LOCUS       NM_001398567            2614 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus asparaginyl-tRNA synthetase 1 (Nars1), transcript
            variant 3, mRNA.
ACCESSION   NM_001398567 XM_006254844
VERSION     NM_001398567.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Park,J.S., Park,M.C., Lee,K.Y., Goughnour,P.C., Jeong,S.J.,
            Kim,H.S., Kim,H.J., Lee,B.J., Kim,S. and Han,B.W.
  TITLE     Unique N-terminal extension domain of human asparaginyl-tRNA
            synthetase elicits CCR3-mediated chemokine activity
  JOURNAL   Int J Biol Macromol 120 (Pt A), 835-845 (2018)
   PUBMED   30171954
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Beaulande,M., Tarbouriech,N. and Hartlein,M.
  TITLE     Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence,
            functional expression in Escherichia coli and characterization as
            human autoantigen
  JOURNAL   Nucleic Acids Res 26 (2), 521-524 (1998)
   PUBMED   9421509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 20, 2021 this sequence version replaced XM_006254844.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1893982.1,
                                           SRR26360176.432742.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000018.1  60275683-60275782   c
            101-183             JAXUCZ010000018.1  60274570-60274652   c
            184-249             JAXUCZ010000018.1  60271540-60271605   c
            250-342             JAXUCZ010000018.1  60271360-60271452   c
            343-432             JAXUCZ010000018.1  60271183-60271272   c
            433-511             JAXUCZ010000018.1  60270046-60270124   c
            512-582             JAXUCZ010000018.1  60268906-60268976   c
            583-669             JAXUCZ010000018.1  60267562-60267648   c
            670-891             JAXUCZ010000018.1  60264975-60265196   c
            892-1091            JAXUCZ010000018.1  60264674-60264873   c
            1092-1227           JAXUCZ010000018.1  60264148-60264283   c
            1228-1341           JAXUCZ010000018.1  60263212-60263325   c
            1342-1473           JAXUCZ010000018.1  60261640-60261771   c
            1474-1605           JAXUCZ010000018.1  60261204-60261335   c
            1606-2614           JAXUCZ010000018.1  60259506-60260514   c
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2614
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /note="asparaginyl-tRNA synthetase 1"
                     /db_xref="GeneID:291556"
                     /db_xref="RGD:1307238"
     exon            1..100
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1737
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /EC_number="6.1.1.22"
                     /note="isoform 3 is encoded by transcript variant 3;
                     asparaginyl-tRNA synthetase, cytoplasmic; asparagine--tRNA
                     ligase, cytoplasmic"
                     /codon_start=1
                     /product="asparagine--tRNA ligase, cytoplasmic isoform 3"
                     /protein_id="NP_001385496.1"
                     /db_xref="GeneID:291556"
                     /db_xref="RGD:1307238"
                     /translation="MSSEVIRGTADMVLAELYVSDREGNDATGDGTKEKPFKTGLKAL
                     MTVGKEPFPTIYVDSQKENERWDVISKSQMKNIKKMWHREQMKSDSREKKEAEDNLRR
                     EKNLEEAKKIIIKNDPSLPEPACVKISALEGYRGQRVKVFGWVHRLRRQGKNLMFLVL
                     RDGTGYLQCVLSDDLCQCYNGVVLSTESSVAVYGTLNLTPKGKQAPGGHELSCDFWEL
                     VGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMITRCFRDHFFDRGY
                     CEVTTPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRA
                     EQSRTRRHLAEFTHVEAECPFLTFEDLLSRLEDLVCDVVDRVLKSPVASIVYDLNPNF
                     KAPKRPFRRMNYSDAIEWLREHDVKKEDGTFYEFGDDIPEAPERLMTDTINEPILLCR
                     FPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRSWDSEEILEGYKREGIDPA
                     PYYWYTDQRKYGTCPHGGYGLGLERFLSWILNRYHIRDVCLYPRFLQRCRP"
     exon            101..183
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            184..249
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            250..342
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            343..432
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            433..511
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            512..582
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            583..669
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            670..891
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1091
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1227
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1341
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1473
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1605
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..2614
                     /gene="Nars1"
                     /gene_synonym="LRRGT00113; Nars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcaaggaa gctttcagtg cacgttgggg tgagctggcg gcagtggtgc agtgtcgatg
       61 tcctcagagg tgatcagggg gactgcagac atggttctag cagagctcta tgtctctgac
      121 cgagaaggaa atgacgcaac gggggatgga accaaggaga aaccatttaa aacaggccta
      181 aaggctttga tgacagttgg aaaagagccg tttcccacca tttatgtgga ttcacagaag
      241 gaaaatgaga ggtgggacgt tatttctaag tcacagatga agaacatcaa aaagatgtgg
      301 caccgagaac agatgaagag tgattcccgg gagaagaaag aggcagaaga taacttacga
      361 agagaaaaga acctggagga agcaaaaaaa attatcatta aaaacgaccc gagcctgccg
      421 gagccagcat gtgtaaagat tagtgcatta gaaggataca gaggccagag agtgaaggtg
      481 tttggctggg tccacaggtt acgaaggcaa ggaaagaatc tgatgttttt ggtgttgcga
      541 gatggtacgg gttatcttca gtgtgtcttg tcagatgact tgtgtcagtg ttacaatgga
      601 gtagtcttgt ccactgagag tagcgtggcg gtatacggga cactgaacct aactccaaag
      661 ggcaaacagg ctccgggagg ccatgagctg agctgtgact tctgggaact ggtggggctg
      721 gccccagctg gaggagctga caacctgatc aatgaggagt ctgatgtgga cgtccagctc
      781 aacaaccggc atatgatgat ccggggagag aacatgtcca aaatcctgaa agcacggtcc
      841 atgatcacca ggtgctttag ggaccacttc ttcgacagag gctactgtga agtaaccact
      901 ccaacactgg tgcagacaca ggtggaaggt ggggccacac tcttcaagct tgactatttt
      961 ggggaagaag catttttgac ccagtcctca cagctgtacc tggagacctg ccttccagcc
     1021 ctgggagatg ttttttgcat agcccagtct tacagggctg aacagtccag gacacgaagg
     1081 catctggctg agttcactca cgtggaagcc gagtgtcctt tcctgacctt cgaggacctc
     1141 ctgagccgtc tagaggacct ggtgtgtgac gtggtggaca gagtcttgaa gtcaccagtg
     1201 gcgagcatag tgtatgacct taacccgaac tttaaagccc ccaaacggcc tttccggcgg
     1261 atgaactatt cagatgccat tgagtggctg agggagcacg atgtaaagaa agaagacggg
     1321 acgttctacg agttcggaga cgatattccc gaagcgcctg agagactgat gacagacacc
     1381 attaatgaac caatcctgct gtgtcggttt cctgtggaga tcaagtcctt ctacatgcag
     1441 cgctgtcctg aggatcctcg gcttaccgaa tctgtggatg tgttgatgcc caatgtcggt
     1501 gagattgtgg gaggctcaat gcgctcctgg gacagtgagg agattctaga aggctataaa
     1561 agggaaggga ttgaccccgc tccttattac tggtatacag atcagagaaa atatggtaca
     1621 tgtcctcacg gagggtatgg cttgggcttg gaacgatttc taagctggat tctgaacagg
     1681 tatcacatcc gagacgtgtg cttgtacccg agatttctcc agcgctgcag gccataacca
     1741 cgtggccctg aagcaggaag gaagtaaaga gttgagactg cctctacaaa agaacaaacg
     1801 cccaattgtc ccttgacttc ctgttggggg tagtagcttt ttcctgtctt tatgtttttt
     1861 cttcccatta tcagaaaaag cagtaggtgt tacttgaaca gcaaatgaca ttaataaaat
     1921 actcaataca aaattttgag aaaatacatg gcatatcact ccttagttat ggagacgttt
     1981 tattgtatta taggttataa tcattgtact aaataaacca tacatgatta ttcagttttt
     2041 aattatggtc tgacgttcca gtaactccat ctttttgtcc tcttaagtgt cactggaatt
     2101 ctttaatcta ttacataatc tgttatagca gacatctaaa agaaattggc tatgtgacaa
     2161 agatgctgga gtcgaataca taccccttac attcacatta atcttttctg aactcataca
     2221 gtgtgtataa tcctgagggg tatgggttga cagggaaaac ttaatgaagg ggaattggat
     2281 tacagtttgc aatgaacgtg atttggatgg tgggttatca aatgattcca acccccttag
     2341 cctttagttt aagaacgggg ggcagttagg gctttcctct ttgatgtaat tcctgagtaa
     2401 caaaaagtaa atctgttccc aaagactttg cacttagcca ccgtagacag ctaagtcatc
     2461 cctgcctttt ccgtgggtgc cgtctgcgct gctcgcacac tcagcaggtt tacagcggct
     2521 gcagtgcaca gttgctctcc cccaaatgca tgtcgtgtgt tccgatgggc tgtactccca
     2581 ctaaccaata aacgaacagt cgctaaaaac caaa
//
