LOCUS       NM_053854               1385 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus N-acetyltransferase 2 (Nat2), mRNA.
ACCESSION   NM_053854
VERSION     NM_053854.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   Stepp,M.W., Doll,M.A., Samuelson,D.J., Sanders,M.A., States,J.C.
            and Hein,D.W.
  TITLE     Congenic rats with higher arylamine N-acetyltransferase 2 activity
            exhibit greater carcinogen-induced mammary tumor susceptibility
            independent of carcinogen metabolism
  JOURNAL   BMC Cancer 17 (1), 233 (2017)
   PUBMED   28359264
  REMARK    GeneRIF: High NAT2 expression is associated with mammary tumor
            susceptibility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Kamel,A.M., Ebid,G.T. and Moussa,H.S.
  TITLE     N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of
            susceptibility to pediatric acute lymphoblastic leukemia
  JOURNAL   Tumour Biol 36 (8), 6341-6348 (2015)
   PUBMED   25804798
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Li,X., Wang,X., Li,Y., Yuan,M., Zhu,J., Su,X., Yao,X., Fan,X. and
            Duan,Y.
  TITLE     Effect of exposure to acute and chronic high-altitude hypoxia on
            the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and
            NAT2 in rats
  JOURNAL   Pharmacology 93 (1-2), 76-83 (2014)
   PUBMED   24557547
  REMARK    GeneRIF: High-altitude hypoxia decreases the activity and
            expression of CYP1A1 and NAT2, but increases that of CYP2D6.
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   Silveira,V.S., Canalle,R., Scrideli,C.A., Queiroz,R.G., Lopes,L.F.
            and Tone,L.G.
  TITLE     CYP3A5 and NAT2 gene polymorphisms: role in childhood acute
            lymphoblastic leukemia risk and treatment outcome
  JOURNAL   Mol Cell Biochem 364 (1-2), 217-223 (2012)
   PUBMED   22215203
REFERENCE   5  (bases 1 to 1385)
  AUTHORS   Potts,L.F., Cambon,A.C., Ross,O.A., Rademakers,R., Dickson,D.W.,
            Uitti,R.J., Wszolek,Z.K., Rai,S.N., Farrer,M.J., Hein,D.W. and
            Litvan,I.
  TITLE     Polymorphic genes of detoxification and mitochondrial enzymes and
            risk for progressive supranuclear palsy: a case control study
  JOURNAL   BMC Med Genet 13, 16 (2012)
   PUBMED   22424094
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1385)
  AUTHORS   Jones,R.F., Land,S.J. and King,C.M.
  TITLE     Recombinant rat and hamster N-acetyltransferases-1 and -2: relative
            rates of N-acetylation of arylamines and N,O-acyltransfer with
            arylhydroxamic acids
  JOURNAL   Carcinogenesis 17 (8), 1729-1733 (1996)
   PUBMED   8761433
REFERENCE   7  (bases 1 to 1385)
  AUTHORS   Doll,M.A. and Hein,D.W.
  TITLE     Cloning, sequencing and expression of NAT1 and NAT2 encoding genes
            from rapid and slow acetylator inbred rats
  JOURNAL   Pharmacogenetics 5 (4), 247-251 (1995)
   PUBMED   8528272
REFERENCE   8  (bases 1 to 1385)
  AUTHORS   Ebisawa,T., Sasaki,Y. and Deguchi,T.
  TITLE     Complementary DNAs for two arylamine N-acetyltransferases with
            identical 5' non-coding regions from rat pineal gland
  JOURNAL   Eur J Biochem 228 (1), 129-137 (1995)
   PUBMED   7882993
REFERENCE   9  (bases 1 to 1385)
  AUTHORS   Vatsis,K.P., Weber,W.W., Bell,D.A., Dupret,J.M., Evans,D.A.,
            Grant,D.M., Hein,D.W., Lin,H.J., Meyer,U.A., Relling,M.V. et al.
  TITLE     Nomenclature for N-acetyltransferases
  JOURNAL   Pharmacogenetics 5 (1), 1-17 (1995)
   PUBMED   7773298
  REMARK    Review article
REFERENCE   10 (bases 1 to 1385)
  AUTHORS   Kelly,S.L. and Sim,E.
  TITLE     Arylamine N-acetyltransferase in Balb/c mice: identification of a
            novel mouse isoenzyme by cloning and expression in vitro
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 347-353 (1994)
   PUBMED   7545952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U01348.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U01348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1385
                     /gene="Nat2"
                     /gene_synonym="Nat2a"
                     /note="N-acetyltransferase 2"
                     /db_xref="GeneID:116632"
                     /db_xref="RGD:70492"
     exon            1..40
                     /gene="Nat2"
                     /gene_synonym="Nat2a"
                     /inference="alignment:Splign:2.1.0"
     exon            41..315
                     /gene="Nat2"
                     /gene_synonym="Nat2a"
                     /inference="alignment:Splign:2.1.0"
     exon            316..1385
                     /gene="Nat2"
                     /gene_synonym="Nat2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1194
                     /gene="Nat2"
                     /gene_synonym="Nat2a"
                     /EC_number="2.3.1.5"
                     /EC_number="2.3.1.118"
                     /note="AT-2; NAT-2; arylamide acetylase 2;
                     N-acetyltransferase type 2; N-Acetyltransferase-2
                     (arylamine N-acetyltransferase); N-acetyltransferase 2
                     (arylamine N-acetyltransferase); N-hydroxyarylamine
                     O-acetyltransferase"
                     /codon_start=1
                     /product="arylamine N-acetyltransferase 2"
                     /protein_id="NP_446306.1"
                     /db_xref="GeneID:116632"
                     /db_xref="RGD:70492"
                     /translation="MDIEAYFERIGYQSSRNKLDLEELTEILQHQIRAIPFENLNIHC
                     GESMELNLEVIFDQVVRKKRGGWCLQVNHLLYWALTKMGFEATMLGGYVFNTPANKYS
                     SGMIHLLVQVTLSGKDYIVDAGFGRSYQMWEPLELTSGKDQPQVPAIFRLTEENGTWY
                     LDQIRREQYVPNQEFVNSDLLEKNKYRKIYSFTLEPRTIEDFESINTYLQTSPASLFT
                     SKSFCSLQTLEGVHCLVGSTLTYRRFSYKDNIDLVEFKSLTEEEIEDVLKTIFGVSLE
                     RKLVPKHGDRFFTI"
ORIGIN      
        1 cctcccacca gcttcctggt ctcaggccct gctacaccgg acatggtctt ccatctctcg
       61 gaacatttct tcaagaactc ggcgaagttg accgacgagt cgggatgctt cttcttgtgc
      121 tcctcctggc acgaagaagg cgtacgagga catcttgccc cgcggcttgt tggggtcccc
      181 cttgcccatg atgaccgcgc agcgtctacc tggcgcgagc tcttccctca gacttccaca
      241 gagagacttc cttccccaag ctccggcgag aactggtcct gagtagggtt tatataacac
      301 ttgtgcaatt gactggaaac catggacatt gaagcatact ttgaaagaat tggttatcag
      361 agttccagga acaaactgga cttggaagaa ttaactgaaa ttcttcaaca ccagatacgg
      421 gctattccct ttgaaaactt gaacatccat tgcggggaat ccatggagct gaatttagaa
      481 gtcatctttg atcaagttgt gaggaagaag cgtggtggat ggtgtctcca ggttaatcat
      541 ctgctgtact gggctctgac caaaatgggc tttgaagcca caatgttggg agggtatgtc
      601 tttaacactc cagccaataa gtacagcagt ggcatgattc acttactagt gcaggtgacc
      661 ctcagtggaa aggactacat tgttgatgct gggtttggac gttcctacca gatgtgggag
      721 cctctggaat taacatcagg gaaggatcag cctcaggtgc ctgccatctt tcgtttgaca
      781 gaagagaatg gaacctggta cttggaccaa atcagaagag agcagtatgt tccaaaccaa
      841 gagtttgtta actcagacct ccttgaaaag aacaaatatc gaaaaatcta ttcctttact
      901 cttgagcccc gcactattga ggattttgag tccattaata cctatcttca gacatcgcca
      961 gcatccttgt ttacaagtaa atcattttgt tccttgcaga ccctagaagg ggttcactgt
     1021 ttggttggct ccaccctcac ttataggaga ttcagttata aggacaatat agatcttgta
     1081 gagtttaaga gtctgactga ggaagaaata gaagacgtac tgaaaactat atttggggtt
     1141 tctttagaga gaaagcttgt gcctaaacat ggtgatcgat tttttaccat ttagaatatg
     1201 cagttttggt gtccttccat gtacttggac tttatgttaa aatgttcaaa ctggtgacaa
     1261 ggacatactt ctgaccatgt tgatgtatgc gaacaaaaac ccaccattgg cttacagcca
     1321 aatttataca gaatttgtgc taatagttaa gtaaaaggaa tagtgtgaaa agcattccca
     1381 ttcaa
//
