LOCUS       NM_001191681            3279 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus N-acetyltransferase 8-like (Nat8l), mRNA.
ACCESSION   NM_001191681 XM_223538
VERSION     NM_001191681.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3279)
  AUTHORS   Di Pietro,V., Amorini,A.M., Tavazzi,B., Vagnozzi,R., Logan,A.,
            Lazzarino,G., Signoretti,S., Lazzarino,G. and Belli,A.
  TITLE     The molecular mechanisms affecting N-acetylaspartate homeostasis
            following experimental graded traumatic brain injury
  JOURNAL   Mol Med 20 (1), 147-157 (2014)
   PUBMED   24515258
  REMARK    GeneRIF: The decrease in N-acetylaspartate following severe
            traumatic brain injury was characterized by profound mitochondrial
            malfunctioning, dramatic repression of Nat8l gene and concomitant
            increase in the ASPA gene and protein levels.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3279)
  AUTHORS   Becker,I., Lodder,J., Gieselmann,V. and Eckhardt,M.
  TITLE     Molecular characterization of N-acetylaspartylglutamate synthetase
  JOURNAL   J Biol Chem 285 (38), 29156-29164 (2010)
   PUBMED   20643647
REFERENCE   3  (bases 1 to 3279)
  AUTHORS   Ariyannur,P.S., Moffett,J.R., Manickam,P., Pattabiraman,N.,
            Arun,P., Nitta,A., Nabeshima,T., Madhavarao,C.N. and
            Namboodiri,A.M.
  TITLE     Methamphetamine-induced neuronal protein NAT8L is the NAA
            biosynthetic enzyme: implications for specialized acetyl coenzyme A
            metabolism in the CNS
  JOURNAL   Brain Res 1335, 1-13 (2010)
   PUBMED   20385109
  REMARK    GeneRIF: Asp-NAT/NAT8L and NAA immunoreactivities correlate very
            well in rat brain, with primary localization in neurons, including
            cortical pyramidal neurons and granule cells of the hippocampus.
REFERENCE   4  (bases 1 to 3279)
  AUTHORS   Wiame,E., Tyteca,D., Pierrot,N., Collard,F., Amyere,M., Noel,G.,
            Desmedt,J., Nassogne,M.C., Vikkula,M., Octave,J.N., Vincent,M.F.,
            Courtoy,P.J., Boltshauser,E. and van Schaftingen,E.
  TITLE     Molecular identification of aspartate N-acetyltransferase and its
            mutation in hypoacetylaspartia
  JOURNAL   Biochem J 425 (1), 127-136 (2009)
   PUBMED   19807691
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3279)
  AUTHORS   Arun,P., Moffett,J.R. and Namboodiri,A.M.
  TITLE     Evidence for mitochondrial and cytoplasmic N-acetylaspartate
            synthesis in SH-SY5Y neuroblastoma cells
  JOURNAL   Neurochem Int 55 (4), 219-225 (2009)
   PUBMED   19524112
REFERENCE   6  (bases 1 to 3279)
  AUTHORS   Niwa,M., Nitta,A., Cen,X., Kitaichi,K., Ozaki,N., Yamada,K. and
            Nabeshima,T.
  TITLE     A novel molecule 'shati' increases dopamine uptake via the
            induction of tumor necrosis factor-alpha in pheochromocytoma-12
            cells
  JOURNAL   J Neurochem 107 (6), 1697-1708 (2008)
   PUBMED   19014384
REFERENCE   7  (bases 1 to 3279)
  AUTHORS   Ariyannur,P.S., Madhavarao,C.N. and Namboodiri,A.M.
  TITLE     N-acetylaspartate synthesis in the brain: mitochondria vs.
            microsomes
  JOURNAL   Brain Res 1227, 34-41 (2008)
   PUBMED   18621030
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XM_223538.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.44766.1,
                                           SRR26643298.54952.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840114 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               JAXUCZ010000014.1  80986898-80987264   c
            368-532             JAXUCZ010000014.1  80985572-80985736   c
            533-3279            JAXUCZ010000014.1  80980629-80983375   c
FEATURES             Location/Qualifiers
     source          1..3279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3279
                     /gene="Nat8l"
                     /gene_synonym="RGD1305719"
                     /note="N-acetyltransferase 8-like"
                     /db_xref="GeneID:289727"
                     /db_xref="RGD:1305719"
     CDS             1..900
                     /gene="Nat8l"
                     /gene_synonym="RGD1305719"
                     /EC_number="2.3.1.17"
                     /note="NAA synthetase; N-acetyltransferase 8-like protein"
                     /codon_start=1
                     /product="N-acetylaspartate synthetase"
                     /protein_id="NP_001178610.1"
                     /db_xref="GeneID:289727"
                     /db_xref="RGD:1305719"
                     /translation="MHCGPPDMVCETKIVATEDHEALPGAKKDALLAAAGAMWPPLPA
                     APGPAAAPPPAAGPQPHGGTGGAGPPEGRGVCIREFRAAEQEAARRIFYDGILERIPN
                     TAFRGLRQHPRTQLLYALLAALCFAVTRSLLLTCLVPAGLLALRYYYSRKVILAYLEC
                     ALHTDMADIEQYYMKPPGSCFWVAVLDGNVVGIVAARAHEEDNTVELLRMSVDSRFRG
                     KGIAKALGRRVLEFAMLHNYSAVVLGTTAVKVAAHKLYESLGFRHMGASDHYVLPGMT
                     LSLAERLFFQVRYHRYRLQLREE"
     exon            1..367
                     /gene="Nat8l"
                     /gene_synonym="RGD1305719"
                     /inference="alignment:Splign:2.1.0"
     exon            368..532
                     /gene="Nat8l"
                     /gene_synonym="RGD1305719"
                     /inference="alignment:Splign:2.1.0"
     exon            533..3279
                     /gene="Nat8l"
                     /gene_synonym="RGD1305719"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcattgtg ggcctcccga catggtctgc gagacgaaga tcgtggctac ggaggaccat
       61 gaggcactgc cgggggccaa gaaggacgcg ctgctcgccg ccgccggagc catgtggccc
      121 ccgctgcccg ccgcgcccgg gccggctgcc gcacccccac ccgcggcagg tccccagccc
      181 cacggaggca ccgggggcgc ggggccgccg gaggggcgcg gcgtgtgcat ccgcgagttc
      241 cgcgcagccg agcaggaggc ggcgcgccgc atcttctacg acggcatctt ggagcgcatc
      301 cccaacacgg ctttccgagg cctgcggcag cacccgcgca cccagctgct ctacgccctg
      361 ctggcggccc tctgttttgc tgtgacccgc tcactgctgc tgacatgcct ggtgccggcc
      421 gggctcctgg ccctgcgcta ctactacagt cgcaaggtga ttctggccta cctggagtgt
      481 gcgctgcaca cggacatggc tgacattgaa cagtactaca tgaagccacc tggttcctgt
      541 ttctgggtgg ctgtgctgga cggcaatgtt gtgggcatcg tggcggctcg ggcccatgag
      601 gaagacaaca cagtggagct gctccgcatg tccgtggact cgcgcttccg cggcaaaggc
      661 atcgccaagg ccctgggcag gagggtgttg gagtttgcca tgctgcacaa ctactctgca
      721 gtggtactgg gcaccacagc cgttaaggtg gccgcccaca agctctatga gtcactgggc
      781 ttcagacaca tgggcgcgag tgatcactac gtgctgcctg gcatgaccct ctcgctggcc
      841 gagcgcctct tcttccaggt ccgctaccac cgctaccgcc tgcagctgcg cgaggagtga
      901 ccaccaccac ctgcccacca ccctgtctgc ccccgtccac ctctgccctc ctgctcgctg
      961 cctagtgcgg ccctgctttc caatgctcac cttggcgttt gtttgggttt tcctttttca
     1021 gcatcctgct ggttcaccac ctggctggtt ctggagccac agggtcccag tccagagtgc
     1081 tcagcagcag cactctggtg gggtggattg tctgcagcta tggcccttgc ctccccagcc
     1141 catcagagtg gctcatcatg ccttgaagag tagcattgtg gaccatctga actatccaca
     1201 aagctgccca gcctgcctcc atcagggaag gactagcttt gcccatcaag cacagaacct
     1261 ctacaacaac ccccccaagg agcagaaccc tggccccagc caggctaagg cccagctatt
     1321 ggcctctgga agaatggtct gctgggctgg ccagccactg ccccatggga ggccaagctg
     1381 gcctcaggcc ctgctttgcc ctgtgcatgc taaggacatg gcctggctgc agcatgccgc
     1441 atgccacagc cccctgcccc gctgcccgcc cagcctggac ttcaggcctg agctggtgag
     1501 ctcccttgtc ctgtcctgag ctggcctctg gagggcctac ctgcctgacc ctgtctgctc
     1561 tctggtgggg cctggcctgg cctaacctgg ctctattcac tcctgctttg ctttgaaatc
     1621 atcttacctc tttccctttt cagtccctgt gcctccttgc tctggctgac ttggctggtc
     1681 acctgggtct ggctcctgta gcaatccact gcacagcatg gtggggattt catggggagg
     1741 gggaacacct cccccaatac ctgttagatc aggtggccac ctcccagctg cctgaggtcc
     1801 catggcctca tgctgtctgt ggggtctgcc ctgtgaatgt aactagccca ggctgttgtt
     1861 ggcaatgcct gccacagctt ctcccagcct gaaacaaccc attctctaat aagttacgta
     1921 gacagaatag cactctgcat gactttaatt cctgggacaa aatggtagtt tgagcctcca
     1981 gacacacatc tgtgtggtgc tagcatatgc acggtctctg gccccatttg atgggggtgg
     2041 gtggccgggt aggtggaaga tttcattttg aagtatggaa ggagactcta atttagtgta
     2101 aatgccccca aagtgctctc acaacacaaa gcttatgagg ctcaggctgc cccttgactc
     2161 cttgtgtgca ggactgaggg gactggaggg tctgagagcc tcataggaag ggctgggcac
     2221 tgctttgggg gcaggagctg gtggttgggg taggtccagc ctcccactac agactactct
     2281 gctaggccat ctcttctcct cgtttctcct ttttgaggtc caatttagaa tccagcctag
     2341 atgggggtgg ggatggccta ggacagggag aggcagtagc tggcagtgtt catgcgccag
     2401 ctgaaacttg gacttagctt tagtgcaggg ggtgcataaa ggcccataca cactctcctg
     2461 tgtggggctt ggggtgagga gtggcaggct aggtagacca tagagctggg cccctggcac
     2521 caaggctgca atgttagaaa ggctctttag agttaatgag ttggtggagc aagcccagct
     2581 tcctgagggg ccttttgtcc tgttagcaat tgaggcattt gcagaacact gtacagaccc
     2641 cgctctcccc tgtacattcc tccctggtgg tgcccggtcc ccacttgggg atgggagttt
     2701 tgtagactgt acagaaatcg gcaccctatt ttcttgcagc tctcagattt tgttaatctg
     2761 gattatacag acagacgtaa agtgttttag caaaatggaa aacaaacagt tgtgcctttt
     2821 ttctcttttc tgtttggatt ggtctcggct cggggctagt tttagttgtt gtgggggtgt
     2881 agggactgct ggtgtctgag gcctgggtgg gcctaagtgg gagccaggtc tgctggacac
     2941 caccagctgc caaggcttct ctgatcctgt gcctttgggg cctgcagtct ggggttggaa
     3001 ggtatggcag agcactggga tcacatgtgc acagagcatg gggaccctgt agccacccat
     3061 gtctctttga tactgacctg ggatgagctc atagtagatt tctccatcct aggaacttgg
     3121 ggggaggtgt ggtccttctg gcctcttggc acctatctgt tcaaggggat ctcttccctc
     3181 tgaacaaccc atggataaag ggaagtgcgc tgggctcgcg agtattcatt gccttctgtt
     3241 gctgccaaga cttggtagag attccaggaa tggatggtg
//
