LOCUS       NM_001399512            3800 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus N-acetyltransferase 10 (Nat10), mRNA.
ACCESSION   NM_001399512 XM_039104927
VERSION     NM_001399512.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3800)
  AUTHORS   Xing,P., Zhou,M., Sun,J., Wang,D., Huang,W. and An,P.
  TITLE     NAT10-mediated ac4C acetylation of TFRC promotes sepsis-induced
            pulmonary injury through regulating ferroptosis
  JOURNAL   Mol Med 30 (1), 140 (2024)
   PUBMED   39251905
  REMARK    GeneRIF: NAT10-mediated ac[4]C acetylation of TFRC promotes
            sepsis-induced pulmonary injury through regulating ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3800)
  AUTHORS   Liu,D., Kuang,Y., Chen,S., Li,R., Su,F., Zhang,S., Qiu,Q., Lin,S.,
            Shen,C., Liu,Y., Liang,L., Wang,J., Xu,H. and Xiao,Y.
  TITLE     NAT10 promotes synovial aggression by increasing the stability and
            translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 83 (9), 1118-1131 (2024)
   PUBMED   38724075
  REMARK    GeneRIF: NAT10 promotes synovial aggression by increasing the
            stability and translation of N4-acetylated PTX3 mRNA in rheumatoid
            arthritis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3800)
  AUTHORS   Arango,D., Sturgill,D., Alhusaini,N., Dillman,A.A., Sweet,T.J.,
            Hanson,G., Hosogane,M., Sinclair,W.R., Nanan,K.K., Mandler,M.D.,
            Fox,S.D., Zengeya,T.T., Andresson,T., Meier,J.L., Coller,J. and
            Oberdoerffer,S.
  TITLE     Acetylation of Cytidine in mRNA Promotes Translation Efficiency
  JOURNAL   Cell 175 (7), 1872-1886 (2018)
   PUBMED   30449621
REFERENCE   4  (bases 1 to 3800)
  AUTHORS   Sharma,S., Langhendries,J.L., Watzinger,P., Kotter,P., Entian,K.D.
            and Lafontaine,D.L.
  TITLE     Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine
            acetyltransferases that modify tRNAs assisted by the adaptor
            Tan1/THUMPD1
  JOURNAL   Nucleic Acids Res 43 (4), 2242-2258 (2015)
   PUBMED   25653167
REFERENCE   5  (bases 1 to 3800)
  AUTHORS   Ito,S., Horikawa,S., Suzuki,T., Kawauchi,H., Tanaka,Y., Suzuki,T.
            and Suzuki,T.
  TITLE     Human NAT10 is an ATP-dependent RNA acetyltransferase responsible
            for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)
  JOURNAL   J Biol Chem 289 (52), 35724-35730 (2014)
   PUBMED   25411247
REFERENCE   6  (bases 1 to 3800)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 3800)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 3800)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 3800)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   10 (bases 1 to 3800)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 10, 2022 this sequence version replaced XM_039104927.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169067.1, SRR26643295.14501.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000003.1  110604657-110604829 c
            174-296             JAXUCZ010000003.1  110602046-110602168 c
            297-388             JAXUCZ010000003.1  110601594-110601685 c
            389-560             JAXUCZ010000003.1  110598595-110598766 c
            561-683             JAXUCZ010000003.1  110597249-110597371 c
            684-745             JAXUCZ010000003.1  110594775-110594836 c
            746-860             JAXUCZ010000003.1  110592941-110593055 c
            861-968             JAXUCZ010000003.1  110592735-110592842 c
            969-1102            JAXUCZ010000003.1  110589301-110589434 c
            1103-1196           JAXUCZ010000003.1  110588270-110588363 c
            1197-1295           JAXUCZ010000003.1  110588050-110588148 c
            1296-1432           JAXUCZ010000003.1  110584741-110584877 c
            1433-1557           JAXUCZ010000003.1  110580175-110580299 c
            1558-1708           JAXUCZ010000003.1  110579683-110579833 c
            1709-1805           JAXUCZ010000003.1  110579044-110579140 c
            1806-1922           JAXUCZ010000003.1  110578261-110578377 c
            1923-2024           JAXUCZ010000003.1  110577427-110577528 c
            2025-2099           JAXUCZ010000003.1  110577273-110577347 c
            2100-2216           JAXUCZ010000003.1  110576622-110576738 c
            2217-2350           JAXUCZ010000003.1  110575840-110575973 c
            2351-2399           JAXUCZ010000003.1  110575621-110575669 c
            2400-2496           JAXUCZ010000003.1  110573454-110573550 c
            2497-2607           JAXUCZ010000003.1  110573257-110573367 c
            2608-2780           JAXUCZ010000003.1  110572258-110572430 c
            2781-2900           JAXUCZ010000003.1  110571664-110571783 c
            2901-2999           JAXUCZ010000003.1  110570898-110570996 c
            3000-3073           JAXUCZ010000003.1  110570336-110570409 c
            3074-3157           JAXUCZ010000003.1  110569454-110569537 c
            3158-3800           JAXUCZ010000003.1  110566582-110567224 c
FEATURES             Location/Qualifiers
     source          1..3800
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..3800
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /note="N-acetyltransferase 10"
                     /db_xref="GeneID:311257"
                     /db_xref="RGD:1306717"
     exon            1..173
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            174..296
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..3263
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /note="N-acetyltransferase 10 (GCN5-related)"
                     /codon_start=1
                     /product="RNA cytidine acetyltransferase"
                     /protein_id="NP_001386441.1"
                     /db_xref="GeneID:311257"
                     /db_xref="RGD:1306717"
                     /translation="MHRKKVDNRIRILIENGVSERQRSLFVVVGDRGKDQVVILHHML
                     SKATVKARPSVLWCYKKELGFSSHRKKRMRQLQKKIKSGTLNIKQDDPFELFVAATNI
                     RYCYYNETHKILGNTFGMCVLQDFEALTPNLLARTVETVEGGGLVVILLRTMNSLKQL
                     YTMTMDVHSRYRTEAHQDVVGRFNERFILSLASCKKCLVIDDQLNILPISSHVASIEA
                     LPPQAPDENLSPAALELQELKESLQDTQPVGVLVDCCKTLDQAKAVLKFIEGISEKTL
                     RSTVALTAARGRGKSAALGLAIAGAVAFGYSNIFVTSPSPDNLHTLFEFVFKGFDALQ
                     YQEHLDYEIVQSLNPEFNKAVIRVNVFREHRQTIQYIHPADAVKLGQAELVVIDEAAA
                     IPLPLVKSLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRQQSAQSQVSTTAENKTTT
                     TARLASARTLHEVSLQESIRYAPGDAVEKWLNDLLCLDCLNITRIVSGCPLPEACELY
                     YVNRDTLFCYHKASEVFLQRLMALYVASHYKNSPNDLQMLSDAPAHHLFCLLPPVPPT
                     QNALPEVLAVVQVCLEGELSRQSILNSLSRGKKASGDLLPWTVSEQFQDPDFGGLSGG
                     RVVRIAVHPDYQGMGYGSRALQLLQMYYEGRFPCLEEKVLETPQEIHTVSSEAVSLLE
                     EVITPRKDLPPLLLKLNERPAERLDYLGVSYGLTPRLLKFWKRAGFVPVYLRQTPNDL
                     TGEHSCIMLKTLADEDEAERGAWLAAFWTDFRRRFLALLSYQFSTFSPALSLNIIQNR
                     NIAKSAPPVLGREHLEALFLPYDLKRLEMYSRNMVDYHLIMDLIPAISRLYFLNQLGD
                     LALSAAQSALLLGMGLQHKSVDQLEKEIELPSGQLMGLFNRIIRKVVKLFNDVQEKAI
                     EEQMVAVKDVVMEPTIKTLSDDLDEAAKEFQEKHKKDVGKLKDMDLSQYIIRGDDEEW
                     NEVLSKAGQNASIVSLKSDKKRKLETKQEPKQSKKLKKSGNNRKDTKLKRKK"
     exon            297..388
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            389..560
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            561..683
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            684..745
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            746..860
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            861..968
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1102
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1196
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1295
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1432
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1557
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1708
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1805
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1922
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2024
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2099
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2216
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2350
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2399
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2496
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2607
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2780
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2900
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..2999
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3073
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3157
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3800
                     /gene="Nat10"
                     /gene_synonym="RGD1306717"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgctagc ccacgtgctg ccacttgagc ggattcccgt gcagcgtcgg ccccttggcg
       61 agctcagctg tgcagcgttt tctccagcaa acctgtcagc ctgcgtggca gctcggtgtc
      121 ctcacgtgca ttcattgtgc gactgcctga ggtccgccgt gccggggacg cagtgatagt
      181 ctttcaccat gcatcggaag aaggtggata accgaattcg aattctcatt gagaatggcg
      241 tatctgagcg gcagaggtct ctttttgttg tagttggaga tcgaggaaaa gatcaggtgg
      301 ttattcttca tcatatgttg tccaaagcaa ctgtgaaggc tcggccctct gtcctgtggt
      361 gttacaagaa agagctggga tttagcagtc atcggaagaa gagaatgcgg cagctacaga
      421 agaagataaa gagtgggacc ttgaacataa agcaagatga cccctttgag ctttttgtag
      481 cagccacaaa cattcgctac tgctactaca atgaaaccca caagattctg ggcaacactt
      541 ttggcatgtg tgtcctccag gactttgaag cattaactcc aaacttgttg gccagaactg
      601 tagaaacagt agaaggtggt ggattggtgg tcatcctctt acggaccatg aactcgctta
      661 agcagctgta cacaatgact atggatgtgc actccaggta caggaccgag gcccatcagg
      721 acgtggtggg aaggtttaac gagaggttta ttctctctct ggcatcttgt aagaagtgtc
      781 tggtcattga tgaccaactc aatatcctgc ccatctcctc ccatgtggcc agcattgaag
      841 ccttacctcc tcaggccccc gatgagaatc tcagtcctgc tgctctggag ctgcaggagt
      901 tgaaagagag cttgcaggac actcagcccg tgggtgtttt ggtggactgc tgcaagaccc
      961 tggaccaggc caaagctgtc ttgaaattca ttgaggggat ctcggagaag accctaagga
     1021 gtactgttgc cctcaccgct gcccgaggac ggggcaagtc tgcggccctg ggcctggcta
     1081 ttgctggggc agtggcattc ggatattcca atatttttgt cacctcccca agcccagata
     1141 acctccacac cctgtttgaa tttgtattta aggggtttga tgctctgcag tatcaggagc
     1201 acctggacta cgagattgta cagtcgctga accccgagtt taataaagcg gtgatcaggg
     1261 taaatgtgtt ccgagagcac aggcagacta tccagtacat ccatcctgca gatgctgtga
     1321 aactgggcca ggctgagctg gttgtgatag atgaagctgc cgctattccc ctccccctgg
     1381 tgaagagctt gcttgggccc tacctggttt tcatggcatc tactatcaat ggctacgagg
     1441 gcactggccg gtcactttcc ctcaaactca tccagcaact ccgtcagcag agtgcccaga
     1501 gccaggtcag caccactgct gagaacaaga ccacgacgac agccagattg gcctcagctc
     1561 ggacattgca tgaggtttcc ctccaagagt caatccggta cgcccctggg gatgcagtgg
     1621 agaagtggct gaatgacctg ctgtgcctgg attgcctcaa catcacccgc atcgtttccg
     1681 gctgcccctt gcctgaggcc tgtgagctct actatgttaa cagagatacc ctcttttgct
     1741 accacaaggc ttctgaggtt tttctgcaga ggctcatggc tctctatgtg gcttcgcatt
     1801 acaagaactc tcccaacgat ctgcagatgc tctcggatgc acctgctcac cacctcttct
     1861 gccttctgcc acctgtgccc cctacccaga atgccctgcc cgaagtgctt gcagttgtcc
     1921 aggtgtgcct tgaaggagag ctttctcgtc agtccatttt gaatagcctg tctagaggca
     1981 aaaaggcttc tggggacctg cttccatgga ctgtgtcaga acagtttcag gatccagact
     2041 ttggaggcct ttctggtgga cgggttgttc gaattgctgt acatccagat taccaaggga
     2101 tgggctacgg cagccgagca ctgcagctgc tgcagatgta ctacgaaggc aggttcccgt
     2161 gtctggagga aaaggtcttg gagacaccac aagaaatcca caccgtgagc agtgaggccg
     2221 tcagcttgtt ggaagaagtt atcactcccc ggaaggatct gcctccctta ctcctcaagt
     2281 tgaatgagag gcctgcagag cgcctagatt atctgggggt ttcctatggg ctgaccccca
     2341 ggctcctcaa gttctggaaa cgagctggat ttgttcctgt ctatttgaga cagaccccaa
     2401 atgacctgac tggagagcac tcctgcatta tgctgaagac actggctgat gaggatgagg
     2461 cggagcgggg agcttggctg gcagcatttt ggaccgattt ccgaagacgg ttcctggccc
     2521 tgctgtctta ccagttcagc accttctctc ctgccctgtc tctgaacatc attcagaaca
     2581 ggaacatagc gaagtcagcc ccaccagtcc taggccggga gcatctggag gccctcttcc
     2641 tcccctatga cctgaagcgg ctggagatgt actctcggaa catggtcgat tatcacctca
     2701 tcatggacct tatcccagcc atttcccgcc tgtacttcct caaccagcta ggggacctgg
     2761 cattgtcagc cgcccagtcg gctcttctcc tgggaatggg cctacagcac aagtccgtgg
     2821 atcagctgga aaaggagatc gagctaccct caggccagtt gatggggctt ttcaaccgga
     2881 tcatccgcaa agtcgtgaag ctgttcaatg atgtgcagga aaaggctatt gaggagcaga
     2941 tggtggcagt gaaggatgtg gtcatggagc ctacgataaa gacgctgagt gatgacctgg
     3001 atgaagcagc aaaggaattc caggagaaac acaagaagga cgtggggaag ctgaaggaca
     3061 tggacctctc tcaatatata atccgtggcg atgatgaaga gtggaatgaa gttttgagca
     3121 aagcagggca gaatgcctcc attgttagtt tgaaaagtga caagaaaagg aaactggaaa
     3181 caaaacaaga acccaaacag agcaagaagt tgaagaagag cggtaacaac agaaaggaca
     3241 cgaaactgaa gagaaagaag tagtgaggcg agtggatgcc agacttctga gctgtgttct
     3301 gctggccagg cagcagcgtg ggcagcgaca gtaccgaggg gcttcagcag aggcaggcac
     3361 catctgcacg cccgccatgg ctggacacaa tcactcccga acagtctgct tagacttggt
     3421 gctgggcaaa gctctggcat tgtcaggggc tgtccgccac tgccccaggt cacagtttca
     3481 ctttcgcttg ttccggctgt gaccttcctg ccctccagca cacagctttc tggaggagtg
     3541 ctctgtctca ctacagactt gccctgacac tcagaggccc agggcagtgg gacctctcct
     3601 gctcttctgg tccatcccgc ctgcggcagg tctgctgtcc tcggggtccc aggaaagtct
     3661 gaggccctta ggtaggctgc aacagctgag ccccaaacgc cttttggttg cctcttcgtt
     3721 tgggagagac tatcaagaga gactgttgct atgcaagtga ggggagagag tatttttaat
     3781 acatgacatc ttggaaaggc
//
