LOCUS       NM_031609               1776 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus NBL1, DAN family BMP antagonist (Nbl1), mRNA.
ACCESSION   NM_031609
VERSION     NM_031609.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1776)
  AUTHORS   Nolan,K., Kattamuri,C., Luedeke,D.M., Angerman,E.B., Rankin,S.A.,
            Stevens,M.L., Zorn,A.M. and Thompson,T.B.
  TITLE     Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1):
            insights for the functional variability across bone morphogenetic
            protein (BMP) antagonists
  JOURNAL   J Biol Chem 290 (8), 4759-4771 (2015)
   PUBMED   25561725
REFERENCE   2  (bases 1 to 1776)
  AUTHORS   Zhou,Y., Tanzie,C., Yan,Z., Chen,S., Duncan,M., Gaudenz,K., Li,H.,
            Seidel,C., Lewis,B., Moran,A., Libby,R.T., Kiernan,A.E. and Xie,T.
  TITLE     Notch2 regulates BMP signaling and epithelial morphogenesis in the
            ciliary body of the mouse eye
  JOURNAL   Proc Natl Acad Sci U S A 110 (22), 8966-8971 (2013)
   PUBMED   23676271
REFERENCE   3  (bases 1 to 1776)
  AUTHORS   Kattamuri,C., Luedeke,D.M., Nolan,K., Rankin,S.A., Greis,K.D.,
            Zorn,A.M. and Thompson,T.B.
  TITLE     Members of the DAN family are BMP antagonists that form highly
            stable noncovalent dimers
  JOURNAL   J Mol Biol 424 (5), 313-327 (2012)
   PUBMED   23063586
REFERENCE   4  (bases 1 to 1776)
  AUTHORS   Hung,W.T., Wu,F.J., Wang,C.J. and Luo,C.W.
  TITLE     DAN (NBL1) specifically antagonizes BMP2 and BMP4 and modulates the
            actions of GDF9, BMP2, and BMP4 in the rat ovary
  JOURNAL   Biol Reprod 86 (5), 158,1-9 (2012)
   PUBMED   22357543
  REMARK    GeneRIF: The findings suggested that the NBL1 gradient in granulosa
            cells, established by oocyte-derived GDF9, may serve as an
            antagonist barrier that modulates the actions of theca-derived BMP4
            and granulosa/theca-derived BMP2 during folliculogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1776)
  AUTHORS   Krizhanovsky,V. and Ben-Arie,N.
  TITLE     A novel role for the choroid plexus in BMP-mediated inhibition of
            differentiation of cerebellar neural progenitors
  JOURNAL   Mech Dev 123 (1), 67-75 (2006)
   PUBMED   16325379
REFERENCE   6  (bases 1 to 1776)
  AUTHORS   Ahmed,A., Kandola,P., Ziada,G. and Parenteau,N.
  TITLE     Purification and partial amino acid sequence of proteins from human
            epidermal keratinocyte conditioned medium
  JOURNAL   J Protein Chem 20 (4), 273-278 (2001)
   PUBMED   11594460
REFERENCE   7  (bases 1 to 1776)
  AUTHORS   Ozaki,T., Hanaoka,E., Naka,M., Nakagawara,A. and Sakiyama,S.
  TITLE     Cloning and characterization of rat BAT3 cDNA
  JOURNAL   DNA Cell Biol 18 (6), 503-512 (1999)
   PUBMED   10390159
REFERENCE   8  (bases 1 to 1776)
  AUTHORS   Hsu,D.R., Economides,A.N., Wang,X., Eimon,P.M. and Harland,R.M.
  TITLE     The Xenopus dorsalizing factor Gremlin identifies a novel family of
            secreted proteins that antagonize BMP activities
  JOURNAL   Mol Cell 1 (5), 673-683 (1998)
   PUBMED   9660951
REFERENCE   9  (bases 1 to 1776)
  AUTHORS   Sakiyama,S., Ozaki,T. and Enomoto,H.
  TITLE     Molecular cloning and characterization of a cDNA showing
            tumor-suppressive activity in V-SRC-transformed 3Y1 rat fibroblasts
  JOURNAL   Adv Enzyme Regul 34, 247-255 (1994)
   PUBMED   7942277
REFERENCE   10 (bases 1 to 1776)
  AUTHORS   Ozaki,T. and Sakiyama,S.
  TITLE     Molecular cloning and characterization of a cDNA showing negative
            regulation in v-src-transformed 3Y1 rat fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 90 (7), 2593-2597 (1993)
   PUBMED   8385338
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031609.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66872.1, BC061833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000005.1  156613016-156613182 c
            168-362             JAXUCZ010000005.1  156605437-156605631 c
            363-474             JAXUCZ010000005.1  156605203-156605314 c
            475-1776            JAXUCZ010000005.1  156601986-156603287 c
FEATURES             Location/Qualifiers
     source          1..1776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1776
                     /gene="Nbl1"
                     /note="NBL1, DAN family BMP antagonist"
                     /db_xref="GeneID:50594"
                     /db_xref="RGD:3151"
     exon            1..167
                     /gene="Nbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..362
                     /gene="Nbl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..732
                     /gene="Nbl1"
                     /note="Neuroblastoma, suppression of tumorigenicity 1 (DNA
                     segment human D1S1733E); neuroblastoma suppressor of
                     tumorigenicity 1; N03; zinc finger protein DAN;
                     neuroblastoma 1, DAN family BMP antagonist"
                     /codon_start=1
                     /product="neuroblastoma suppressor of tumorigenicity 1
                     precursor"
                     /protein_id="NP_113797.2"
                     /db_xref="GeneID:50594"
                     /db_xref="RGD:3151"
                     /translation="MLWVLVGTVLPVMLLAAPPPINKLALFPDKSAWCEAKNITQIVG
                     HSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHE
                     EVPRVDKLVEKIVHCSCQACGKEPSHEGLNVYMQGEDGPGSQPGSHSHSHPHPGGQTP
                     EPEEPPGAPQVEEEGAED"
     exon            363..474
                     /gene="Nbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1776
                     /gene="Nbl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcctcgcg cccgcccggg gccgcagacg gccagcagcg aagcacagcc gagcctcgcg
       61 gggccgtccc agcccgagga cctcgggcct gcgacccccg cggctcgcat cccactttct
      121 aagacctcta agaggacgcg ccgcgctctt cgcggccgcc gcgcgcgttc cagggctccg
      181 gaggtgacag gcacaatgct ttgggtcctg gtggggactg ttctccctgt catgttgctg
      241 gctgccccgc cacccatcaa caagctggcc ctgtttccgg acaagagtgc ctggtgcgaa
      301 gccaagaaca tcacgcagat tgtgggccac agcggctgtg aggccaagtc tatccagaac
      361 agggcgtgcc taggacaatg cttcagttac agcgtcccca acaccttccc gcagtccaca
      421 gagtccctgg tgcactgtga ctcctgcatg ccggcccagt ccatgtggga gattgtgacc
      481 ttggagtgcc ccggccacga ggaggtgccc agggtggaca agctggttga gaagattgta
      541 cactgcagct gccaagcctg cggcaaggaa cccagtcatg agggcctgaa cgtctacatg
      601 cagggtgaag atgggccagg ctcccagcca ggatcgcact cccactccca tccccaccct
      661 ggtggccaga cccctgaacc tgaagaacct cctggagccc ctcaagttga ggaagagggg
      721 gctgaggact gagggccccc aactcttcct cccctcttgt cccctgtgga atgtctggtc
      781 ccaccctcca gggaagaggg aggggagagg cagaggcccc cctccccctc tggcactaga
      841 tggacttgga atgttgcctg gttgccatgg agatctgaag ggaggggctg gagccaagct
      901 gcacgattta atatatgcaa gatgagggga ggaagcagac atctttggga cttttctttt
      961 ggaaggtgaa gtgtggtctt tcctttcagc cttctggaga ggagccctct ggatagagag
     1021 gaagcaggtt gagctgctga ggatgactga gatcctcaga tagggcaggc ccaggtcagg
     1081 acccagacaa cggatggggc aggatcccca gtgacgggca gagggtgggt atcatgtcag
     1141 catccccttt gcaggaggat ctaggtagga agacagctgg cagaagtcgg aaactccagc
     1201 cccataggtt tccctaaagg cctcccctca tgtaacccct tcaatggagt ggcttaggag
     1261 tcaggctggg gcaggaccct gctgactcag gtgccagagt gtcactgaag aagaaagaag
     1321 atccccctcc cccacaccct gtccctccct ccagagatct tagctctttg ctctccccaa
     1381 gttctggact cttctgaaaa cagctgcaac cggtcctgcc gtccttgggg ctggtctttc
     1441 tgaaagaggt gacagtttat ccccatcacc tgggaccgta gtggacagga ggcccctgcc
     1501 tagggcccct gctgacctca gctttctcta gctccttatt ctatccactc cttcttccca
     1561 gctgcacttt aaccttaggg cagggcaggt ggcgaggaag ggccctctgt ctccttatct
     1621 gctggcacca ttgtgtccag ggggttgcca gctcaccccc tccctggggg tgccccagcc
     1681 catggctgtt tgacgagagc cttagagctt gtaactagta gccatctccc ctgaacctga
     1741 gtgtttccat gaataaaatg ccttcaacgc ctctac
//
