LOCUS       NM_001037316            1705 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus N-acetyltransferase 1 (Nat1), transcript variant
            3, mRNA.
ACCESSION   NM_001037316
VERSION     NM_001037316.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Liu,Y.J., Meng,F.T., Wang,L.L., Zhang,L.F., Cheng,X.P. and
            Zhou,J.N.
  TITLE     Apolipoprotein E influences melatonin biosynthesis by regulating
            NAT and MAOA expression in C6 cells
  JOURNAL   J Pineal Res 52 (4), 397-402 (2012)
   PUBMED   22225631
  REMARK    GeneRIF: A higher level of melatonin was demonstrated in cultured
            ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in
            ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB
            expression decreased in ApoE4-C6 cells.
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Potts,L.F., Cambon,A.C., Ross,O.A., Rademakers,R., Dickson,D.W.,
            Uitti,R.J., Wszolek,Z.K., Rai,S.N., Farrer,M.J., Hein,D.W. and
            Litvan,I.
  TITLE     Polymorphic genes of detoxification and mitochondrial enzymes and
            risk for progressive supranuclear palsy: a case control study
  JOURNAL   BMC Med Genet 13, 16 (2012)
   PUBMED   22424094
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1705)
  AUTHORS   Blomeke,B., Brans,R., Coenraads,P.J., Dickel,H., Bruckner,T.,
            Hein,D.W., Heesen,M., Merk,H.F. and Kawakubo,Y.
  TITLE     Para-phenylenediamine and allergic sensitization: risk modification
            by N-acetyltransferase 1 and 2 genotypes
  JOURNAL   Br J Dermatol 161 (5), 1130-1135 (2009)
   PUBMED   19663877
REFERENCE   4  (bases 1 to 1705)
  AUTHORS   Dai,Y., Leng,S., Li,L., Niu,Y., Huang,H., Liu,Q., Duan,H.,
            Cheng,J., Liu,Q. and Zheng,Y.
  TITLE     Effects of genetic polymorphisms of N-Acetyltransferase on
            trichloroethylene-induced hypersensitivity dermatitis among exposed
            workers
  JOURNAL   Ind Health 47 (5), 479-486 (2009)
   PUBMED   19834256
REFERENCE   5  (bases 1 to 1705)
  AUTHORS   Barker,D.F., Walraven,J.M., Ristagno,E.H., Doll,M.A., States,J.C.
            and Hein,D.W.
  TITLE     Quantitative tissue and gene-specific differences and developmental
            changes in Nat1, Nat2, and Nat3 mRNA expression in the rat
  JOURNAL   Drug Metab Dispos 36 (12), 2445-2451 (2008)
   PUBMED   18799802
  REMARK    GeneRIF: Results demonstrate differential tissue-specific and
            developmental regulation of the rat Nat1 and Nat2 genes.
REFERENCE   6  (bases 1 to 1705)
  AUTHORS   Jones,R.F., Land,S.J. and King,C.M.
  TITLE     Recombinant rat and hamster N-acetyltransferases-1 and -2: relative
            rates of N-acetylation of arylamines and N,O-acyltransfer with
            arylhydroxamic acids
  JOURNAL   Carcinogenesis 17 (8), 1729-1733 (1996)
   PUBMED   8761433
REFERENCE   7  (bases 1 to 1705)
  AUTHORS   Ebisawa,T., Sasaki,Y. and Deguchi,T.
  TITLE     Complementary DNAs for two arylamine N-acetyltransferases with
            identical 5' non-coding regions from rat pineal gland
  JOURNAL   Eur J Biochem 228 (1), 129-137 (1995)
   PUBMED   7882993
REFERENCE   8  (bases 1 to 1705)
  AUTHORS   Vatsis,K.P., Weber,W.W., Bell,D.A., Dupret,J.M., Evans,D.A.,
            Grant,D.M., Hein,D.W., Lin,H.J., Meyer,U.A., Relling,M.V. et al.
  TITLE     Nomenclature for N-acetyltransferases
  JOURNAL   Pharmacogenetics 5 (1), 1-17 (1995)
   PUBMED   7773298
  REMARK    Review article
REFERENCE   9  (bases 1 to 1705)
  AUTHORS   Kelly,S.L. and Sim,E.
  TITLE     Arylamine N-acetyltransferase in Balb/c mice: identification of a
            novel mouse isoenzyme by cloning and expression in vitro
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 347-353 (1994)
   PUBMED   7545952
REFERENCE   10 (bases 1 to 1705)
  AUTHORS   Omura,G.A.
  TITLE     Combination therapy with 5-azacytidine plus
            beta-2'-deoxythioguanosine in adult acute leukemia
  JOURNAL   Cancer Treat Rep 61 (5), 915-917 (1977)
   PUBMED   70273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001037316.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078765.1, CK472095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN16676811
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000016.1  26989141-26989214   c
            75-1705             JAXUCZ010000016.1  26984897-26986527   c
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1705
                     /gene="Nat1"
                     /gene_synonym="Nat"
                     /note="N-acetyltransferase 1"
                     /db_xref="GeneID:116631"
                     /db_xref="RGD:70490"
     exon            1..74
                     /gene="Nat1"
                     /gene_synonym="Nat"
                     /inference="alignment:Splign:2.1.0"
     exon            75..1705
                     /gene="Nat1"
                     /gene_synonym="Nat"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..953
                     /gene="Nat1"
                     /gene_synonym="Nat"
                     /EC_number="2.3.1.5"
                     /note="AT-1; NAT-1; arylamide acetylase 1;
                     N-acetyltransferase type 1; N-acetyltransferase 1
                     (arylamine N-acetyltransferase); N-acetyltransferase
                     (arylamine N-acetyltransferase)"
                     /codon_start=1
                     /product="arylamine N-acetyltransferase 1"
                     /protein_id="NP_001032393.1"
                     /db_xref="GeneID:116631"
                     /db_xref="RGD:70490"
                     /translation="MDIEAYFERIGYKNSVNKLDLATLTEVLQHQMRAVPFENLSMHC
                     GEAMCLGLEATFDHIVRKKRGGWCLQVNHLLYWALTKMGFETTMLGGYVYITPVNKYS
                     SEMVHLLVQVTISDRNYIVDSAYGSSYQMWEPLELTSGKDQPQVPAIFRLTEENGTWY
                     LDQIRREQDVPNQEFVNSDLLEKSKYRKIYSFTLEPRTIEDFEYVNTYLQTSPASVFV
                     STSFCSLQTSEGVCCLIGSTLTSRRFSYKDNVDLVEFKSLTEEEIEDVLKTTFGISLE
                     KKFVPKHGELVFTI"
ORIGIN      
        1 gttttcacca agaagaagaa acattctaag acattaaacc tgacaaccag cctacataca
       61 acttagtact acagggagcc atggacatcg aagcatactt cgaaaggatt ggttacaaga
      121 actcagtgaa taagttggac ttggccacat taactgaagt tcttcaacac cagatgcgag
      181 cagttccttt tgagaatctt agtatgcact gtggagaagc catgtgtctg ggcttagagg
      241 ccacttttga ccacatagta aggaaaaagc ggggtgggtg gtgtctccag gttaatcatc
      301 tgctgtactg ggctctgacc aaaatgggtt ttgaaaccac aatgttggga ggatatgttt
      361 acataactcc agtcaacaaa tatagcagtg aaatggtcca ccttctagta caagtgacca
      421 tcagtgacag gaactacatt gtggattctg cctatggaag ctcctaccag atgtgggagc
      481 ctctggaatt aacctcaggg aaggatcagc ctcaggtgcc tgccatcttt cgtttgacag
      541 aagagaatgg aacctggtac ttggaccaaa tcagaagaga gcaggatgtt ccaaaccaag
      601 agtttgttaa ctcggacctc cttgaaaaga gcaaatatcg aaaaatctat tcctttactc
      661 ttgagccccg cactattgag gattttgaat atgtgaatac ctaccttcag acatcgccag
      721 cctctgtgtt tgtaagcaca tcgttctgtt ccttgcagac ctcagaaggg gtttgctgtt
      781 taattggttc cacccttaca agtaggagat tcagttataa ggacaatgta gatctggttg
      841 agtttaagag tctgactgag gaagaaatag aagatgtact gaaaaccaca tttggcattt
      901 ctttggagaa aaagtttgtg cccaaacatg gcgaactcgt ttttactatt tagggtaaat
      961 tgttctccat tattatctca gtcttaaaca ttctaaaaat atgcaaatac atatccataa
     1021 cagaaatcgc acagctcaat attgatcaac taatgacctg tatcttctat ttcctacatt
     1081 ttatacaaaa cgaaacccag ttgtcctgtc atttcaccaa taaaaatacc gccagttata
     1141 atgaaataaa cctgatcatg gatgtaacga caatcctctc aacattaatc aacaaaaatt
     1201 acttatcgaa gaggtggcga tcttgggagc catattcatt tacaaacctc tcaacatcat
     1261 tttatggttg aactcagatg aaaaatgaat gaatatgaat gatcagagaa cagcaggaag
     1321 taaagtcagg cagactaaat ctgaggtcca aggtttacaa gaaaccaccc gtacaactta
     1381 ggattagaat aaagcaaaga agaatgaacc atcattacag gtccaggtaa cttcccagtc
     1441 ctcaaaacag aactcacgcc agtggacctg ggctctggga ttaggtgcca agacaatgac
     1501 acggcttaga aggcttagaa tttcttccag agataatttt gcagacacag ttctttttgt
     1561 atctgatttt tttttaacta tgagaatact ggtattaagt gatttatacc ttatatataa
     1621 taatctttgt agcctataat atatgtttct tggaaaaaca ttatttgtca agtatattaa
     1681 gtgttaaata tatattaaca ttata
//
