LOCUS       NM_001398738            3029 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus asparaginyl-tRNA synthetase 2, mitochondrial
            (Nars2), transcript variant 1, mRNA.
ACCESSION   NM_001398738 XM_039105947
VERSION     NM_001398738.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3029)
  AUTHORS   Simon,M., Richard,E.M., Wang,X., Shahzad,M., Huang,V.H.,
            Qaiser,T.A., Potluri,P., Mahl,S.E., Davila,A., Nazli,S.,
            Hancock,S., Yu,M., Gargus,J., Chang,R., Al-Sheqaih,N., Newman,W.G.,
            Abdenur,J., Starr,A., Hegde,R., Dorn,T., Busch,A., Park,E., Wu,J.,
            Schwenzer,H., Flierl,A., Florentz,C., Sissler,M., Khan,S.N., Li,R.,
            Guan,M.X., Friedman,T.B., Wu,D.K., Procaccio,V., Riazuddin,S.,
            Wallace,D.C., Ahmed,Z.M., Huang,T. and Riazuddin,S.
  TITLE     Mutations of human NARS2, encoding the mitochondrial
            asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh
            syndrome
  JOURNAL   PLoS Genet 11 (3), e1005097 (2015)
   PUBMED   25807530
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 22, 2021 this sequence version replaced XM_039105947.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.2635.1,
                                           SRR26643297.2625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               JAXUCZ010000001.1  160711717-160712120
            405-514             JAXUCZ010000001.1  160718415-160718524
            515-635             JAXUCZ010000001.1  160720647-160720767
            636-776             JAXUCZ010000001.1  160722302-160722442
            777-857             JAXUCZ010000001.1  160735932-160736012
            858-952             JAXUCZ010000001.1  160758360-160758454
            953-1085            JAXUCZ010000001.1  160777979-160778111
            1086-1184           JAXUCZ010000001.1  160785053-160785151
            1185-1222           JAXUCZ010000001.1  160785260-160785297
            1223-1289           JAXUCZ010000001.1  160789215-160789281
            1290-1427           JAXUCZ010000001.1  160793724-160793861
            1428-1525           JAXUCZ010000001.1  160815810-160815907
            1526-1552           JAXUCZ010000001.1  160818027-160818053
            1553-3029           JAXUCZ010000001.1  160821835-160823311
FEATURES             Location/Qualifiers
     source          1..3029
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3029
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /note="asparaginyl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:293128"
                     /db_xref="RGD:1305145"
     exon            1..404
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1697
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /EC_number="6.1.1.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Nars2, similar to CG6796-PA; probable asparaginyl-tRNA
                     synthetase, mitochondrial; probable asparagine--tRNA
                     ligase, mitochondrial; asparaginyl-tRNA synthetase 2
                     (mitochondrial)(putative)"
                     /codon_start=1
                     /product="asparaginyl-tRNA synthetase isoform 1"
                     /protein_id="NP_001385667.1"
                     /db_xref="GeneID:293128"
                     /db_xref="RGD:1305145"
                     /translation="MLGARRLLGALRLCSSVSCPRPRATAKLRVRDALGVQDASGECV
                     TVQGWIRSVRSQKEVLFLHVNDGSSLESLQVVADSSFDSRELAFGSSVQVQGQLVKSQ
                     SKRQNVELKAEKIEVVGTCEAKAFPIKYKERHPLEYLRQYPHLRCRTNALGSILRVRS
                     EATAAIHSYFKDNGFMHIHTPVLTSNDCEGAGELFQVEPSSKIKVPEENFFDVPAFLT
                     VSGQLHLEVMSGAFTQVFTFGPTFRAENSQSRRHLAEFYMVEAEVSFVESLQDLMQVM
                     EGLFKATTEMVLSHCPEDVELCHQFIASGQKDRLEHMLKNNFLIISYAEAIEILKQAS
                     QNFTFTPKWGVDLQTEHEKYLVRHCGNIPVFVINYPSELKPFYMRENEDDPQNTVAAV
                     DLLVPGVGELFGGSLREERYHVLEQRLARSGLTKAYQWYLDLRKFGSVPHGGFGMGFE
                     RYLQCILGVDNIKDVIPFPRFTHSCLL"
     exon            405..514
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            515..635
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            636..776
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            777..857
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            858..952
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1085
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1184
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1222
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1289
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1427
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1525
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1552
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..3029
                     /gene="Nars2"
                     /gene_synonym="RGD1305145"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgtaacg tgctttaact ctgggtatgg gctctggacc cacctacact gtaacatagg
       61 tctccgtgtt cggtgtagta gaaccttctg tgctttcggg agctggacgc ggaggagggc
      121 tcctgcagga acggcttggg gcgcggaggg aagagcgacc cgagagcctg acggcaggac
      181 tgtgcgggtg aagaaagctg ctctggcgga ctgcgagccg gaacgtaccc cggccgtccc
      241 ttggatctct ggccggtctc accatgctcg gggcccggcg cctgctcgga gcgctgcgcc
      301 tctgttcctc tgtttcctgc cccaggcccc gcgcgactgc caaactgcgc gtgcgggacg
      361 ctcttggggt ccaggacgcg agtggggagt gcgtaacggt gcaggggtgg atccggtcag
      421 tcagatccca gaaggaagtt ttgttcctgc atgtaaatga cggctcttct ttggaaagtc
      481 ttcaggttgt tgcagattca agcttcgaca gtagagaatt ggcttttggg agttctgtgc
      541 aagtccaagg gcagctggtc aaaagtcagt ccaagaggca aaatgtggaa ctgaaggcag
      601 agaagattga agttgttgga acctgtgaag ccaaggcatt tcctataaag tataaggaga
      661 ggcatcctct ggagtacctg agacagtacc ctcacctgag gtgtcggact aatgctctgg
      721 gttccatact gagagtccgc agtgaagcca cagctgctat tcattcctac tttaaggaca
      781 acggcttcat gcacatccat accccagtcc tcacgtccaa tgactgtgag ggggccggag
      841 agctctttca agtggagcct tcaagcaaaa taaaggtacc cgaggagaat ttctttgatg
      901 ttcctgcttt cttaactgtc tcaggacaac ttcacctaga agtgatgtca ggagctttta
      961 cccaagtgtt taccttcggc ccaacgttcc gagctgagaa ttcgcagagc cggagacacc
     1021 tggctgaatt ctatatggtc gaagccgagg tttcttttgt tgaaagcctt caggatctca
     1081 tgcaggtcat ggaaggactc ttcaaggcca ccaccgagat ggttctctca cactgtcctg
     1141 aagatgttga actgtgtcac cagttcatag cttctggcca gaaggacaga ctagaacata
     1201 tgctaaaaaa caacttccta atcatctctt atgcagaagc aattgagatc ttaaagcaag
     1261 catcccagaa cttcaccttt acacccaagt ggggtgttga tctacaaact gaacatgaga
     1321 agtacctggt gagacactgt ggcaacatac cagtctttgt cattaactat ccatcagaac
     1381 tcaagccctt ctacatgcgg gagaatgaag atgatcctca gaacacagtt gctgctgtag
     1441 atcttctggt tcctggagtt ggggagctct ttggaggtag cctcagggag gaacggtacc
     1501 atgtcctaga gcagcgacta gcaagatcag gacttacgaa agcctatcag tggtacctgg
     1561 accttcgcaa gtttggatct gtgccgcatg gaggcttcgg gatgggattt gaacgctact
     1621 tacaatgtat cctaggagtt gacaatatca aagatgttat cccttttcca agatttactc
     1681 attcgtgtct tttgtagctg aaagattgtt taatgagaag ttctccatgg ccatgagtat
     1741 gtatggagaa gactgggggt ctgtgttctg gaaatgtgga gttcagggca caattcataa
     1801 tatatgaaaa atacaaatgg tcttgatcac cttgaggagt caaaggcttt tcatggacaa
     1861 actcctgcaa ggagaaatac taagagcaag tgggctctca aatccgttac ctaagttaag
     1921 aagaaagcag tagtggcagg gctgtccggc cactggagga gctggcacag gagagtaact
     1981 tgagcctggg taacatctca agaaagaaga aaggaagaca tggaggtgta gacactcaga
     2041 gtgcctgatg gtcctgcctc accttgcttc agatcttggt agctcacttc cctttggttt
     2101 gttttgtttt tggttttttt tgggggggga ggggttgttt tggtttttaa acaactagtg
     2161 gctaaaaaat aaggtgatgc cgaccctttt ctcccttgcc atttaaacca acaacgccag
     2221 tcttactctc ggtgctttac tcagcttcat agaagaaaat attccttttc agggtctaaa
     2281 tcaattaatg aagtggctat tctgaattga aatattcatc attgagtagt gaaaaaaatc
     2341 acatttaata actgttgatc tttagtttta aaagttaaag agctaacatt aaccatttaa
     2401 acttgtcaat cattgttcta gttcatttat attagatgtt tataatattt ttaatagtca
     2461 ttaaaatgct tttctaagtt gatacctatg aaagaagtta tttttaaatt cctcttgatc
     2521 ctttccccat gaaatctgga agaaagatat ctttaatcaa aggtggtatt ggaaatgtgg
     2581 ccaaatctac aagatgggta attttagaat atggtgtggc ctggtagact gtgactggtg
     2641 ccacttttga gtgctcaaga tctgagactt ctaacacctt ggacaacacc acttgctttg
     2701 tataggctga aacatcattt cttcagagct gttacagtac ttggacacac ttgtatttgt
     2761 gtgtatctga aatcatgctt gaactggaaa tgcaactcag gtagagcatt ggcctagcat
     2821 ggcaaatgcg ctctgggttt gatccgaggc gtgggtagga cttgggggtg tcatgctgtt
     2881 aaagctcttg acttgtttta gtcttcactg ggcttcattt atgtggatct attgttggtt
     2941 gtacattcag ttgaatttat atgtatcaaa ttatcaaata attttaaaat aacatgcata
     3001 cctaaaataa ttttcaaagt ttcattgga
//
