LOCUS       NP_981954                837 aa            linear   ROD 01-APR-2024
DEFINITION  neural cell adhesion molecule 2 precursor [Rattus norvegicus].
ACCESSION   NP_981954 XP_221679
VERSION     NP_981954.2
DBSOURCE    REFSEQ: accession NM_203409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 837)
  AUTHORS   Kulahin,N., Kristensen,O., Rasmussen,K.K., Olsen,L., Rydberg,P.,
            Vestergaard,B., Kastrup,J.S., Berezin,V., Bock,E., Walmod,P.S. and
            Gajhede,M.
  TITLE     Structural model and trans-interaction of the entire ectodomain of
            the olfactory cell adhesion molecule
  JOURNAL   Structure 19 (2), 203-211 (2011)
   PUBMED   21300289
REFERENCE   2  (residues 1 to 837)
  AUTHORS   Yoshihara,S., Omichi,K., Yanazawa,M., Kitamura,K. and Yoshihara,Y.
  TITLE     Arx homeobox gene is essential for development of mouse olfactory
            system
  JOURNAL   Development 132 (4), 751-762 (2005)
   PUBMED   15677725
REFERENCE   3  (residues 1 to 837)
  AUTHORS   Hamlin,J.A., Fang,H. and Schwob,J.E.
  TITLE     Differential expression of the mammalian homologue of fasciclin II
            during olfactory development in vivo and in vitro
  JOURNAL   J Comp Neurol 474 (3), 438-452 (2004)
   PUBMED   15174086
  REMARK    GeneRIF: Fasciclin II is detectable early in the development of the
            rat olfactory epithelium. mRNA is evident on RT-PCR and in situ
            hybridization by embryonic day E12.5, and protein is apparent by
            immunohistochemistry by E13.5.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 25, 2020 this sequence version replaced NP_981954.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.65894.1,
                                           SRR26360194.1436891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     Protein         1..837
                     /product="neural cell adhesion molecule 2 precursor"
                     /note="fasciclin II"
                     /calculated_mol_wt=91095
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2012
     Region          21..113
                     /region_name="IgI_1_NCAM-2"
                     /note="First immunoglobulin (Ig)-like domain of neural
                     cell adhesion molecule NCAM-2; member of the I-set of Ig
                     superfamily (IgSF) domains; cd05866"
                     /db_xref="CDD:409452"
     Region          21..26
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409452"
     Region          29..33
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409452"
     Region          35..45
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409452"
     Site            order(36,38..39)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:409452"
     Region          49..55
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409452"
     Region          58..60
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409452"
     Region          66..72
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409452"
     Region          74..82
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409452"
     Region          89..96
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409452"
     Region          101..112
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409452"
     Region          117..193
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          132..136
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..152
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          169..173
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          183..187
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          191..194
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          209..298
                     /region_name="IgI_1_MuSK"
                     /note="agrin-responsive first immunoglobulin-like domains
                     (Ig1) of the MuSK ectodomain; a member of the I-set of
                     IgSF domains; cd20970"
                     /db_xref="CDD:409562"
     Region          209..212
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409562"
     Region          217..222
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409562"
     Region          228..235
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409562"
     Region          241..246
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409562"
     Region          248..250
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409562"
     Region          257..260
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409562"
     Region          264..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409562"
     Region          277..284
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409562"
     Region          290..298
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409562"
     Region          300..397
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          318..322
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          331..335
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          363..367
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          377..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          390..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          401..479
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          496..588
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(496,561,576)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(577..578,580..581)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          594..678
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(594,658,673)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(674..675,677..678)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..837
                     /gene="Ncam2"
                     /gene_synonym="Ocam; OCAM-GPI"
                     /coded_by="NM_203409.2:178..2691"
                     /db_xref="GeneID:288280"
                     /db_xref="RGD:1303131"
ORIGIN      
        1 mslllsfyll gllvssgqal lqvtislskv elsvgeskff tctaigepes idwynpqgek
       61 iistqrvmlq kegvrsrlti ynaniedagi yrcqatdakg qtqeatvvle iyqkltfrev
      121 lspqefkqge daevvcrvss spapavswly hneevttipd nrfavlannn lqilninksd
      181 egiyrcegrv eargeidfrd iivivnvppa ivmpqksfna taergeemtl tckasgspdp
      241 aiswfrngkl ieenekyilk gsnteltvrn iinkdggsyv ckatnkaged qkqaflqvfv
      301 qphilqlkne ttsenghvtl iceaegepvp eitwkraidg vtfsegdksp dgrievkgqh
      361 grsslhirdv klsdsgrydc eaasrigghq rsmhldieya pkfvsnqtmy yswegnpini
      421 scdvkanppa sihwrreklv lpakntthlk thsvgrkmil eiaptsdndf grynctatnr
      481 igtrfqeyil eladvpsspr gvkiielsqt takisfnkpe shggvpihhy qvdvkevtse
      541 twkivrshgv qttvvlssle pnttyevrva avngkgqgdy skieifqtlp vrepsppsih
      601 gqpssgksfk isitkqddgg apileyivky rskdkedqwl ekkvqgnkdh iilehlqwtm
      661 gyevqitaan rlgyseptvy efsmppkpni ikdtlfnglg lgaiiglgva alllilvvtd
      721 vscffirqcg llmcitrrmc gkksgssgks keleegkaay lkdgskepiv emrtederit
      781 nhedgspvne pnettpltep eklplkeeng kevlnaetie ikvsndiiqs keddika
//
