LOCUS       NM_001013052            1866 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus N-acetyltransferase 3 (Nat3), mRNA.
ACCESSION   NM_001013052 XM_224762
VERSION     NM_001013052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Barker,D.F., Walraven,J.M., Ristagno,E.H., Doll,M.A., States,J.C.
            and Hein,D.W.
  TITLE     Quantitative tissue and gene-specific differences and developmental
            changes in Nat1, Nat2, and Nat3 mRNA expression in the rat
  JOURNAL   Drug Metab Dispos 36 (12), 2445-2451 (2008)
   PUBMED   18799802
  REMARK    GeneRIF: Nat3 expression is at least 2 to 3 orders of magnitude
            less than that of Nat1 or Nat2 in rat tissues.
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Walraven,J.M., Barker,D.F., Doll,M.A. and Hein,D.W.
  TITLE     Tissue expression and genomic sequences of rat N-acetyltransferases
            rNat1, rNat2, rNat3, and Functional characterization of a novel
            rNat3*2 genetic variant
  JOURNAL   Toxicol Sci 99 (2), 413-421 (2007)
   PUBMED   17567587
  REMARK    GeneRIF: 10 of the 12 rat strains had reference rNat3*1 ORFs,
            strains ACI and COP had a variant rNat3*2 ORF characterized by a
            G619>T transversion (A207S).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 30, 2022 this sequence version replaced NM_001013052.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000016.1  26942482-26942642   c
            162-1866            JAXUCZ010000016.1  26916288-26917992   c
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1866
                     /gene="Nat3"
                     /note="N-acetyltransferase 3"
                     /db_xref="GeneID:290681"
                     /db_xref="RGD:1307575"
     exon            1..161
                     /gene="Nat3"
                     /inference="alignment:Splign:2.1.0"
     exon            162..1866
                     /gene="Nat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1040
                     /gene="Nat3"
                     /EC_number="2.3.1.5"
                     /codon_start=1
                     /product="arylamine N-acetyltransferase 3"
                     /protein_id="NP_001013070.2"
                     /db_xref="GeneID:290681"
                     /db_xref="RGD:1307575"
                     /translation="MDIEAYFERIGYQKSTNKLDLQTLTEILQHQIRAIPFENLNIHC
                     GKPMELSLEATFHHIVKKKRGGWCLQVNHLLYWALTMIGFEVTMLGGCVYSPPTCKYS
                     NTMIHLLLQVTISGKKYVVDSAFPFSCQMWEPLELTSGKDQPQVPAIFHLTEGNGIWY
                     LGQTKRQEFVPNQEFIDSNFLEKNKHRKIYSFTLEPRTIEDFQNVSAYYQKSPTSVMT
                     NTSLCSLHTQEGVHGLVGTILIHKKFNYKDNVDLVEFKTLKEEEIEEVLKRVFGIRLE
                     TKLVPKCGNWLFTI"
ORIGIN      
        1 actgaaacca gactgtggac gaatgccata gaggagcctg cagggctgct gcacttcagc
       61 gtcttgtcac aagaactgcc agccttcagg gaacccggac atgaaaggat cgtatcagat
      121 ggacaggctt ggctgtcacc cactcagaga gtacgcagct agagaccatg gacattgaag
      181 cgtactttga aagaattggt tatcagaagt ccacgaacaa actggacttg caaacattaa
      241 ctgaaatcct tcagcatcag atacgggcta tcccttttga gaacttgaac atccattgtg
      301 ggaaacccat ggaactgagc ttagaggcca cttttcatca cattgtgaag aagaagcggg
      361 gtgggtggtg tcttcaagtc aatcatcttc tttactgggc tctgaccatg ataggttttg
      421 aggtcacaat gttaggagga tgtgtttata gccctccaac ctgcaaatat agcaacacta
      481 tgattcacct tctactacag gtgaccatca gtggcaaaaa atatgttgta gatagtgcat
      541 tcccattttc ctgccagatg tgggagcctc tggaattgac atctggaaag gatcagcctc
      601 aggtgcctgc catcttccac ttgacagaag ggaatggaat ttggtatctg ggacaaacta
      661 aaagacaaga atttgttcca aaccaagaat tcattgattc taattttctt gagaagaaca
      721 aacatagaaa aatctactct tttactcttg aacctcgaac gattgaagat ttccagaacg
      781 tgagtgcata ctaccagaaa tctccaacat ctgtgatgac aaacacatca ctttgctccc
      841 tgcataccca agaaggggtc catggtttag taggcaccat tcttatccat aagaaattca
      901 attataagga caatgtagat cttgtggagt ttaagactct gaaggaagaa gaaatagaag
      961 aagtcctgaa gcgcgttttt ggtattcgct tggagacaaa gcttgtgccc aaatgtggta
     1021 attggctttt tactatttag agtaagaaag gagaatggtc ttcaatgttt ctatatgtac
     1081 ttattctttc atgtaaaata atcaaattat tcaaattagg tgacaaaata agaagccatg
     1141 agttattaga acaaagttct tcaacgattg actggtatca tatcaacatc tgtcccctcc
     1201 attacattaa gaaaatcata gacatacaat tgctttttct gtaagattaa ccactcaggt
     1261 aactaaatga cttttaaata aatgtgcaat taaaaatgta atcacagtaa aagtacttta
     1321 atgataatat agttattttg atatctacta taaaatcctc catgttgact cattgttgaa
     1381 ttcattcaaa ggttataatg gtagttaggt aaagtgtaca gtgaaaggtt catgttcctc
     1441 cagcaaagat tcagattaat ttttacaaca tgcccttata tgacataagg cagaaacagg
     1501 gaagaataag atttagtgtt ggttacaagt aattctgaaa ataagaatga taccagtaga
     1561 aagtactgag agatgaaaag ccatgaactt ggcacagctg gtcaggtctc gcacaatggc
     1621 cttggcagtt tcaattctgt attcatgaag tttctcaaat tgttaccatt catatttaga
     1681 gtatattact tccattaaat agtttatata taaagtagta attgtacatt atagaataca
     1741 aatcagatag aaaacacagc atgaaagaat acagttgact aaaacagtaa gaatcagaga
     1801 ttttttaaaa aaggagtagc tatattttga gtctaggtga attttccaca cttttgtctt
     1861 cttcaa
//
