LOCUS       NM_080585               1504 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus NSF attachment protein alpha (Napa), mRNA.
ACCESSION   NM_080585
VERSION     NM_080585.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1504)
  AUTHORS   Gruden,M.A., Ratmirov,A.M., Storozheva,Z.I. and Sewell,R.D.E.
  TITLE     Analysis of NAPA Gene Expression in Brain Structures of Wistar Rats
            during the Formation of Long-Term Spatial Memory and Physical
            Activity under Stress Situation
  JOURNAL   Bull Exp Biol Med 175 (6), 810-813 (2023)
   PUBMED   37979021
  REMARK    GeneRIF: Analysis of NAPA Gene Expression in Brain Structures of
            Wistar Rats during the Formation of Long-Term Spatial Memory and
            Physical Activity under Stress Situation.
REFERENCE   2  (bases 1 to 1504)
  AUTHORS   Xi,Z., Deng,W., Wang,L., Xiao,F., Li,J., Wang,Z., Wang,X., Mi,X.,
            Wang,N. and Wang,X.
  TITLE     Association of Alpha-Soluble NSF Attachment Protein with Epileptic
            Seizure
  JOURNAL   J Mol Neurosci 57 (3), 417-425 (2015)
   PUBMED   26156199
  REMARK    GeneRIF: alphaSNAP expression showed no change in
            pilocarpine-induced epileptic rats in the acute phase, but in the
            chronic phase levels were lower. siRNA decreased the time of
            latency to seizure and increased the incidence of chronic
            idiopathic epilepsy seizures.
REFERENCE   3  (bases 1 to 1504)
  AUTHORS   Chen,D., Li,L., Yan,J., Yang,X., You,Y., Zhou,Y. and Ling,X.
  TITLE     The loss of alphaSNAP downregulates the expression of occludin in
            the intestinal epithelial cell of acute pancreatitis model
  JOURNAL   Pancreatology 14 (5), 347-355 (2014)
   PUBMED   25278303
  REMARK    GeneRIF: In severe acute pancreatitis, downregulated expression of
            alphaSNAP in intestinal epithelial cells leads to reduced occludin
            expression, apoptosis of intestinal epithelial cells, and increased
            permeability of the intestinal barrier.
REFERENCE   4  (bases 1 to 1504)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   5  (bases 1 to 1504)
  AUTHORS   Vivona,S., Cipriano,D.J., O'Leary,S., Li,Y.H., Fenn,T.D. and
            Brunger,A.T.
  TITLE     Disassembly of all SNARE complexes by N-ethylmaleimide-sensitive
            factor (NSF) is initiated by a conserved 1:1 interaction between
            alpha-soluble NSF attachment protein (SNAP) and SNARE complex
  JOURNAL   J Biol Chem 288 (34), 24984-24991 (2013)
   PUBMED   23836889
  REMARK    GeneRIF: a model of NSF-mediated disassembly in which the reaction
            is initiated by a 1:1 interaction between alpha-SNAP and the
            ternary SNARE complex, followed by NSF binding.
REFERENCE   6  (bases 1 to 1504)
  AUTHORS   Wong,S.H., Zhang,T., Xu,Y., Subramaniam,V.N., Griffiths,G. and
            Hong,W.
  TITLE     Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially
            associated with the early endosome
  JOURNAL   Mol Biol Cell 9 (6), 1549-1563 (1998)
   PUBMED   9614193
REFERENCE   7  (bases 1 to 1504)
  AUTHORS   Hanson,P.I., Roth,R., Morisaki,H., Jahn,R. and Heuser,J.E.
  TITLE     Structure and conformational changes in NSF and its membrane
            receptor complexes visualized by quick-freeze/deep-etch electron
            microscopy
  JOURNAL   Cell 90 (3), 523-535 (1997)
   PUBMED   9267032
REFERENCE   8  (bases 1 to 1504)
  AUTHORS   Bock,J.B., Klumperman,J., Davanger,S. and Scheller,R.H.
  TITLE     Syntaxin 6 functions in trans-Golgi network vesicle trafficking
  JOURNAL   Mol Biol Cell 8 (7), 1261-1271 (1997)
   PUBMED   9243506
REFERENCE   9  (bases 1 to 1504)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   10 (bases 1 to 1504)
  AUTHORS   Schmidt,D.D. and Messner,E.
  TITLE     The female hysterical personality disorder
  JOURNAL   J Fam Pract 4 (3), 573-577 (1977)
   PUBMED   845572
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_080585.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X89968.1, FQ216375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000001.1  85915435-85915577
            144-223             JAXUCZ010000001.1  85924319-85924398
            224-340             JAXUCZ010000001.1  85925818-85925934
            341-387             JAXUCZ010000001.1  85929403-85929449
            388-465             JAXUCZ010000001.1  85929922-85929999
            466-521             JAXUCZ010000001.1  85930160-85930215
            522-606             JAXUCZ010000001.1  85930290-85930374
            607-711             JAXUCZ010000001.1  85931013-85931117
            712-780             JAXUCZ010000001.1  85932076-85932144
            781-831             JAXUCZ010000001.1  85932474-85932524
            832-1504            JAXUCZ010000001.1  85933372-85934044
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1504
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /note="NSF attachment protein alpha"
                     /db_xref="GeneID:140673"
                     /db_xref="RGD:620855"
     exon            1..143
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..933
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /note="SNAP-alpha; N-ethylmaleimide sensitive fusion
                     protein attachment protein alpha;
                     N-ethylmaleimide-sensitive factor attachment protein,
                     alpha"
                     /codon_start=1
                     /product="alpha-soluble NSF attachment protein"
                     /protein_id="NP_542152.1"
                     /db_xref="GeneID:140673"
                     /db_xref="RGD:620855"
                     /translation="MDTSGKQAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEI
                     YARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAIN
                     CLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDVEKAIAHYEQSADYYKGEESNSS
                     ANKCLLKVAGYAAQLEQYQKAIDIYEQVGTSAMDSPLLKYSAKDYFFKAALCHFCIDM
                     LNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTESVKEYDSISRLDQWL
                     TTMLLRIKKTIQGDEEDLR"
     exon            144..223
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            224..340
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            341..387
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            388..465
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            466..521
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            522..606
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            607..711
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            712..780
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            781..831
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1504
                     /gene="Napa"
                     /gene_synonym="alpha-SNAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcttggc tgtgtcgggc ctgaaccgag cagctgcgcg acgtcatgga cacctccggg
       61 aagcaggctg aggctatggc gctgctggct gaagcggagc gcaaggtgaa gaactcgcag
      121 tccttcttct ccggcctctt tggaggttca tccaaaatag aggaagcatg cgagatctat
      181 gccagagctg cgaacatgtt caagatggcc aagaactgga gcgctgctgg gaacgctttc
      241 tgccaggctg cccaactgca cctacagctc cagagcaagc acgatgcagc cacctgcttt
      301 gtggacgccg gcaacgcttt caagaaagct gacccccaag aggccattaa ctgtctgatg
      361 agagcaattg agatctatac agacatgggc agattcacaa tcgcagccaa gcaccacatc
      421 tccattgctg agatctatga gacagaactg gtggatgtag agaaggccat tgcccactac
      481 gagcaatctg cagactacta caaaggagaa gagtccaaca gctcagccaa caagtgtctg
      541 ctgaaggtgg ctggctacgc cgcacagctg gagcagtacc agaaggctat cgacatctat
      601 gagcaggtgg ggaccagcgc catggacagt cccctcctca agtacagcgc caaagactac
      661 ttcttcaagg cggccctttg ccacttctgc atcgacatgc tgaacgccaa gcttgctgtt
      721 cagaagtatg aggagctgtt ccctgccttc tcggattccc gggaatgcaa gctgatgaaa
      781 aagctgctgg aagcccatga ggaacagaat gtggacagct acacagagtc ggtgaaggaa
      841 tatgactcca tctccagact ggaccagtgg cttaccacca tgcttctacg aatcaagaag
      901 accattcagg gtgatgagga agacctgcgc taggcctcca gccactgcct tccacccatc
      961 tgtctgtcac agaggtggag ccaacacctc ccaccaggag tctgaaggag tgggtgcaat
     1021 gtaggcctca tcctccaggg caccaggcaa gctctcctgg atggctggtc accctatgcc
     1081 cactgcgtcc ttcaccccgc catttattta agctcccaaa ggtgtcctcc tgctctggaa
     1141 aacccacctg gacagattct ccaatacaga cttctctgtg tgcttcagga acctggagtc
     1201 agcatccagt cccatctcct gaccagcagt gtactaaggc tatttccata tctcctacct
     1261 tgtcccctag cagagataag aacacaggta gttctgagac ttgctctccc tggctggggg
     1321 tagcctctgc ccctggagct ttcccttgtt cctacaatgc caacctctca ggttagaccc
     1381 agccctggag ctcacagggt gccttggccc tgccctgccc tgcacctgct tctctccctg
     1441 catccaggtc tgtctgtcga cttgaagctg cggctggccc aagaaagaca ataaaacctg
     1501 ccac
//
