LOCUS       NM_001108908            1461 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus nanos C2HC-type zinc finger 2 (Nanos2), mRNA.
ACCESSION   NM_001108908 XM_001075271 XM_344868
VERSION     NM_001108908.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1461)
  AUTHORS   Pandey V, Tripathi A and Dubey PK.
  TITLE     Expression and intracellular localization of Nanos2-homologue
            protein in primordial germ cells and spermatogonial stem cells
  JOURNAL   Zygote 27 (2), 82-88 (2019)
   PUBMED   30888312
  REMARK    GeneRIF: Stage-specific expression of Nanos2 occurred on different
            embryonic developmental days, while during the postnatal period
            Nanos2 expression is restricted to undifferentiated spermatogonia
            and spermatogonial stem cells .
REFERENCE   2  (bases 1 to 1461)
  AUTHORS   Bhandari D, Raisch T, Weichenrieder O, Jonas S and Izaurralde E.
  TITLE     Structural basis for the Nanos-mediated recruitment of the CCR4-NOT
            complex and translational repression
  JOURNAL   Genes Dev 28 (8), 888-901 (2014)
   PUBMED   24736845
REFERENCE   3  (bases 1 to 1461)
  AUTHORS   Saba R, Kato Y and Saga Y.
  TITLE     NANOS2 promotes male germ cell development independent of meiosis
            suppression
  JOURNAL   Dev Biol 385 (1), 32-40 (2014)
   PUBMED   24183939
REFERENCE   4  (bases 1 to 1461)
  AUTHORS   Jorgensen A, Nielsen JE, Blomberg Jensen M, Graem N and Rajpert-De
            Meyts E.
  TITLE     Analysis of meiosis regulators in human gonads: a sexually
            dimorphic spatio-temporal expression pattern suggests involvement
            of DMRT1 in meiotic entry
  JOURNAL   Mol Hum Reprod 18 (11), 523-534 (2012)
   PUBMED   22899867
REFERENCE   5  (bases 1 to 1461)
  AUTHORS   Geyer CB, Saba R, Kato Y, Anderson AJ, Chappell VK, Saga Y and Eddy
            EM.
  TITLE     Rhox13 is translated in premeiotic germ cells in male and female
            mice and is regulated by NANOS2 in the male
  JOURNAL   Biol Reprod 86 (4), 127 (2012)
   PUBMED   22190708
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1461)
  AUTHORS   Suzuki A, Igarashi K, Aisaki K, Kanno J and Saga Y.
  TITLE     NANOS2 interacts with the CCR4-NOT deadenylation complex and leads
            to suppression of specific RNAs
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3594-3599 (2010)
   PUBMED   20133598
REFERENCE   7  (bases 1 to 1461)
  AUTHORS   Sada A, Suzuki A, Suzuki H and Saga Y.
  TITLE     The RNA-binding protein NANOS2 is required to maintain murine
            spermatogonial stem cells
  JOURNAL   Science 325 (5946), 1394-1398 (2009)
   PUBMED   19745153
REFERENCE   8  (bases 1 to 1461)
  AUTHORS   Kusz KM, Tomczyk L, Sajek M, Spik A, Latos-Bielenska A, Jedrzejczak
            P, Pawelczyk L and Jaruzelska J.
  TITLE     The highly conserved NANOS2 protein: testis-specific expression and
            significance for the human male reproduction
  JOURNAL   Mol Hum Reprod 15 (3), 165-171 (2009)
   PUBMED   19168545
REFERENCE   9  (bases 1 to 1461)
  AUTHORS   Suzuki A and Saga Y.
  TITLE     Nanos2 suppresses meiosis and promotes male germ cell
            differentiation
  JOURNAL   Genes Dev 22 (4), 430-435 (2008)
   PUBMED   18281459
REFERENCE   10 (bases 1 to 1461)
  AUTHORS   Tsuda M, Sasaoka Y, Kiso M, Abe K, Haraguchi S, Kobayashi S and
            Saga Y.
  TITLE     Conserved role of nanos proteins in germ cell development
  JOURNAL   Science 301 (5637), 1239-1241 (2003)
   PUBMED   12947200
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344868.3, XM_001075271.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1461
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1461
                     /gene="Nanos2"
                     /gene_synonym="RGD1562436"
                     /note="nanos C2HC-type zinc finger 2"
                     /db_xref="GeneID:365213"
                     /db_xref="RGD:1562436"
     exon            1..1461
                     /gene="Nanos2"
                     /gene_synonym="RGD1562436"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..490
                     /gene="Nanos2"
                     /gene_synonym="RGD1562436"
                     /codon_start=1
                     /product="nanos homolog 2"
                     /protein_id="NP_001102378.1"
                     /db_xref="GeneID:365213"
                     /db_xref="RGD:1562436"
                     /translation="MDLPPFDRWRDYFNLSQVVLGIIQSRKQRLEDEVSEELASRPQG
                     MSERGLEVSPGSLATACNFCKHNGESRHVYTSHQLKTPEGVVVCPILRHYVCPLCGAT
                     GDQAHTLKYCPLNSSQQSLYRRSGRNSAGRRVKR"
ORIGIN      
        1 ataactcctg ctcctgcctt ctgacctcac agcccctgtc ccagaccctc tccagtgccc
       61 acagccacac ataagtgtca tggacctgcc accctttgac aggtggagag actactttaa
      121 cctgagccag gtggtgctgg gtataattca gagccggaag caaagactgg aggatgaggt
      181 gtctgaggaa ctggcctcca ggccccaagg gatgagtgag cggggcctgg aggtctcccc
      241 cggaagtctg gctactgcat gcaacttttg caagcacaac ggagagtctc gtcacgtcta
      301 cacctcacac cagctgaaga cgcctgaagg ggtggtagtg tgtcccatcc tgaggcatta
      361 cgtatgtcct ctctgtgggg ccactggcga ccaggcgcat acactcaagt attgcccact
      421 caacagcagc cagcagtctc tctaccgtcg cagtggacga aactcagctg gtcgcagagt
      481 caagcgataa gtgaggccct gtgaggtacc tatcacccat gtcccagacc ctccttctga
      541 tcctagcacc ctctgctatg ctcacccagc cctctggagg tccctggatc ttaacgttct
      601 ctgtgccttc aagatcctga aacattggga aatactggca gcccagactg tgtctcagac
      661 agtcctggtt actgggagaa ccattctcca tggaccgtgt gaatcttggg tagcttcttt
      721 tggattatga gggactggtg atgatgctaa gatggtctct ttgacttctc agttcccctg
      781 tgaagatccc ttgggggatc cttggatttg ccatcctgta gaattctagt ctgacgggcc
      841 agtcttcaga atctggggac agggccagag acggatcctg attgtcactg ccaagaagtt
      901 gatgctggcg ctgactgaga gaccatccat ctaccttcac cttcagcact ggcagactca
      961 aaatttctcc atggaccatt caagttcagc cctcagttcc atgattgtgc cgtctgtccg
     1021 aaataagagg gttcaggaac gagaggaggg tcggtcgaga ggagggtcgg gtcgggaccc
     1081 cctgggaagg ctgccagatt atttgtaacc tcacagactg cttcgggtga gctcaagccc
     1141 acagatctct cgcttcatta ctaaccccag ttcactctgt tcctgctccc agccccagtc
     1201 gttgatggat ccctaccccc gacccctgtg ggtgatagac atgtctctct tccacctgta
     1261 cagtattgtt gagtgtgtta agtcagtgtg cgtcccacgg tgaggagagt ctgagacctc
     1321 atgggaatgg cgactgctta ggttttaatt ttagggtcag aaaagaatgc caattgggtt
     1381 ttatgctgtt taagaggtgg gcttggatat tggatgagga gtgggtgctg tctcctgaat
     1441 aaagtgttgt tgttagtcgg c
//
