LOCUS       NM_001108402            1279 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus NAD(P)HX dehydratase (Naxd), mRNA.
ACCESSION   NM_001108402 XM_001076079 XM_341468
VERSION     NM_001108402.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Van Bergen,N.J., Guo,Y., Rankin,J., Paczia,N., Becker-Kettern,J.,
            Kremer,L.S., Pyle,A., Conrotte,J.F., Ellaway,C., Procopis,P.,
            Prelog,K., Homfray,T., Baptista,J., Baple,E., Wakeling,M.,
            Massey,S., Kay,D.P., Shukla,A., Girisha,K.M., Lewis,L.E.S.,
            Santra,S., Power,R., Daubeney,P., Montoya,J., Ruiz-Pesini,E.,
            Kovacs-Nagy,R., Pritsch,M., Ahting,U., Thorburn,D.R., Prokisch,H.,
            Taylor,R.W., Christodoulou,J., Linster,C.L., Ellard,S. and
            Hakonarson,H.
  TITLE     NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative
            disorder exacerbated by febrile illnesses
  JOURNAL   Brain 142 (1), 50-58 (2019)
   PUBMED   30576410
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
  REMARK    GeneRIF: The human, mouse, and rat Carkd genes contain a first exon
            with two alternative 3' splice sites and two putative initiator ATG
            codons; the second exon also comprises a highly conserved ATG
            codon.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473970.2.
            
            [WARNING] On Mar 17, 2025 this sequence was replaced by
            NM_001108402.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341468.2, XM_001076079.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225763.1, SRR8487227.345378.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1279
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /note="NAD(P)HX dehydratase"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
     exon            1..63
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1007
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /EC_number="4.2.1.93"
                     /note="carbohydrate kinase domain containing;
                     ATP-dependent NAD(P)HX dehydratase; carbohydrate kinase
                     domain-containing protein"
                     /codon_start=1
                     /product="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"
                     /protein_id="NP_001101872.1"
                     /db_xref="GeneID:361185"
                     /db_xref="RGD:1562691"
                     /translation="MGIRCVAIRACGGVLQRALSLHTAHATKDMDNLFQLVRNIVPAL
                     TSKKHKGQDGRIGIVGGCQEYTGAPYFAGISALKVGADLTHVFCAREAAPVIKSYSPE
                     LIVHPVLDSSDAVEEVEKWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVI
                     DADGLWLIAQRPALVHGYQKAVLTPNHVEFSRLWDAVLSSPMDTSNHSGSVLKLSQAL
                     GNITIVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMAHWALRAGPEKT
                     NGSSPLLVAAWGACTLTRECNHLAFQKYGRSTTTTDMIAEVGAAFSKLFTT"
     exon            64..214
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            215..260
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            261..349
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            350..458
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            459..509
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            510..614
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            615..735
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            736..856
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1279
                     /gene="Naxd"
                     /gene_synonym="Carkd; RGD1562691"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccggaagt ccgctggacg gtcatgggca tccggtgtgt ggcgatccgc gcctgcggag
       61 gagttttaca aagagcactg tccctccaca cagcgcacgc aacaaaggac atggacaacc
      121 tttttcagtt ggtgaggaac attgtgcctg ctctgacgtc gaagaaacac aaggggcaag
      181 atggaaggat aggcatagtc gggggctgtc aagagtacac aggagcaccg tattttgcag
      241 gaatctcagc tctgaaagtg ggtgcagatt tgacccacgt attctgtgcc agggaggccg
      301 cgccagtgat caagtcctac agcccagagc tgatcgtcca ccccgtcctt gacagttctg
      361 acgctgttga ggaggtggag aaatggctcc ccaggctgca tgcccttgtc gtgggacctg
      421 gcctaggtag ggacgacctt cttctcaaca acgtgagggg catcttggaa tcaaccaagg
      481 ccagggacat ccctgtcgtc attgacgcgg acggcctgtg gctgattgct cagcggccag
      541 ccctcgtcca cggctaccag aaggccgttc tcacccccaa ccatgtggag ttcagcagac
      601 tctgggacgc tgtgctcagt agtcctatgg acaccagtaa tcacagtgga tctgtgttga
      661 agctcagcca ggccctgggg aacatcacca tagtccagaa aggagagcag gacctgatct
      721 ccaacggcca gcaggtgctt gtgtgcaacc aggaaggcag cagtcgccgg tgtggtgggc
      781 aaggagatct cctgtcaggc tccctgggtg tcatggcaca ctgggccctc cgtgctggac
      841 cagagaaaac caacggctcc agcccgctcc tggtggctgc ctggggtgcg tgcacactca
      901 caagggagtg taaccatctg gccttccaga agtacgggcg ttccacaacc actaccgaca
      961 tgatcgctga ggtgggagct gccttcagca agctcttcac gacctgagcc ggcacagact
     1021 gagtcctcca tcgcctagcc ttgggctcag cagcacttga tggattttag cctgaagtag
     1081 ctgacaggat ttaggacgtg gctgtccgac tactgtagag ttgagatgtt aaggacacta
     1141 atctggtctc cgtggttttc tgggcttctc agaaaagtct gaggagaaaa tgagagtaaa
     1201 ccctcccagc agcccacctg gattgggctg gctctgacac agacatttgg agtccatggc
     1261 tgttcattca ttgattctg
//
