LOCUS       NM_207609               1851 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus nicotinate phosphoribosyltransferase (Naprt),
            mRNA.
ACCESSION   NM_207609 XM_235435
VERSION     NM_207609.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Houtkooper,R.H., Canto,C., Wanders,R.J. and Auwerx,J.
  TITLE     The secret life of NAD+: an old metabolite controlling new
            metabolic signaling pathways
  JOURNAL   Endocr Rev 31 (2), 194-223 (2010)
   PUBMED   20007326
  REMARK    Review article
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Hara,N., Yamada,K., Shibata,T., Osago,H., Hashimoto,T. and
            Tsuchiya,M.
  TITLE     Elevation of cellular NAD levels by nicotinic acid and involvement
            of nicotinic acid phosphoribosyltransferase in human cells
  JOURNAL   J Biol Chem 282 (34), 24574-24582 (2007)
   PUBMED   17604275
  REMARK    GeneRIF: NA elevates cellular NAD levels through NAPRT function
            and, thus, protects the cells against stress, partly due to lack of
            feedback inhibition of NAPRT but not NamPRT by NAD
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Shin,M., Mori,Y., Kimura,A., Fujita,Y., Yoshida,K., Sano,K. and
            Umezawa,C.
  TITLE     NAD+ biosynthesis and metabolic fluxes of tryptophan in hepatocytes
            isolated from rats fed a clofibrate-containing diet
  JOURNAL   Biochem Pharmacol 52 (2), 247-252 (1996)
   PUBMED   8694849
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_207609.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY214330.1, SRR26643287.18545.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000007.1  109460514-109460817 c
            305-432             JAXUCZ010000007.1  109460224-109460351 c
            433-515             JAXUCZ010000007.1  109460061-109460143 c
            516-646             JAXUCZ010000007.1  109459816-109459946 c
            647-762             JAXUCZ010000007.1  109459591-109459706 c
            763-959             JAXUCZ010000007.1  109459039-109459235 c
            960-1100            JAXUCZ010000007.1  109458825-109458965 c
            1101-1185           JAXUCZ010000007.1  109458471-109458555 c
            1186-1266           JAXUCZ010000007.1  109458293-109458373 c
            1267-1369           JAXUCZ010000007.1  109458096-109458198 c
            1370-1524           JAXUCZ010000007.1  109457863-109458017 c
            1525-1632           JAXUCZ010000007.1  109457669-109457776 c
            1633-1851           JAXUCZ010000007.1  109457360-109457578 c
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1851
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /note="nicotinate phosphoribosyltransferase"
                     /db_xref="GeneID:315085"
                     /db_xref="RGD:1302945"
     exon            1..304
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1695
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /EC_number="6.3.4.21"
                     /note="NAPRTase; nicotinate phosphoribosyltransferase
                     domain-containing protein 1; nicotinate
                     phosphoribosyltransferase-like protein; nicotinate
                     phosphoribosyltransferase domain containing 1"
                     /codon_start=1
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="NP_997492.2"
                     /db_xref="GeneID:315085"
                     /db_xref="RGD:1302945"
                     /translation="MEMELDDQGHMVVRPLLTDLYQATMGLGYWRAGRACEEAEFELF
                     FRHCPFGGSFALTAGLQDCIRFLRAFRLRDADVQFLASVLPPDTDPAFFEHLRALDCS
                     RVSVRALPEGSLAFPGVPLLQVSGPLLLVQLLETPLLCLVSYASLVATNAARLRLIAG
                     PDKRLLEMGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFITS
                     FLGSEVPPDPMLAPASSEGPAVDLPASVNLWLKRVCIYLGLEEREPHPGERAAFVAYA
                     LAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAKEIRGI
                     FRTVGAEFQMPWLEFVPIAVSNNIDEKELARLAQKGSEVNVIGIGTNVVTCPKQPSMG
                     CVYKLVSVGGQPRIKLTEESQKRILPGSKAAFRFLDSEGSLLLDLLQLAEEPPPKAGQ
                     ELRVWLQGAQEPCTVKPAQVEPLLRLYLQQGQPYEPLPSLEESRAFAQQSLSRLRPAH
                     KQLQNPAVYQVALSEKLRALVDSLSARGAL"
     exon            305..432
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..515
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..646
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..762
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..959
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1100
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1185
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1266
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1369
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1524
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1632
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1851
                     /gene="Naprt"
                     /gene_synonym="Naprt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtgagtcg gttgtctgga cctgtgccct agggggtgga gtaggcgcca ttaatccaga
       61 gcctgtgtac cctgcggaat ggagatggag ctggacgacc aggggcacat ggtggtgcgg
      121 ccgctgctca ccgacctcta ccaggctaca atggggctgg gatactggcg tgcgggccgg
      181 gcatgtgagg aagcagagtt cgaactcttc ttccgccact gccccttcgg aggttccttt
      241 gccctgaccg ctggcctgca ggactgtata cgctttcttc gcgccttccg tctgcgcgat
      301 gcagatgtgc agttcctggc ttcagtgcta cccccagaca ctgaccctgc gttcttcgag
      361 caccttcgag cccttgactg ctctcgggtg tcggtgcgag ccctgccgga gggttccctc
      421 gctttccctg gtgtgccact tctgcaggtg tcggggcctc ttcttctggt acagctgcta
      481 gagactccgc tgctgtgtct ggtcagctac gctagcctcg tagccaccaa tgctgctcgg
      541 cttcgcttga ttgcaggacc ggacaagaga ctactagaga tgggcttgcg gcgagctcag
      601 ggtcccgatg ggggcttcac ggcctccatt tacagctacc tgggtgggtt tgacagcagc
      661 agcaacacac ttgctggaca actgagaggt gtgcccgtgg cagggaccct ggcccactcc
      721 ttcatcactt catttttggg tagtgaggta ccccctgacc cgatgttggc tccagcttct
      781 agtgagggcc ctgccgtgga cctgcctgcc agtgtaaatt tgtggctgaa gcgtgtgtgc
      841 atctacttgg ggctggagga gcgggagcca catccggggg aacgcgcagc atttgtggcc
      901 tatgcgctgg ccttcccccg ggctttccag ggcctgctag attcctacag cgtacgcagg
      961 agtggtcttc ctaacttcct ggcagtagcc ctggcacttg gggaactggg ctacagggca
     1021 gtgggtgtga ggctggacag cggtgacctg cttcagcagg ctaaggagat ccgagggatc
     1081 tttcgaactg ttggtgctga gttccagatg ccctggctag agttcgttcc cattgcagtc
     1141 agcaacaaca ttgacgagaa ggagctggca aggctagccc aaaagggcag tgaggtgaat
     1201 gtcatcggca ttggcaccaa tgtggtcact tgtcccaaac agccttctat gggctgtgtc
     1261 tacaagctgg tgtccgtggg aggccaacct cgaataaagc tgacggagga atcccagaag
     1321 agaatactgc cagggagcaa ggctgccttc cggttcctgg actctgaggg gtctttgcta
     1381 ctggacctac tgcagttagc agaagagccc ccacccaagg ctgggcagga actcagggta
     1441 tggcttcagg gggcccagga gccctgcact gtgaagccag cccaggtgga gccattgctg
     1501 cgactgtacc tgcaacaggg acagccgtat gaaccacttc catctctgga agagtccaga
     1561 gcctttgccc agcagtccct gagccgcctc cgacctgctc ataagcagct gcagaaccct
     1621 gctgtatacc aggtcgcatt gtcagagaag cttcgggcac tggtggacag tctgagtgct
     1681 cgaggtgccc tgtgaaaaag atcacaaaga acacgactct ctcttcccac aactttgtca
     1741 gccacgtgtc attagttcac aaatttctgc tgctcacttg ggacttccag ggctgggctg
     1801 gagttaggag tatgaggagg tgcagccccg gtgaataaaa aaaaaaaaaa a
//
