LOCUS       NM_001399741            3248 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus non-SMC condensin II complex, subunit H2
            (Ncaph2), transcript variant 1, mRNA.
ACCESSION   NM_001399741 XM_006242187
VERSION     NM_001399741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3248)
  AUTHORS   Woodward,J., Taylor,G.C., Soares,D.C., Boyle,S., Sie,D., Read,D.,
            Chathoth,K., Vukovic,M., Tarrats,N., Jamieson,D., Campbell,K.J.,
            Blyth,K., Acosta,J.C., Ylstra,B., Arends,M.J., Kranc,K.R.,
            Jackson,A.P., Bickmore,W.A. and Wood,A.J.
  TITLE     Condensin II mutation causes T-cell lymphoma through
            tissue-specific genome instability
  JOURNAL   Genes Dev 30 (19), 2173-2186 (2016)
   PUBMED   27737961
REFERENCE   2  (bases 1 to 3248)
  AUTHORS   Martin,C.A., Murray,J.E., Carroll,P., Leitch,A., Mackenzie,K.J.,
            Halachev,M., Fetit,A.E., Keith,C., Bicknell,L.S., Fluteau,A.,
            Gautier,P., Hall,E.A., Joss,S., Soares,G., Silva,J., Bober,M.B.,
            Duker,A., Wise,C.A., Quigley,A.J., Phadke,S.R., Wood,A.J.,
            Vagnarelli,P. and Jackson,A.P.
  CONSRTM   Deciphering Developmental Disorders Study
  TITLE     Mutations in genes encoding condensin complex proteins cause
            microcephaly through decatenation failure at mitosis
  JOURNAL   Genes Dev 30 (19), 2158-2172 (2016)
   PUBMED   27737959
  REMARK    Erratum:[Genes Dev. 2017 May 1;31(9):953. doi:
            10.1101/gad.300871.117.. PMID: 28566537]
REFERENCE   3  (bases 1 to 3248)
  AUTHORS   Houlard,M., Godwin,J., Metson,J., Lee,J., Hirano,T. and Nasmyth,K.
  TITLE     Condensin confers the longitudinal rigidity of chromosomes
  JOURNAL   Nat Cell Biol 17 (6), 771-781 (2015)
   PUBMED   25961503
REFERENCE   4  (bases 1 to 3248)
  AUTHORS   Nishide,K. and Hirano,T.
  TITLE     Overlapping and non-overlapping functions of condensins I and II in
            neural stem cell divisions
  JOURNAL   PLoS Genet 10 (12), e1004847 (2014)
   PUBMED   25474630
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3248)
  AUTHORS   Lee,J., Ogushi,S., Saitou,M. and Hirano,T.
  TITLE     Condensins I and II are essential for construction of bivalent
            chromosomes in mouse oocytes
  JOURNAL   Mol Biol Cell 22 (18), 3465-3477 (2011)
   PUBMED   21795393
REFERENCE   6  (bases 1 to 3248)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3248)
  AUTHORS   Gosling,K.M., Makaroff,L.E., Theodoratos,A., Kim,Y.H., Whittle,B.,
            Rui,L., Wu,H., Hong,N.A., Kennedy,G.C., Fritz,J.A., Yates,A.L.,
            Goodnow,C.C. and Fahrer,A.M.
  TITLE     A mutation in a chromosome condensin II subunit, kleisin beta,
            specifically disrupts T cell development
  JOURNAL   Proc Natl Acad Sci U S A 104 (30), 12445-12450 (2007)
   PUBMED   17640884
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 13, 2022 this sequence version replaced XM_006242187.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.41696.1,
                                           SRR26643295.29824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000007.1  122302579-122302759
            182-283             JAXUCZ010000007.1  122307119-122307220
            284-339             JAXUCZ010000007.1  122309908-122309963
            340-424             JAXUCZ010000007.1  122310080-122310164
            425-493             JAXUCZ010000007.1  122310244-122310312
            494-573             JAXUCZ010000007.1  122310397-122310476
            574-719             JAXUCZ010000007.1  122310582-122310727
            720-803             JAXUCZ010000007.1  122311184-122311267
            804-901             JAXUCZ010000007.1  122311804-122311901
            902-973             JAXUCZ010000007.1  122315987-122316058
            974-1040            JAXUCZ010000007.1  122316262-122316328
            1041-1148           JAXUCZ010000007.1  122316476-122316583
            1149-1202           JAXUCZ010000007.1  122316691-122316744
            1203-1273           JAXUCZ010000007.1  122316863-122316933
            1274-1367           JAXUCZ010000007.1  122317019-122317112
            1368-1439           JAXUCZ010000007.1  122317204-122317275
            1440-1495           JAXUCZ010000007.1  122317355-122317410
            1496-1597           JAXUCZ010000007.1  122317545-122317646
            1598-1747           JAXUCZ010000007.1  122317853-122318002
            1748-3248           JAXUCZ010000007.1  122318070-122319570
FEATURES             Location/Qualifiers
     source          1..3248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3248
                     /gene="Ncaph2"
                     /note="non-SMC condensin II complex, subunit H2"
                     /db_xref="GeneID:300149"
                     /db_xref="RGD:1565937"
     exon            1..181
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1888
                     /gene="Ncaph2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     condensin-2 complex subunit H2"
                     /codon_start=1
                     /product="condensin-2 complex subunit H2 isoform 1"
                     /protein_id="NP_001386670.1"
                     /db_xref="GeneID:300149"
                     /db_xref="RGD:1565937"
                     /translation="MEDVEVRFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISF
                     DEGKTTMNFIEAALLIQGSACVYSKKVEYLYSLVYQALDFISGKRRAKQLSLVQEDGS
                     NRAVNSGTPCETEDEFLSLDDFPDSRANVDLKNDQASSELLIIPLLPMALVAPDEVEK
                     SSNPLYSCQGEVLASRKDFRMNTCTPDPRGSFMLDPVGMCPVEPVDVHPMPRSQKDAE
                     EAEEQPMAVSRNGSPVSVRSISQEPDGPALSSGDEDAEDVAELPEVALEPAEPRTSQQ
                     TAILPRRYMLRERQGAPEPASQPQETPDPWQSLDPFDSLDSKLFQKGKPYSVPPGVEE
                     APGQKRKRKGATKLQDFHQWYLDAYAEHPDGRRARRKGPSFADMEVLYWKHVKEQLET
                     LQKLRRRKMTERWLPGAKQDLWPAEEERLEEPLEDLGVADDFLEAEEYVEESEGVMPR
                     EAAGLDAEAIPESLKYEELVRRNVELFIATSQKFIQETELSQRIRDWEDTIQPLLQEQ
                     EQHVPFDIHTYGDQLVSRFPQLNEWCPFAELVAGQPAFEVCRSMLASLQLANDYTVEI
                     TQQPGLEAAVDTMSLRLLTHQRAHMRFQTYAAPSMAQP"
     exon            182..283
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..339
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..424
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..493
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..573
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..719
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..803
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..901
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..973
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1040
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1148
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1202
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1273
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1367
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1439
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1495
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1597
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1747
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..3248
                     /gene="Ncaph2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaacacca aaatggcgcc agaaccagta gcaggttgaa ccaagtttcc gggcctctag
       61 tccctttctg gacatggagg atgtggaggt gcgctttgct cacctcttgc agcccatccg
      121 agatctcact aagaactggg aggtggacgt ggcggctcag ctgggcgagt atctggagga
      181 gctggaccag atctgcattt cttttgatga aggtaaaacc acgatgaact tcattgaggc
      241 agcactgttg atccagggtt cagcctgtgt ctacagtaaa aaggtggaat acctctactc
      301 gctggtctac caggctctcg actttatctc aggcaagagg cgagccaagc agctttcttt
      361 agtgcaggaa gatgggagca accgggctgt caactcaggg actccctgtg aaacagagga
      421 tgagttcctg tcactggatg acttccccga ctcccgggct aacgtggatc tgaaaaatga
      481 ccaggcatcc agtgaactgc ttatcattcc ccttctgccc atggccctgg tggcccctga
      541 tgaagtggaa aagagcagca accccttgta cagctgtcag ggtgaggtct tggccagccg
      601 gaaggatttc aggatgaaca catgtacccc cgaccccaga ggttccttta tgttggatcc
      661 agtgggaatg tgtcctgtgg agcctgtaga cgtgcacccc atgccaagga gccagaaaga
      721 tgctgaggag gctgaggagc agccgatggc agtgtcgagg aacgggagtc ctgtgtctgt
      781 gcgcagcatc tcccaagagc cagatggccc agcgctcagc agtggagatg aggacgcaga
      841 ggatgtagca gagctcccgg aggttgctct agagcctgca gagcccagga cctcacagca
      901 gactgccatc ttgccaagga gatacatgct tcgggaacgg caaggggccc cggaacctgc
      961 ctcccagccg caggagaccc cagacccctg gcaaagcctg gacccttttg actccttgga
     1021 ctctaagctc ttccagaaag gtaaacccta ttctgtgcca cccggtgtgg aggaggctcc
     1081 aggacagaag cgcaaaagga agggtgccac caagttgcag gacttccacc agtggtacct
     1141 ggatgcctat gctgaacacc ctgacggcag gagggctcgg cggaagggcc caagctttgc
     1201 agacatggaa gtcctgtatt ggaaacacgt aaaagaacag ctcgagaccc ttcagaagct
     1261 gcggagacgt aagatgaccg agagatggct acctggggcc aagcaggacc tgtggcctgc
     1321 agaggaggaa cgcttggaag agcccctaga agacctaggg gtagcagatg actttctaga
     1381 ggccgaagag tacgtagaag agtctgaggg ggtgatgcct agggaagctg ctggcctaga
     1441 tgcagaggcc ataccagagt ccctgaaata cgaggagctg gtccgaagga atgtggaact
     1501 cttcattgcc acctcccaga agtttattca ggagacggag ctgagccagc gcatcaggga
     1561 ctgggaagat accatccagc ccctgctcca ggagcaggag cagcatgtgc cctttgatat
     1621 ccacacctac ggggaccagt tggtttcacg gttcccccag ctcaatgaat ggtgcccctt
     1681 tgcagagctt gtggctgggc agcctgcttt tgaggtgtgc cgctccatgc tggcttcctt
     1741 gcaactggcc aatgactata cggtggagat cacccagcag ccaggcctgg aggcagctgt
     1801 agacacgatg tctctgagac tgctcacaca tcagcgagcc cacatgcgct tccagaccta
     1861 tgctgcccca tctatggccc agccttgagt ggacagtgtt taagcagggg tagaaggtag
     1921 tatatacctg gaagtctttg cccgttatgt gctatagggc cattcactcc agtgctgcct
     1981 cctggctggc ctagcctaat aaagcgttgc taccccacct gttcactcaa caaaccattt
     2041 aaatgggctg ctggtacaga gcatacacac agattaagta catccattta atgacagggc
     2101 ctaggcagta cacagttcag ggcagtatgc tatggaaggc agctatgtgc cggcgtacac
     2161 tctctacaat ctgctctgct gacctgctac gaccatagta atcagtgaag agaccatctg
     2221 ggttgagcaa gtagatggca atggaatggt ccacaatata gtcctggtcc tcgtccttgg
     2281 gaccagcgct gtagtataca cggtagttgc gactagcatg ggccacttgt tctgtagaac
     2341 cagtcagacc cagcagcctt gggtggaatt cttgcacata tcgggccatg gctgccacgt
     2401 catctcgttc tgggtccaca gtgacgaaga caggctgcac caggggcagc tcaggctctg
     2461 cctcgagctt ctgcactacc tgcaccagct tttccagctc atcggggcaa atatcagggc
     2521 agtgagtaaa accaaagtac atcagcaccc actggcctcg gaagtcggct ttgcatcgag
     2581 gctggccttt gtggtccagt aggctgaagt caccctggcc cacagcagcc tggcgcaggg
     2641 cctctgtccg ctgttgttgg cgccactgtt ccttctcagc tctagcggcc agccaggccc
     2701 agcctagccc agccccaaac agggcagtga tcaacagtct agtccttagc ccagggcctt
     2761 ggtgttggcc ttggccttgc cccgaccaat gccgggaatt tatgtgcaga gtttcacccc
     2821 ttgagatcct gagaaggggt ttgaactgag agagcttggg ccaagctttg ggccctagag
     2881 ccagtagcat catggacctg aagctcctga aaaaagaaca gaggtggcag aagtcagaaa
     2941 agaacggaca aggtgcctag gcctccactg ctggagaaac atctccacat tcaaccaggt
     3001 tagagagctc cctgcactgg ctcgcctgaa ctcagaactg ccctgccttc agctgcactt
     3061 caggcagcac caaatatcca tagctggttt gctctaactt agttctttaa ccagggactc
     3121 tcagcctcat tacccaccct atggagaacc cacaccacaa ctgccagact tccctgtggg
     3181 tgcctggaag cacggagagt atgagtgcat gtctctattt acaataaatt gattttttta
     3241 aaaaggga
//
