LOCUS       NM_053561               2122 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus nucleosome assembly protein 1-like 1 (Nap1l1),
            mRNA.
ACCESSION   NM_053561 XM_346790
VERSION     NM_053561.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Qiao,H., Li,Y., Feng,C., Duo,S., Ji,F. and Jiao,J.
  TITLE     Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and
            Differentiation in the Developing Brain
  JOURNAL   Cell Rep 22 (9), 2279-2293 (2018)
   PUBMED   29490266
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Reddy,D., Bhattacharya,S., Jani,V., Sonavane,U., Joshi,R. and
            Gupta,S.
  TITLE     Biochemical and Biophysical Characterisation of Higher Oligomeric
            Structure of Rat Nucleosome Assembly Protein 1
  JOURNAL   Protein J 37 (1), 58-69 (2018)
   PUBMED   29209909
  REMARK    GeneRIF: Molecular dynamic simulation (MDS) of the two structures
            also revealed that rNAP1 dimer is more stable owing to the
            extensive hydrogen bonding in comparison to yNAP1. Further, in
            vitro kinase assay showed that the phosphorylation of rNAP1 favors
            oligomerization with no effect on its histone binding capacity
REFERENCE   3  (bases 1 to 2122)
  AUTHORS   Takahashi,N., Hozumi,Y., Tanaka,T., Okada,M., Iseki,K., Hayasaka,K.
            and Goto,K.
  TITLE     Cellular expression and localization of DGKzeta-interacting
            NAP1-like proteins in the brain and functional implications under
            hypoxic stress
  JOURNAL   Histochem Cell Biol 142 (5), 461-471 (2014)
   PUBMED   24893663
  REMARK    GeneRIF: The molecular interaction between DGKzeta and Nap1l1 was
            attenuated after hypoxic stress.
REFERENCE   4  (bases 1 to 2122)
  AUTHORS   Schimmack,S., Taylor,A., Lawrence,B., Alaimo,D.,
            Schmitz-Winnenthal,H., Buchler,M.W., Modlin,I.M. and Kidd,M.
  TITLE     A mechanistic role for the chromatin modulator, NAP1L1, in
            pancreatic neuroendocrine neoplasm proliferation and metastases
  JOURNAL   Epigenetics Chromatin 7, 15 (2014)
   PUBMED   25071868
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2122)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   6  (bases 1 to 2122)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   7  (bases 1 to 2122)
  AUTHORS   Nagata,T., Takahashi,Y., Ishii,Y., Asai,S., Nishida,Y., Murata,A.,
            Koshinaga,T., Fukuzawa,M., Hamazaki,M., Asami,K., Ito,E., Ikeda,H.,
            Takamatsu,H., Koike,K., Kikuta,A., Kuroiwa,M., Watanabe,A.,
            Kosaka,Y., Fujita,H., Miyake,M. and Mugishima,H.
  TITLE     Transcriptional profiling in hepatoblastomas using high-density
            oligonucleotide DNA array
  JOURNAL   Cancer Genet Cytogenet 145 (2), 152-160 (2003)
   PUBMED   12935928
REFERENCE   8  (bases 1 to 2122)
  AUTHORS   Line,A., Slucka,Z., Stengrevics,A., Silina,K., Li,G. and Rees,R.C.
  TITLE     Characterisation of tumour-associated antigens in colon cancer
  JOURNAL   Cancer Immunol Immunother 51 (10), 574-582 (2002)
   PUBMED   12384809
REFERENCE   9  (bases 1 to 2122)
  AUTHORS   Cataldo,L.M., Zhang,Y., Lu,J. and Ravid,K.
  TITLE     Rat NAP1: cDNA cloning and upregulation by Mpl ligand
  JOURNAL   Gene 226 (2), 355-364 (1999)
   PUBMED   9931510
REFERENCE   10 (bases 1 to 2122)
  AUTHORS   Simon,H.U., Mills,G.B., Kozlowski,M., Hogg,D., Branch,D., Ishimi,Y.
            and Siminovitch,K.A.
  TITLE     Molecular characterization of hNRP, a cDNA encoding a human
            nucleosome-assembly-protein-I-related gene product involved in the
            induction of cell proliferation
  JOURNAL   Biochem J 297 (Pt 2) (Pt 2), 389-397 (1994)
   PUBMED   8297347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO574484.1, AF062594.1, CF110129.1, CA511505.1 and BE117287.1.
            
            On Oct 8, 2005 this sequence version replaced NM_053561.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF062594.1, SRR8487227.146230.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               CO574484.1         17-135
            120-697             AF062594.1         105-682
            698-1582            CF110129.1         133-1017
            1583-1621           CA511505.1         414-452
            1622-2122           BE117287.1         1-501               c
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2122
                     /gene="Nap1l1"
                     /note="nucleosome assembly protein 1-like 1"
                     /db_xref="GeneID:89825"
                     /db_xref="RGD:71094"
     exon            1..145
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..182
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1341
                     /gene="Nap1l1"
                     /note="NAP-1-related protein"
                     /codon_start=1
                     /product="nucleosome assembly protein 1-like 1"
                     /protein_id="NP_446013.2"
                     /db_xref="GeneID:89825"
                     /db_xref="RGD:71094"
                     /translation="MADIDNKEQSELDQDLEDVEEVEEEETGEETKIKARQLTVQMMQ
                     NPQILAALQERLDGLVDTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHDL
                     ERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEVSEELKEKAKIEDEKKDEE
                     KEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFILEFHF
                     EPNEYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKK
                     QKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPENGDLDDDAEAILAADFEIGHFLRERI
                     IPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ"
     exon            183..268
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..371
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..513
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..594
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..723
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..795
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..935
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1081
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1101
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1224
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1254
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1305
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..2106
                     /gene="Nap1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttttagcg ccatctgctc gcggcgccgc ctcccgctcc tcccgccgcc gccgccgccg
       61 ccgccgccgc cgccgccgcc gccgccctga gtcactgcct gcgcagctcc ggccgctcgg
      121 ctccgcgtcc gagcctcctg gaacgatatt tggagttctt aaaagatggc agacattgac
      181 aacaaagaac agtctgaact tgatcaagat ttggaagatg ttgaagaagt agaagaagaa
      241 gaaacgggtg aagaaacaaa aatcaaagca cgtcagctaa ctgttcagat gatgcaaaat
      301 cctcagattc ttgcagctct tcaggaaaga cttgatggtc tggtagacac accaacagga
      361 tacattgaaa gcttgcctaa ggtagtcaaa agacgggtga atgctctcaa gaatcttcaa
      421 gttaaatgtg cacagataga agccaaattc tatgaggaag ttcatgacct tgagagaaag
      481 tatgctgttc tctatcagcc tctgtttgat aagcgatttg agatcattaa tgcaatttat
      541 gaacctacag aagaagaatg tgaatggaaa ccagatgagg aagatgaagt ttcggaggag
      601 ctgaaagaaa aggccaagat tgaagatgag aaaaaggatg aagaaaaaga agaccctaaa
      661 ggaattcctg agttttggtt gacagttttt aagaatgttg atttgctcag tgatatggtt
      721 caggaacatg acgaacctat tctgaagcac ttgaaagata ttaaagtgaa gttttcggac
      781 gctggccagc ctatgagttt tatcttagaa tttcactttg aacccaacga atatttcaca
      841 aatgaagtgt taacaaagac ttacaggatg aggtcagaac cagatgattc tgatcccttt
      901 tcttttgatg gaccagaaat tatgggttgt acagggtgcc agatagattg gaaaaaagga
      961 aagaatgtta ctttgaaaac cattaagaag aagcagaaac acaagggccg tgggacagtt
     1021 cgtactgtga ctaaaacagt ttccaatgat tctttcttta acttttttgc tcctcctgaa
     1081 gttcctgaga atggagatct ggatgacgat gctgaggcaa tactggctgc agactttgaa
     1141 attggtcact ttttacgtga gcgtataatc ccaagatcag tgttatactt cactggagaa
     1201 gctattgagg acgatgacga tgactatgat gaagaaggtg aagaagctga tgaggaaggg
     1261 gaagaagaag gagatgagga aaacgatcca gactatgacc caaagaagga tcaaaaccca
     1321 gccgagtgca agcagcagtg agcagtgact ggccttgagg acggcctccc tgtaatagcc
     1381 taaacatgac tcatttactt acagccttat ggttttgtat tttcttgata gaatcagtaa
     1441 gtttctaagg gaaaggaaat tgatattttg cagaccaatt tgttctaacc agcatcccaa
     1501 ctctagctct gtcagccacg ttaccgcatc caccctttac tgcatgctca ggtcgctgca
     1561 gtctggttct cctgggagat tttcatcatg tagctattgg atacaattat gaaaaccaac
     1621 tgttgaacat atttggagta gctgtttctt tcctagagaa ccaaagctgt ttcagctggt
     1681 agaacaggtt gaagcccgcc tgcattagct gtgctttccg ttatgtttag agggatgcac
     1741 aggcacgaca tcattccagg aaggaaaatt gtggttaaga atttccagta agatcatact
     1801 taatagctga gatttttaag gcatttttat gttttcaatg acataacaaa agtcaactca
     1861 tgcttatagc aaggtgaaca aaccctaggt tctcttcaga cgttaattga tagtatttaa
     1921 tgtacgttga aagttaacct ccattaatga catcttttct ttgtggtagg gcctaccttc
     1981 tgctttcctg gaaaagatga atatacatca tttgaaccta ttttgagttt ttctgttgtt
     2041 ttgtttgcct aattttgttt ttatagctta aaataaaaat atgacacagt cttagctctc
     2101 acgggaaaaa aaaaaaaaaa aa
//
