LOCUS       NM_001014785            2850 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nuclear cap binding protein subunit 1 (Ncbp1),
            mRNA.
ACCESSION   NM_001014785 XM_216408
VERSION     NM_001014785.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Gebhardt,A., Habjan,M., Benda,C., Meiler,A., Haas,D.A., Hein,M.Y.,
            Mann,A., Mann,M., Habermann,B. and Pichlmair,A.
  TITLE     mRNA export through an additional cap-binding complex consisting of
            NCBP1 and NCBP3
  JOURNAL   Nat Commun 6, 8192 (2015)
   PUBMED   26382858
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2850)
  AUTHORS   Lubas,M., Andersen,P.R., Schein,A., Dziembowski,A., Kudla,G. and
            Jensen,T.H.
  TITLE     The human nuclear exosome targeting complex is loaded onto newly
            synthesized RNA to direct early ribonucleolysis
  JOURNAL   Cell Rep 10 (2), 178-192 (2015)
   PUBMED   25578728
REFERENCE   3  (bases 1 to 2850)
  AUTHORS   Gonatopoulos-Pournatzis,T. and Cowling,V.H.
  TITLE     Cap-binding complex (CBC)
  JOURNAL   Biochem J 457 (2), 231-242 (2014)
   PUBMED   24354960
  REMARK    Review article
            Erratum:[Biochem J. 2014 Feb 15;458(1):185]
REFERENCE   4  (bases 1 to 2850)
  AUTHORS   Pabis,M., Neufeld,N., Steiner,M.C., Bojic,T., Shav-Tal,Y. and
            Neugebauer,K.M.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   5  (bases 1 to 2850)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2850)
  AUTHORS   Calero,G., Wilson,K.F., Ly,T., Rios-Steiner,J.L., Clardy,J.C. and
            Cerione,R.A.
  TITLE     Structural basis of m7GpppG binding to the nuclear cap-binding
            protein complex
  JOURNAL   Nat Struct Biol 9 (12), 912-917 (2002)
   PUBMED   12434151
REFERENCE   7  (bases 1 to 2850)
  AUTHORS   Ishigaki,Y., Li,X., Serin,G. and Maquat,L.E.
  TITLE     Evidence for a pioneer round of mRNA translation: mRNAs subject to
            nonsense-mediated decay in mammalian cells are bound by CBP80 and
            CBP20
  JOURNAL   Cell 106 (5), 607-617 (2001)
   PUBMED   11551508
REFERENCE   8  (bases 1 to 2850)
  AUTHORS   Wilson,K.F., Fortes,P., Singh,U.S., Ohno,M., Mattaj,I.W. and
            Cerione,R.A.
  TITLE     The nuclear cap-binding complex is a novel target of growth factor
            receptor-coupled signal transduction
  JOURNAL   J Biol Chem 274 (7), 4166-4173 (1999)
   PUBMED   9933612
REFERENCE   9  (bases 1 to 2850)
  AUTHORS   Flaherty,S.M., Fortes,P., Izaurralde,E., Mattaj,I.W. and
            Gilmartin,G.M.
  TITLE     Participation of the nuclear cap binding complex in pre-mRNA 3'
            processing
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 11893-11898 (1997)
   PUBMED   9342333
REFERENCE   10 (bases 1 to 2850)
  AUTHORS   Izaurralde,E., Lewis,J., Gamberi,C., Jarmolowski,A., McGuigan,C.
            and Mattaj,I.W.
  TITLE     A cap-binding protein complex mediating U snRNA export
  JOURNAL   Nature 376 (6542), 709-712 (1995)
   PUBMED   7651522
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092199.1.
            
            On Apr 20, 2005 this sequence version replaced XM_216408.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092199.1, SRR8487231.78732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2850
                     /gene="Ncbp1"
                     /note="nuclear cap binding protein subunit 1"
                     /db_xref="GeneID:298075"
                     /db_xref="RGD:1308973"
     exon            1..103
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2442
                     /gene="Ncbp1"
                     /note="CBP80; NCBP 80 kDa subunit; 80 kDa nuclear
                     cap-binding protein; nuclear cap binding protein subunit
                     1, 80kDa"
                     /codon_start=1
                     /product="nuclear cap-binding protein subunit 1"
                     /protein_id="NP_001014785.1"
                     /db_xref="GeneID:298075"
                     /db_xref="RGD:1308973"
                     /translation="MSRRRHSYENDGGQPHKRRKTSDANETEDHLESLICKVGEKSAC
                     SLESNLEGLAGVLEADLPNYKSKILRLLCTVARLLPEKLTIYTTLVGLLNARNYNFGG
                     EFVEAMIRQLKESLKANNYNEAVYLVRFLSDLVNCHVIAAPSMVAMFENFVSVTQEED
                     VPQVRRDWYVYAFLSSLPWVGKELYEKKDAEMDRIFSSTESYLKRRQKTHVPMLQVWT
                     ADKPHPQEEYLDCLWAQIQKLKKDRWQERHILRPYLAFDSILCEALQHNLPPFTPPPH
                     TEDSVYPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHCIIKSYWKERKTCAA
                     QLVSYPGKNKIPLNYHIVEVIFAELFQLPAPPHIDVMYTTLLIELCKLQPGSLPQVLA
                     QATEMLYMRLDTMSTTCVDRFINWFSHHLSNFQFRWSWEDWSDCLTQDLESPKPKFVR
                     EVLEKCMRLSYHQHILDIVPPTFSALCPANPTCIYKYGDESSNSLPGHSVALCLSVAF
                     KSKATNDEIFSILKDVPNPNQVDDDDEGFRFNPLKIEVFVQTLLHLAAKSFSHSFSAL
                     AKFHEVFKTLAESDKGKLHVLRVMFEVWRNHPQMIAVLVDKMIRTQIVDCAAVANWIF
                     SSELSRDFTRLFVWEILHSTIRKMNKHVLKIQKELEEAKEKLARQHKRRSDDDDRGSD
                     RKDGALEEQIERLQEKVESAQSEQKNLFLVIFQRFIMILTEHLVRCETDGTSILTPWY
                     KNCIERLQQIFLQHHQIIQQYMVTLENLLFTAELDPHILAVFQQFCALQA"
     exon            104..192
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..293
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..450
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..558
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..680
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..750
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..966
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1064
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1128
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1239
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1304
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1367
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1442
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1546
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1669
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1772
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1866
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1970
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2085
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2214
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2328
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2827
                     /gene="Ncbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcagccc gacggttctg gtgttgcagg cgacccgcaa ctcagatccg ctgcgcatca
       61 gcaagcagca tgtcgcggag gcggcacagc tacgagaacg atggtggaca acctcacaaa
      121 aggaggaaga catcagatgc aaatgaaacg gaagatcatt tggaatcttt aatatgcaaa
      181 gtaggggaaa agagcgcttg ctctttagag agcaatctcg aaggcctggc tggtgtttta
      241 gaagctgatc ttcctaacta caagagcaag atcttaaggc tcctttgtac agttgcacgt
      301 ctgttacctg agaagctaac aatttataca acattagttg gactgctgaa tgccagaaat
      361 tataactttg gaggagaatt tgtagaagct atgattcgtc aacttaaaga atcgctaaaa
      421 gcaaacaact ataatgaagc tgtatatttg gtccgttttc tgtctgatct tgtgaactgt
      481 catgtgattg ctgccccatc tatggttgct atgtttgaga attttgtaag tgtaactcag
      541 gaagaagatg tgcctcaagt gcgacgggat tggtatgtgt acgcgtttct gtcatccttg
      601 ccctgggttg ggaaggagtt gtatgaaaag aaagatgcag aaatggaccg catcttctcc
      661 agcaccgaaa gctatctcaa aagacgccag aagactcatg tgcccatgtt acaagtatgg
      721 actgccgata agccacaccc ccaagaagag tatttagatt gcctgtgggc ccagattcag
      781 aaattgaaaa aggaccggtg gcaggaaagg cacatcctaa gaccctacct tgcctttgac
      841 agcatcctct gtgaagcact acagcacaac ctgcctcctt tcacaccacc gcctcacacc
      901 gaagactccg tgtacccaat gcccagggtc atcttcagga tgtttgacta cacagacgac
      961 ccagagggtc ctgttatgcc agggagccat tcagtagaga ggtttgtcat agaggagaat
     1021 cttcattgca tcataaaatc ctactggaag gaaaggaaaa cttgtgctgc ccagttggtg
     1081 agttatccag gcaagaacaa gatcccattg aactaccaca tagtggaggt gatctttgca
     1141 gagctgtttc agcttccagc gcctccgcac attgatgtga tgtacacgac actgctgatc
     1201 gaactgtgca aacttcagcc gggctctctg ccccaagtgc ttgcacaggc cactgagatg
     1261 ctgtacatgc gtctggacac catgagtacc acgtgtgttg acaggtttat taattggttt
     1321 tctcatcatc taagtaattt tcaattccgc tggagctggg aagattggtc agattgtctt
     1381 actcaggatc ttgaaagtcc caaaccaaag tttgtaagag aagttctaga gaaatgtatg
     1441 aggttgtctt accatcagca tatattagat atcgttcctc ccaccttctc agctctgtgt
     1501 cctgcaaacc caacctgcat ttacaagtat ggagacgaaa gtagcaattc tcttcctgga
     1561 cattccgtgg cactctgttt atctgttgct tttaaaagta aggcaaccaa cgatgaaatc
     1621 ttcagcattc tgaaggacgt accaaatcct aaccaggttg atgatgacga tgaagggttc
     1681 agatttaatc ccttgaaaat agaagtcttt gtccagactc tgctgcactt agctgccaag
     1741 tccttcagtc actccttcag tgctcttgca aagtttcatg aagtcttcaa aactctagca
     1801 gaaagtgata aggggaagct gcatgtgctg agagtcatgt ttgaagtctg gaggaatcac
     1861 ccgcagatga ttgctgtact ggttgataag atgattcgta cacagattgt tgactgtgct
     1921 gcagtagcaa actggatctt ctcatcagag ctgtctcgtg actttacgag gttgtttgtg
     1981 tgggaaattt tgcactctac aattcgtaag atgaataagc atgttctgaa gatccagaaa
     2041 gagctggaag aagctaaaga gaaactagca aggcagcaca aacgacgcag tgatgatgat
     2101 gaccggggca gcgacaggaa ggacggtgcc ctggaggagc aaatcgaaag gctgcaggag
     2161 aaagtggagt ctgctcagag cgagcaaaag aaccttttcc tcgtcatctt ccagcgtttc
     2221 atcatgatct tgactgaaca cttggtgcgc tgtgaaaccg atgggaccag tatattgacc
     2281 ccgtggtata agaactgcat cgagaggctg cagcagatct tcctacagca tcaccagata
     2341 atccagcagt acatggtgac cctggagaac ctgctcttca cggcagagtt agatcctcac
     2401 atcctggctg tgttccagca gttctgtgct ctgcaggcct aacagtcacg ttttcccctt
     2461 tttattatct tgaaataact tgtctgaatt ttgatggttt gaatgtttgc tttcctgtag
     2521 tagcctttca cttcctaaag gaaatggggg aggagtgtga ggaacatgag ctgaccgacc
     2581 tttagttgcc ctgaagggca agtgttactc gatgacagtg atgttatggt gactgtagag
     2641 ttgtacatat gggatagatt tgatactttt tctccttagt gcacagaaca agaggtttga
     2701 ggtgttcgaa atgcaaggtc aggcttgcaa aatagtagat acaaccgaca ggctatcccc
     2761 ggggagcgta gcttttctct gctcctggga aacatggctg gaataaactg cagttgtgtt
     2821 ttttaaaaaa aaaaaaaaaa aaaaaaaaaa
//
