LOCUS       NM_001005543            2627 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus nuclear autoantigenic sperm protein (Nasp), mRNA.
ACCESSION   NM_001005543 XM_216505
VERSION     NM_001005543.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2627)
  AUTHORS   Zhang,M., Liu,H., Gao,Y., Zhu,Z., Chen,Z., Zheng,P., Xue,L., Li,J.,
            Teng,M. and Niu,L.
  TITLE     Structural Insights into the Association of Hif1 with Histones
            H2A-H2B Dimer and H3-H4 Tetramer
  JOURNAL   Structure 24 (10), 1810-1820 (2016)
   PUBMED   27618665
REFERENCE   2  (bases 1 to 2627)
  AUTHORS   Kato,D., Osakabe,A., Tachiwana,H., Tanaka,H. and Kurumizaka,H.
  TITLE     Human tNASP promotes in vitro nucleosome assembly with histone H3.3
  JOURNAL   Biochemistry 54 (5), 1171-1179 (2015)
   PUBMED   25615412
REFERENCE   3  (bases 1 to 2627)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   4  (bases 1 to 2627)
  AUTHORS   Ma,W., Xie,S., Ni,M., Huang,X., Hu,S., Liu,Q., Liu,A., Zhang,J. and
            Zhang,Y.
  TITLE     MicroRNA-29a inhibited epididymal epithelial cell proliferation by
            targeting nuclear autoantigenic sperm protein (NASP)
  JOURNAL   J Biol Chem 287 (13), 10189-10199 (2012)
   PUBMED   22194605
  REMARK    GeneRIF: an increase of miR-29a, and hence decrease of Nasp, may
            contribute to inhibit cell proliferation during postnatal organ
            development.
REFERENCE   5  (bases 1 to 2627)
  AUTHORS   Stanton,P.G., Sluka,P., Foo,C.F., Stephens,A.N., Smith,A.I.,
            McLachlan,R.I. and O'Donnell,L.
  TITLE     Proteomic changes in rat spermatogenesis in response to in vivo
            androgen manipulation; impact on meiotic cells
  JOURNAL   PLoS One 7 (7), e41718 (2012)
   PUBMED   22860010
REFERENCE   6  (bases 1 to 2627)
  AUTHORS   Wang,M., Shi,J.L., Cheng,G.Y., Hu,Y.Q. and Xu,C.
  TITLE     The antibody against a nuclear autoantigenic sperm protein can
            result in reproductive failure
  JOURNAL   Asian J Androl 11 (2), 183-192 (2009)
   PUBMED   19219058
  REMARK    Erratum:[Asian J Androl. 2009 Jul;11(4):492]
REFERENCE   7  (bases 1 to 2627)
  AUTHORS   Richardson,R.T., Alekseev,O.M., Grossman,G., Widgren,E.E.,
            Thresher,R., Wagner,E.J., Sullivan,K.D., Marzluff,W.F. and
            O'Rand,M.G.
  TITLE     Nuclear autoantigenic sperm protein (NASP), a linker histone
            chaperone that is required for cell proliferation
  JOURNAL   J Biol Chem 281 (30), 21526-21534 (2006)
   PUBMED   16728391
REFERENCE   8  (bases 1 to 2627)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 2627)
  AUTHORS   Alekseev,O.M., Bencic,D.C., Richardson,R.T., Widgren,E.E. and
            O'Rand,M.G.
  TITLE     Overexpression of the Linker histone-binding protein tNASP affects
            progression through the cell cycle
  JOURNAL   J Biol Chem 278 (10), 8846-8852 (2003)
   PUBMED   12509435
REFERENCE   10 (bases 1 to 2627)
  AUTHORS   Richardson,R.T., Batova,I.N., Widgren,E.E., Zheng,L.X.,
            Whitfield,M., Marzluff,W.F. and O'Rand,M.G.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081913.1.
            
            [WARNING] On Mar 19, 2025 this sequence was replaced by
            NM_001005543.2.
            
            On Oct 8, 2004 this sequence version replaced XM_216505.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2627
                     /gene="Nasp"
                     /note="nuclear autoantigenic sperm protein"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
     exon            1..126
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            127..224
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..2496
                     /gene="Nasp"
                     /note="nuclear autoantigenic sperm protein
                     (histone-binding)"
                     /codon_start=1
                     /product="nuclear autoantigenic sperm protein"
                     /protein_id="NP_001005543.1"
                     /db_xref="GeneID:298441"
                     /db_xref="RGD:1359609"
                     /translation="MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAK
                     KLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARME
                     NGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAE
                     GQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIP
                     GLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETS
                     EDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLS
                     GQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSE
                     TKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANE
                     ETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWD
                     MLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEA
                     HDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYE
                     KEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMI
                     ASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSG
                     NEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC"
     exon            225..272
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            273..383
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            384..464
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            465..574
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            575..1555
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1635
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1721
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1795
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1984
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2151
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2208
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2286
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2415
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2603
                     /gene="Nasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagacctg tcaccttctc gggtatcccc gtcagaaaga aaccctcggg actacttttt
       61 ccacagtcgc agagactcac tggttccact taattgtgga atctctaggc tggctcccat
      121 tcagaagcag tatactgccc actggcccac cacctcaggg gaacgatggc cacagagtct
      181 acagccactg ctgccatcgc cgcggaactg gtttccgctg acaaagttga agatgctcct
      241 gctccttcta cctctgcaga taaaatggag agtctggatg tggatagtga agctaagaaa
      301 ctactgggat taggacagaa acatctggtg atgggtgaca ttccagcagc tgttaatgca
      361 ttccaagaag cagctagtct tttaggtaag aagtatggag aaacggctaa tgagtgtgga
      421 gaagccttct ttttttatgg gaagtcactt ctggagttgg ccagaatgga gaatggagtg
      481 ttgggaaatg ccttagaagg agtgcatgta gaagaggaag aaggagaaaa aacagaagat
      541 gaatctttgg tagaaaataa tgataatgta gatgaggaag caagggaaga gttgagagaa
      601 caggtttatg acgccatggg agaaaaagaa gccaaaaaag cagaaggcca gtctctgaca
      661 aagcctgaaa ctgataaaga acaggaaagt gaagtggaga agggtggaag agaagatatg
      721 gatataagtg agcctgcaga gaagctccag gaaaaagttg aatcgacttc aaagcagtta
      781 actgaatcct ctgaagaggc aaaagaagca gcaataccag gactgaatga agatgaggtc
      841 acttctggga agacagaaca ggaatcattg tgtactgagg aaggaaaatc catttctgga
      901 gtttatgttc aaaataaaga attcagagaa gcagtgcctc aggaggaggg agaggaaatg
      961 ataagcttag aaaaaaagcc aaaagaaact tcagaagatc agactattgg ggctccagaa
     1021 aagcaggaca ctttaatgaa ggtggtagaa atagaagctg aaatagactc tgaagtcaag
     1081 tcagtggatg tgggtgggga ggagccgaag gatcagggag ctatctctga gagtgaacta
     1141 ggaaaggctg ttcttatgca actctcaggg caagatgttg aagtatcacc agtagtggct
     1201 gcagaggctg gatcagaagt ctctgagaag ccagggcagg agattacagt tcttcccaac
     1261 aatggtccag ttgttggaca atcatctgca ggagatcaaa ctcctagtga accacagaat
     1321 tctgcagaaa gactgtcaga aactaaagat ggcgcaagtg tagaggaggt caaggcagag
     1381 ctggttcctg aacaggagga agctatgcct cctgtagaag agtctgaggc agctggagat
     1441 ggggttgaga ccaaggtagc ccagagggcc acggagaaag cacctgaaga caaatttaag
     1501 atagctgcta atgaagagac acaagagaga gacgaacaga tgaaagaggg tgaagaaact
     1561 gaaggctcag aggaagaaga caaagaaaat gacaaggctg aagaaacaac aaatgaatca
     1621 gttcttgaaa aaaagactct tcaagaaaat gaagaagagg agattgggaa tttagaactt
     1681 gcctgggata tgctagattt agccaagatt atttttaaga ggcaagaaac aaaagaagcc
     1741 cagctttatg ctgcacaagc ccatcttaaa cttggagaag ttagtgttga atctgagaat
     1801 tatatccaag ctgtggagga gtttcaggct tgcctaagcc tgcaagagca gtatttggaa
     1861 gctcacgatc gtctccttgc ggagactcac taccagttgg gtttggccta tggttacaac
     1921 tctcagtatg atgaggctgt agcacagttt ggcaaatcta ttgacgtcat tgagaagaga
     1981 atggctgtac tacttgagca gatgaaggag gctgaaggat catttactga atacgagaaa
     2041 gaaatcgagg agctgaaaga actgctcccc gagattcggg agaagataga ggatgcaaag
     2101 gagtctcagc ggagtgggaa tgtagctgag ctggctctga aggccactct ggtcgagagc
     2161 tctacttcag gtttcactcc tagtggagct ggtgcctcgg tatccatgat tgccagtaga
     2221 aaaccaacag atggcgcttc ctcatcaaac tgtgtcactg atatttctca tcttgtcaga
     2281 aagaagagga aaccagagga agagagtccc cggaaagatg atgcaaagaa agctaaacca
     2341 gaaccagagg tgaatggagg cagtggagat gctgtctcca gtggaaatga agtttcagaa
     2401 aacatggagg cagaggctga gaatcaggct gagagccaga caacagcaga agggacagtg
     2461 gactctgcag ctacagttaa aagcactgca tgttaagagg cgagcagaac cttcctcctg
     2521 agggaaagtg gttttgtaca taatgtattt tttcactttt ggggattctt tttgtataac
     2581 tccaataaag attgtaggca acaaaaaaaa aaaaaaaaaa aaaaaaa
//
