LOCUS       NM_053543               3662 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus neurochondrin (Ncdn), mRNA.
ACCESSION   NM_053543
VERSION     NM_053543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3662)
  AUTHORS   Johansen,V.B.I., Hampson,E., Tsonou,E., Pantarelli,C., Chu,J.Y.,
            Crossland,L., Okkenhaug,H., Massey,A.J., Hornigold,D.C.,
            Welch,H.C.E. and Chetwynd,S.A.
  TITLE     The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the
            morphology, cell cycle and survival of PC12 cells
  JOURNAL   Sci Rep 13 (1), 18237 (2023)
   PUBMED   37880240
  REMARK    GeneRIF: The GPCR adaptor protein Norbin regulates S1PR1
            trafficking and the morphology, cell cycle and survival of PC12
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3662)
  AUTHORS   Xu,Y., Li,Z., Yao,L., Zhang,X., Gan,D., Jiang,M., Wang,N., Chen,G.
            and Wang,X.
  TITLE     Altered Norbin Expression in Patients with Epilepsy and a Rat Model
  JOURNAL   Sci Rep 7 (1), 13970 (2017)
   PUBMED   29070854
  REMARK    GeneRIF: Low norbin expression is associated with Epilepsy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3662)
  AUTHORS   Westin,L., Reuss,M., Lindskog,M., Aperia,A. and Brismar,H.
  TITLE     Nanoscopic spine localization of Norbin, an mGluR5 accessory
            protein
  JOURNAL   BMC Neurosci 15, 45 (2014)
   PUBMED   24670218
  REMARK    GeneRIF: Norbin associates with actin rather than with PSD-95 in
            dendritic spines.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3662)
  AUTHORS   Oku,S., Takahashi,N., Fukata,Y. and Fukata,M.
  TITLE     In silico screening for palmitoyl substrates reveals a role for
            DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in
            its targeting to Rab5-positive endosomes
  JOURNAL   J Biol Chem 288 (27), 19816-19829 (2013)
   PUBMED   23687301
  REMARK    GeneRIF: In silico screening for palmitoyl substrates reveals a
            role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin
            palmitoylation in its targeting to Rab5-positive endosomes.
REFERENCE   5  (bases 1 to 3662)
  AUTHORS   Wang,H., Duan,X., Ren,Y., Liu,Y., Huang,M., Liu,P., Wang,R.,
            Gao,G., Zhou,L., Feng,Z. and Zheng,W.
  TITLE     FoxO3a negatively regulates nerve growth factor-induced neuronal
            differentiation through inhibiting the expression of neurochondrin
            in PC12 cells
  JOURNAL   Mol Neurobiol 47 (1), 24-36 (2013)
   PUBMED   23086522
  REMARK    GeneRIF: FoxO3a inhibits NGF-induced neuronal differentiation, at
            least in part, by suppressing the expression of NCDN.
REFERENCE   6  (bases 1 to 3662)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3662)
  AUTHORS   Schwaibold,E.M. and Brandt,D.T.
  TITLE     Identification of Neurochondrin as a new interaction partner of the
            FH3 domain of the Diaphanous-related formin Dia1
  JOURNAL   Biochem Biophys Res Commun 373 (3), 366-372 (2008)
   PUBMED   18572016
  REMARK    GeneRIF: Neurochondrin is a novel Dia1 interacting protein.
REFERENCE   8  (bases 1 to 3662)
  AUTHORS   Shinozaki,K., Kume,H., Kuzume,H., Obata,K. and Maruyama,K.
  TITLE     Norbin, a neurite-outgrowth-related protein, is a cytosolic protein
            localized in the somatodendritic region of neurons and distributed
            prominently in dendritic outgrowth in Purkinje cells
  JOURNAL   Brain Res Mol Brain Res 71 (2), 364-368 (1999)
   PUBMED   10521593
REFERENCE   9  (bases 1 to 3662)
  AUTHORS   Ishiduka,Y., Mochizuki,R., Yanai,K., Takatsuka,M., Nonomura,T.,
            Niida,S., Horiguchi,H., Maeda,N. and Fukamizu,A.
  TITLE     Induction of hydroxyapatite resorptive activity in bone marrow cell
            populations resistant to bafilomycin A1 by a factor with restricted
            expression to bone and brain, neurochondrin
  JOURNAL   Biochim Biophys Acta 1450 (1), 92-98 (1999)
   PUBMED   10231559
REFERENCE   10 (bases 1 to 3662)
  AUTHORS   Shinozaki,K., Maruyama,K., Kume,H., Kuzume,H. and Obata,K.
  TITLE     A novel brain gene, norbin, induced by treatment of
            tetraethylammonium in rat hippocampal slice and accompanied with
            neurite-outgrowth in neuro 2a cells
  JOURNAL   Biochem Biophys Res Commun 240 (3), 766-771 (1997)
   PUBMED   9398642
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087000.1.
            
            On Apr 4, 2007 this sequence version replaced NM_053543.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087000.1, SRR8487230.89971.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3662
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /note="neurochondrin"
                     /db_xref="GeneID:89791"
                     /db_xref="RGD:621734"
     exon            1..391
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2548
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /note="neurite outgrowth-related protein from the rat
                     brain"
                     /codon_start=1
                     /product="neurochondrin"
                     /protein_id="NP_445995.2"
                     /db_xref="GeneID:89791"
                     /db_xref="RGD:621734"
                     /translation="MSCCDLAAAGQLGKAGIMASDCEPALNQAESRNPTLERYLGALR
                     EAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHV
                     LRALGVALLACFCSDPELASHPQVLNKIPILCTFLTARGDPDDAARRSMIDDTYQCLT
                     AVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDL
                     LAVLRGLSEDFQRAEDASKFELCQLLPLFLPPTTVPPECHRDLQAGLARILGSKLSSW
                     QRNPALKLAARLAHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVV
                     TACYALMELGIQECTRCEQSLLKEPQKVQLVSIMKEAIGAVIHYLLRVGPEKQKEPFV
                     FASVRILGAWLAEETSSLRKEVCQLLPFLVRYAKTLYEEAEEASDISQQVANLAISPT
                     TPGPAWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTS
                     VLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLA
                     ANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSP
                     DYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPE
                     MVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP"
     exon            392..532
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            533..1501
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1743
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1968
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2111
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..3635
                     /gene="Ncdn"
                     /gene_synonym="Norbin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcccgga gaaagacttc gccgctcggg gccgcagcct ggtgagctca gcccccttca
       61 agccctcccc tgcatctcag ccggagcctc tccgaaccgg cgctgatcga tgccgagact
      121 ccccagggac cctatcgcga ctccatcgtg ccatatctcg acatcaccgt accctgtcga
      181 gactccattt tgtcacaacc cctttcaata tttatctatt atatatattt ttaaaatttg
      241 ccctatcata tttgggggct gtccccttca tgtcgtgatt tcgctgtgat ctctccgtga
      301 catcaccgcg ccatcgtgaa gtgtgatctc atcgctgccc tgtcgttcga cttcatcaat
      361 gtcgtgttgt gacctggctg cggcgggaca gttgggcaag gcgggcatca tggcctcgga
      421 ttgtgagcca gctctgaacc aggcagagag ccgaaacccc accctggagc gctacctggg
      481 agccctccgt gaggccaaga atgacagcga gcagtttgca gccctgctgc tagtaaccaa
      541 ggcagtcaaa gcaggtgaca ttgacgccaa aactcgacgt aggatctttg atgctgttgg
      601 gttcaccttt cccaaccgac tcctgactac taaggaggcc cctgatggct gccctgacca
      661 cgttctccgg gccctgggcg tggccctgct ggcctgtttc tgcagcgacc ctgaactagc
      721 cagccatccc caggtcctga acaagatccc catcctttgc acattcctga cagcccgagg
      781 ggatcctgat gatgctgccc gccgctccat gattgatgac acctaccagt gcctgacagc
      841 tgttgcaggc acaccccgag ggccccgaca cctcattgct ggtggcacag tgtctgccct
      901 gtgccaggca tacctggggc atggctatgg ctttgaccag gccctggcac tcctggtggg
      961 gctgctggct gctgcagaga cacagtgctg gaaggaggca gagcccgacc tgctggctgt
     1021 gttgcgaggc ctcagcgagg atttccaaag agctgaagat gccagcaagt ttgagctctg
     1081 ccagctgctg ccccttttcc tgcccccaac aactgtgccc cctgaatgcc accgggatct
     1141 gcaggctggg ctggcacgca tcctaggaag caagttgagc tcctggcagc gcaatcctgc
     1201 actgaagctg gcagcccgcc tggctcatgc ctgcggctcc gactggatcc cagtgggcag
     1261 ctctgggagc aagtttctgg ccctcctggt gaatctggcc tgcgtggagg tgcgactggc
     1321 tctcgaggag acaggcacag aggtgaaaga agacgtggta actgcctgct atgcccttat
     1381 ggagttgggg atccaggagt gtacccgctg tgagcagtcc ctgctgaagg agccccagaa
     1441 agttcagctc gtgagcatca tgaaagaggc catcggagct gtcattcact acctgctgcg
     1501 ggtggggcca gagaagcaga aagagccctt tgtgtttgcc tctgtacgga tcctgggtgc
     1561 ctggctggcg gaggagacct catccctgcg taaggaggtg tgccaactgc tgcccttcct
     1621 tgtccgatat gccaagacac tctatgagga ggctgaggag gccagtgaca tttcgcagca
     1681 ggtggctaac ttggccatct ctcccactac accagggcct gcttggccag gggatgctct
     1741 ccggctcctc cttcctggct ggtgccacct gactgttgaa gatggtcccc gggagatttt
     1801 gatcaaggaa ggagccccct cacttctgtg caagtacttc ctgcagcagt gggaactcac
     1861 atcccctggc catgatacct cagtgctgcc agacagcgtg gagatcggcc tacagacctg
     1921 ttgccacatc ttcctcaacc tggtggtcac cgctcccggg ctgatcaagc gcgacgcctg
     1981 cttcacatcc cttatgaaca ccctgatgac gtcactgccc tcactagtgc agcagcaagg
     2041 aagactgctt ctagctgcca acgtggccac cttgggcctc ctaatggccc ggctccttag
     2101 cacctctcca gctctccaag gaactccggc ctcccgaggt ttcttcgcag ctgccatcct
     2161 ctttctgtca cagtcccatg tggcacgggc cacccctggc tctgaccagg cggtgttggc
     2221 cctgtcccct gactatgagg gcatctgggc cgacttgcaa gagctctggt tcttgggcat
     2281 gcaggccttc acaggttgtg tccctctgtt gccctggctg gcccctgccg ccctgcgttc
     2341 ccgctggcca caggagctgc tacagctgct aggtagtgta agccccaact ctgtcaagcc
     2401 cgagatggtg gctgcctacc agggcgtgct cgtggaattg gcgcgggcaa accggctatg
     2461 ccgggaggcc atgaggctgc aggcgggtga agaaacagcc agccattacc gcatggctgc
     2521 tttggagcag tgcctgtcag agccctgagg ggcatccagt gggtatagac ccaggggcgg
     2581 gcagcgaggg aaggagggag gaggcatctt ccctgaagcc cccaaactgg accccttctt
     2641 cagaccccca caaacacccc agctttctgg cttttctgag ggctagggcg tgatgcccac
     2701 ctctcaagta taagaaactg catcctgcct ccagccccct tggggcaggg attggcttgg
     2761 aacagaggtt ggccccgcca ggccggggaa ggttggagaa gtccccagga agagggcaac
     2821 taagtgtcat tatacccagc gtctggctcc ctgacaggag ggaggtccca gggtaggagc
     2881 gggctggcag gcgcagactg cctcagccca tgtgccctgc cggccagggc gtggcctccc
     2941 caaggctgtg gtgccccttc tggctccccc aggccaggtc cgcgcccttt aaattggccg
     3001 tttggctttt gccttcggtc cttttggaca gagagcaggc tcaggccatt gacatcacag
     3061 ttcttccttt caactctagt gacccggggt ccgagttgcc cctatgcttc cagggcaatt
     3121 tggagcagac agaccagtgg ggggcgggga acctccttcc acctgcgctt ccttgagggg
     3181 accggagtgc ccttggtccc aggtctcttg agcttttgtg tcatgttgca gcagagtgaa
     3241 gatgggggtt gggggttatt tattttgctt gtccttatct ctgcttggac acctgagcat
     3301 cagctccctg tgcccctgct gccatctggc ctggctggag ccaggaacag gaggtcacat
     3361 caccctagaa tccgcatgtt ttccctgtga ttgcactcca ctgccaccgt ggtgcctggc
     3421 ttcagttccc ctcccccccg tccctgctaa gactcttctc tgcagggaga cgcgactggc
     3481 ggctccagca ggaactacct ttctgaaccc gtggagaccc gcatacacct gaccccttgc
     3541 ttccgcccct ccccccagtg cgttctgtga tcgccaagtt caaagctgtg cacatgtgga
     3601 cactcaataa atgtttattg gtgatgagaa gcctcaaaaa aaaaaaaaaa aaaaaaaaaa
     3661 aa
//
