LOCUS       NM_001024765            4352 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus NBR1, autophagy cargo receptor (Nbr1), mRNA.
ACCESSION   NM_001024765 XM_220926
VERSION     NM_001024765.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4352)
  AUTHORS   Chan,N.C., Salazar,A.M., Pham,A.H., Sweredoski,M.J., Kolawa,N.J.,
            Graham,R.L., Hess,S. and Chan,D.C.
  TITLE     Broad activation of the ubiquitin-proteasome system by Parkin is
            critical for mitophagy
  JOURNAL   Hum Mol Genet 20 (9), 1726-1737 (2011)
   PUBMED   21296869
REFERENCE   2  (bases 1 to 4352)
  AUTHORS   Itakura,E. and Mizushima,N.
  TITLE     p62 Targeting to the autophagosome formation site requires
            self-oligomerization but not LC3 binding
  JOURNAL   J Cell Biol 192 (1), 17-27 (2011)
   PUBMED   21220506
REFERENCE   3  (bases 1 to 4352)
  AUTHORS   Whitehouse,C.A., Waters,S., Marchbank,K., Horner,A., McGowan,N.W.,
            Jovanovic,J.V., Xavier,G.M., Kashima,T.G., Cobourne,M.T.,
            Richards,G.O., Sharpe,P.T., Skerry,T.M., Grigoriadis,A.E. and
            Solomon,E.
  TITLE     Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of
            postnatal osteoblastic bone formation and p38 MAPK activity
  JOURNAL   Proc Natl Acad Sci U S A 107 (29), 12913-12918 (2010)
   PUBMED   20616007
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4428]
REFERENCE   4  (bases 1 to 4352)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 4352)
  AUTHORS   Waters,S., Marchbank,K., Solomon,E., Whitehouse,C. and Gautel,M.
  TITLE     Interactions with LC3 and polyubiquitin chains link nbr1 to
            autophagic protein turnover
  JOURNAL   FEBS Lett 583 (12), 1846-1852 (2009)
   PUBMED   19427866
REFERENCE   6  (bases 1 to 4352)
  AUTHORS   Kirkin,V., Lamark,T., Sou,Y.S., Bjorkoy,G., Nunn,J.L., Bruun,J.A.,
            Shvets,E., McEwan,D.G., Clausen,T.H., Wild,P., Bilusic,I.,
            Theurillat,J.P., Overvatn,A., Ishii,T., Elazar,Z., Komatsu,M.,
            Dikic,I. and Johansen,T.
  TITLE     A role for NBR1 in autophagosomal degradation of ubiquitinated
            substrates
  JOURNAL   Mol Cell 33 (4), 505-516 (2009)
   PUBMED   19250911
REFERENCE   7  (bases 1 to 4352)
  AUTHORS   Lange,S., Xiang,F., Yakovenko,A., Vihola,A., Hackman,P.,
            Rostkova,E., Kristensen,J., Brandmeier,B., Franzen,G., Hedberg,B.,
            Gunnarsson,L.G., Hughes,S.M., Marchand,S., Sejersen,T., Richard,I.,
            Edstrom,L., Ehler,E., Udd,B. and Gautel,M.
  TITLE     The kinase domain of titin controls muscle gene expression and
            protein turnover
  JOURNAL   Science 308 (5728), 1599-1603 (2005)
   PUBMED   15802564
REFERENCE   8  (bases 1 to 4352)
  AUTHORS   Dimitrov,S., Brennerova,M. and Forejt,J.
  TITLE     Expression profiles and intergenic structure of head-to-head
            oriented Brca1 and Nbr1 genes
  JOURNAL   Gene 262 (1-2), 89-98 (2001)
   PUBMED   11179671
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC095903.1.
            
            On Jun 10, 2005 this sequence version replaced XM_220926.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..4352
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /note="NBR1, autophagy cargo receptor"
                     /db_xref="GeneID:303554"
                     /db_xref="RGD:69195"
     exon            1..92
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            93..159
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            160..276
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3126
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /note="neighbor of BRCA1 gene 1 protein; next to the
                     Brca1; ovarian carcinoma antigen CA125"
                     /codon_start=1
                     /product="next to BRCA1 gene 1 protein"
                     /protein_id="NP_001019936.1"
                     /db_xref="GeneID:303554"
                     /db_xref="RGD:69195"
                     /translation="MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTI
                     QIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGCHVVDEVLPQTVVEKQ
                     ATARTGKKPLAHYSSLVRVLGSDMKTTEEPTAEARSPVPCDTDKPQDKPPDWFTSYLE
                     MFREQVVKETVEKLEQRLQEKLVLQKPPFSSSPSEVSMPISEEETLFLPENQFSWHIA
                     CSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYSHDTNHILLKFRRPVVISSEPFFYSK
                     YPTPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLW
                     NSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGT
                     KFIKHWRMKNTGNVKWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHIGVVSVEFIA
                     PTLEGTYTLHWRLSHKGQQFGPRVWCSIIVDPFPSSESPVNLERDGISSSKADDFTCE
                     QEEAFLLAEEEIPLGEVTKQTEGTGSSAPQKTQHAASERELYIPSVDLLTAQDLLSFE
                     LLDINIVQELERVPHNTPVDVTPRMSPLPHDSPLIEKPGLGRIQEESEGAGLKASPDS
                     TVLTKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQL
                     YSTEEQQPLMLPGFCRKDSSLKFALPEEGPHGDEREEIVHIAEEEAIEEEDVQDEEVQ
                     SQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGQEPAEAR
                     ERLPERESQPKEQSISDILTTSQHLDTVPLVPEVAGLPAALSRSAPCGQYEAPRVDSP
                     VTIQEVLPVPDHVRGEPRGSTGLANSRQKSCDHSRHHNGSSIAGGLVKGALSVAASAY
                     KALFSGPPVTAQPVISEDQTAALMAHLFEMGFCDRQLNLRLLRKHNHNILQVVTELLQ
                     VNNNDWYSHRY"
     exon            277..339
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            340..358
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            359..381
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            382..579
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            580..657
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            658..875
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1043
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1253
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1413
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1704
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1854
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1930
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2041
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2206
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2281
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2696
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2788
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2846
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2952
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..4328
                     /gene="Nbr1"
                     /gene_synonym="Ca125; RGD1311421"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttagattca ccccgcaggg atagcagccg agctggccgc gaacgattct tgcactggcc
       61 actggcaagc gccccccgtg ggcggaaagc tggctgacct agaactcttg gactcctgct
      121 accatcctgc tgcaacttcc tgagtaactg ggactacagc tccagcccga cagcatggaa
      181 ccacaggtta ctctaaatgt gacttttaaa aatgaaactc aaagctttct ggtttcggat
      241 ccagaaaata caacttgggc tgatgttgaa gctatggtaa aagtttcatt tgatctgaat
      301 actatccaaa taaaatacct ggatgaggaa aatgaggaga tatccatcaa tagtcaagga
      361 gaatatgaag aagcacttaa gatggctaac attaagcaag gaaatcaact acagatgcaa
      421 gtccacgaag ggtgccatgt tgtagatgaa gtgctccccc aaactgtagt agaaaaacaa
      481 gcaactgcca ggacagggaa gaagccactc gcacattact cttcgctggt aagagtcttg
      541 ggatcagata tgaagaccac agaggagcct acagcagagg cacgttcacc tgttccttgt
      601 gacaccgaca agcctcaaga caagccccca gactggttta caagctacct ggagatgttc
      661 agagaacaag tggtgaagga aacggtggag aagcttgaac agaggttgca ggagaagctt
      721 gtcctccaga agccaccctt cagttcctca ccctcagaag tctcaatgcc tatttcagag
      781 gaggaaaccc tgtttttgcc agagaaccag ttcagctggc atattgcttg tagccactgc
      841 caaaagagga tcgtcggtgt gcgctaccag tgtagcctct gcccatccta caacatttgt
      901 gaagattgtg aagctggacc ttactcccat gacactaacc acattttgct aaaatttcgg
      961 agacctgttg tgatttcctc tgagccattt ttctactcaa agtatcccac tcctcgtctg
     1021 cctgctgctt tggaacaagt caggctccaa aagcaggtgg ataagaattt tgtgaaagca
     1081 gaaaagcaaa ggttgcgggc tgagaagaaa cagcggaagg cagaggtcaa agagcttaaa
     1141 aagcagctga aactccaccg gaagattcat ttgtggaatt caatccatgg actccagagt
     1201 cccaagtcgc ctttgggtcg acctgagagc ttgctgcagt ctaacaccct catgcttcct
     1261 ttgcagccct gtgccccagt tatgccaaca ctcagtgcag cattcgtgga tgagaatttg
     1321 cctgatggga ctcatcttca gccaggaacc aagtttatca aacactggag gatgaaaaac
     1381 acagggaatg tgaagtggag cgcagacaca aagctcaagt tcatgtgggg aaacttgact
     1441 ctggcttcta cagagaagaa ggatgttttg gttccctgct tgaaggctgg acacatcggg
     1501 gtggtgtctg tggagttcat cgccccaacc ttggagggga catacacttt gcattggcgt
     1561 ctctctcaca aaggccagca gtttgggcct cgggtctggt gcagtatcat agtggatcct
     1621 tttccttcct ctgagagccc tgttaacctt gaaagggatg ggattagctc aagcaaagct
     1681 gatgacttca cctgtgagca agaggaagct tttcttctag ctgaagaaga gattccattg
     1741 ggtgaggtga caaagcagac agaagggaca ggatccagtg ccccacagaa gacacaacat
     1801 gctgccagtg agagggagct ctacattcca tccgtggacc ttctgactgc ccaggacctg
     1861 ctgtcctttg aactgctgga tataaacatt gttcaagaat tggagagagt gccacacaac
     1921 acccctgtgg atgtgactcc ccgcatgtct cctctgccgc atgacagccc tttaatagag
     1981 aagccaggct tggggcggat acaggaagag agtgaagggg cgggattgaa agcatctcct
     2041 gattccactg tattaacaaa gagaaaggcc gagacccctg cttcagtcga agaaacggag
     2101 gaagacctga gtgggaccca atttgtgtgt gagactgtaa tccgatccct aaccttggat
     2161 gctgctccag accacaaccc tccttgcagg cagaggtccc cacagaggga attacagctg
     2221 tattccacag aagaacagca gcctcttatg ctgcccggat tctgcagaaa ggattcttcc
     2281 ttgaaatttg ccttgcctga agaaggacca catggagatg agagggagga gattgtccac
     2341 attgctgagg aagaagccat tgaggaagag gatgtccaag atgaagaagt tcagagtcag
     2401 tcttctgctt cctctgaaga ttatatcatc atcctgcctg agtgctttga taccagccgc
     2461 cccctggggg actccatgta cagctctgcg ctctcccagc caggcctgga gcgaggggct
     2521 gaaggtgaac ctgggatcga gtctgggcag gaaccagctg aggctagaga gagactcccg
     2581 gaaagggaga gccagccaaa ggagcagagc atcagtgaca tcctcacgac ctcacagcat
     2641 ctggacacag tgcctctagt cccagaagtg gcaggacttc cagcagcact gtccaggagc
     2701 gccccttgtg gacagtatga ggcaccacga gtggattcac cagttaccat ccaagaagtt
     2761 ctcccagtcc ccgatcacgt cagaggagag cccagaggct caacaggact cgcaaacagc
     2821 cgacagaaga gctgtgacca ctcaaggcac cacaatggga gcagcattgc tggaggactg
     2881 gtgaaagggg ctttgtctgt tgctgcctct gcgtacaagg ccctgttttc tgggccacca
     2941 gtcactgcac agcccgtcat ttctgaagat cagaccgcag ccctgatggc ccatctcttt
     3001 gaaatgggat tctgcgacag gcagctgaac ctaagactgc tgagaaaaca caatcacaat
     3061 atcctgcagg ttgtgacaga gctcctccaa gtgaacaaca acgactggta cagccaccgc
     3121 tattgaggac tggcctcgta ttaaataact gcctgccgct cagaggtggt ctgtgccgtc
     3181 atgtcattga ggtgtgggtg gaagcccttg cttgcttttt aatctgatga atctatgtcg
     3241 agcgtccctg aattgtcaaa gccgtacctg ttacagtatt ttttggagca atcaaaggcc
     3301 agaacttaaa ttttcacttt agaaatggat gaatggtagg aagacagttt tcaactgatc
     3361 tggacagaac tctctctgct gtagtatgtg gaagcgtgta acttggactt cctgtagact
     3421 gcttctcctt ctgcttgtat tgaagttgag tattttcctt tggtttatgt ggatgttttt
     3481 aatgggctgt taaatgttag tttggttttt ctgtttttta aagattaacc ttgaatgttt
     3541 tcaagaatta ttctaatttc tataaccaac cccaagcttc atagctatgt aaagacagca
     3601 gatcaagaaa gtcatgtccc taaaagactt agtaaataag taacactttg ctttcagaag
     3661 acctggcagg aacctggaag gatggcaggc atgctggtta acccacagca cctactggac
     3721 agcgtctgtc aaagtaactc tgcatacatt ttttaaggaa aaatcctggg tagtgtgaaa
     3781 tattttgcta gtcctataaa gagggggaaa cccacctgtt ggagaaaggg aacgttaaca
     3841 tcatcttttt ttctgtcaca gcagatggta aggaggacag gtgtgtgtaa atattcacat
     3901 cagtaaggtt acggtgcgaa ggaggggaca cacatgctgg tgacgtctcg aatgtgtgta
     3961 atccccttct gaggtgtcca gccaagagca agaagtagtg cttgggggct aacccacaga
     4021 aaggtcagtt taccactaca gtaagtggga agaagcttcc tttcagagtt ctaggtctca
     4081 tttagtttat aaaagggcac tttgggtaca gatgggtaca gaggtcacaa cactaaagat
     4141 tttactcctg gtaagaattt gagagaagga atctggactc cagttcaaag gggaaagata
     4201 ggtgaaatag tattatttaa cttagttggt atttataata aatggcgatt ttaattattc
     4261 ataatatgtt tatttacagt ctaactcttg aatgcttcta aataaaccac aattcaaact
     4321 gcaaccaaaa aaaaaaaaaa aaaaaaaaaa aa
//
