying enzyme for organophosphorus nerve poisons
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 6195-6200 (2005)
   PUBMED   15840715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166533.1.
            
            On Jun 1, 2008 this sequence version replaced NM_001127524.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166533.1, CK601109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..2099
                     /gene="Nceh1"
                     /gene_synonym="Aadacl1; RGD1311104"
                     /note="neutral cholesterol ester hydrolase 1"
                     /db_xref="GeneID:294930"
                     /db_xref="RGD:1311104"
     exon            1..184
                     /gene="Nceh1"
                     /gene_synonym="Aadacl1; RGD1311104"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1273
                     /gene="Nceh1"
                     /gene_synonym="Aadacl1; RGD1311104"
                     /EC_number="3.1.1.71"
                     /note="NCEH; arylacetamide deacetylase-like 1; 2-acetyl
                     MAGE hydrolase; acetylalkylglycerol acetylhydrolase"
                     /codon_start=1
                     /product="neutral cholesterol ester hydrolase 1"
                     /protein_id="NP_001120996.1"
                     /db_xref="GeneID:294930"
                     /db_xref="RGD:1311104"
                     /translation="MRSSCVLLAALLALVAYYVYIPLPSAVSDPWKLMLLDATFRGAQ
                     QVSNLIHSLGLSHHLITLNFIIISFGKKSARSSPRVKVTDTDFDGVEVRVFEGPPKPD
                     EPLRRSVVYIHGGGWALASAKISYYDQLCTAMAEELNAVIVSIEYRLVPQVYFPEQIH
                     DVIRATKYFLQPEVLDKYKVDPGRVGVSGDSAGGNLAAALGQQFTYVESLKNKLKLQA
                     LIYPVLQALDFNTPSYQQSMNTPILPRHVMVRYWVDYFKGNYDFVEAMIVNNHTSLDV
                     ERAAALRARLDWTSLLPSSIKKNYKPVLQTIGDARIVKEIPQLLDAAASPLIAEQEVL
                     QALPKTYILTCEHDVLRDDGIMYAKRLESAGVNVTLDHFEDGFHGCMIFTSWPTNFSV
                     GIRTRDSYFKWLDQNL"
     exon            185..413
                     /gene="Nceh1"
                     /gene_synonym="Aadacl1; RGD1311104"
                     /inference="alignment:Splign:2.1.0"
     exon            414..483
                     /gene="Nceh1"
                     /gene_synonym="Aadacl1; RGD1311104"
                     /inference="alignment:Splign:2.1.0"
     exon            484..655
                     /gene="Nceh1"
                     /gene_synonym="Aadacl1; RGD1311104"
                     /inference="alignment:Splign:2.1.0"
     exon            656..2078
                     /gene="Nceh1"
                     /gene_synonym="Aadacl1; RGD1311104"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcgcaccat actgcggtca gctccggaca gccgggcctg gggacaatga ggtcgtcatg
       61 cgtcctactg gccgcgctgc tggcgctagt cgcctactac gtgtacatcc cactgcccag
      121 cgctgtgtcc gacccctgga aactgatgct gctggatgcc actttccgcg gcgcgcagca
      181 agtgagtaac ctgatacatt ccctgggact gagccaccat ctgatcacac tgaatttcat
      241 catcatctct tttggcaaga aaagcgcaag gtcttctcca agagtgaagg tgacggacac
      301 tgacttcgat ggcgtggagg tccgagtatt cgaaggccct ccaaaaccag atgagccgct
      361 gcgccgcagt gtggtctata tccacggagg aggctgggcc ttggccagtg caaaaatcag
      421 ctactatgac cagctgtgca cagcaatggc cgaggagctg aacgccgtca tcgtttctat
      481 tgaatacagg ctagttccac aggtttattt tcctgagcaa attcatgatg tcatccgggc
      541 caccaaatac ttcctacagc cagaagtctt agacaagtac aaggtggacc ctggaagagt
      601 cggcgtttct ggagacagtg ccggtgggaa tttggctgca gcccttggac agcagtttac
      661 ctacgttgaa agcctgaaga ataagctcaa actacaggct ttgatctacc cggtcctgca
      721 ggctttggac ttcaacacac cctcttatca gcagagcatg aatactccca tcctgcctcg
      781 ccacgtcatg gtgaggtact gggtagacta cttcaagggc aactatgact ttgtagaggc
      841 aatgattgtg aacaatcaca cttcacttga tgtagaaagg gctgcagccc tcagggcccg
      901 tctggactgg acatccctgt tgccctcatc catcaaaaag aactacaagc ctgtcttaca
      961 gaccataggg gacgccagaa tcgtcaagga gatcccccag ctgctggacg ccgctgcttc
     1021 cccgctcatc gcagagcagg aagtgcttca ggccctcccg aagacctaca tcctcacgtg
     1081 cgagcatgat gtcctgcgtg acgacgggat catgtacgcc aagcgcctgg agagtgcggg
     1141 tgtgaacgtg accttggacc actttgagga cggcttccat ggctgtatga ttttcacaag
     1201 ctggccgacc aacttctctg taggaatccg gactagggat agttacttca aatggctgga
     1261 tcaaaacctg tgatggagga aactcctcag acgcacgaag cacttgacct ccgtttgctt
     1321 tggaaaaacc tgcgcttttc aaccatctgc accttttcct cgtttcacat tagtactgat
     1381 atctgtaccc tacagacctt ataattattt acaaagtgac tcttgactaa cgcagtgaaa
     1441 aaacatctga acctggtttc ccaaatgcta ggaatggccc cagtttgagg agctagaaat
     1501 agccttaggt cctgcctcta gtgtgttctt tccagaagtt tttacagctg tgggtgaggc
     1561 agtaaattct gaggaacaaa aacaacagca gcaacaggac catgttctgc agtttgctct
     1621 ggttgacatg ggctgcagag cagagcctag tggacactct tgagggcagc ccctggcaat
     1681 gcatgtcctc cgtctcccgg ggtggttgtg tgtcctgtgg gaattttgac aggatttcta
     1741 gcaagacaga tttcttctca aaagctttcc ttcgggagta ttactcttct gagctagatg
     1801 ctataaattc agtgaaacta aaagaatact tgaaagttag tttgtactgc tattctcaga
     1861 aaacgtgagg ctgcgtgtac tggttatttc cttgggaaaa tcttttggga acaaacgtat
     1921 ttaactgtag agtaagtttc ctattgtgaa ataagtaaag gtagaaaaat aacagcctgt
     1981 tgttacttaa gaatactcct ggcataaatt actaaaagtg gtgtgtgtat atatttggga
     2041 tagtaaggaa ataaattatg tttaataata acttaaaaaa aaaaaaaaaa aaaaaaaaa
//
