LOCUS       NM_001395707            6876 bp    mRNA    linear   ROD 23-JAN-2024
DEFINITION  Rattus norvegicus neural cell adhesion molecule 1 (Ncam1),
            transcript variant 1, mRNA.
ACCESSION   NM_001395707 XM_006242988
VERSION     NM_001395707.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6876)
  AUTHORS   Markosyan,V., Safiullov,Z., Izmailov,A., Fadeev,F., Sokolov,M.,
            Kuznetsov,M., Trofimov,D., Kim,E., Kundakchyan,G., Gibadullin,A.,
            Salafutdinov,I., Nurullin,L., Bashirov,F. and Islamov,R.
  TITLE     Preventive Triple Gene Therapy Reduces the Negative Consequences of
            Ischemia-Induced Brain Injury after Modelling Stroke in a Rat
  JOURNAL   Int J Mol Sci 21 (18), 6858 (2020)
   PUBMED   32962079
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6876)
  AUTHORS   Cheng,B.F., Lian,J.J., Yang,H.J., Wang,L., Yu,H.H., Bi,J.J.,
            Gao,Y.X., Chen,S.J., Wang,M. and Feng,Z.W.
  TITLE     Neural cell adhesion molecule regulates chondrocyte hypertrophy in
            chondrogenic differentiation and experimental osteoarthritis
  JOURNAL   Stem Cells Transl Med 9 (2), 273-283 (2020)
   PUBMED   31742919
REFERENCE   3  (bases 1 to 6876)
  AUTHORS   Voronkov,D.N., Stavrovskaya,A.V., Stelmashook,E.V., Genrikhs,E.E.
            and Isaev,N.K.
  TITLE     Neurodegenerative Changes in Rat Brain in Streptozotocin Model of
            Alzheimer's Disease
  JOURNAL   Bull Exp Biol Med 166 (6), 793-796 (2019)
   PUBMED   31028587
REFERENCE   4  (bases 1 to 6876)
  AUTHORS   Kim,P., Scott,M.R. and Meador-Woodruff,J.H.
  TITLE     Abnormal ER quality control of neural GPI-anchored proteins via
            dysfunction in ER export processing in the frontal cortex of
            elderly subjects with schizophrenia
  JOURNAL   Transl Psychiatry 9 (1), 6 (2019)
   PUBMED   30664618
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6876)
  AUTHORS   Serra,M.P., Poddighe,L., Boi,M., Sanna,F., Piludu,M.A., Sanna,F.,
            Corda,M.G., Giorgi,O. and Quartu,M.
  TITLE     Effect of Acute Stress on the Expression of BDNF, trkB, and
            PSA-NCAM in the Hippocampus of the Roman Rats: A Genetic Model of
            Vulnerability/Resistance to Stress-Induced Depression
  JOURNAL   Int J Mol Sci 19 (12), 3745 (2018)
   PUBMED   30477252
  REMARK    GeneRIF: A rat genetic model of vulnerability/resistance to
            stress-induced depression showed differential pattern of expression
            of BDNF, trkB, and PSA-NCAM in the hippocampus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6876)
  AUTHORS   Reyes,A.A., Small,S.J. and Akeson,R.
  TITLE     At least 27 alternatively spliced forms of the neural cell adhesion
            molecule mRNA are expressed during rat heart development
  JOURNAL   Mol Cell Biol 11 (3), 1654-1661 (1991)
   PUBMED   1996115
REFERENCE   7  (bases 1 to 6876)
  AUTHORS   Small,S.J. and Akeson,R.
  TITLE     Expression of the unique NCAM VASE exon is independently regulated
            in distinct tissues during development
  JOURNAL   J Cell Biol 111 (5 Pt 1), 2089-2096 (1990)
   PUBMED   1699951
REFERENCE   8  (bases 1 to 6876)
  AUTHORS   Chen,A.S., Reyes,A. and Akeson,R.
  TITLE     Transcription initiation sites and structural organization of the
            extreme 5' region of the rat neural cell adhesion molecule gene
  JOURNAL   Mol Cell Biol 10 (7), 3314-3324 (1990)
   PUBMED   1694009
REFERENCE   9  (bases 1 to 6876)
  AUTHORS   DiFiglia,M., Marshall,P., Covault,J. and Yamamoto,M.
  TITLE     Ultrastructural localization of molecular subtypes of
            immunoreactive neural cell adhesion molecule (NCAM) in the adult
            rodent striatum
  JOURNAL   J Neurosci 9 (12), 4158-4168 (1989)
   PUBMED   2592994
REFERENCE   10 (bases 1 to 6876)
  AUTHORS   Small,S.J., Haines,S.L. and Akeson,R.A.
  TITLE     Polypeptide variation in an N-CAM extracellular immunoglobulin-like
            fold is developmentally regulated through alternative splicing
  JOURNAL   Neuron 1 (10), 1007-1017 (1988)
   PUBMED   2483093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000198.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001395707.2.
            
            On Aug 2, 2021 this sequence version replaced XM_006242988.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840115
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               JACYVU010000198.1  11978588-11978847   c
            261-335             JACYVU010000198.1  11744957-11745031   c
            336-554             JACYVU010000198.1  11743130-11743348   c
            555-698             JACYVU010000198.1  11742118-11742261   c
            699-836             JACYVU010000198.1  11741436-11741573   c
            837-954             JACYVU010000198.1  11740245-11740362   c
            955-1127            JACYVU010000198.1  11739689-11739861   c
            1128-1270           JACYVU010000198.1  11733317-11733459   c
            1271-1300           JACYVU010000198.1  11727393-11727422   c
            1301-1451           JACYVU010000198.1  11722936-11723086   c
            1452-1636           JACYVU010000198.1  11722328-11722512   c
            1637-1733           JACYVU010000198.1  11721882-11721978   c
            1734-1904           JACYVU010000198.1  11721389-11721559   c
            1905-2036           JACYVU010000198.1  11719741-11719872   c
            2037-2161           JACYVU010000198.1  11699857-11699981   c
            2162-2342           JACYVU010000198.1  11696578-11696758   c
            2343-2550           JACYVU010000198.1  11686381-11686588   c
            2551-2667           JACYVU010000198.1  11685328-11685444   c
            2668-3480           JACYVU010000198.1  11683548-11684360   c
            3481-6876           JACYVU010000198.1  11678940-11682335   c
FEATURES             Location/Qualifiers
     source          1..6876
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..6876
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /note="neural cell adhesion molecule 1"
                     /db_xref="GeneID:24586"
                     /db_xref="RGD:67378"
     exon            1..260
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..3601
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="neural cell adhesion molecule 1 isoform 1
                     precursor"
                     /protein_id="NP_001382636.1"
                     /db_xref="GeneID:24586"
                     /db_xref="RGD:67378"
                     /translation="MLRTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVA
                     GDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVVTAED
                     GTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVIL
                     KKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQ
                     SIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIR
                     NVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASG
                     DPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAG
                     EYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF
                     RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA
                     DTPSSPSIDRVEPYSSTAQVQFDEPEATGGVPILKYKAEWKSLGEEAWHSKWYDAKEA
                     NMEGIVTIMGLKPETRYAVRLAALNGKGLGEISAATEFKTQPVREPSAPKLEGQMGED
                     GNSIKVNLIKQDDGGSPIRHYLVKYRAKLASEWKPEIRLPSGSDHVMLKSLDWNAEYE
                     VYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVM
                     DITCYFLNKCGLLMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEER
                     TPNHDGGKHTEPNETTPLTEPELPADTTATVEDMLPSVTTVTTNSDTITETFATAQNS
                     PTSETTTLTSSIAPPATTVPESNSVPAGQATPSKGVTASSSSPPASVPKVAPLVDLSD
                     TPTSAPSANNLSSTVLANQGAVLSPSTPASAGETSKVPATSKPSPTPTPTPAGAASPL
                     AAVAAPATEAPQAKQEAPSTKGLDPEPTQPGTVKNPTEAATAPASPKSKAPSVSTTNP
                     SQGEDLKMDEGNFKTPDIDLAKDVFAALGSPAPATGASGQASELAPSTADSAVPPAPA
                     KTEKGPVETKSEPQESEAKPAPTEVKTVPNEATQTKENESKA"
     exon            261..335
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            336..554
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            555..698
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            699..836
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            837..954
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1127
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1270
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1300
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1451
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1636
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1733
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1904
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2036
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2161
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2342
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2550
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2667
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..3480
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..6876
                     /gene="Ncam1"
                     /gene_synonym="Cd56; N-CAM; N-CAM-1; Ncam; NCAM-1; NCAM-C;
                     NCAMC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggctggg gctgtcactc attctccgct cagcgcgtga acgcagctcg gcagtggctg
       61 gcaagaaaca attctgcaaa aataatcata cccagcctgg caattgtctg ctcctcggtc
      121 cattgctccg ccgccgtcca cagtcgcttg caagggaagg cactgaattt accgcggcca
      181 gaacatccct cccagccggc agtttacaat gctgcgaact aaggatctca tctggacttt
      241 gtttttcctg ggaactgcag tttccctgca ggtagatatt gttcccagcc aaggagaaat
      301 cagcgttgga gagtccaaat tcttcctgtg tcaagtggca ggagatgcca aagataagga
      361 catctcctgg ttctccccca acggggagaa actgagccca aaccagcagc ggatctcagt
      421 ggtgtggaac gatgatgact cctctaccct caccatctac aacgccaaca ttgatgatgc
      481 cggcatttac aagtgcgtgg tcaccgctga agacggcacc cagtccgagg ccactgtcaa
      541 tgtgaagatc ttccagaagc tcatgttcaa gaatgcgcca accccacagg agtttaagga
      601 aggggaagat gctgtgattg tctgtgatgt ggtcagctct ctgcccccaa ccatcatctg
      661 gaaacacaaa ggccgagatg tcatcctgaa aaaagatgtc cggttcatag tcctatccaa
      721 caactacctg cagatccgag gcatcaagaa aacagatgag ggcacttacc gctgtgaagg
      781 caggatcctg gcccgggggg agatcaactt caaggacatt caggtcattg tgaatgtacc
      841 acccactgtc caggccagac agagcatcgt gaatgccact gccaacctgg gccagtctgt
      901 caccctggtg tgtgatgccg atggcttccc agagcccacc atgagctgga caaaggatgg
      961 ggaacccata gagaatgagg aggaagatga cgagaagcac atcttcagtg acgacagttc
     1021 ggagctgacc atcaggaatg tggacaaaaa tgacgaagcc gaatacgtct gcatcgctga
     1081 gaacaaggct ggcgagcagg atgcctccat ccacctcaag gtcttcgcaa agcccaaaat
     1141 cacctatgta gagaatcaga cagccatgga actagaggag caagtcactc tgacatgtga
     1201 agcctccgga gaccccattc cttccatcac ctggagaacg tccacccgaa acatcagcag
     1261 tgaagaaaag gcatcgtgga ctcgaccaga gaagcaagag actctagatg ggcacatggt
     1321 ggtacgcagc catgctcgtg tgtcctccct gaccctgaag agcatccagt acacagatgc
     1381 tggagaatac atctgcactg ccagcaacac catcggccag gactcccagt ccatgtacct
     1441 tgaagttcaa tatgctccca agctccaggg ccctgtagct gtgtacactt gggaagggaa
     1501 ccaggtgaac atcacctgtg aggtctttgc ctacccaagt gccacaatct cctggttccg
     1561 agatggccag ttgctgccaa gctccaacta cagcaatatc aagatctaca acaccccatc
     1621 tgcgagctat ctggaggtaa cccctgattc cgaaaatgac tttggaaact acaactgcac
     1681 agcggtgaac cgtattggac aggagtcctt ggaattcatc ctggttcaag cagatacacc
     1741 atcttcccca tccatcgacc gggtggaacc atactccagc acagcacagg tacaatttga
     1801 tgagccagaa gccacaggtg gagttcccat cctcaaatac aaggctgagt ggaagtcgct
     1861 gggtgaagaa gcatggcatt ccaagtggta tgatgccaaa gaagccaaca tggaagggat
     1921 tgtcaccatc atgggcctga agcctgagac aaggtacgcg gtacgactgg cggccctcaa
     1981 cggcaagggg ctgggcgaga tcagtgcagc cactgagttc aagacacagc cagtccggga
     2041 acccagcgca cccaagctgg aagggcagat gggagaggac gggaactcca tcaaggtgaa
     2101 cctgatcaag caggatgacg gcggctcccc catcagacac tatctggtca agtacagagc
     2161 gaagctcgcc tccgagtgga aaccagagat caggctcccg tccggcagtg accacgtcat
     2221 gctcaagtcc ctagactgga acgccgagta cgaagtatat gtggtagctg agaaccagca
     2281 aggaaaatcc aaggcagctc acttcgtgtt caggacttca gcccagccca cggccatccc
     2341 agccaatggc agccccactg caggcctgag cacaggcgcc attgtgggca tcctcattgt
     2401 cattttcgtc ctactcctgg tggtcatgga catcacctgc tacttcctga acaagtgtgg
     2461 cctgctcatg tgcatcgctg ttaacctgtg cggcaaagcg gggcccggag ccaagggcaa
     2521 agacatggag gagggcaagg ctgctttctc gaaagatgag tctaaagaac ccattgtaga
     2581 ggtccgaacg gaggaggaac ggactccaaa ccatgacgga gggaagcaca cagagcccaa
     2641 cgagaccaca ccactgacag agcccgagct gcctgccgac accacagcca ctgtcgagga
     2701 catgctgcct tctgtcacca ccgtcaccac taactctgac actatcaccg aaacctttgc
     2761 cactgctcag aacagcccta ccagtgagac caccacactg acctccagta ttgccccacc
     2821 ggccacaact gtgccagagt caaattctgt gcccgctggt caggccaccc cttccaaggg
     2881 tgtcactgct tcatcctcct cgcccccagc ctcagtccca aaagttgccc ctcttgttga
     2941 cctgagtgat accccaacct cagctccctc tgctaacaat ctgtcctcca ctgtcctggc
     3001 taaccaagga gctgtactca gtcctagcac acctgccagt gcgggagaga cctccaaggt
     3061 ccctgcaacc agtaagccct cccccactcc cacccccact ccagccgggg cagccagccc
     3121 cttagcagca gtagccgccc ctgccacaga agccccccag gccaagcagg aagcccccag
     3181 caccaaaggt ctggacccag agcccaccca gcctggcacc gtgaagaacc caactgaggc
     3241 agccacagcc cctgctagcc cgaagagcaa ggctccctcc gtcagcacca caaacccttc
     3301 ccagggcgag gacttaaaaa tggacgaagg gaacttcaag accccagata ttgaccttgc
     3361 aaaggatgtt tttgcagccc tgggctctcc tgctcccgcc actggggcca gtggacaagc
     3421 ctctgagctt gctccttcca ctgcagacag cgctgtgcct cccgcaccag caaagaccga
     3481 gaagggtcct gtagaaacaa agtccgagcc ccaggagtca gaagcaaagc cagcgccaac
     3541 tgaagtcaag acggtcccca atgaagccac acaaacgaaa gagaatgaga gcaaagcatg
     3601 atgggtacca gcaaaaagca aagatcaaaa taacaaattg acacagcggc ttcaccagag
     3661 catccccaaa taaccccccc cctctctctc tctctctctc tcacacacac acacacacac
     3721 acacacacac acacacacac acacactcac tcctctagtg tcttttgcct tttaaaaaaa
     3781 caacaaaaaa cagataaaca tgggattgcc tttttgtagg tttctagaaa gggctccttt
     3841 gttgcacact cacttgttaa gaaaaaaaaa gagacaaaaa ggttaaaccc acagccaaac
     3901 taggacactc cgttccctga aaccatttaa aaatcaaaca aaagggcccc aaattaagaa
     3961 tctaggaagc tcagactgaa gagaaaaaca agaaaaagaa aaagaaagaa aaaaaatcta
     4021 ggcttgctcg ggaaggctgc aattgatgtt accggattgg cacagatcag tttcagaaaa
     4081 atgcttccaa gatcttagac taaccgagtg aaccaagtcc acagtttatt tttatacttt
     4141 cagtcaagtt gggactctgt agacctcaca aataagttat actttccgtt cactttgtat
     4201 ttgttccgta tgcaaagtgt ggcactctag ctagctgcgt tcagttccca tgtagactcc
     4261 tgtttcttag gaagaatgcc aaaatcgcag cttattcgat ctctctctct cgcttttggt
     4321 ttctcctcca ctgtttcttt ccctttcttc ctcttttcca agtttgcttt ccagtgttta
     4381 caagttgaca gacgtttgac cttggttgtg tttaatgtcc gtgtaaaata gctgcccccc
     4441 cccacccttg tttttttctt taagcaacag gtaccccata gaggcaggta gaaccctccc
     4501 aggttgtttt cagtgtgggt gaaggttaca aaggatgatt gtttacagtg gctctatccc
     4561 ccgtccccca gccatccccc acccgacccc tgctgattct gattcaatgc agtttttacc
     4621 tgtatcaaac tgggatgaaa gcctctcctt ctgaactgat tttgccttcc cctcccccac
     4681 ccccgtttat ttctgttgct gtttcttggg gggggggggg gggggatggg ggatgttaga
     4741 ccactttcag attagctgcc acctgcctgt gtctgtgaca ctggacctgc ctcccaggtg
     4801 tctgcacacc cttcctctga aggactcctt tggctttgtt gaatgaagca gagaagattg
     4861 tatagttggg gctggtcttg gtgaacacac tttttttttc ttttttcttt tctttttcta
     4921 ccccaggcac cccctttttg tagaaagcca aataaaatat atacatacca tttcctttag
     4981 agcccagaat ctagatttga gcggaagagc gcgtgtgctt cagggaagta gtgtctcctt
     5041 ttggaaatct attgaagtaa agtgacatcg gccttctgtt cagttaggca acatttgtaa
     5101 aaaacaaaaa caaaaacaaa acaaaataaa taccgtctgg agttaaaata cagctctcct
     5161 ggatcggaaa ccaagtgggg ggggggggga aatacagaaa ctttcagggg gatgggaggg
     5221 gggggagaag ggaaaagcca gctctttgta tagaagtttt gcttttgttt ttcattctgc
     5281 tttagaaccg caagcttgtg cactgtggat gcgtgaatat tttagtgtga aacgtgtttt
     5341 tgtcatagta ttgaaataaa acttcaacat agtttggttg tggaaggtat agcagatagt
     5401 tcagaaaaaa ataaaaaaaa aacaaacaaa caactattca ggaaacaaaa caaacaaatc
     5461 ccaaaaggaa accggaatca aagcctttca ataggcaata aaacacagtg atgctgatga
     5521 agaggccacc aagccaactg atgtccccca agacagagtg ttcctttccc aaactttccc
     5581 aaaaagtgac aagaggtttg gatggccaga cgtccccgtg ttcactctgt gggccacaca
     5641 ccccagtgtt ctgacacttc tgcagtgtga ccagtggtga tactagatta taatttcaaa
     5701 ctgtgaaaaa taatggtctt gtcatttgct cagtgtgggg ttattttgca ttttctcagc
     5761 tcccggggat ggaaatggag gatcccagaa cactcagcag ggcacctttc attccagggc
     5821 ccacacagat ccacagtcca catgcactgg tcttcaggaa gagctgacag gtagacaact
     5881 ctgagggcac atagcagaat gggagcggtg gctagcacct gagccaggtc ctcgtggtgt
     5941 gggcagactc cccaggccac agcctgtcct gggaaatctc tttcccatat tatgaagtcg
     6001 gtggcttgac ccactaggcc aagggcacac tgtacctcct ggaaatggtg tatttcactc
     6061 tgtggttgga catactgagc tcaacactga cgataggaaa agacagaggt atggccaacc
     6121 ccaaaattac gtggcccaga gtagctgact cccagaacac tggccctacc atttgctgga
     6181 atccaagact gcccacactt tgatatgcct ctctccttgt tcatatgttt gtctcgggca
     6241 tgcatgggtt ttcctttctt ccttttcctt cttctttttt tcatagcagt attctctcta
     6301 aaaatcaaag agggagacag tatatttccc acctgttctt tatgtgaaga aataagcact
     6361 tagttttctg ttgggttttt gttgtcgttt tttgttttct gtttttgttt tgtttgtttg
     6421 ttttagtttt tggaaggagg gacggactcc accaatgtca gggtcggcgt gtcctgtcta
     6481 tgtggcatac attttatcac ataaagacca gcatggccaa gttctgtggg aaggctaccc
     6541 aggtgccatg agtggggtct cccactcctg aagggccaag gtgtatccaa caggattcta
     6601 tgttctcatt ttctatggaa cctcccacat cccagggtct caccctcagc tgtccgtctg
     6661 gatggtggtg atctcacctc cattaacatt cttacgcagc attctgtact tcgggggcct
     6721 tctctcttgt tataaaactt tttactgagt gaaacatcaa caccaccttt gtttccattc
     6781 ccactgctgt aaatactgag tactaactga gaattttgac tttgcattct gtcagaatac
     6841 ttgtgttcaa taaaaattga aagaaaaaaa aagcaa
//
