LOCUS       NM_199381               3776 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus N-acyl phosphatidylethanolamine phospholipase D
            (Napepld), mRNA.
ACCESSION   NM_199381 XM_006235911 XM_231294
VERSION     NM_199381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3776)
  AUTHORS   Geurts,L., Everard,A., Van Hul,M., Essaghir,A., Duparc,T.,
            Matamoros,S., Plovier,H., Castel,J., Denis,R.G., Bergiers,M.,
            Druart,C., Alhouayek,M., Delzenne,N.M., Muccioli,G.G.,
            Demoulin,J.B., Luquet,S. and Cani,P.D.
  TITLE     Adipose tissue NAPE-PLD controls fat mass development by altering
            the browning process and gut microbiota
  JOURNAL   Nat Commun 6, 6495 (2015)
   PUBMED   25757720
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3776)
  AUTHORS   Magotti,P., Bauer,I., Igarashi,M., Babagoli,M., Marotta,R.,
            Piomelli,D. and Garau,G.
  TITLE     Structure of human N-acylphosphatidylethanolamine-hydrolyzing
            phospholipase D: regulation of fatty acid ethanolamide biosynthesis
            by bile acids
  JOURNAL   Structure 23 (3), 598-604 (2015)
   PUBMED   25684574
REFERENCE   3  (bases 1 to 3776)
  AUTHORS   Bari,M., Battista,N., Valenza,M., Mastrangelo,N., Malaponti,M.,
            Catanzaro,G., Centonze,D., Finazzi-Agro,A., Cattaneo,E. and
            Maccarrone,M.
  TITLE     In vitro and in vivo models of Huntington's disease show
            alterations in the endocannabinoid system
  JOURNAL   FEBS J 280 (14), 3376-3388 (2013)
   PUBMED   23659592
REFERENCE   4  (bases 1 to 3776)
  AUTHORS   Sagar,D.R., Staniaszek,L.E., Okine,B.N., Woodhams,S., Norris,L.M.,
            Pearson,R.G., Garle,M.J., Alexander,S.P., Bennett,A.J.,
            Barrett,D.A., Kendall,D.A., Scammell,B.E. and Chapman,V.
  TITLE     Tonic modulation of spinal hyperexcitability by the endocannabinoid
            receptor system in a rat model of osteoarthritis pain
  JOURNAL   Arthritis Rheum 62 (12), 3666-3676 (2010)
   PUBMED   20722027
REFERENCE   5  (bases 1 to 3776)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3776)
  AUTHORS   Simon,G.M. and Cravatt,B.F.
  TITLE     Endocannabinoid biosynthesis proceeding through
            glycerophospho-N-acyl ethanolamine and a role for
            alpha/beta-hydrolase 4 in this pathway
  JOURNAL   J Biol Chem 281 (36), 26465-26472 (2006)
   PUBMED   16818490
REFERENCE   7  (bases 1 to 3776)
  AUTHORS   Morishita,J., Okamoto,Y., Tsuboi,K., Ueno,M., Sakamoto,H.,
            Maekawa,N. and Ueda,N.
  TITLE     Regional distribution and age-dependent expression of
            N-acylphosphatidylethanolamine-hydrolyzing phospholipase D in rat
            brain
  JOURNAL   J Neurochem 94 (3), 753-762 (2005)
   PUBMED   15992380
  REMARK    GeneRIF: These results demonstrated wide distribution of NAPE-PLD
            in various brain regions and its age-dependent expression,
            suggesting the central role of this enzyme in the formation of
            anandamide and other N-acylethanolamines in the brain.
REFERENCE   8  (bases 1 to 3776)
  AUTHORS   Fernandez-Tome,M., Favale,N., Kraemer,L., Gabriela Marquez,M.,
            Speziale,E. and Sterin-Speziale,N.
  TITLE     p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary
            phosphatidylcholine homeostasis
  JOURNAL   Biochem Biophys Res Commun 320 (4), 1055-1062 (2004)
   PUBMED   15249196
  REMARK    GeneRIF: Our results indicate that PGD(2) stimulatory effect
            involves both PLD and ERK1/2-MAPK activation, and both pathways
            operate independently of PC synthesis homeostasis.
REFERENCE   9  (bases 1 to 3776)
  AUTHORS   Okamoto,Y., Morishita,J., Tsuboi,K., Tonai,T. and Ueda,N.
  TITLE     Molecular characterization of a phospholipase D generating
            anandamide and its congeners
  JOURNAL   J Biol Chem 279 (7), 5298-5305 (2004)
   PUBMED   14634025
REFERENCE   10 (bases 1 to 3776)
  AUTHORS   Moesgaard,B., Petersen,G., Jaroszewski,J.W. and Hansen,H.S.
  TITLE     Age dependent accumulation of N-acyl-ethanolamine phospholipids in
            ischemic rat brain. A (31)P NMR and enzyme activity study
  JOURNAL   J Lipid Res 41 (6), 985-990 (2000)
   PUBMED   10828091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_006235911.4, NM_199381.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.864330.1,
                                           SRR26360190.1277774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000004.1  14253260-14253430
            172-481             JAXUCZ010000004.1  14268307-14268616
            482-1128            JAXUCZ010000004.1  14276705-14277351
            1129-1243           JAXUCZ010000004.1  14283342-14283456
            1244-3776           JAXUCZ010000004.1  14288478-14291010
FEATURES             Location/Qualifiers
     source          1..3776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3776
                     /gene="Napepld"
                     /gene_synonym="NAPE-PLD"
                     /note="N-acyl phosphatidylethanolamine phospholipase D"
                     /db_xref="GeneID:296757"
                     /db_xref="RGD:735197"
     exon            1..171
                     /gene="Napepld"
                     /gene_synonym="NAPE-PLD"
                     /inference="alignment:Splign:2.1.0"
     exon            172..481
                     /gene="Napepld"
                     /gene_synonym="NAPE-PLD"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1378
                     /gene="Napepld"
                     /gene_synonym="NAPE-PLD"
                     /EC_number="3.1.4.54"
                     /note="NAPE-hydrolyzing phospholipase D"
                     /codon_start=1
                     /product="N-acyl-phosphatidylethanolamine-hydrolyzing
                     phospholipase D"
                     /protein_id="NP_955413.1"
                     /db_xref="GeneID:296757"
                     /db_xref="RGD:735197"
                     /translation="MDENENSQSPAPSHQYPKETLRKRQNSVQNSGGSESSRLSRKSF
                     KLDYRLEEDVTKSKKGKDGRFVNPWPTWKNVSIPNVLRWLIMEKDHSSVPGSKEELDK
                     ELPVLKPYFISDPEEAGVREAGLRVTWLGHATLMVEMDELILLTDPMFSSRASPSQYM
                     GPKRFRRPPCTISELPPIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLGLLDW
                     MQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPW
                     NRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDV
                     QAKRSVAIHWGTFALANEHYLEPPVKLNEALERYGLKSEDFFILKHGESRYLNTDDKA
                     FEET"
     exon            482..1128
                     /gene="Napepld"
                     /gene_synonym="NAPE-PLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1243
                     /gene="Napepld"
                     /gene_synonym="NAPE-PLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..3776
                     /gene="Napepld"
                     /gene_synonym="NAPE-PLD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcctgaa cgcctgcggg agagcctcgg tgctgttatc ctggatcctc gcgggaggcg
       61 gttcgccgtc cgtggttctc cttctcaggt ttgctccttc gtcccagtat cggcgtggag
      121 cagcctttct ggggctgttt ggacacctcg ttgaagtgca gcgggtttcg acttcccacg
      181 gaaagacatg gatgaaaatg agaacagcca gtctccagcg ccaagccatc agtatccaaa
      241 agaaacactg aggaagcgtc agaattcagt gcagaattca ggaggaagcg agtcttccag
      301 gctctccagg aaaagcttca agctggacta cagactggag gaggacgtaa ccaaatcaaa
      361 gaaaggaaaa gacgggagat ttgtgaaccc atggccaacg tggaagaacg tctctatccc
      421 aaacgtgctc agatggctga taatggagaa agatcacagc agtgtcccgg gttccaaaga
      481 ggagcttgac aaagaactcc cagtgcttaa gccttatttt atcagtgacc cggaagaagc
      541 tggagtgaga gaggctggcc tacgagtcac gtggctggga cacgcgacgc tgatggtgga
      601 aatggacgag ctcatcctcc tcacggatcc catgttcagc tctcgagcct ctccctcgca
      661 gtacatgggt ccgaagcggt tccgccgtcc cccgtgtacc ataagcgaac tgcccccaat
      721 agatgctgtc ctcattagtc acaaccacta cgaccacctg gactacggct ctgtcctggc
      781 tctgaatgaa cggtttggca gtgagctgag gtggttcgtg ccgctgggcc ttctcgactg
      841 gatgcagaag tgtggctgtg agaacgtgat tgagctcgac tggtgggagg agaattgcgt
      901 ccctggccat gataaggtca ccttcgtttt cacgccctcc caacattggt gtaaaaggac
      961 cctcctggat gacaacaagg ttctgtgggg cagctggtct gtgctagggc cttggaatcg
     1021 gttctttttc gctggggata ctggttactg ccctgctttt gaagagattg gaaaaaggtt
     1081 tggtcctttt gacctcgcgg ctattcccat tggagcttat gagccaaggt ggtttatgaa
     1141 ataccaacat gctgacccag aggatgctgt aaggattcac attgacgttc aagccaagag
     1201 atccgtggcg attcactggg ggacttttgc cttagctaat gagcattact tagagccgcc
     1261 ggtgaaactg aatgaagctc tagagagata tggactcaag agtgaagact tcttcatcct
     1321 gaagcacgga gagtcacgat acttgaatac cgatgataaa gcctttgagg aaacatgaaa
     1381 gtcggaatta tcagtggaag catgaaaaga ctaagaaagt aacaaatatt acgacacttt
     1441 ccacgaggaa acaatttctg caagtgtgtg ttttgttctg tatcataact tgccaattga
     1501 taagatttgc ttacataaac tgtgggagtc tagggatggg ctatttaaga aactgtccaa
     1561 tatggacttt aaaaaaatca taccaatgat acagacattg caaaatctta ttttttatca
     1621 gaacactcta ttttagtggc agtaaaattt ctgaggttgt gaaaaactga cattacagtt
     1681 ctatttcttt ttctattcag ggctttctat aatggtcagt caagctttac ctaccgagat
     1741 cacacacaga cacacacaca cacacacaca ccacaccccc acacacacac cacaaccccc
     1801 ccacaccaca cacacacacc cccacacctc ccacacacac accacacaca cacacactct
     1861 tatagtcaca tgataagctt gccctcctca cggtgactaa ctgctggtca tggtgatgca
     1921 catctgcagc ctagcgctcc aaaggataaa gcaggcaggt gacaagttca aggccaactg
     1981 gagccacaag tgagatgagg aaacattagc ttacatgcca aatgttaagt gattttattt
     2041 tgttaagtat aagaacatag gtgttaggac taaatttatt gttttttaaa atagattttt
     2101 ttattgtggt cagatataca ttgcataaaa ttgtcgtttt aactatggtg aaaagcagct
     2161 ctttggcccc aggcattcac attttttgtg cagccatgag cacagagtac ttacatttct
     2221 aagagggcat catctacaca gctgcacttc ccaggttgag gccgatcggc agggaaggga
     2281 agagtgggtt tgagacttag agcaagggtt taatttcaaa ggcagacttt ctgccaagca
     2341 cagctgtaac taaggtatct cccagaggag agcgtagagc ctgaatgtga atacagcacg
     2401 caccggaatt atttcctttt ctacttcctc tatacacatt ctctttcctg ctctcagctc
     2461 caaccccaga tatgtcagta cgatttataa gtatgtttta catgacttgg aggtggtata
     2521 tatattttta tattaaatga cctataagca caattgtacc tttagtaagc cattgtgaaa
     2581 tacctggttg ttgtcttttt aagactgtgg gatctgctga acagagtctt tgtcccagca
     2641 tgcctctgca ctcacaggtt tgttatgagc ctcgaggaag tgagctgctg gggtattagg
     2701 gcattcagtc ttctagacca atggtacaaa acacagcacg ttttctctat gtcaaacatt
     2761 gtatagggaa tactcagtaa tttgatgcat ttgcatgggt gatgcatgcc accttggcct
     2821 ctcatcagaa tttcgtccat cccttcgtgg acctgattac cccacaatat gtaacttacg
     2881 tgtggaccca atattgccat gcacaagagg acaagttaac ctacctccga aggcagagaa
     2941 taattctttt tttcaagcac tttagaaatc cgagggagaa aacttaagat atcactctga
     3001 tacagaccag cacagtagac agctgaagag catcccatga tgcattgctc ctgtccggac
     3061 accacctcac ccacttacct tgtgacttga ttgagagggg aagagccaat gcaagcagtc
     3121 gtcagaatgt agtattttta tataaaatgt tcacatcagt tgggaaatgt gtgctgtcac
     3181 actgcgtgtg tagtgaactc ggcacagagg tactaaagca caagattcca cttaaagtca
     3241 gcttcaggga aaccgggcaa gcatcagctc cccactgcaa gcagacatga atctggaccc
     3301 tagggccggg ggtgccagcc ttgggcacac agctccaccg ggtaccactg tagccattgt
     3361 gtttctgtaa gccatactga aaattctctt aagcaactga tgtagcttaa gtgttgctcc
     3421 gtgaatggcc ttggcactgc ttgtgtgtcc acacctacgg ttcgaggcct tcctcatgag
     3481 cgtgatttgt gttcaggtcc ccagattgaa ctgggcctgc cttgtttgtt ttttttttta
     3541 ggcttcctca tggtttttgt ttctgtttac atgttaagct ccatgtgtta tgaagtgcat
     3601 cacatctctc taccacaaac accctagtga atggtttcca ctttattttt ctaatctaca
     3661 tttcaaaggc tatatgtgta aagtgaaaat aaattttgaa gaaaatcttg ttagtctaac
     3721 atacattgta aaactgtcta gcctacttct aaataaaata aatattatgg aaggta
//
