LOCUS       NM_001399227             935 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus NAD(P)HX epimerase (Naxe), mRNA.
ACCESSION   NM_001399227 XM_006232609
VERSION     NM_001399227.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 935)
  AUTHORS   Kremer,L.S., Danhauser,K., Herebian,D., Petkovic Ramadza,D.,
            Piekutowska-Abramczuk,D., Seibt,A., Muller-Felber,W., Haack,T.B.,
            Ploski,R., Lohmeier,K., Schneider,D., Klee,D., Rokicki,D.,
            Mayatepek,E., Strom,T.M., Meitinger,T., Klopstock,T., Pronicka,E.,
            Mayr,J.A., Baric,I., Distelmaier,F. and Prokisch,H.
  TITLE     NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and
            Cause a Lethal Neurometabolic Disorder of Early Childhood
  JOURNAL   Am J Hum Genet 99 (4), 894-902 (2016)
   PUBMED   27616477
REFERENCE   2  (bases 1 to 935)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
  REMARK    GeneRIF: After partial purification, quantification of NAD(P)HX
            dehydratase and epimerase activities in rat tissues indicates that
            both CARDKD (carbohydrate kinase domain protein) and AIBP protein
            are widely distributed.
REFERENCE   3  (bases 1 to 935)
  AUTHORS   Fang,L., Choi,S.H., Baek,J.S., Liu,C., Almazan,F., Ulrich,F.,
            Wiesner,P., Taleb,A., Deer,E., Pattison,J., Torres-Vazquez,J.,
            Li,A.C. and Miller,Y.I.
  TITLE     Control of angiogenesis by AIBP-mediated cholesterol efflux
  JOURNAL   Nature 498 (7452), 118-122 (2013)
   PUBMED   23719382
REFERENCE   4  (bases 1 to 935)
  AUTHORS   Jha,K.N., Shumilin,I.A., Digilio,L.C., Chertihin,O., Zheng,H.,
            Schmitz,G., Visconti,P.E., Flickinger,C.J., Minor,W. and Herr,J.C.
  TITLE     Biochemical and structural characterization of apolipoprotein A-I
            binding protein, a novel phosphoprotein with a potential role in
            sperm capacitation
  JOURNAL   Endocrinology 149 (5), 2108-2120 (2008)
   PUBMED   18202122
REFERENCE   5  (bases 1 to 935)
  AUTHORS   Ritter,M., Buechler,C., Boettcher,A., Barlage,S., Schmitz-Madry,A.,
            Orso,E., Bared,S.M., Schmiedeknecht,G., Baehr,C.H., Fricker,G. and
            Schmitz,G.
  TITLE     Cloning and characterization of a novel apolipoprotein A-I binding
            protein, AI-BP, secreted by cells of the kidney proximal tubules in
            response to HDL or ApoA-I
  JOURNAL   Genomics 79 (5), 693-702 (2002)
   PUBMED   11991719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006232609.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158876.1, EX488124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000002.1  175818694-175818889 c
            197-305             JAXUCZ010000002.1  175818497-175818605 c
            306-416             JAXUCZ010000002.1  175818283-175818393 c
            417-530             JAXUCZ010000002.1  175818086-175818199 c
            531-678             JAXUCZ010000002.1  175817343-175817490 c
            679-935             JAXUCZ010000002.1  175816824-175817080 c
FEATURES             Location/Qualifiers
     source          1..935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..935
                     /gene="Naxe"
                     /gene_synonym="AI-BP; Apoa1bp"
                     /note="NAD(P)HX epimerase"
                     /db_xref="GeneID:295229"
                     /db_xref="RGD:1304699"
     exon            1..196
                     /gene="Naxe"
                     /gene_synonym="AI-BP; Apoa1bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..881
                     /gene="Naxe"
                     /gene_synonym="AI-BP; Apoa1bp"
                     /EC_number="5.1.99.6"
                     /note="apolipoprotein A-I-binding protein; NAD(P)H-hydrate
                     epimerase"
                     /codon_start=1
                     /product="NAD(P)H-hydrate epimerase precursor"
                     /protein_id="NP_001386156.1"
                     /db_xref="GeneID:295229"
                     /db_xref="RGD:1304699"
                     /translation="MSGLRTLLGLGLLVAGSRLPRIASRQSVCRAGPIWWGTQHRSSE
                     TMASAAVKYLSQEEAQAVDEELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSKSP
                     PTVLVICGPGNNGGDGLVCARHLKLFGYQPTIYYPKRPNKPLFTGLVTQCQKMDIPFL
                     GEMPPEPMMVDELYELVVDAIFGFSFKGDVREPFHSILSVLSGLTVPIASIDIPSGWD
                     VEKGNPSGIQPDLLISLTAPKKSATQFTGRYHYLGGRFVPPALEKKYQLNLPAYPDTE
                     CVYRLQ"
     exon            197..305
                     /gene="Naxe"
                     /gene_synonym="AI-BP; Apoa1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            306..416
                     /gene="Naxe"
                     /gene_synonym="AI-BP; Apoa1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            417..530
                     /gene="Naxe"
                     /gene_synonym="AI-BP; Apoa1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            531..678
                     /gene="Naxe"
                     /gene_synonym="AI-BP; Apoa1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            679..935
                     /gene="Naxe"
                     /gene_synonym="AI-BP; Apoa1bp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgctgtg caggcgacgc tctgtgtgtc gaatgtccgg gctgcggacg ctgctggggt
       61 tggggctgct agttgcaggc tcgcgcctgc cacggatcgc aagccggcag agtgtgtgcc
      121 gtgcagggcc catttggtgg ggaacgcagc accggagctc ggagaccatg gcgagtgcgg
      181 cggtgaagta cctgagccag gaggaggctc aggccgtgga cgaggagctt tttaacgaat
      241 accagttcag cgtggatcaa ctcatggagc tggccgggtt gagctgtgcc acggccattg
      301 ccaaggctta tccccccacg tctatgtcca agagtccccc gactgtcttg gtcatctgtg
      361 gccccggaaa taacggaggg gatgggctgg tctgtgcgcg acacctcaaa ctttttggtt
      421 accagccaac tatctattac cccaaaagac ctaacaaacc actcttcact gggctagtga
      481 ctcagtgtca gaaaatggac atccctttcc ttggtgaaat gcccccagag cccatgatgg
      541 tggatgagct gtatgaattg gtggtggatg ccatcttcgg cttcagtttc aagggcgatg
      601 ttcgggagcc gttccacagt atcctgagtg tcttgagtgg actcactgtg cccatcgcta
      661 gcatcgatat tccttcagga tgggatgtag agaagggaaa ccctagtgga atccaaccag
      721 acttactcat ctcactgacg gcacccaaga agtctgcaac tcagtttact ggccgatatc
      781 attacctcgg agggcgtttt gtaccacctg ctctagaaaa gaagtaccag ctgaacctgc
      841 cagcctaccc tgacacagag tgtgtctacc gtcttcagta agggaggtga ggaggcaggt
      901 ttctcaataa agacttggta ccttctatct tgaaa
//
