LOCUS       NM_138873               2601 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus nibrin (Nbn), mRNA.
ACCESSION   NM_138873
VERSION     NM_138873.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Gao,L., Lv,Q., Huang,Y., Fan,Y., Zhao,L., Zhao,Y., Wang,X., Mo,D.,
            Lu,H. and Wang,D.
  TITLE     Effect of silencing SSB1 gene on the expression of NBS1 in
            irradiated rat submandibular gland cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 110-118 (2024)
   PUBMED   38372104
  REMARK    GeneRIF: Effect of silencing SSB1 gene on the expression of NBS1 in
            irradiated rat submandibular gland cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   Rivera,T., Haggblom,C., Cosconati,S. and Karlseder,J.
  TITLE     A balance between elongation and trimming regulates telomere
            stability in stem cells
  JOURNAL   Nat Struct Mol Biol 24 (1), 30-39 (2017)
   PUBMED   27918544
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   Naccarati,A., Rosa,F., Vymetalkova,V., Barone,E., Jiraskova,K., Di
            Gaetano,C., Novotny,J., Levy,M., Vodickova,L., Gemignani,F.,
            Buchler,T., Landi,S., Vodicka,P. and Pardini,B.
  TITLE     Double-strand break repair and colorectal cancer: gene variants
            within 3' UTRs and microRNAs binding as modulators of cancer risk
            and clinical outcome
  JOURNAL   Oncotarget 7 (17), 23156-23169 (2016)
   PUBMED   26735576
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Chang,F.T., McGhie,J.D., Chan,F.L., Tang,M.C., Anderson,M.A.,
            Mann,J.R., Andy Choo,K.H. and Wong,L.H.
  TITLE     PML bodies provide an important platform for the maintenance of
            telomeric chromatin integrity in embryonic stem cells
  JOURNAL   Nucleic Acids Res 41 (8), 4447-4458 (2013)
   PUBMED   23444137
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Lovric,J., Mano,M., Zentilin,L., Eulalio,A., Zacchigna,S. and
            Giacca,M.
  TITLE     Terminal differentiation of cardiac and skeletal myocytes induces
            permissivity to AAV transduction by relieving inhibition imposed by
            DNA damage response proteins
  JOURNAL   Mol Ther 20 (11), 2087-2097 (2012)
   PUBMED   22850678
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   Zhu,X.D., Kuster,B., Mann,M., Petrini,J.H. and de Lange,T.
  TITLE     Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and
            human telomeres
  JOURNAL   Nat Genet 25 (3), 347-352 (2000)
   PUBMED   10888888
REFERENCE   7  (bases 1 to 2601)
  AUTHORS   Lombard,D.B. and Guarente,L.
  TITLE     Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear
            bodies and meiotic telomeres
  JOURNAL   Cancer Res 60 (9), 2331-2334 (2000)
   PUBMED   10811102
REFERENCE   8  (bases 1 to 2601)
  AUTHORS   Lim,D.S., Kim,S.T., Xu,B., Maser,R.S., Lin,J., Petrini,J.H. and
            Kastan,M.B.
  TITLE     ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
  JOURNAL   Nature 404 (6778), 613-617 (2000)
   PUBMED   10766245
REFERENCE   9  (bases 1 to 2601)
  AUTHORS   Carney,J.P., Maser,R.S., Olivares,H., Davis,E.M., Le Beau,M.,
            Yates,J.R. 3rd, Hays,L., Morgan,W.F. and Petrini,J.H.
  TITLE     The hMre11/hRad50 protein complex and Nijmegen breakage syndrome:
            linkage of double-strand break repair to the cellular DNA damage
            response
  JOURNAL   Cell 93 (3), 477-486 (1998)
   PUBMED   9590181
REFERENCE   10 (bases 1 to 2601)
  AUTHORS   Varon,R., Vissinga,C., Platzer,M., Cerosaletti,K.M.,
            Chrzanowska,K.H., Saar,K., Beckmann,G., Seemanova,E., Cooper,P.R.,
            Nowak,N.J., Stumm,M., Weemaes,C.M., Gatti,R.A., Wilson,R.K.,
            Digweed,M., Rosenthal,A., Sperling,K., Concannon,P. and Reis,A.
  TITLE     Nibrin, a novel DNA double-strand break repair protein, is mutated
            in Nijmegen breakage syndrome
  JOURNAL   Cell 93 (3), 467-476 (1998)
   PUBMED   9590180
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF218575.1.
            
            On Aug 30, 2012 this sequence version replaced NM_138873.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF218575.1, BC085700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132274, SAMD00132279
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2601              AF218575.1         5-2605
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..2601
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /note="nibrin"
                     /db_xref="GeneID:85482"
                     /db_xref="RGD:621420"
     exon            1..72
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2288
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /function="required for MRE11, RAD50 and NBS1
                     colocalization at nuclear foci in response to DNA
                     double-strand breaks"
                     /note="nijmegen breakage syndrome protein 1 homolog"
                     /codon_start=1
                     /product="nibrin"
                     /protein_id="NP_620228.1"
                     /db_xref="GeneID:85482"
                     /db_xref="RGD:621420"
                     /translation="MWKLLPAASAAPGEPCRLLAGVEYIVGRKNCAILIENDQSISRN
                     HAVLRVNFPVTSLSQTDEIPTLIIKDNSKYGTFINEEKMQNGLSSTLKTGDRVTFGVF
                     ESKFRVEYEPLVVCSSCLDVSGKTVLNQAILQLGGLTANSWTEECTHLAMSSVKVTIK
                     TICALICGRPIVKPEYFSEFLKAVESKTQPPEIESFYPPIDEPAIGNKSVDLSGRRER
                     KQIFKGKTFVFLNAKQHKKLGSAVVFGGGEARLMAEGGEEEQSFFSAPGTCVVDVGIT
                     NTQLIITDSQRKWIHLIMDILQRHDLRPIPEAEIGLAVIFMTTESYCNPQGQPCTEVK
                     TTTPGPSLSQGLSANGKVIPSAPMNMTTYVADTESEPADTCMSLSERPEEVKIFGLDQ
                     NSRKLLQGTCNIKETSNQSSNSNNAASNTLVRGKAPNYQLSPMKCPAASKNKDWSSQQ
                     QLNSIKNYFQPCSRKRERDEENPEQSSCKSSRVELSCSLLEQTQPAEPSLWKSKDHES
                     QSETLGRASNASSVGGIDIKPNGKSPDSKSFSTEDLRARKRKEVDLSTEEEVLEELLR
                     STKPELAVQVKVEKQEADVSIRKKPRMDAERNQHLNGGPVPESNSALQEDETEKKDEL
                     QIEAWSTKREVSNTDELQDSSEELPRKLLLTEFRSLVVHNNSSRNLCPLNGRGELKNF
                     KKFKKATCPGAGKLPHIIGGSDLIGHHARKNTELEEWLKHEMEVQKQQAKEDSLADDL
                     FRYNPNVKRR"
     exon            73..206
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..355
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..515
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..619
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..737
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..931
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1029
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1159
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1432
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1874
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1943
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2096
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2210
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2260
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2601
                     /gene="Nbn"
                     /gene_synonym="Nbs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcgcatgt cgcagtgttc tgagacgccg gactcatgtg gaagctgctc ccggccgcaa
       61 gtgcggctcc aggagaacca tgtcgacttt tggctggcgt agagtacatt gttgggagga
      121 aaaactgtgc cattctaatc gaaaatgatc agtcaatcag tcgaaatcat gctgtattaa
      181 gagtaaactt tcctgtaacc agtttgagtc aaacggatga aattcctaca ttaataataa
      241 aagataattc taagtatgga acctttatta acgaagaaaa aatgcagaat ggcctttctt
      301 ccactttgaa gacaggagat agagttacct ttggggtgtt tgaaagtaaa ttcagagtag
      361 aatacgagcc tttggttgtt tgctcttctt gtttagatgt ctctgggaaa actgttttaa
      421 accaagctat attacagctt ggaggactca ctgcaaacag ctggacagaa gagtgtactc
      481 accttgccat gtcatcagtc aaagtcacca ttaaaactat atgtgcactc atttgtggac
      541 gtccaattgt aaagccagaa tacttttctg aatttctcaa agcagttgag tccaagacac
      601 aacctccaga aattgaaagt ttttacccac ccatcgatga accagctatt ggaaataaaa
      661 gtgtcgatct gtccggacga cgtgaaagaa aacaaatctt caaaggaaaa acattcgtgt
      721 ttttaaatgc caagcagcat aagaaactcg gctcggcagt tgttttcgga ggtggggaag
      781 ccaggctgat ggcagaagga ggtgaagagg aacagagctt cttctcagct cccggaacct
      841 gtgttgttga cgtaggaata acaaacacac agctcataat tacggactcc cagaggaagt
      901 ggattcattt gataatggat atacttcaaa ggcatgatct cagacctatt cctgaagcag
      961 agattggatt ggctgttatt tttatgacta cagagagtta ctgtaatccg cagggccagc
     1021 cttgtacaga ggtaaagacg acgactccag gaccaagcct ttcccagggc ctgtcagcca
     1081 atggaaaagt catccccagt gcgccaatga atatgaccac atacgtagct gacacagaat
     1141 cagagccagc agatacatgt atgtctctga gtgaaagacc agaagaagta aagatctttg
     1201 gactcgatca aaactctaga aagcttttac aaggaacatg caatataaag gagacctcta
     1261 atcaaagctc caattctaac aatgcagcat caaatacact ggttagggga aaggccccga
     1321 actatcagct ttcaccaatg aaatgtcctg ctgcaagtaa aaataaagat tggtcttctc
     1381 agcagcagct gaactccatc aaaaactact tccagccatg ctccagaaaa agggaaaggg
     1441 atgaagaaaa tccagaacag tcctcatgca aatcgtcaag agtggaactg tcttgttctc
     1501 ttttagaaca aacgcaacct gcagaaccct cactgtggaa aagcaaagac catgagtctc
     1561 agagtgagac tctgggcagg gcatccaatg cctcatctgt gggtggaata gacataaaac
     1621 ccaatgggaa gagtcctgac agtaagtcat tttccacaga agatcttaga gcaagaaaaa
     1681 gaaaagaagt ggatttgtct acagaagagg aagtgttgga agagttactc aggagcacaa
     1741 agccagagct ggcagttcaa gtgaaggttg aaaagcagga ggcagatgtc agcatcagaa
     1801 agaagcccag gatggatgca gagaggaatc agcacctgaa cggtggccca gtgccagaaa
     1861 gcaacagcgc acttcaagaa gatgaaacag aaaagaaaga tgagcttcag atagaagcat
     1921 ggtcaacaaa acgtgaagta tctaatactg atgagcttca ggacagcagt gaggaacttc
     1981 caagaaaact gctgctgact gaatttaggt cactggttgt ccataataac tcttccagaa
     2041 atctgtgccc actaaatggt cgtggtgaac tgaagaattt caagaaattc aagaaggcta
     2101 cgtgtcctgg agcaggaaag cttccacaca ttattggagg atcagattta ataggtcacc
     2161 atgctcgaaa gaatactgaa ttagaagagt ggttgaaaca tgaaatggag gtacagaaac
     2221 aacaagcgaa agaagactct cttgctgatg atctgtttag atataatcct aatgtaaaaa
     2281 gaagataatt gaaccttata aagaaagcta gagaaacaca tttctacttc agaccaactg
     2341 ggatacgtga atgtagtaca tagaaattac caatgcttta aggcttcagt ttattaaata
     2401 aagcaaattc cattcctttt gtgtggtctc tggggtaata aataatttcc cccctcactt
     2461 taaatgtgtt tcttactaag taattaccac aatcttagtg tccaaaatcc tgaaactaca
     2521 ttaagggtaa gaccaaagtc tcttatccac tagctgattg atttccaccg tgggttgggg
     2581 agttatatct atatacaaat a
//
